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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_BONE_CARTILAGE_EXALLC for full statistics.

Malignant neoplasm of bone and articular cartilage

DOID Endpoint Browser

C3_BONE_CARTILAGE

bone neoplasm: A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

307

6. Filter based on genotype QC (FinnGen only)

307

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4

Similar endpoints

↥

List of similar endpoints to Malignant neoplasm of bone and articular cartilage based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 307 134 173
Unadjusted period prevalence (%) 0.06 0.05 0.08
Median age at first event (years) 50.08 47.61 52.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
289
Matched controls
2887
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
102.1
98.9
105
16
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
120.4
47.5
50
5
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
47.2
44
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
485.1
43.4
42
*
L03AA02
ATC
filgrastim; parenteral
24.1
41.8
60
31
130
Kela drug reimbursment
Malignant tumour
9.8
40.9
90
127
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
37.3
35
*
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
+∞
32.9
31
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11.0
31.2
62
70
N02AA05
ATC
oxycodone; systemic
5.8
31.0
103
253
JN4BD
NOMESCO Finland
Extensive body CT
6.3
29.9
90
194
N03AX16
ATC
pregabalin; oral
4.6
27.1
116
367
NF3AA
NOMESCO Finland
Femur X-ray examination
17.5
26.0
41
27
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
25.4
24
*
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
25.4
24
*
H02AB02
ATC
dexamethasone; systemic
5.8
25.0
78
172
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
17.8
25.0
39
25
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
24.3
23
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
260.6
24.0
24
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
8.0
24.0
57
86
C90.0
ICD-10 Finland
Multiple myeloma
27.5
23.6
32
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
23.3
182
933
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
71.1
23.2
26
*
NER30
NOMESCO Finland
Extended excision of soft tissue tumour of pelvis
+∞
23.2
22
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
8.6
23.0
52
72
WF049
NOMESCO Finland
Radiotherapy of metastasis
11.0
21.7
42
44
R4110
NOMESCO Finland
Physiotherapy
3.7
21.6
125
497
C90.2
ICD-10 Finland
Extramedullary plasmacytoma
+∞
21.1
20
*
A04AA01
ATC
ondansetron; systemic, rectal
6.7
20.9
56
100
XW000
NOMESCO Finland
Bone marrow biopsy
9.0
20.8
45
58
B01AB05
ATC
enoxaparin; parenteral
3.5
20.5
131
558
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.3
20.3
145
668
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
19.3
126
540
NG4AA
NOMESCO Finland
Lower leg X-ray examination
11.3
19.0
36
36
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
22.8
19.0
27
13
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.6
18.8
35
34
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.9
18.7
89
295
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.7
18.2
55
114
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
17.9
17
*
A03FA01
ATC
metoclopramide; systemic, rectal
3.5
17.9
99
370
XX3DW
NOMESCO Finland
Time consuming IT work
4.8
17.2
61
151
JN4AD
NOMESCO Finland
Body CT examination
5.1
16.5
55
127
GD1AD
NOMESCO Finland
Thorax CT examination
8.2
16.4
37
51
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
12.8
15.9
28
24
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.5
15.9
35
46
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
+∞
15.8
15
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
15.7
51
114
WW500
NOMESCO Finland
Blood transfusion
6.9
15.0
38
62
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
14.9
60
168
B01AB10
ATC
tinzaparin; parenteral
5.8
14.8
43
84
9220/3-C41.3
ICD-O-3
Chondrosarcoma, NOS, of rib, sternum, clavicle and associated joints
+∞
14.7
14
*
C41.49
ICD-10 Finland
Malignant tumor of the pelvic bones, sacrum and coccyx other or unspecified histology
+∞
14.7
14
*
C40.02
ICD-10 Finland
Chondrosarcoma of the scapula and long bones of the upper extremity
+∞
14.7
14
*
L03AA13
ATC
pegfilgrastim; parenteral
8.1
14.7
33
45
WX402
NOMESCO Finland
General anaesthesia
3.6
14.6
74
253
WF004
NOMESCO Finland
Palliative radiotherapy
11.8
14.3
26
24
WW300
NOMESCO Finland
Transfer of autologic stem cells
31.8
14.0
18
6
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.1
13.8
45
101
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
78.9
13.7
15
*
GAE06
NOMESCO Finland
Excision of lesion of chest wall
+∞
13.6
13
*
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
27.3
13.5
18
7
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
14.8
13.5
22
16
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
13.0
13.4
23
19
WX306
NOMESCO Finland
Lumbar epidural anesthesy
5.6
13.2
39
78
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.7
12.8
37
72
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
33.7
12.7
16
5
9370/3-C41.4
ICD-O-3
Chordoma, NOS, of pelvic bones, sacrum, coccyx and associated joints
+∞
12.6
12
*
C41.42
ICD-10 Finland
Chondrosarcoma of the pelvic bones, sacrum and coccyx
+∞
12.6
12
*
L71
ICPC
Malignant neoplasm musculoskeletal
135.6
12.5
13
*
A04AA02
ATC
granisetron; systemic, transdermal
5.0
12.4
41
93
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
39.4
12.3
15
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
10.8
12.2
23
23
153
Kela drug reimbursment
Lenalidomid
28.1
12.2
16
6
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
28.1
12.2
16
6
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
17.3
11.8
18
11
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
6.9
11.7
29
46
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
8.1
11.7
26
35
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
67.8
11.7
13
*
9101
FHL
Bone biopsy
67.8
11.7
13
*
ZX120
NOMESCO Finland
Intravenous
3.8
11.7
52
158
C41.32
ICD-10 Finland
Chondrosarcoma of the ribs, sternum and clavicle
+∞
11.5
11
*
C40.00
ICD-10 Finland
Malignant tumor of the scapula and the long bones of the upper extremity without histology
124.7
11.5
12
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
11.2
11.5
21
20
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.3
11.5
35
73
WZC30
NOMESCO Finland
Teaching
3.3
11.3
61
215
JN4CD
NOMESCO Finland
Very extensive body CT
6.0
11.3
31
57
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.5
11.0
53
172
TPX15
NOMESCO Finland
Removal of vascular injection port
62.3
10.7
12
*
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
10.5
10
*
C41.40
ICD-10 Finland
Pelvic bones, sacrum and coccyx
+∞
10.5
10
*
9220/3-C40.0
ICD-O-3
Chondrosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
10.5
10
*
R50.9
ICD-10 Finland
Fever, unspecified
3.1
10.5
63
240
L04AX04
ATC
lenalidomide; oral
24.4
10.3
14
6
N02BE01
ATC
paracetamol; systemic, rectal
2.9
10.2
253
2036
N02AX02
ATC
tramadol; systemic, rectal
2.3
10.2
138
823
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
17.5
10.0
15
9
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
17.5
10.0
15
9
WF002
NOMESCO Finland
Radical radiotherapy
4.9
9.9
32
71
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
8.9
9.7
20
24
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
56.9
9.7
11
*
329
Kela drug reimbursment
Lenalidomide
31.2
9.5
12
*
Z51.5
ICD-10 Finland
Palliative care
4.2
9.4
36
95
C41.22
ICD-10 Finland
Chondrosarcoma of the spine
+∞
9.4
9
*
9220/3-C41.4
ICD-O-3
Chondrosarcoma, NOS, of pelvic bones, sacrum, coccyx and associated joints
+∞
9.4
9
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
9.4
9
*
9731/3-C41.3
ICD-O-3
Plasmacytoma, NOS, of rib, sternum, clavicle and associated joints
+∞
9.4
9
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.9
9.3
30
67
ZX090
NOMESCO Finland
Other technic of radiotherapy
6.5
9.1
23
38
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
38.0
9.1
11
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
9.1
8.9
18
21
R52.0
ICD-10 Finland
Acute pain
7.6
8.9
20
28
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.7
8.7
29
67
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.3
8.7
32
82
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
4.6
8.6
29
68
J01MA12
ATC
levofloxacin; systemic
2.7
8.6
65
284
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
20.8
8.5
12
6
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
20.8
8.5
12
6
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
8.4
80
396
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
9.9
8.4
16
17
NEA20
NOMESCO Finland
Exploration of soft tissue of pelvis,v
+∞
8.4
8
*
NER20
NOMESCO Finland
Incomplete excision of soft tissue tumour of pelvis
+∞
8.4
8
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
8.4
8
*
C41.41
ICD-10 Finland
Osteosarcoma of the pelvic bones, sacrum and coccyx
+∞
8.4
8
*
C41.82
ICD-10 Finland
Overall chondrosarcoma in bone and articular cartilage
+∞
8.4
8
*
9731/3-C41.2
ICD-O-3
Plasmacytoma, NOS, of vertebral column
+∞
8.4
8
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
+∞
8.4
8
*
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
8.4
8
*
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
8.4
8
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.8
8.3
20
31
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
5.9
8.2
22
40
WF003
NOMESCO Finland
Adjuvant radiotherapy
6.2
8.2
21
36
L28
ICPC
Limited function/disability (L)
2.7
8.1
60
258
2392A
ICD-9 Finland
Neoplasm of unspecified nature, Bone, soft tissue and skin
34.4
8.1
10
*
WX002
NOMESCO Finland
Sedation and analgesia
2.5
8.1
71
334
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
22.8
8.1
11
5
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
9.8
7.9
15
16
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
7.8
45
166
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
7.8
7.8
17
23
NFB60
NOMESCO Finland
Demanding prosthetic replacement of hip
19.0
7.7
11
6
NF3AD
NOMESCO Finland
Femur CT
82.1
7.5
8
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
82.1
7.5
8
*
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
82.1
7.5
8
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
82.1
7.5
8
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
7.4
43
159
ZXA05
NOMESCO Finland
Left side
2.2
7.4
87
473
AA1AA
NOMESCO Finland
Head X-ray examination
9.7
7.4
14
15
GAE23
NOMESCO Finland
Resection of chest wall and prosthetic repair
+∞
7.3
7
*
9680/3-C41.4
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of pelvic bones, sacrum, coccyx and associated joints
+∞
7.3
7
*
C41.3
ICD-10 Finland
Malignant neoplasm: Ribs, sternum and clavicle
+∞
7.3
7
*
NK6AT
NOMESCO Finland
Bone biopsy with ultrasound guidance
+∞
7.3
7
*
C40.10
ICD-10 Finland
Malignant tumor of the upper limb's short bones without histology
+∞
7.3
7
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
16.3
7.3
11
7
D70.82
ICD-10 Finland
Drug-induced neutropenia
8.3
7.2
15
19
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.4
7.2
34
109
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
9.1
7.1
14
16
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
7.1
70
350
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.4
7.1
20
39
L03AA14
ATC
lipegfilgrastim; parenteral
7.8
7.0
15
20
J04AB02
ATC
rifampicin; systemic
11.3
6.9
12
11
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
6.8
59
273
GDB10
NOMESCO Finland
Wedge resection of lung
41.0
6.8
8
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
6.5
24
63
NF3BA
NOMESCO Finland
Femur extensive X-ray examination
71.3
6.4
7
*
9102
FHL
Trepanation or removal of the local bone process
14.7
6.4
10
7
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
6.4
32
107
JN6AD
NOMESCO Finland
CT of torso and neck
8.4
6.4
13
16
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
8.4
6.4
13
16
ZXA00
NOMESCO Finland
Right side
2.0
6.3
88
509
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
4.7
6.3
20
45
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
6.3
41
164
J05AB01
ATC
aciclovir; systemic
2.2
6.3
69
361
NGB99
NOMESCO Finland
Other primary prosthetic replacement of knee joint, other or unspecified
+∞
6.3
6
*
NJ3DG
NOMESCO Finland
Very extensive MRI examination of extremities with high intensity magnet
+∞
6.3
6
*
GDA20
NOMESCO Finland
Excision of lesion of lung
+∞
6.3
6
*
9220/3-C41.0
ICD-O-3
Chondrosarcoma, NOS, of bones of skull and face and associated joints
+∞
6.3
6
*
C49.20
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the lower extremity including the hip without histology
+∞
6.3
6
*
NGR40
NOMESCO Finland
Extensive excision of tumor of knee or lower leg with repair
+∞
6.3
6
*
C40.23
ICD-10 Finland
Ewing's sarcoma in the long bones of the lower extremity
+∞
6.3
6
*
C40.12
ICD-10 Finland
Chondrosarcoma of the short bones of the upper extremity
+∞
6.3
6
*
C40.93
ICD-10 Finland
Malignant tumor in unspecified locations in the bones and articular cartilage of the extremities
+∞
6.3
6
*
C41.00
ICD-10 Finland
Malignant tumor of the skull or facial bone without histology
+∞
6.3
6
*
C41.09
ICD-10 Finland
Malignant tumor of the skull or facial bones other or unspecified histology
+∞
6.3
6
*
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
27.3
6.3
8
*
B01AB04
ATC
dalteparin; parenteral
4.2
6.2
22
55
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
6.2
95
568
NG1AD
NOMESCO Finland
Knee CT examination
6.9
6.1
14
21
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
5.0
6.0
18
38

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: C3_BONE_CARTILAGE – Malignant neoplasm of bone and articular cartilage

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).