No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1179 |
4. Check minimum number of eventsNone |
1179 |
5. Include endpointsNone |
1179 |
6. Filter based on genotype QC (FinnGen only) |
1179 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D14
- Name in latin
- Neoplasma benignum laryngis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Larynx
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Larynx
- Benign neoplasm of middle ear and respiratory system
- Benign neoplasm of middle ear and respiratory system
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7637 | 2657 | 4895 |
| Only index persons | 6316 | 2327 | 3989 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.08 | 0.14 |
| Only index persons | 0.13 | 0.09 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 55.93 | 55.72 | 55.94 |
| Only index persons | 54.31 | 54.47 | 54.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1179 | 386 | 793 |
| Unadjusted period prevalence (%) | 0.28 | 0.13 | 0.35 |
| Median age at first event (years) | 56.07 | 52.05 | 58.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1075
- Matched controls
- 10751
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
228.5
323.0
411
29
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
+∞
323.0
907
*
UDQ22
NOMESCO Finland
Microlaryngoscopy
192.9
260.3
263
18
UDQ12
NOMESCO Finland
Flexible laryngoscopy
17.7
189.1
313
244
DQA10
NOMESCO Finland
Biopsy of larynx
238.1
178.1
179
9
ZXC10
NOMESCO Finland
Use of laser
26.7
134.3
189
85
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
129.5
128.4
136
12
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
136.1
114.7
121
10
21210
ICD-8 Finland
Benign neoplasm of respiratory system, Larynx
+∞
111.4
105
*
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
210.1
110.8
113
6
2121A
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Larynx
+∞
104.9
99
*
J38.3
ICD-10 Finland
Other diseases of vocal cords
41.4
99.7
125
34
1420
FHL
Laryngomicroscopy
50.9
94.7
114
25
J37.0
ICD-10 Finland
Chronic laryngitis
15.2
91.0
156
119
J38.1
ICD-10 Finland
Polyp of vocal cord and larynx
41.8
84.8
106
28
UDQ02
NOMESCO Finland
Direct laryngoscopy
43.5
71.0
88
22
8070/3-C32.0
ICD-O-3
Squamous cell carcinoma, NOS, of glottis
120.8
63.6
68
6
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
120.2
53.3
57
5
UJC01
NOMESCO Finland
Scopy of lower throat
19.8
50.0
76
41
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
45.3
45.8
56
13
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
41.3
381
1842
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
40.2
282
1149
R49.0
ICD-10 Finland
Dysphonia
15.2
39.5
66
46
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
106.5
38.0
41
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.7
37.3
137
327
WX734
NOMESCO Finland
JET-ventilation
369.1
36.2
36
*
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
191.3
36.0
37
*
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
186.0
35.0
36
*
R49.08
ICD-10 Finland
Other specified dysphonia
11.7
34.6
65
59
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
10.3
34.5
69
71
B977, D141
ICD-10 Finland
NA
+∞
33.5
32
*
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
17.8
32.6
51
30
DQB30
NOMESCO Finland
Laryngectomy
+∞
32.5
31
*
A02BC05
ATC
esomeprazole; systemic
2.2
31.5
480
2891
J38.7
ICD-10 Finland
Other diseases of larynx
164.7
30.8
32
*
ZXE00
NOMESCO Finland
One hour or less
2.2
30.7
479
2909
R49.01
ICD-10 Finland
Functional dysphonia
7.9
30.5
71
95
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.5
30.3
156
501
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
19.2
30.3
46
25
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.6
29.3
106
248
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
27.2
459
2833
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
143.6
26.7
28
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
10.0
25.4
51
53
DQB70
NOMESCO Finland
Total excision of vocal cord
127.8
23.7
25
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.2
23.2
130
441
R13
ICD-10 Finland
Dysphagia
3.6
23.2
112
340
J38.2
ICD-10 Finland
Nodules of vocal cords
26.5
22.7
31
12
A02BC02
ATC
pantoprazole; systemic
1.9
22.4
697
5276
H02AB06
ATC
prednisolone; systemic
1.8
19.6
516
3610
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
18.9
173
789
GB3AV
NOMESCO Finland
NA
101.8
18.6
20
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
7.8
18.0
41
54
R07.0
ICD-10 Finland
Pain in throat
3.5
17.7
84
251
WX402
NOMESCO Finland
General anaesthesia
2.2
17.6
192
952
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
4.3
17.5
65
157
UJC02
NOMESCO Finland
Rigid oesophagoscopy
8.3
16.9
37
46
4760A
ICD-9 Finland
Chronic laryngitis and laryngotracheitis, Chronic laryngitis
91.5
16.6
18
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
7.2
16.2
39
56
WF002
NOMESCO Finland
Radical radiotherapy
3.2
16.2
89
298
GBB00
NOMESCO Finland
Tracheostomy
7.1
16.0
39
57
R49.09
ICD-10 Finland
Unspecified dysphonia
11.0
15.5
29
27
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
15.4
392
2653
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
10.6
15.3
29
28
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
15.0
326
2094
1430
FHL
Laryngoscopy (direct)
57.5
14.8
17
*
A02BC03
ATC
lansoprazole; oral
1.8
14.8
316
2018
4509
FHL
Other measure in this category
151.9
14.5
15
*
D10.7
ICD-10 Finland
Benign neoplasm: Hypopharynx
151.9
14.5
15
*
R03BB04
ATC
tiotropium bromide; inhalant
2.2
13.9
145
698
R03AC02
ATC
salbutamol; inhalant
1.6
13.8
508
3787
J01DA01
ATC
[U] cefalexin; systemic
1.6
13.8
645
5131
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
12.9
489
3653
J01AA02
ATC
doxycycline; systemic
1.7
12.6
786
6665
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
12.2
105
460
130
Kela drug reimbursment
Malignant tumour
2.2
11.9
121
576
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.8
11.9
77
288
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
11.8
463
3462
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
30.4
11.7
15
5
C14.1
ICD-10 Finland
Malignant neoplasm of laryngopharynx unspecified
+∞
11.5
11
*
8070/3-C32.1
ICD-O-3
Squamous cell carcinoma, NOS, of supraglottis
121.2
11.4
12
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.3
11.2
56
176
A02BC01
ATC
omeprazole; systemic
1.7
11.2
292
1951
N07BA03
ATC
varenicline; oral
3.0
11.0
63
217
GBB13
NOMESCO Finland
Revision of tracheostomy
43.8
10.9
13
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
6.1
10.9
29
49
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
10.9
160
889
UJF32
NOMESCO Finland
Coloscopy
1.7
10.8
270
1781
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
10.8
78
310
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.3
10.8
32
62
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
10.8
333
2328
R06.0
ICD-10 Finland
Dyspnoea
1.7
10.6
252
1639
N02AA05
ATC
oxycodone; systemic
1.9
10.6
170
974
ENA10
NOMESCO Finland
Biopsy of pharynx
16.2
10.4
16
10
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
10.3
278
1871
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
8.9
10.3
21
24
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
23.6
10.3
14
6
UDC00
NOMESCO Finland
Ear microscopy
2.4
10.2
87
382
A07AA02
ATC
nystatin; oral
2.5
10.1
78
325
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
10.0
372
2716
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
40.4
10.0
12
*
4784A
ICD-9 Finland
Other diseases of upper respiratory tract, Polyp of vocal cord or larynx[POLYPUS PLICAE VOCALIS]
16.9
9.9
15
9
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
9.8
218
1386
Z50.5
ICD-10 Finland
Speech therapy
5.6
9.7
27
49
50808
ICD-8 Finland
Other diseases of upper respiratory tract, Alii definiti
13.5
9.7
16
12
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
100.9
9.4
10
*
D10.5
ICD-10 Finland
Benign neoplasm: Other parts of oropharynx
30.3
9.4
12
*
A03FA01
ATC
metoclopramide; systemic, rectal
1.7
9.3
205
1295
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.0
9.3
54
189
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
9.2
169
1009
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
9.2
312
2217
H02AB04
ATC
methylprednisolone; systemic
1.9
9.1
148
849
ZXB10
NOMESCO Finland
Medial
6.9
8.9
21
31
R23
ICPC
Voice symptom/complaint
5.2
8.8
26
51
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
7.3
8.8
20
28
ZXA05
NOMESCO Finland
Left side
1.6
8.7
260
1788
ZXD20
NOMESCO Finland
Day surgery
1.9
8.7
137
777
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
8.6
212
1384
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
8.6
72
315
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.5
8.3
64
267
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.2
8.3
80
374
J02AC01
ATC
fluconazole; systemic
1.5
8.0
303
2195
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
6.6
7.9
19
29
XX3DW
NOMESCO Finland
Time consuming IT work
2.0
7.9
107
574
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
10.9
7.8
14
13
R21
ICPC
Throat symptom/complaint
1.8
7.8
145
869
J38.4
ICD-10 Finland
Oedema of larynx
15.1
7.7
12
8
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
5.6
7.7
21
38
J01FA10
ATC
azithromycin; systemic
1.4
7.7
495
4003
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
7.6
192
1256
R53
ICD-10 Finland
Malaise and fatigue
1.6
7.6
186
1211
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.6
166
1046
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
6.2
7.6
19
31
R95
ICPC
Chron obstructive pulmonary disease
3.0
7.5
41
140
N05BA01
ATC
diazepam; systemic, rectal
1.8
7.5
136
809
J01DB01
ATC
cefalexin; oral
1.5
7.4
789
7002
J20
ICD-10 Finland
Acute bronchitis
2.0
7.4
88
451
A02BA02
ATC
ranitidine; systemic
1.6
7.4
204
1367
J01CA04
ATC
amoxicillin; systemic
1.5
7.3
754
6639
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.3
204
1373
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
6.3
7.3
18
29
R03BA05
ATC
fluticasone; inhalant
1.7
7.2
162
1028
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
30.2
7.2
9
*
ZXA10
NOMESCO Finland
Bilateral
1.6
7.2
180
1179
J01FA06
ATC
roxithromycin; oral
1.4
7.1
370
2857
J39.2
ICD-10 Finland
Other diseases of pharynx
5.7
7.1
19
34
J01MA12
ATC
levofloxacin; systemic
1.6
7.0
196
1319
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
3.0
6.9
38
131
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
4.8
6.9
21
44
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
6.9
99
545
N02BE01
ATC
paracetamol; systemic, rectal
1.5
6.8
836
7553
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
6.8
362
2799
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
5.4
6.8
19
36
R04.2
ICD-10 Finland
Haemoptysis
2.5
6.8
49
200
C320, 8077, 2
ICD-O-3
NA
40.3
6.8
8
*
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
40.3
6.8
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.7
416
3315
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
6.7
856
7778
R4130
NOMESCO Finland
Speech therapy
3.2
6.7
32
101
J04.0
ICD-10 Finland
Acute laryngitis
3.5
6.6
29
85
UGB02
NOMESCO Finland
Tracheoscopy
12.3
6.6
11
9
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
12.3
6.6
11
9
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
8.8
6.6
13
15
GD1AD
NOMESCO Finland
Thorax CT examination
2.4
6.6
55
240
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
6.5
79
409
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
6.5
634
5461
C32.2
ICD-10 Finland
Malignant neoplasm: Subglottis
70.2
6.4
7
*
J38.6
ICD-10 Finland
Stenosis of larynx
70.2
6.4
7
*
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.4
329
2527
H02AB07
ATC
prednisone; oral
1.7
6.4
145
921
M02AA07
ATC
piroxicam; topical
1.4
6.3
343
2657
UJC12
NOMESCO Finland
Flexible oesophagoscopy
6.0
6.3
16
27
WX400
NOMESCO Finland
Inhalation anesthesy
2.7
6.3
41
157
UGC02
NOMESCO Finland
Rigid bronchoscopy
18.1
6.3
9
5
DQB00
NOMESCO Finland
Excision of lesion of larynx
+∞
6.3
6
*
D14.2
ICD-10 Finland
Benign neoplasm: Trachea
+∞
6.3
6
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
6.2
131
815
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
5.8
6.2
16
28
M54.5
ICD-10 Finland
Low back pain
1.5
6.1
272
2027
H03AA01
ATC
levothyroxine sodium; systemic
1.6
6.1
178
1208
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_LARYNX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LARYNX | 1.44 [1.24, 1.67] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.792 |
During the follow-up period (1.1.1998 — 31.12.2019), 365 out of 1646 females with CD2_BENIGN_LARYNX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LARYNX | 1.766 [1.57, 1.99] | < 0.001 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 973 out of 3146 males with CD2_BENIGN_LARYNX died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_LARYNX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.328% |
| 5 | 1.02% | 1.903% |
| 10 | 2.305% | 4.549% |
| 15 | 4.399% | 8.697% |
| 20 | 7.596% | 14.442% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_LARYNX – Benign neoplasm: Larynx
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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