Malignant neoplasm of parotid gland, excluding all cancers (controls excluding all cancers)

C3_PAROTIDGLAND_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C07
  • Hospital discharge: ICD-9 1420
  • Hospital discharge: ICD-8 1420
  • Cause of death: ICD-10 C07
  • Cause of death: ICD-9 1420
  • Cause of death: ICD-8 1420
  • Cancer registry: Topography ICD-O-3 C07
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

336

4. Check minimum number of events

None

336

5. Include endpoints

None

336

6. Filter based on genotype QC (FinnGen only)

336

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of parotid gland, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 336 155 181
Unadjusted period prevalence (%) 0.07 0.05 0.08
Median age at first event (years) 61.79 58.74 64.39

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
249
Matched controls
2491
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C07.70
ICD-10 Finland
Malignant tumor of the superficial part of the parotid gland
+∞
169.9
143
*
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
199.3
159.8
154
20
ELB50
NOMESCO Finland
Total parotidectomy
1545.0
106.5
96
*
ELB40
NOMESCO Finland
Partial parotidectomy
180.9
99.8
99
9
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
63.3
58
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
32.1
59.9
80
36
130
Kela drug reimbursment
Malignant tumour
+∞
54.2
50
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
49.7
46
*
8550/3-C07.9
ICD-O-3
Acinar cell carcinoma of parotid gland
+∞
43.0
40
*
C07.71
ICD-10 Finland
Malignant tumor in the deep part of the parotid gland
+∞
40.8
38
*
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
237.0
40.1
40
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
37.4
35
*
A03FA01
ATC
metoclopramide; systemic, rectal
8.6
34.4
83
137
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
135.1
33.6
35
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
30.9
29
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.3
30.0
116
350
8430/3-C07.9
ICD-O-3
Mucoepidermoid carcinoma of parotid gland
+∞
29.8
28
*
WF002
NOMESCO Finland
Radical radiotherapy
163.3
28.3
29
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
15.4
28.1
47
37
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
17.7
27.2
43
29
WX408
NOMESCO Finland
General anesthesy, balanced
4.7
25.9
113
374
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
25.4
24
*
C08.89
ICD-10 Finland
Malignant overall tumor the large salivary glands anna or unspecified histology
+∞
25.4
24
*
XX3DW
NOMESCO Finland
Time consuming IT work
11.2
25.2
49
53
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
24.4
23
*
H02AB02
ATC
dexamethasone; systemic
35.1
24.4
31
10
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
+∞
23.3
22
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
25.1
22.3
31
14
8070/3-C07.9
ICD-O-3
Squamous cell carcinoma, NOS, of parotid gland
+∞
22.2
21
*
8500/3-C07.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of parotid gland
+∞
21.1
20
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
21.1
20
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
21.1
20
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
21.1
20
*
C07
ICD-10 Finland
Malignant neoplasm of parotid gland
+∞
20.1
19
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
114.2
19.9
21
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
19.0
18
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
19.0
18
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
17.9
17
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
17.9
17
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
45.7
17.6
21
5
G51.0
ICD-10 Finland
Bell palsy
13.5
17.4
30
25
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
16.9
16
*
8200/3-C07.9
ICD-O-3
Adenoid cystic carcinoma of parotid gland
+∞
16.9
16
*
C08.99
ICD-10 Finland
Malignant tumor of unspecified large salivary gland, other or unspecified histology
+∞
16.9
16
*
ELB00
NOMESCO Finland
Excision or exploration of lesion of salivary gland
96.7
16.8
18
*
JN4BD
NOMESCO Finland
Extensive body CT
8.1
16.6
38
54
R4190
NOMESCO Finland
Nutritional therapy
26.6
16.3
22
9
A04AA01
ATC
ondansetron; systemic, rectal
16.5
15.2
24
16
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
85.3
14.7
16
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
14.7
14
*
9699/3-C07.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of parotid gland
+∞
14.7
14
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
14.7
14
*
WX402
NOMESCO Finland
General anaesthesia
4.6
14.7
54
140
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
15.7
14.4
23
16
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
79.6
13.7
15
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
79.6
13.7
15
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
13.7
13
*
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
147.7
13.6
14
*
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
13.2
13.4
23
19
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
12.6
12
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
12.6
12
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
12.6
12
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
11.9
12.3
22
20
L03AA02
ATC
filgrastim; parenteral
68.3
11.7
13
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
7.2
11.7
28
43
8140/3-C07.9
ICD-O-3
Adenocarcinoma, NOS, of parotid gland
+∞
11.5
11
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
11.5
11
*
8562/3-C07.9
ICD-O-3
Epithelial-myoepithelial carcinoma of parotid gland
+∞
11.5
11
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
11.5
11
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
11.5
11
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
125.6
11.5
12
*
XW000
NOMESCO Finland
Bone marrow biopsy
9.2
10.8
22
26
ZXE20
NOMESCO Finland
More than three and less than five hours
3.5
10.7
53
177
A07AA02
ATC
nystatin; oral
5.6
10.6
31
62
C61
ICD-10 Finland
Malignant neoplasm of prostate
114.6
10.5
11
*
H02.2
ICD-10 Finland
Lagophthalmos
114.6
10.5
11
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
114.6
10.5
11
*
SAA03
NOMESCO Finland
Extended examination of mouth
2.5
10.5
108
577
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
+∞
10.5
10
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
10.5
10
*
C08.94
ICD-10 Finland
Mucoepidermoid carcinoma of an unspecified large salivary gland
+∞
10.5
10
*
WX110
NOMESCO Finland
Local anesthesy
2.5
10.4
173
1186
Z51.5
ICD-10 Finland
Palliative care
10.7
10.2
19
19
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
10.2
105
561
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
41.9
10.1
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
10.0
118
670
S04
ICPC
Lump/swelling localized
4.3
10.0
37
96
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
9.5
112
632
PJA10
NOMESCO Finland
Exploration of lymph nodes
103.8
9.5
10
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
103.8
9.5
10
*
AAH50
NOMESCO Finland
Cranial nerve anastomosis
103.8
9.5
10
*
EL4AT
NOMESCO Finland
Salivary gland cytology with ultrasound guidance
22.7
9.4
13
6
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
9.4
9
*
116
Kela drug reimbursment
Prostate cancer
+∞
9.4
9
*
9691/3-C07.9
ICD-O-3
Follicular lymphoma, grade 2 of parotid gland
+∞
9.4
9
*
9591/3-C07.9
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of parotid gland
+∞
9.4
9
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
9.4
9
*
115
Kela drug reimbursment
Breast cancer
+∞
9.4
9
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
+∞
9.4
9
*
8010/3-C07.9
ICD-O-3
Carcinoma, NOS, of parotid gland
+∞
9.4
9
*
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
+∞
9.4
9
*
9680/3-C07.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of parotid gland
+∞
9.4
9
*
L02BB03
ATC
bicalutamide; oral
+∞
9.4
9
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
9.4
9
*
UDC00
NOMESCO Finland
Ear microscopy
4.4
9.4
34
86
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
6.7
9.3
23
37
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
51.9
8.7
10
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
5.8
8.7
24
45
ED1AA
NOMESCO Finland
Mandipular X-ray examination
28.6
8.6
11
*
DEB00
NOMESCO Finland
Cortical mastoidectomy
93.1
8.5
9
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
93.1
8.5
9
*
N02AA05
ATC
oxycodone; systemic
3.2
8.4
46
163
8941/3-C07.9
ICD-O-3
Carcinoma ex pleomorphic adenoma of parotid gland
+∞
8.4
8
*
EP1BG
NOMESCO Finland
MRI examination of soft tissue of neck with high intesity magnet
+∞
8.4
8
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
EBA10
NOMESCO Finland
Surgical removal of tooth
3.7
8.2
36
109
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.3
8.2
42
144
ZXA00
NOMESCO Finland
Right side
2.4
7.9
83
436
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
15.7
7.8
12
8
4405
FHL
Partial removal of the parotid gland
46.5
7.8
9
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
8.5
7.7
16
20
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
8.5
7.7
16
20
WZC30
NOMESCO Finland
Teaching
3.5
7.7
36
115
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
19.1
7.7
11
6
ZXA05
NOMESCO Finland
Left side
2.4
7.7
78
402
K05.30
ICD-10 Finland
Periodontitis complex
3.1
7.5
42
152
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
82.4
7.5
8
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
82.4
7.5
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
7.4
104
619
S18
ICPC
Laceration/cut
2.1
7.4
111
681
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
7.3
7
*
ELB60
NOMESCO Finland
Radical parotidectomy sacrificing the facial nerve
+∞
7.3
7
*
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
+∞
7.3
7
*
8502/3-C07.9
ICD-O-3
Secretory carcinoma of parotid gland
+∞
7.3
7
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
7.3
7
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
7.3
7
*
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
+∞
7.3
7
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
4404
FHL
Complete removal of the parotid gland
+∞
7.3
7
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
7.3
7
*
8147/3-C07.9
ICD-O-3
Basal cell adenocarcinoma of parotid gland
+∞
7.3
7
*
SCA04
NOMESCO Finland
Guidance on care of mouth and oral mucosa
+∞
7.3
7
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
+∞
7.3
7
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.0
6.9
21
45
H02.1
ICD-10 Finland
Ectropion of eyelid
17.3
6.8
10
6
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
41.2
6.8
8
*
ZZR00
NOMESCO Finland
Flap of skin
23.2
6.7
9
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
12.7
6.6
11
9
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
12.7
6.6
11
9
H60.4
ICD-10 Finland
Cholesteatoma of external ear
71.6
6.5
7
*
UJC01
NOMESCO Finland
Scopy of lower throat
14.8
6.4
10
7
DFF00
NOMESCO Finland
Pure tone audiometry
3.3
6.4
31
102
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.3
6.4
67
348
L02AE02
ATC
leuprorelin; implant, parenteral
18.6
6.3
9
5
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
6.3
6
*
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
C08.90
ICD-10 Finland
Malignant tumor in unspecified large salivary gland without histology
+∞
6.3
6
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
6.3
6
*
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
27.4
6.3
8
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
27.4
6.3
8
*
JN4AD
NOMESCO Finland
Body CT examination
5.8
6.1
16
29
K11.2
ICD-10 Finland
Sialoadenitis
6.3
6.1
15
25
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
10.4
6.1
11
11

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_PAROTIDGLAND_EXALLC – Malignant neoplasm of parotid gland, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).