Depression medications

ANTIDEPRESSANTS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

136285

6. Filter based on genotype QC (FinnGen only)

131176

Control definitions (FinnGen only)

Control exclude
NEURO_COMORBIDITIES

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1301037 797631 495459
Only index persons 1186033 738521 447512
Unadjusted period prevalence (%)
Whole population 19.33 22.85 13.84
Only index persons 23.35 27.15 17.08
Median age at first event (years)
Whole population 45.17 45.51 44.51
Only index persons 43.34 43.69 42.76

-FinnGen-

Key figures

All Female Male
Number of individuals 131176 85811 45365
Unadjusted period prevalence (%) 29.93 33.70 22.78
Median age at first event (years) 44.50 42.24 48.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
170
Matched controls
1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
445.8
67.5
68
*
N06AB03
ATC
fluoxetine; oral
801.2
64.5
64
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
152.0
63.9
69
6
N06AB10
ATC
escitalopram; oral
157.3
58.3
63
5
N06AB06
ATC
sertraline; oral
337.2
55.2
57
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
118.4
52.9
59
6
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
29.0
49.7
73
34
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
151.4
48.5
53
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
117.9
46.4
52
5
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
45.8
44.9
58
15
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
124.0
41.2
46
*
IGP01
NOMESCO Finland
Psychiatric family contact
199.3
36.1
39
*
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
192.7
35.1
38
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
132.8
35.0
39
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
99.6
34.0
39
*
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
+∞
32.7
33
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
337.8
32.2
34
*
ZY010
NOMESCO Finland
Hospital outpatient
29.0
32.0
46
17
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
119.9
32.0
36
*
N05AX08
ATC
risperidone; systemic
56.7
31.5
39
7
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
325.1
31.2
33
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
312.6
30.2
32
*
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
30.2
29.0
41
14
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
62.0
26.2
32
5
F90.0
ICD-10 Finland
Disturbance of activity and attention
16.8
24.0
41
25
P01
ICPC
Feeling anxious/nervous/tense
8.8
23.1
56
71
IGV01
NOMESCO Finland
Psychiatric network contact
121.0
23.0
26
*
N05AX12
ATC
aripiprazole; systemic
115.5
22.0
25
*
F93.89
ICD-10 Finland
Other childhood emotional disorders
115.5
22.0
25
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
+∞
21.5
22
*
N06AX26
ATC
vortioxetine; oral
+∞
21.5
22
*
N06AX16
ATC
venlafaxine; oral
209.7
21.1
23
*
N05BA04
ATC
oxazepam; oral
110.1
21.1
24
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
10.4
21.0
45
45
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
16.2
20.9
36
22
Z2446
NOMESCO Finland
Social worker
10.3
20.0
43
43
SPAT1389
SPAT
Visit based on need for special support
7.3
20.0
55
83
N06BA04
ATC
methylphenidate; oral
14.9
19.7
35
23
SPAT1307
SPAT
Psychosocial counselling and guidance
7.5
19.4
52
75
ZYC01
NOMESCO Finland
Remote contact by phone
28.0
18.9
27
9
P76
ICPC
Depressive disorder
38.5
18.9
25
6
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
+∞
18.5
19
*
IEP03
NOMESCO Finland
Focused parental counselling
49.7
17.5
22
*
N06AX11
ATC
mirtazapine; oral
62.8
17.3
21
*
N06AX12
ATC
bupropion; oral
89.4
17.2
20
*
P03
ICPC
Feeling depressed
9.4
17.1
38
40
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
14.2
16.8
30
20
Z2445
NOMESCO Finland
Psychologist
7.9
16.7
42
54
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
15.4
16.2
28
17
IEP99
NOMESCO Finland
Other psychiatric family intervention
56.2
15.4
19
*
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
10.9
15.3
31
27
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
17.7
15.3
25
13
N05AH03
ATC
olanzapine; systemic
79.4
15.3
18
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
149.0
15.3
17
*
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
+∞
14.5
15
*
F32.1
ICD-10 Finland
Moderate depressive episode
74.5
14.3
17
*
C07AA05
ATC
propranolol; systemic
14.6
13.7
24
15
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
+∞
13.5
14
*
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
69.7
13.4
16
*
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
129.8
13.4
15
*
SPAT1240
SPAT
Therapeutic discussion
7.7
13.3
33
41
P74
ICPC
Anxiety disorder/anxiety state
17.1
12.8
21
11
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
+∞
12.6
13
*
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
+∞
12.6
13
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
12.6
13
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
21.0
12.5
19
8
F84.5
ICD-10 Finland
Asperger syndrome
22.6
12.1
18
7
F32
ICD-10 Finland
Depressive episode
34.8
12.0
16
*
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
19.8
11.6
18
8
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
19.8
11.6
18
8
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
60.1
11.5
14
*
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
55.5
10.6
13
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
+∞
10.6
11
*
ZY000
NOMESCO Finland
Hospital inpatient
+∞
10.6
11
*
Z2221
NOMESCO Finland
Medical doctor
4.1
10.6
47
116
R5599
NOMESCO Finland
Other rehabilitation service
25.9
10.5
15
5
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
101.9
10.5
12
*
F40.1
ICD-10 Finland
Social phobias
30.1
10.2
14
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
10.4
10.0
20
17
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
14.8
10.0
17
10
F41.1
ICD-10 Finland
Generalized anxiety disorder
37.0
9.9
13
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
50.9
9.7
12
*
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
24.0
9.7
14
5
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
+∞
9.6
10
*
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
18.5
9.6
15
7
IEP01
NOMESCO Finland
Psychoeducation, family
92.8
9.6
11
*
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
92.8
9.6
11
*
N06AB04
ATC
citalopram; systemic
92.8
9.6
11
*
IEP02
NOMESCO Finland
Child-centred family therapy
33.9
9.0
12
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
46.4
8.8
11
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.6
8.7
26
42
Z3231
NOMESCO Finland
Registered nurse
2.9
8.7
65
234
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
+∞
8.6
9
*
F34.1
ICD-10 Finland
Dysthymia
+∞
8.6
9
*
F41.00
ICD-10 Finland
Moderate panic disorder
+∞
8.6
9
*
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
25.4
8.5
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.6
8.4
25
40
Z07
ICPC
Education problem
9.9
8.4
17
15
N03AX09
ATC
lamotrigine; oral
20.3
8.0
12
5
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
41.9
7.9
10
*
P06
ICPC
Sleep disturbance
7.2
7.8
19
23
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.7
7.7
27
52
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.7
77
325
H03AA01
ATC
levothyroxine sodium; systemic
75.0
7.7
9
*
N06AX21
ATC
duloxetine; oral
75.0
7.7
9
*
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
+∞
7.7
8
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
7.7
8
*
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
+∞
7.7
8
*
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
+∞
7.7
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
5.4
7.6
23
38
Z3226
NOMESCO Finland
Physiotherapist
3.3
7.5
41
118
Z71.8
ICD-10 Finland
Other specified counselling
3.1
7.2
45
140
D01
ICPC
Abdominal pain/cramps general
3.0
7.2
48
157
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
37.5
7.0
9
*
F41.8
ICD-10 Finland
Other specified anxiety disorders
37.5
7.0
9
*
C07AB07
ATC
bisoprolol; oral
8.6
7.0
15
15
F51.0
ICD-10 Finland
Nonorganic insomnia
7.7
7.0
16
18
T36
ICD-10 Finland
Poisoning by systemic antibiotics
15.4
6.8
11
6
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
66.3
6.8
8
*
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
+∞
6.7
7
*
F39
ICD-10 Finland
Unspecified mood [affective] disorder
+∞
6.7
7
*
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
+∞
6.7
7
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
+∞
6.7
7
*
IAB03
NOMESCO Finland
Neuropsychiatric consultation
+∞
6.7
7
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
+∞
6.7
7
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
+∞
6.7
7
*
R51.80
ICD-10 Finland
Headache
3.5
6.7
32
83
N03AX16
ATC
pregabalin; oral
10.0
6.6
13
11
K30
ICD-10 Finland
Functional dyspepsia
11.3
6.5
12
9
R4190
NOMESCO Finland
Nutritional therapy
5.2
6.5
20
34
ZXE10
NOMESCO Finland
More than one and less than three hours
2.8
6.4
49
172
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
6.4
38
113
F41.09
ICD-10 Finland
UNS Panic Syndrome
25.0
6.4
9
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
25.0
6.4
9
*
M03BX02
ATC
tizanidine; oral
6.1
6.4
17
24
D11
ICPC
Diarrhoea
3.5
6.1
29
75

Mortality – FinRegistry

Association

Association between endpoint ANTIDEPRESSANTS and mortality.

Females

Parameter HR [95% CI] p-value
ANTIDEPRESSANTS 1.488 [1.39, 1.6] < 0.001
Birth year 0.991 [0.98, 1.0] 0.031

During the follow-up period (1.1.1998 — 31.12.2019), 103249 out of 611724 females with ANTIDEPRESSANTS died.

Males

Parameter HR [95% CI] p-value
ANTIDEPRESSANTS 1.798 [1.66, 1.95] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 79482 out of 387224 males with ANTIDEPRESSANTS died.

Mortality risk

Mortality risk for people of age

years, who have ANTIDEPRESSANTS.

N-year risk Females Males
1 0.079% 0.249%
5 0.594% 1.465%
10 1.431% 3.877%
15 2.817% 7.036%
20 5.127% 11.528%

Relationships between endpoints

Index endpoint: ANTIDEPRESSANTS – Depression medications

GWS hits: 35

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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