hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1261 |
6. Filter based on genotype QC (FinnGen only) |
1261 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12357 | 6434 | 5535 |
| Only index persons | 8979 | 4855 | 4124 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.18 | 0.15 |
| Only index persons | 0.17 | 0.18 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 51.74 | 53.46 | 50.94 |
| Only index persons | 47.59 | 47.37 | 47.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1261 | 662 | 599 |
| Unadjusted period prevalence (%) | 0.24 | 0.23 | 0.26 |
| Median age at first event (years) | 54.16 | 48.53 | 60.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1142
- Matched controls
- 11421
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
323.0
347
*
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
243.7
225
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.0
140.0
358
613
XW000
NOMESCO Finland
Bone marrow biopsy
11.4
102.0
201
209
WW500
NOMESCO Finland
Blood transfusion
9.2
79.7
176
221
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
70.4
303
880
D58.0
ICD-10 Finland
Hereditary spherocytosis
+∞
61.0
58
*
D58.2
ICD-10 Finland
Other haemoglobinopathies
+∞
59.9
57
*
TK800
NOMESCO Finland
Hemodialysis
12.9
55.2
100
84
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
54.6
52
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.5
53.8
99
86
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
53.6
51
*
ZX120
NOMESCO Finland
Intravenous
4.4
53.5
218
585
L04AA06
ATC
mycophenolic acid; systemic
15.7
51.2
85
58
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
49.3
463
2298
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
49.3
47
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.8
48.4
177
424
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
48.3
46
*
127
Kela drug reimbursment
Transplant complication
18.6
48.2
75
43
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
48.1
430
2063
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.8
47.1
125
203
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.5
46.6
147
298
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.0
44.8
92
99
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
43.4
581
3430
H02AB06
ATC
prednisolone; systemic
2.4
41.6
612
3757
Z94.0
ICD-10 Finland
Kidney transplant status
19.5
41.4
63
34
B03XA02
ATC
darbepoetin alfa; parenteral
11.4
41.4
79
74
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.9
40.4
141
319
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
33.3
39.1
51
16
A11CC03
ATC
alfacalcidol; systemic
9.3
38.6
82
94
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
37.7
36
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.2
37.7
153
402
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
22.6
37.3
54
25
D56.0
ICD-10 Finland
Alpha thalassaemia
+∞
36.7
35
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
14.5
36.5
62
45
C03CA01
ATC
furosemide; systemic
2.4
36.3
405
2122
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
24.8
35.6
50
21
M04AA01
ATC
allopurinol; systemic
3.1
34.7
217
806
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
51.7
33.7
40
8
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
33.6
306
1428
Z49.1
ICD-10 Finland
Extracorporeal dialysis
11.6
33.6
63
57
A12AA04
ATC
calcium carbonate; oral
10.5
33.4
66
66
B03XA01
ATC
erythropoietin; parenteral
15.6
33.4
55
37
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.8
33.2
68
73
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
15.1
33.0
55
38
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.3
32.9
128
322
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.8
32.4
53
35
D56.3
ICD-10 Finland
Thalassaemia trait
+∞
31.4
30
*
L04AD01
ATC
ciclosporin; systemic
9.5
30.7
64
71
28200
ICD-8 Finland
Hereditary haemolytic anaemias, Familial acholuric jaundice
+∞
30.3
29
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
30.2
235
995
R50.9
ICD-10 Finland
Fever, unspecified
2.7
30.1
233
981
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
51.5
29.5
35
7
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
21.2
29.3
43
21
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
21.2
29.3
43
21
N08.2*D57.8
ICD-10 Finland
Glomerular disorders in sickle-cell disorders
+∞
29.3
28
*
D57.3
ICD-10 Finland
Sickle-cell trait
+∞
29.3
28
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
28.9
339
1781
D56.1
ICD-10 Finland
Beta thalassaemia
+∞
28.2
27
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.1
28.1
117
312
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
27.9
247
1121
D64.8
ICD-10 Finland
Other specified anaemias
11.5
27.8
52
47
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.3
27.4
44
28
D56.91
ICD-10 Finland
Thalassemia minor
+∞
27.2
26
*
D56.99
ICD-10 Finland
Thalassaemia, unspecified
+∞
27.2
26
*
N18.0
ICD-10 Finland
End-stage renal disease
11.8
27.1
50
44
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
26.9
171
635
V03AE02
ATC
sevelamer; oral
28.5
26.8
36
13
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
14.6
26.8
45
32
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
26.1
25
*
UJF32
NOMESCO Finland
Coloscopy
2.2
26.0
331
1792
H02AB07
ATC
prednisone; oral
2.6
25.9
208
890
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
9.1
25.5
54
62
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
24.0
23
*
V03AE01
ATC
polystyrene sulfonate; oral
10.0
23.4
47
49
A02BC02
ATC
pantoprazole; systemic
1.9
22.8
720
5432
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
22.7
81
186
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.3
22.4
60
99
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
18.8
21.8
33
18
L04AX01
ATC
azathioprine; systemic
4.0
21.6
89
235
N18.8
ICD-10 Finland
Other chronic renal failure
5.4
21.5
65
125
3AC01
NOMESCO Finland
NA
13.2
20.7
36
28
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.2
20.3
80
203
B01AA03
ATC
warfarin; systemic
2.1
20.2
258
1377
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
11.5
20.0
37
33
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.0
20.0
83
221
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
10.1
19.7
39
40
JMA10
NOMESCO Finland
Transabdominal total splenectomy
18.1
19.6
30
17
137
Kela drug reimbursment
Uraemia requiring dialysis
11.6
19.6
36
32
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
40.8
19.5
24
6
L04AA01
ATC
[U] ciclosporin; systemic
7.6
19.3
45
61
JN4BD
NOMESCO Finland
Extensive body CT
2.6
19.2
156
663
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.0
19.1
27
12
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
18.8
18
*
D58.9
ICD-10 Finland
Hereditary haemolytic anaemia, unspecified
+∞
18.8
18
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
5.7
18.8
54
98
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.7
18.8
54
98
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
18.7
228
1185
WW400
NOMESCO Finland
Plasmaferesis
39.1
18.6
23
6
WW200
NOMESCO Finland
Immunization
5.0
18.4
60
126
JN4AD
NOMESCO Finland
Body CT examination
2.9
18.1
114
417
6BA02
NOMESCO Finland
NA
23.2
17.8
25
11
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
17.7
17
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
37.3
17.6
22
6
WX892
NOMESCO Finland
Monitored bed care
2.9
17.6
113
417
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.3
17.4
66
162
L01AA01
ATC
cyclophosphamide; systemic
24.5
17.4
24
10
2820A
ICD-9 Finland
Hereditary haemolytic anaemias, Hereditary spherocytosis
+∞
16.7
16
*
D59.6
ICD-10 Finland
Haemoglobinuria due to haemolysis from other external causes
+∞
16.7
16
*
1XC02
NOMESCO Finland
NA
10.3
16.5
32
32
B03BA03
ATC
hydroxocobalamin; parenteral
3.2
16.2
86
280
L03AA02
ATC
filgrastim; parenteral
4.7
16.2
55
121
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.1
16.1
44
75
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
16.1
73
210
J01MA12
ATC
levofloxacin; systemic
2.0
16.0
230
1277
H02AB04
ATC
methylprednisolone; systemic
2.2
15.9
179
892
196
Kela drug reimbursment
Paricalcitol and cinacalcet
14.7
15.9
26
18
B05DB
ATC
Hypertonic solutions
14.7
15.9
26
18
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
7.7
15.7
36
48
D70.89
ICD-10 Finland
Neutropenic splenomegaly
7.5
15.5
36
49
B01AB05
ATC
enoxaparin; parenteral
1.8
15.4
336
2157
B82
ICPC
Anaemia other/unspecified
4.8
15.3
51
110
R4110
NOMESCO Finland
Physiotherapy
1.8
15.3
309
1933
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
15.3
175
881
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
15.2
152
716
Z49.0
ICD-10 Finland
Preparatory care for dialysis
9.3
15.2
31
34
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
18.0
15.2
23
13
N02AX02
ATC
tramadol; systemic, rectal
1.7
15.0
448
3156
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
14.9
304
1905
B01AB10
ATC
tinzaparin; parenteral
2.8
14.8
96
359
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.9
14.7
90
324
D59.2
ICD-10 Finland
Drug-induced nonautoimmune haemolytic anaemia
+∞
14.6
14
*
B05DA
ATC
Isotonic solutions
12.1
14.6
26
22
J01MA14
ATC
moxifloxacin; systemic
2.5
14.5
116
489
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
8.4
14.3
31
38
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
11.5
14.3
26
23
Z49.2
ICD-10 Finland
Other dialysis
10.6
14.3
27
26
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.8
14.2
60
164
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
43.0
14.1
17
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.6
14.1
49
111
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
14.1
246
1459
ZX108
NOMESCO Finland
Inhalation
11.1
14.0
26
24
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
14.0
245
1452
Z31.5
ICD-10 Finland
Genetic counselling
3.4
13.9
69
214
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
14.9
13.6
22
15
122
Kela drug reimbursment
Aplastic anaemia
+∞
13.6
13
*
M05BA04
ATC
alendronic acid; oral
2.5
13.5
105
436
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
16.4
13.5
21
13
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
13.4
118
522
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
13.4
86
318
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.2
13.4
51
127
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
10.6
13.3
25
24
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
13.3
100
408
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
40.6
13.2
16
*
SPAT1255
SPAT
Intravenous administration of medicine
2.7
13.1
90
349
H02AB09
ATC
hydrocortisone; systemic
4.4
13.0
47
111
WX002
NOMESCO Finland
Sedation and analgesia
1.9
12.7
219
1288
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
12.7
74
258
321
Kela drug reimbursment
Paricalcitol and cinacalcet
15.6
12.6
20
13
J05AB11
ATC
valaciclovir; oral
2.1
12.6
148
753
D56.2
ICD-10 Finland
Delta-beta thalassaemia
+∞
12.5
12
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
12.4
132
641
C09AA02
ATC
enalapril; systemic
1.8
12.2
229
1382
N02AA05
ATC
oxycodone; systemic
2.0
12.1
170
926
TK810
NOMESCO Finland
Hemofiltration
18.3
12.1
18
10
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
12.0
115
533
J01FF01
ATC
clindamycin; systemic
1.7
11.9
298
1968
C07AB07
ATC
bisoprolol; oral
1.6
11.9
492
3707
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
11.9
193
1109
V03AE03
ATC
lanthanum carbonate; oral
14.8
11.8
19
13
C08CA01
ATC
amlodipine; oral
1.6
11.8
371
2609
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.7
11.8
29
44
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
11.8
80
306
R06.0
ICD-10 Finland
Dyspnoea
1.7
11.8
268
1721
6753
FHL
Transabdominal splenectomy
30.4
11.7
15
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
11.6
181
1024
A02BC01
ATC
omeprazole; systemic
1.7
11.6
301
2007
A46
ICD-10 Finland
Erysipelas
2.0
11.5
156
835
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
5.7
11.5
32
57
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
11.5
11
*
V03AC03
ATC
deferasirox; oral
+∞
11.5
11
*
D57.1
ICD-10 Finland
Sickle-cell anaemia without crisis
+∞
11.5
11
*
D58.1
ICD-10 Finland
Hereditary elliptocytosis
+∞
11.5
11
*
D58.8
ICD-10 Finland
Other specified hereditary haemolytic anaemias
+∞
11.5
11
*
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
11.5
129
641
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.2
11.3
42
103
R31
ICD-10 Finland
Unspecified haematuria
2.2
11.2
116
554
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
11.0
111
526
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
11.0
246
1569
Z99.2
ICD-10 Finland
Dependence on renal dialysis
43.7
10.9
13
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.8
10.7
44
119
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
60.6
10.6
12
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.3
10.6
95
426
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.3
10.5
38
91
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.9
10.5
62
220
I50.0
ICD-10 Finland
Congestive heart failure
2.4
10.5
92
409
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
7.8
10.4
23
30
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
10.4
227
1432
TGC00
NOMESCO Finland
Bronchial lavation
3.8
10.4
43
117
A41.9
ICD-10 Finland
Sepsis, unspecified
3.1
10.3
55
182
C90.0
ICD-10 Finland
Multiple myeloma
6.1
10.3
27
45
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.6
10.3
46
133
H05BX01
ATC
cinacalcet; oral
9.7
10.3
20
21
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
19.0
10.3
15
8
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
19.0
10.3
15
8
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.9
10.1
60
213
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
14.7
10.0
16
11
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
14.7
10.0
16
11
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
10.0
123
636
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
9.6
9.8
19
20
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
9.8
106
517
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
7.5
9.7
22
30
L01AA02
ATC
chlorambucil; oral
13.5
9.7
16
12
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.0
9.6
53
180
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.1
9.5
50
165
C03DA01
ATC
spironolactone; oral
2.0
9.5
119
620
N08.2*D89.82
ICD-10 Finland
Nepropathy caused by deposition of the light chain of the immunoglobulins
100.8
9.4
10
*
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
100.8
9.4
10
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
17.7
9.4
14
8
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
17.7
9.4
14
8
D55.0
ICD-10 Finland
Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
+∞
9.4
9
*
ZX112
NOMESCO Finland
Subcutaneous
3.9
9.4
37
97
M31.1
ICD-10 Finland
Thrombotic microangiopathy
21.9
9.4
13
6
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
21.9
9.4
13
6
SPAT1088
SPAT
Blood transfusion
10.8
9.3
17
16
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
10.8
9.3
17
16
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
4.5
9.2
31
70
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.2
9.2
47
152
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
9.1
344
2498
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.9
9.1
53
187
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
6.0
9.1
24
41
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.5
9.0
41
121
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
7.1
9.0
21
30
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
10.1
9.0
17
17
A04AA01
ATC
ondansetron; systemic, rectal
2.3
9.0
85
391
L01BB05
ATC
fludarabine; systemic
37.0
9.0
11
*
WX882
NOMESCO Finland
High dependency care
3.0
9.0
49
166
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
9.0
142
808
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
7.5
8.9
20
27
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.6
8.9
65
263
A05AA02
ATC
ursodeoxycholic acid; oral
4.8
8.9
28
59
UJF92
NOMESCO Finland
Capsular endoscopy
3.9
8.9
35
92
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
10.8
8.8
16
15
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
9.6
8.8
17
18
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.2
8.8
45
146
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.7
394
2972
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
8.7
50
174
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
50.4
8.7
10
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
50.4
8.7
10
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
7.7
8.7
19
25
E87.5
ICD-10 Finland
Hyperkalaemia
4.4
8.6
30
70
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
8.6
418
3199
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.5
8.6
38
110
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.1
8.6
32
80
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
16.4
8.6
13
8
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.0
8.5
114
608
104
Kela drug reimbursment
Thyroid insufficiency
2.3
8.5
74
329
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
27.7
8.5
11
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
20.2
8.5
12
6
PJA10
NOMESCO Finland
Exploration of lymph nodes
6.0
8.5
22
37
C08CA05
ATC
nifedipine; systemic
2.3
8.5
79
363
C02CA01
ATC
prazosin; oral
4.4
8.5
29
67
WX872
NOMESCO Finland
Intensive care
2.6
8.4
58
228
D57.0
ICD-10 Finland
Sickle-cell anaemia with crisis
+∞
8.3
8
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
8.3
8
*
28299
ICD-8 Finland
Hereditary haemolytic anaemias, Other
+∞
8.3
8
*
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
5.3
8.3
24
46
C07AB02
ATC
metoprolol; systemic
1.6
8.3
221
1468
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.3
242
1646
205
Kela drug reimbursment
Chronic hypertension
1.5
8.2
291
2075
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
14.6
8.2
13
9
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
14.6
8.2
13
9
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.6
8.2
27
60
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
11.8
8.1
14
12
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
17.3
8.1
12
7
N19
ICD-10 Finland
Unspecified kidney failure
3.0
8.1
44
150
A10AE04
ATC
insulin glargine; parenteral
2.0
8.0
101
528
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
22.2
8.0
11
5
K29.7
ICD-10 Finland
Gastritis, unspecified
3.0
8.0
44
151
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.3
7.9
38
118
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.1
7.9
87
430
R80
ICD-10 Finland
Isolated proteinuria
7.8
7.9
17
22
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.8
7.9
32
87
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
4.4
7.8
27
63
R53
ICD-10 Finland
Malaise and fatigue
1.6
7.8
209
1387
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
10.9
7.8
14
13
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.4
7.8
61
258
R4190
NOMESCO Finland
Nutritional therapy
2.8
7.7
49
182
J05AB01
ATC
aciclovir; systemic
1.6
7.7
193
1258
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.8
7.7
31
84
I50.1
ICD-10 Finland
Left ventricular failure
2.5
7.6
57
235
J01DB01
ATC
cefalexin; oral
1.5
7.6
847
7550
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.0
7.6
103
552
L04AA05
ATC
[U] tacrolimus; systemic
18.5
7.6
11
6
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
18.5
7.6
11
6
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
7.6
207
1383
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.4
7.6
35
106
C08DB01
ATC
diltiazem; oral
2.3
7.6
65
287
1512
Kela drug reimbursment
Ibrutinib
25.2
7.6
10
*
L01XX52
ATC
venetoclax; oral
25.2
7.6
10
*
390
Kela drug reimbursment
Ibrutinib
25.2
7.6
10
*
399
Kela drug reimbursment
Venetoclax
25.2
7.6
10
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
25.2
7.6
10
*
C02AC05
ATC
moxonidine; oral
2.6
7.6
52
203
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.1
7.6
40
134
D45
ICD-10 Finland
Polycythaemia vera
6.2
7.6
19
31
A41.8
ICD-10 Finland
Other specified sepsis
4.2
7.5
27
66
R11
ICD-10 Finland
Nausea and vomiting
2.1
7.5
88
446
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
80.6
7.4
8
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.2
7.4
71
330
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.3
892
8055
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
7.3
513
4181
B01AB04
ATC
dalteparin; parenteral
2.4
7.3
60
258
D56.8
ICD-10 Finland
Other thalassaemias
+∞
7.3
7
*
D56
ICD-10 Finland
Thalassaemia
+∞
7.3
7
*
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
+∞
7.3
7
*
KAS40
NOMESCO Finland
Excision of transplanted kidney
+∞
7.3
7
*
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
7.3
7
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
3.7
7.3
30
83
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
7.2
57
242
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.3
7.2
65
295
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.1
7.2
82
414
H03AA01
ATC
levothyroxine sodium; systemic
1.6
7.2
215
1470
K92.1
ICD-10 Finland
Melaena
2.3
7.1
65
296
Z94.1
ICD-10 Finland
Heart transplant status
20.1
7.1
10
5
K83
ICPC
Heart valve disease NOS
5.3
7.1
20
38
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
7.0
108
608
D86.0
ICD-10 Finland
Sarcoidosis of lung
5.2
6.9
20
39
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.9
6.9
18
31
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
6.9
172
1119
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
6.9
163
1046
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
7.6
6.9
15
20
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
13.9
6.9
11
8
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.5
6.8
30
88
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
6.8
72
349
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
5.1
6.8
20
40
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.4
6.7
30
89
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
6.7
257
1856
7151
FHL
Kidney transplantation
22.6
6.7
9
*
L01XE27
ATC
[U] ibrutinib; oral
22.6
6.7
9
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
6.7
82
426
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
12.3
6.6
11
9
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
6.5
36
125
WX610
NOMESCO Finland
Patient controlled analgesia
10.1
6.5
12
12
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
70.2
6.4
7
*
5828A
ICD-9 Finland
Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,EI NEFR SDR]
70.2
6.4
7
*
6112
FHL
Installation of a peritoneal dialysis or lavage catheter in an operating room
70.2
6.4
7
*
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
14.4
6.4
10
7
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
14.4
6.4
10
7
L03AA13
ATC
pegfilgrastim; parenteral
2.7
6.4
42
162
C09CA06
ATC
candesartan; oral
1.5
6.4
201
1387
S97
ICPC
Chronic ulcer skin
2.2
6.3
62
294
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
11.1
6.3
11
10
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.3
140
882
WX110
NOMESCO Finland
Local anesthesy
1.4
6.3
682
5929
D64
ICD-10 Finland
Other anaemias
18.1
6.3
9
5
6119
FHL
Other measure in this category
+∞
6.3
6
*
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
6.3
6
*
D55.2
ICD-10 Finland
Anaemia due to disorders of glycolytic enzymes
+∞
6.3
6
*
107
Kela drug reimbursment
Pernicious anaemia
3.5
6.2
27
79
AC1
HP
MVR mechanical
26.8
6.2
8
*
B81
ICPC
Anaemia vit B12/folate deficiency
2.6
6.2
44
176
ZX121
NOMESCO Finland
Central venous catheter
7.1
6.2
14
20
A02BC05
ATC
esomeprazole; systemic
1.4
6.2
387
3064
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.8
6.2
101
579
ZXA00
NOMESCO Finland
Right side
1.5
6.2
265
1956
81
HP
Angiography of the heart and coronary arteries
2.0
6.2
72
367
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.5
6.1
26
75
RS220
NOMESCO Finland
NA
4.1
6.1
22
55
K92.0
ICD-10 Finland
Haematemesis
2.9
6.1
33
114
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
6.1
127
786
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
12.6
6.1
10
8
Z94.4
ICD-10 Finland
Liver transplant status
8.6
6.1
12
14
A06AD11
ATC
lactulose; oral
1.6
6.1
150
974
A07AA09
ATC
vancomycin; oral
4.4
6.1
20
46
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
6.7
6.0
14
21
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.0
172
1161
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
6.1
6.0
15
25
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
3.7
6.0
24
66
Mortality – FinRegistry
↥Association
Association between endpoint D3_HAEMOLYTICANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMOLYTICANAEMIA | 2.473 [2.14, 2.85] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 1256 out of 4383 females with D3_HAEMOLYTICANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMOLYTICANAEMIA | 2.749 [2.33, 3.24] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1102 out of 3793 males with D3_HAEMOLYTICANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_HAEMOLYTICANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.505% |
| 5 | 1.307% | 3.3% |
| 10 | 3.425% | 7.845% |
| 15 | 6.329% | 14.152% |
| 20 | 10.539% | 23.642% |
Relationships between endpoints
↥Index endpoint: D3_HAEMOLYTICANAEMIA – Haemolytic anaemias
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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