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Viral infections of the central nervous system

DOID EFO Endpoint Browser PheWeb

AB1_VIRAL_CNS

viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A80-A89
  • Hospital discharge: ICD-9 — 04[5-9]|071|06[2-4]
  • Hospital discharge: ICD-8 — 04[0-3]|06[2-5]|071
  • Cause of death: ICD-10 — A80-A89
  • Cause of death: ICD-9 — 04[5-9]|071|06[2-4]
  • Cause of death: ICD-8 — 04[0-3]|06[2-5]|071

2 out of 7 registries used, show all original rules.

2626

4. Check minimum number of events

None

2626

5. Include endpoints

2962

6. Filter based on genotype QC (FinnGen only)

2962

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26420 13206 13059
Only index persons 23392 11811 11581
Unadjusted period prevalence (%)
Whole population 0.37 0.38 0.36
Only index persons 0.44 0.43 0.44
Median age at first event (years)
Whole population 31.76 34.52 28.71
Only index persons 30.31 33.40 27.16

-FinnGen-

Key figures

All Female Male
Number of individuals 2962 1770 1192
Unadjusted period prevalence (%) 0.57 0.60 0.53
Median age at first event (years) 35.98 34.45 38.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2713
Matched controls
27127
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A87.9
ICD-10 Finland
Viral meningitis, unspecified
3380.3
323.0
998
5
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
323.0
620
*
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
+∞
294.2
277
*
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
+∞
209.1
198
*
TAB00
NOMESCO Finland
Lumbar puncture
9.7
206.1
448
544
R51.80
ICD-10 Finland
Headache
3.5
123.5
679
2340
AA1AD
NOMESCO Finland
CT of head and brain
3.1
121.3
835
3391
06599
ICD-8 Finland
Viral encephalitis, unspecified
+∞
100.6
96
*
G03.9
ICD-10 Finland
Meningitis, unspecified
51.8
83.2
100
20
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.9
78.3
353
998
04300
ICD-8 Finland
NA
+∞
68.0
65
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
36.5
66.1
85
24
5AB01
NOMESCO Finland
NA
131.0
60.1
64
5
R50.9
ICD-10 Finland
Fever, unspecified
2.6
55.0
473
2067
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
54.3
52
*
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
52.2
50
*
A84.8
ICD-10 Finland
Other tick-borne viral encephalitis
+∞
51.2
49
*
A87.8
ICD-10 Finland
Other viral meningitis
507.0
50.6
50
*
04499
ICD-8 Finland
Late effects of actue poliomyelitis
+∞
49.1
47
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
48.9
1097
7217
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
48.9
196
492
04597
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Suspecta
+∞
48.0
46
*
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
+∞
48.0
46
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
46.4
470
2220
A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
44.9
43
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
44.2
405
1815
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.9
42.3
143
302
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.5
42.0
206
615
N02AX02
ATC
tramadol; systemic, rectal
1.8
41.7
1081
7346
A89
ICD-10 Finland
Unspecified viral infection of central nervous system
413.6
41.2
41
*
N03AX14
ATC
levetiracetam; systemic
5.4
39.8
124
239
R41.0
ICD-10 Finland
Disorientation, unspecified
5.1
37.1
121
246
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.4
36.7
190
591
0498X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Other specified non-arthropod-borne viral diseases of central nervous system
+∞
36.5
35
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
35.5
269
1076
A85.8
ICD-10 Finland
Other specified viral encephalitis
+∞
35.5
34
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.1
33.5
135
340
N03AX16
ATC
pregabalin; oral
1.9
32.8
620
3732
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
32.8
546
3145
J05AB11
ATC
valaciclovir; oral
2.2
32.3
381
1906
R42
ICD-10 Finland
Dizziness and giddiness
1.9
32.0
543
3142
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.9
29.8
85
148
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
29.5
936
6563
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
29.2
366
1876
N71
ICPC
Meningitis/encephalitis
151.6
28.7
30
*
H02AB06
ATC
prednisolone; systemic
1.6
28.6
1160
8654
R51
ICD-10 Finland
Headache
2.9
27.6
182
667
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
27.4
540
3270
B00.4
ICD-10 Finland
Herpesviral encephalitis
+∞
27.1
26
*
B94.1
ICD-10 Finland
Sequelae of viral encephalitis
+∞
27.1
26
*
B34.9
ICD-10 Finland
Viral infection, unspecified
3.9
26.8
112
293
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
26.3
1168
8851
R4120
NOMESCO Finland
Occupational therapy
2.7
26.2
193
758
J01AA02
ATC
doxycycline; systemic
1.6
25.9
1954
16766
N02BE01
ATC
paracetamol; systemic, rectal
1.7
25.1
2186
19361
A81.0
ICD-10 Finland
Creutzfeldt-Jakob disease
+∞
25.0
24
*
J01DB01
ATC
cefalexin; oral
1.6
24.9
2127
18709
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
8.1
24.9
56
70
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.7
24.2
84
184
R03AC02
ATC
salbutamol; inhalant
1.5
24.1
1327
10493
N03AX12
ATC
gabapentin; oral
1.9
24.0
403
2303
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
23.9
268
1303
B91
ICD-10 Finland
Sequelae of poliomyelitis
20.8
23.9
35
17
N03AF02
ATC
oxcarbazepine; oral
3.4
23.4
119
366
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
23.3
448
2678
1380A
ICD-9 Finland
Late effects of acute poliomyelitis[SEQUELAE POLIOMYELITIDIS]
+∞
22.9
22
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
22.8
665
4490
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.1
21.8
86
214
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
21.1
286
1504
M03BX02
ATC
tizanidine; oral
1.5
21.1
1559
12966
A81.2
ICD-10 Finland
Progressive multifocal leukoencephalopathy
+∞
20.9
20
*
F05.9
ICD-10 Finland
Delirium, unspecified
4.8
20.7
70
150
ZX120
NOMESCO Finland
Intravenous
2.1
20.6
247
1236
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
20.5
886
6565
G44.2
ICD-10 Finland
Tension-type headache
1.8
20.1
356
2063
0479X
ICD-9 Finland
Meningitis due to enterovirus, Unspecified viral meningitis
+∞
19.8
19
*
N06AA09
ATC
amitriptyline; systemic
2.0
19.5
248
1272
N05BA01
ATC
diazepam; systemic, rectal
1.8
19.4
336
1928
R53
ICD-10 Finland
Malaise and fatigue
1.7
19.2
502
3276
G41.9
ICD-10 Finland
Status epilepticus, unspecified
10.4
19.1
37
36
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
18.3
19.1
29
16
A02BC02
ATC
pantoprazole; systemic
1.4
19.0
1534
12851
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
19.0
594
4057
G02.0*A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
18.8
18
*
N03AG01
ATC
valproic acid; systemic, rectal
2.3
18.7
182
827
G05.1
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
100.7
18.6
20
*
J01FF01
ATC
clindamycin; systemic
1.6
18.3
650
4578
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
18.2
219
1099
N03AX18
ATC
lacosamide; systemic
8.6
18.1
39
46
N01
ICPC
Headache
1.9
18.1
293
1642
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
18.1
374
2275
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
18.1
261
1403
N06AX21
ATC
duloxetine; oral
1.9
18.0
275
1510
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
17.8
1280
10432
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
17.8
503
3345
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
17.7
17
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
17.7
330
1941
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
42.3
17.3
21
5
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
17.1
198
977
N05CF01
ATC
zopiclone; oral
1.5
16.9
715
5223
J01MA02
ATC
ciprofloxacin; systemic
1.5
16.8
868
6610
A41.9
ICD-10 Finland
Sepsis, unspecified
3.0
16.7
98
336
G05.1*A85.0
ICD-10 Finland
Encephalitis, myelitis or encephalomyelitis (in) enteroviral
+∞
16.7
16
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
6.6
16.6
42
64
J01MA12
ATC
levofloxacin; systemic
1.7
16.6
414
2657
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.7
16.5
71
193
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.3
16.5
157
709
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
16.3
356
2198
J01DA01
ATC
[U] cefalexin; systemic
1.4
16.3
1536
13061
P01AB01
ATC
metronidazole; oral, rectal
1.4
16.3
945
7355
N02AA05
ATC
oxycodone; systemic
1.8
15.9
296
1738
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
15.9
1133
9148
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
15.9
280
1616
N06AX11
ATC
mirtazapine; oral
1.5
15.9
754
5631
N05BA04
ATC
oxazepam; oral
1.5
15.8
587
4155
A02BC05
ATC
esomeprazole; systemic
1.4
15.7
923
7185
183
Kela drug reimbursment
Lamotrigin and topiramate
6.0
15.7
43
73
N03AF01
ATC
carbamazepine; oral, rectal
2.4
15.7
138
598
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
4.1
15.7
60
147
N06AB04
ATC
citalopram; systemic
1.6
15.7
512
3518
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
15.6
890
6883
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
15.5
213
1123
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
15.1
649
4740
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
14.0
15.0
25
18
J01FA06
ATC
roxithromycin; oral
1.4
14.9
953
7519
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
14.8
377
2428
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
14.8
304
1839
G43.9
ICD-10 Finland
Migraine, unspecified
2.2
14.7
158
755
04301
ICD-8 Finland
NA
+∞
14.6
14
*
J01FA10
ATC
azithromycin; systemic
1.4
14.3
1464
12501
R11
ICD-10 Finland
Nausea and vomiting
1.9
14.1
200
1067
J02AC01
ATC
fluconazole; systemic
1.4
14.1
947
7521
XA400
NOMESCO Finland
EEG
6.7
14.0
35
53
N06AB10
ATC
escitalopram; oral
1.5
14.0
501
3508
M01AE02
ATC
naproxen; oral, rectal
1.4
13.8
1392
11817
N05BA09
ATC
clobazam; oral
7.8
13.8
31
40
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
4.2
13.7
52
127
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.8
13.7
57
152
04500
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Coxsackie virus
+∞
13.5
13
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.0
13.2
173
897
N03AE01
ATC
clonazepam; systemic
2.1
13.0
141
677
A02BC01
ATC
omeprazole; systemic
1.5
12.8
604
4471
N05AH04
ATC
quetiapine; oral
1.5
12.7
410
2796
J01CA04
ATC
amoxicillin; systemic
1.4
12.7
2060
18784
J05AB01
ATC
aciclovir; systemic
1.5
12.7
490
3483
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
12.5
240
1420
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
12.5
393
2663
04699
ICD-8 Finland
Other enterovirus diseases of central nervous system
+∞
12.5
12
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
17.4
12.5
19
11
120
Kela drug reimbursment
Hypogammaglobulinaemia
17.4
12.5
19
11
M54.5
ICD-10 Finland
Low back pain
1.4
12.4
761
5912
WX892
NOMESCO Finland
Monitored bed care
2.0
12.3
166
869
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.8
12.3
51
136
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
12.3
133
638
R4110
NOMESCO Finland
Physiotherapy
1.4
12.3
574
4240
A02BC03
ATC
lansoprazole; oral
1.4
12.2
620
4652
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
37.7
12.2
15
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
12.2
297
1889
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
12.0
560
4132
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
11.9
179
976
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
11.9
661
5039
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
11.7
514
3743
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
11.5
589
4422
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
11.5
450
3204
G02.0*B02.1
ICD-10 Finland
Zoster meningitis
+∞
11.5
11
*
JN4BD
NOMESCO Finland
Extensive body CT
1.8
11.4
218
1288
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
11.3
174
956
WX730
NOMESCO Finland
Conventional respirator
3.8
11.3
47
126
N06AX16
ATC
venlafaxine; oral
1.6
11.3
340
2279
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
11.2
523
3852
N03AB02
ATC
phenytoin; systemic
4.4
11.2
39
89
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
11.2
147
764
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
4.9
11.1
35
72
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
11.1
310
2041
R55
ICD-10 Finland
Syncope and collapse
1.7
11.0
220
1320
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
11.0
99
436
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.4
11.0
94
405
M01AB05
ATC
diclofenac; systemic, rectal
1.3
11.0
1583
13974
N03AX09
ATC
lamotrigine; oral
2.1
10.9
124
609
N29
ICPC
Neurological sympt/complt other
3.4
10.8
51
152
H02AB09
ATC
hydrocortisone; systemic
2.9
10.8
65
230
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
4.5
10.8
37
83
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
10.8
645
4968
J01EA01
ATC
trimethoprim; systemic
1.4
10.7
541
4040
A28
ICPC
Limited function/disability NOS
1.6
10.7
260
1649
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
21.5
10.7
15
7
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.2
10.6
55
176
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
10.6
381
2658
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.7
10.6
211
1266
H02AB07
ATC
prednisone; oral
1.6
10.6
308
2046
A69.2
ICD-10 Finland
Lyme disease
2.2
10.6
110
521
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.9
10.6
153
827
C01CA24
ATC
epinephrine; parenteral
1.9
10.6
160
875
A02BA02
ATC
ranitidine; systemic
1.5
10.5
394
2772
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
10.5
384
2688
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
1.9
10.5
148
791
5CM18
NOMESCO Finland
NA
10.1
10.5
20
20
M25.5
ICD-10 Finland
Pain in joint
1.4
10.5
632
4874
B01AA03
ATC
warfarin; systemic
1.5
10.4
334
2270
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
10.4
10
*
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
10.4
10
*
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
32.6
10.3
13
*
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
10.2
422
3031
R06.0
ICD-10 Finland
Dyspnoea
1.4
10.2
494
3662
N99
ICPC
Neurological disease other
4.2
10.1
37
89
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
10.0
614
4748
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.1
10.0
107
512
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
9.9
345
2386
B01AB05
ATC
enoxaparin; parenteral
1.4
9.9
598
4606
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.2
9.9
95
435
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
9.9
855
6976
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.7
9.8
224
1396
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
9.7
157
880
A06AD11
ATC
lactulose; oral
1.6
9.7
270
1776
SPAT1254
SPAT
Administration of medicine
1.5
9.7
315
2149
N70
ICPC
Poliomyelitis
13.4
9.7
16
12
ZXA10
NOMESCO Finland
Bilateral
1.5
9.6
381
2711
N03AX11
ATC
topiramate; oral
2.5
9.6
73
298
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
9.6
327
2254
UJF32
NOMESCO Finland
Coloscopy
1.4
9.5
516
3898
C07AB07
ATC
bisoprolol; oral
1.3
9.5
905
7474
L28
ICPC
Limited function/disability (L)
1.5
9.5
298
2014
N02AC04
ATC
dextropropoxyphene; oral
2.4
9.4
80
343
F07.1
ICD-10 Finland
Postencephalitic syndrome
+∞
9.4
9
*
C03CA01
ATC
furosemide; systemic
1.4
9.3
492
3700
F05.8
ICD-10 Finland
Other delirium
6.0
9.2
24
40
J01CA08
ATC
pivmecillinam; oral
1.3
9.2
888
7343
SPAT1216
SPAT
Assessment of functional ability
1.5
9.1
289
1958
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
4.3
9.1
32
75
G41.0
ICD-10 Finland
Grand mal status epilepticus
11.5
9.1
16
14
H02AB04
ATC
methylprednisolone; systemic
1.5
9.0
305
2098
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.9
9.0
126
673
J01FA09
ATC
clarithromycin; systemic
1.3
9.0
732
5899
N30.0
ICD-10 Finland
Acute cystitis
1.5
8.9
292
1990
N05CF02
ATC
zolpidem; oral
1.4
8.9
390
2830
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.1
8.9
97
468
7840A
ICD-9 Finland
Symptoms involving head and neck, Headache
4.2
8.9
32
77
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
4.4
8.8
30
68
J03.9
ICD-10 Finland
Acute tonsillitis, unspecified
1.9
8.7
132
726
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
8.7
256
1704
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.0
8.7
103
519
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.0
8.5
108
556
N05BA12
ATC
alprazolam; oral
1.6
8.5
221
1429
J01MA14
ATC
moxifloxacin; systemic
1.7
8.5
179
1094
G03.8
ICD-10 Finland
Meningitis due to other specified causes
90.3
8.4
9
*
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
8.4
2292
21663
A46
ICD-10 Finland
Erysipelas
1.5
8.4
254
1704
M01AX17
ATC
nimesulide; oral
1.4
8.4
484
3690
R07.3
ICD-10 Finland
Other chest pain
1.6
8.4
199
1257
6BA02
NOMESCO Finland
NA
7.9
8.4
18
23
0632A
ICD-9 Finland
Tick-borne viral encephalitis, Central European encephalitis[PUUTIAISEN VÄLITTÄMÄ ENKEFALIITTI (KUMLINGE)]
+∞
8.3
8
*
A87.2
ICD-10 Finland
Lymphocytic choriomeningitis
+∞
8.3
8
*
B02.1
ICD-10 Finland
Zoster meningitis
+∞
8.3
8
*
G03.0
ICD-10 Finland
Nonpyogenic meningitis
+∞
8.3
8
*
A84.1
ICD-10 Finland
Central European tick-borne encephalitis
+∞
8.3
8
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
8.3
672
5402
R06AE07
ATC
cetirizine; oral
1.3
8.3
1020
8681
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
1.9
8.3
120
651
N05CD07
ATC
temazepam; oral
1.6
8.2
239
1584
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.6
8.2
211
1360
G44.8
ICD-10 Finland
Other specified headache syndromes
3.5
8.2
36
104
R03DC03
ATC
montelukast; oral
1.4
8.1
346
2495
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.7
8.1
167
1013
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
8.1
411
3065
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
8.0
350
2533
UKC02
NOMESCO Finland
Cystoscopy
1.5
8.0
270
1853
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.5
8.0
60
245
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.7
8.0
156
934
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.0
7.9
99
509
64090
ICD-8 Finland
Artificial termination of pregnancy performed for medical reasons, Woman's illness or physical defect (medicines. Cause)
4.2
7.9
28
67
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.7
7.9
146
858
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.7
7.9
160
969
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.8
7.8
142
829
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.8
908
7658
G81.9
ICD-10 Finland
Hemiplegia, unspecified
3.8
7.7
31
83
M79.6
ICD-10 Finland
Pain in limb
1.3
7.7
763
6298
N28
ICPC
Limited function/disability (N)
3.3
7.7
36
109
G03.1
ICD-10 Finland
Chronic meningitis
45.1
7.7
9
*
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
6.4
7.7
19
30
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
7.7
283
1983
PA7BD
NOMESCO Finland
CT angiography of neck and brain
3.1
7.7
39
126
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.6
7.6
51
196
UJF30
NOMESCO Finland
Ileoscopy through colon
1.6
7.6
199
1286
WX110
NOMESCO Finland
Local anesthesy
1.3
7.6
1677
15259
R01AD09
ATC
mometasone; nasal
1.3
7.6
1037
8922
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.6
7.6
209
1371
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.4
7.5
402
3020
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.5
7.5
241
1641
WX704
NOMESCO Finland
Intubation
1.7
7.5
151
913
R47.0
ICD-10 Finland
Dysphasia and aphasia
4.0
7.4
28
71
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
3.2
7.4
37
118
G05.1*B01.1
ICD-10 Finland
Varicella encephalitis
80.3
7.4
8
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.1
7.4
80
389
N05AX08
ATC
risperidone; systemic
1.7
7.3
160
989
N06AA10
ATC
nortriptyline; systemic
2.6
7.3
51
199
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
4.7
7.3
23
49
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
3.2
7.3
36
114
A81.8
ICD-10 Finland
Other atypical virus infections of central nervous system
+∞
7.3
7
*
A87
ICD-10 Finland
Viral meningitis
+∞
7.3
7
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.7
7.2
149
906
B02.0
ICD-10 Finland
Zoster encephalitis
15.8
7.2
11
7
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.6
7.2
170
1073
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.7
7.2
152
930
A88.1
ICD-10 Finland
Epidemic vertigo
20.1
7.1
10
5
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
7.1
656
5357
R25.2
ICD-10 Finland
Cramp and spasm
2.4
7.1
54
224
N06AB03
ATC
fluoxetine; oral
1.5
7.1
264
1853
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
8.8
7.0
14
16
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.0
7.0
90
468
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.1
7.0
36
118
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.7
7.0
131
775
L17
ICPC
Foot/toe symptom/complaint
1.3
6.9
499
3932
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.7
6.9
141
855
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
2.0
6.9
87
448
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.8
6.9
107
597
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
6.9
1246
11027
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.0
6.9
87
451
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.9
567
4556
F43.1
ICD-10 Finland
Post-traumatic stress disorder
2.2
6.8
63
285
N06AX03
ATC
mianserin; oral
1.9
6.8
93
497
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
3.2
6.8
33
104
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.5
6.8
237
1641
L03
ICPC
Low back symptom/complaint
1.3
6.8
500
3952
R29.1
ICD-10 Finland
Meningismus
40.1
6.8
8
*
32309
ICD-8 Finland
Encephalitis, myelitis and encephalomyelitis, Unspecified
40.1
6.8
8
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
16.7
6.7
10
6
A03
ICPC
Fever
1.4
6.7
365
2748
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
6.7
1116
9777
R03BA02
ATC
budesonide; inhalant
1.4
6.7
380
2881
S06.0
ICD-10 Finland
Concussion
1.5
6.7
224
1537
S20.2
ICD-10 Finland
Contusion of thorax
1.9
6.7
97
527
F43.21
ICD-10 Finland
Adaptation disorder with prolonged depression
3.4
6.6
30
90
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
7.8
6.6
14
18
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
1.9
6.6
91
488
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.0
6.6
35
118
S18
ICPC
Laceration/cut
1.3
6.6
839
7125
C08DA01
ATC
verapamil; systemic
2.0
6.6
80
408
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.7
6.6
124
737
G40
ICD-10 Finland
Epilepsy
3.6
6.6
27
75
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
8.7
6.5
13
15
SPAT1229
SPAT
Assessment of need for aid
1.6
6.5
145
902
J01.1
ICD-10 Finland
Acute frontal sinusitis
2.7
6.5
42
158
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.5
6.5
185
1224
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
4.0
6.5
24
61
G43.3
ICD-10 Finland
Complicated migraine
2.6
6.5
44
173
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.0
6.4
81
420
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
1.8
6.4
97
537
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
6.4
222
1537
M01AH05
ATC
etoricoxib; oral
1.2
6.4
1326
11879
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.3
1262
11247
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.6
6.3
148
934
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
1.9
6.3
85
454
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.4
6.3
312
2316
R40.2
ICD-10 Finland
Coma, unspecified
4.0
6.3
23
58
M01AB55
ATC
diclofenac, combinations; oral
1.7
6.3
126
761
G05.1*B02.0
ICD-10 Finland
Zoster encephalitis
+∞
6.2
6
*
0459X
ICD-9 Finland
Acute poliomyelitis, unspecified[POLIOMYELITIS ACUTA NUD,NUD]
+∞
6.2
6
*
A81.9
ICD-10 Finland
Atypical virus infection of central nervous system, unspecified
+∞
6.2
6
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.5
6.2
187
1253
P01BA02
ATC
hydroxychloroquine; oral
1.6
6.2
175
1155
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
1.7
6.2
112
657
M05BA04
ATC
alendronic acid; oral
1.6
6.2
142
889
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
1.9
6.2
80
420
C08CA01
ATC
amlodipine; oral
1.3
6.2
622
5120
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.1
6.2
67
329
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.1
6.2
66
320
M54.2
ICD-10 Finland
Cervicalgia
1.6
6.2
145
915
G43.8
ICD-10 Finland
Other migraine
2.8
6.2
36
128
M79.1
ICD-10 Finland
Myalgia
1.4
6.2
261
1882
M02AA07
ATC
piroxicam; topical
1.3
6.2
728
6117
G93.4
ICD-10 Finland
Encephalopathy, unspecified
7.7
6.1
13
17
RS221
NOMESCO Finland
NA
2.7
6.1
37
136
W19
ICD-10 Finland
Unspecified fall
1.5
6.1
184
1237
SPAT1301
SPAT
No procedures
1.3
6.1
653
5425
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
6.1
191
1293
R02
ICPC
Shortness of breath/dyspnoea
1.5
6.1
231
1630
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
6.1
567
4629
WX882
NOMESCO Finland
High dependency care
2.3
6.0
53
237
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
2.5
6.0
43
171
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.5
6.0
215
1499
TPH07
NOMESCO Finland
Cathetrisation of artery
1.5
6.0
180
1205
SPAT1263
SPAT
Sampling
1.2
6.0
944
8192

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_VIRAL_CNS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_CNS 1.972 [1.72, 2.26] < 0.001
Birth year 0.992 [0.98, 1.0] 0.077

During the follow-up period (1.1.1998 — 31.12.2019), 1041 out of 7272 females with AB1_VIRAL_CNS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_CNS 1.907 [1.66, 2.2] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1073 out of 7452 males with AB1_VIRAL_CNS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_CNS.

N-year risk Females Males
1 0.143% 0.403%
5 1.046% 2.112%
10 2.439% 5.56%
15 4.779% 10.616%
20 8.764% 17.503%

Relationships between endpoints

↥

Index endpoint: AB1_VIRAL_CNS – Viral infections of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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