Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
569 |
4. Check minimum number of eventsNone |
569 |
5. Include endpointsNone |
569 |
6. Filter based on genotype QC (FinnGen only) |
569 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_EXCL
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D72
- Name in latin
- Eosinophilia
Similar endpoints
↥List of similar endpoints to
Eosinophilic disease (BM)
based on the number of shared cases.
Similar with more cases:
- Eosinophilia
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3527 | 1843 | 1656 |
| Only index persons | 3164 | 1666 | 1498 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 54.37 | 53.72 | 55.30 |
| Only index persons | 53.92 | 52.99 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 569 | 302 | 267 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 56.84 | 52.68 | 61.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 501
- Matched controls
- 5020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D72.1
ICD-10 Finland
Eosinophilia
+∞
323.0
489
*
J45.9
ICD-10 Finland
Asthma, unspecified
35.0
148.0
196
90
J45.1
ICD-10 Finland
Nonallergic asthma
511.4
124.6
119
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
18.7
118.0
194
163
H02AB06
ATC
prednisolone; systemic
9.0
110.6
359
1089
J45.0
ICD-10 Finland
Predominantly allergic asthma
77.1
102.1
114
19
J18.9
ICD-10 Finland
Pneumonia, unspecified
20.1
98.2
154
108
R03DC03
ATC
montelukast; oral
12.8
84.8
163
181
R03BB04
ATC
tiotropium bromide; inhalant
33.3
78.9
104
39
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
54.1
78.5
93
21
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
292.9
75.6
75
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.7
72.2
314
1133
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
47.9
66.9
81
20
R03AC02
ATC
salbutamol; inhalant
5.2
65.3
328
1332
J32.4
ICD-10 Finland
Chronic pansinusitis
651.0
60.0
58
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
11.3
59.9
120
136
R03AK08
ATC
formoterol and beclometasone; inhalant
65.2
59.3
68
12
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
625.6
57.8
56
*
XW000
NOMESCO Finland
Bone marrow biopsy
19.9
57.3
88
53
UGC12
NOMESCO Finland
Flexible bronchoscopy
27.3
57.1
79
34
J33.0
ICD-10 Finland
Polyp of nasal cavity
111.1
55.1
59
6
R03BA05
ATC
fluticasone; inhalant
7.8
54.7
139
234
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
153.9
53.0
55
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
20.0
52.3
80
47
TDM10
NOMESCO Finland
Puncture of maxillary antrum
538.4
50.3
49
*
J45
ICD-10 Finland
Asthma
14.0
49.2
87
74
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
45.8
226
806
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
11.9
45.5
87
87
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
11.8
44.5
85
85
R01AD08
ATC
fluticasone; nasal
4.5
44.1
194
615
XG474
NOMESCO Finland
Exhalation nntrogen oxide
43.0
43.8
54
14
J46
ICD-10 Finland
Status asthmaticus
430.1
40.7
40
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
44.1
39.2
48
12
R03BA08
ATC
ciclesonide; inhalant
9.9
37.8
79
93
J45.8
ICD-10 Finland
Mixed asthma
108.4
37.3
40
*
R03AK07
ATC
formoterol and budesonide; inhalant
5.2
36.2
126
304
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
35.8
34
*
R01AD09
ATC
mometasone; nasal
3.4
35.6
261
1218
TGC00
NOMESCO Finland
Bronchial lavation
193.3
35.2
36
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
31.5
34.9
46
16
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
20.6
34.8
52
28
J33.8
ICD-10 Finland
Other polyp of sinus
+∞
34.8
33
*
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
+∞
34.8
33
*
H02AB04
ATC
methylprednisolone; systemic
5.7
34.7
109
232
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.2
34.5
290
1487
R03AC12
ATC
salmeterol; inhalant
29.6
34.4
46
17
DHB20
NOMESCO Finland
Polypectomy of internal nose
348.6
33.3
33
*
H02AB07
ATC
prednisone; oral
5.7
33.1
103
216
R96
ICPC
Asthma
9.7
32.9
69
81
R50.9
ICD-10 Finland
Fever, unspecified
5.4
32.7
107
238
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.4
32.0
133
381
R03BA01
ATC
beclometasone; inhalant
6.0
31.9
94
184
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
31.4
110
264
XQ800
NOMESCO Finland
Prick test
8.7
31.2
70
92
J31.0
ICD-10 Finland
Chronic rhinitis
13.6
30.8
54
44
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
20.4
30.2
45
24
A02BC02
ATC
pantoprazole; systemic
3.1
30.2
348
2129
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
16.1
28.9
47
32
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
23.4
28.7
41
19
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
16.7
28.7
46
30
R06.0
ICD-10 Finland
Dyspnoea
3.9
28.5
136
437
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
+∞
28.4
27
*
J01MA14
ATC
moxifloxacin; systemic
7.6
28.4
69
103
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
8.1
28.3
66
92
R03AK11
ATC
formoterol and fluticasone; inhalant
45.3
28.1
34
8
J01MA12
ATC
levofloxacin; systemic
4.1
27.8
121
357
R03AC13
ATC
formoterol; inhalant
13.8
27.7
48
38
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.8
27.3
100
249
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
26.6
173
702
R06AE07
ATC
cetirizine; oral
2.8
26.3
246
1271
R03BA02
ATC
budesonide; inhalant
4.5
26.1
102
270
XG410
NOMESCO Finland
Flow-volume spirometry
20.0
26.1
39
21
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
20.4
25.6
38
20
R01AD12
ATC
fluticasone furoate; nasal
3.1
25.4
176
744
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.1
25.0
85
194
R03DA04
ATC
theophylline; systemic, rectal
14.8
24.5
41
30
J01AA02
ATC
doxycycline; systemic
2.9
23.7
395
2805
WZC30
NOMESCO Finland
Teaching
4.0
23.2
101
294
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
23.1
76
167
J34.2
ICD-10 Finland
Deviated nasal septum
68.3
23.0
26
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
65.5
22.0
25
*
A02BC01
ATC
omeprazole; systemic
2.9
21.9
166
730
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
229.4
21.8
22
*
R05
ICD-10 Finland
Cough
3.4
21.7
121
429
R03AC03
ATC
terbutaline; inhalant
4.4
20.9
80
206
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
80.2
20.8
23
*
J47
ICD-10 Finland
Bronchiectasis
218.5
20.7
21
*
C03CA01
ATC
furosemide; systemic
3.0
20.3
142
589
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.6
20.0
41
46
DPA30
NOMESCO Finland
Sphenotomy
207.7
19.7
20
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.5
19.6
208
1101
R03DC01
ATC
zafirlukast; oral
35.9
19.1
24
7
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.9
18.8
134
558
J01FA06
ATC
roxithromycin; oral
2.5
18.5
200
1061
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
18.4
92
298
UDM02
NOMESCO Finland
Sinoscopy
45.8
18.4
22
5
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
18.3
117
453
ZX112
NOMESCO Finland
Subcutaneous
14.4
18.0
30
22
J01DB01
ATC
cefalexin; oral
2.6
17.7
413
3194
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
186.2
17.6
18
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
17.6
210
1163
H02AB09
ATC
hydrocortisone; systemic
14.6
17.5
29
21
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
10.9
17.4
33
32
JN4BD
NOMESCO Finland
Extensive body CT
3.9
17.1
74
212
E0000UV
ATC
NA
2.3
16.9
212
1200
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
16.8
106
406
M05BA04
ATC
alendronic acid; oral
4.8
16.8
58
134
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
16.8
16
*
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
3.0
16.7
109
426
R06AX27
ATC
desloratadine; oral
2.6
16.4
146
687
J01FA09
ATC
clarithromycin; systemic
2.4
16.2
166
845
R02
ICPC
Shortness of breath/dyspnoea
4.4
16.2
60
149
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.4
16.2
61
154
R01AD01
ATC
beclometasone; nasal
3.3
16.1
88
303
ZXA10
NOMESCO Finland
Bilateral
2.9
15.9
108
433
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
15.7
116
489
Z88.6
ICD-10 Finland
Personal history of allergy to analgesic agent
+∞
15.7
15
*
D07AC01
ATC
betamethasone; topical
2.3
15.6
180
968
J01CA04
ATC
amoxicillin; systemic
2.4
15.4
399
3100
WX002
NOMESCO Finland
Sedation and analgesia
2.7
15.1
120
526
J01FF01
ATC
clindamycin; systemic
2.5
15.1
147
721
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.3
15.1
57
144
J01FA10
ATC
azithromycin; systemic
2.1
14.9
285
1911
DJD20
NOMESCO Finland
Plastic repair of septum of nose
58.5
14.9
17
*
GD1AD
NOMESCO Finland
Thorax CT examination
7.7
14.7
34
47
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
154.2
14.5
15
*
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
17.6
14.4
22
13
R06AE09
ATC
levocetirizine; oral
3.0
14.3
92
354
R06.2
ICD-10 Finland
Wheezing
8.4
14.3
31
39
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
14.1
180
1006
R01AD05
ATC
budesonide; nasal
4.5
13.9
50
120
J33.9
ICD-10 Finland
Nasal polyp, unspecified
24.6
13.9
19
8
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.8
13.9
61
177
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
13.7
93
370
3028
Kela drug reimbursment
Mepolizumab
+∞
13.6
13
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
13.6
13
*
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
+∞
13.6
13
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
16.8
13.6
21
13
A02BC05
ATC
esomeprazole; systemic
2.2
13.5
196
1151
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.4
13.4
49
120
UJF32
NOMESCO Finland
Coloscopy
2.4
13.2
134
664
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
13.2
50
127
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
13.0
73
256
L04AA06
ATC
mycophenolic acid; systemic
23.2
13.0
18
8
DHB50
NOMESCO Finland
Turbinoplasty
51.4
12.9
15
*
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
7.6
12.7
29
40
297
Kela drug reimbursment
NA
+∞
12.5
12
*
2883X
ICD-9 Finland
Diseases of white blood cells, Eosinophilia[EOSINOPHILIA, NUD]
+∞
12.5
12
*
R03DX09
ATC
mepolizumab; parenteral
+∞
12.5
12
*
C07AB07
ATC
bisoprolol; oral
2.0
12.3
223
1426
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.4
12.2
60
191
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
7.3
12.0
28
40
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
19.5
11.7
17
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
11.6
114
554
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
14.0
11.5
19
14
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
+∞
11.5
11
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
+∞
11.5
11
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
+∞
11.5
11
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.8
11.4
28
43
B03XA02
ATC
darbepoetin alfa; parenteral
15.5
11.4
18
12
R03BB01
ATC
ipratropium bromide; inhalant
9.9
11.3
22
23
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.3
11.3
42
105
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
13.1
11.2
19
15
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
11.2
103
485
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
11.1
129
677
XX3DW
NOMESCO Finland
Time consuming IT work
3.0
11.1
68
252
A07AA02
ATC
nystatin; oral
4.9
11.1
36
78
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
11.0
97
445
S97
ICPC
Chronic ulcer skin
4.8
11.0
36
79
R06AX13
ATC
loratadine; oral
2.6
11.0
83
349
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.5
10.9
38
89
SPAT1254
SPAT
Administration of medicine
2.7
10.9
77
312
R06AX22
ATC
ebastine; oral
2.5
10.9
93
418
UDQ12
NOMESCO Finland
Flexible laryngoscopy
6.2
10.7
28
47
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.9
10.7
66
247
J30.3
ICD-10 Finland
Other allergic rhinitis
9.5
10.6
21
23
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
10.6
79
332
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
10.5
134
729
A46
ICD-10 Finland
Erysipelas
2.8
10.5
71
278
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
10.5
56
190
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
112.2
10.5
11
*
B01AA03
ATC
warfarin; systemic
2.4
10.4
98
464
J96.1
ICD-10 Finland
Chronic respiratory failure
+∞
10.4
10
*
D07AD01
ATC
clobetasol; topical
2.5
10.4
86
383
R53
ICD-10 Finland
Malaise and fatigue
2.5
10.3
88
397
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
23.9
10.3
14
6
XG405
NOMESCO Finland
Education on PEF monitoring
23.9
10.3
14
6
R01AD11
ATC
triamcinolone; nasal
3.3
10.2
52
170
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
10.0
212
1403
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
10.0
200
1295
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
9.9
142
810
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
7.2
9.9
23
33
D07AC13
ATC
mometasone; topical
2.0
9.8
146
847
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
56.1
9.7
11
*
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
56.1
9.7
11
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.3
9.6
18
18
SPAT1263
SPAT
Sampling
1.9
9.6
205
1359
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.4
9.5
46
145
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
9.5
55
198
Z49.1
ICD-10 Finland
Extracorporeal dialysis
12.7
9.4
16
13
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
+∞
9.4
9
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
9.4
9
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
+∞
9.4
9
*
E000001
ATC
NA
2.2
9.3
103
525
L29.9
ICD-10 Finland
Pruritus, unspecified
6.9
9.2
22
33
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
9.1
60
232
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.7
9.1
30
67
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
10.3
9.1
17
17
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
9.1
41
123
DHA10
NOMESCO Finland
Biopsy of cavity of nose
37.4
9.0
11
*
A41.9
ICD-10 Finland
Sepsis, unspecified
6.3
9.0
23
38
EMB10
NOMESCO Finland
Tonsillectomy
24.5
8.9
12
5
I50.9
ICD-10 Finland
Heart failure, unspecified
3.1
8.9
50
174
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.2
8.9
33
83
D07AA02
ATC
hydrocortisone; topical
2.5
8.8
73
321
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
8.8
169
1071
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
8.8
56
214
L50.9
ICD-10 Finland
Urticaria, unspecified
5.2
8.8
26
52
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
7.1
8.6
20
29
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
28.0
8.5
11
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.1
8.4
18
23
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
13.0
8.4
14
11
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
8.4
78
365
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.4
8.4
39
120
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
+∞
8.4
8
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
11.0
8.3
15
14
NH3EA
NOMESCO Finland
Feet X-ray examination with load
7.3
8.3
19
27
R4110
NOMESCO Finland
Physiotherapy
2.0
8.3
119
676
M05BX04
ATC
denosumab; parenteral
4.7
8.3
27
60
N05BA04
ATC
oxazepam; oral
2.0
8.2
109
600
TK800
NOMESCO Finland
Hemodialysis
8.3
8.1
17
21
49300
ICD-8 Finland
Asthma, bronchiale
8.3
8.1
17
21
L04AX01
ATC
azathioprine; systemic
4.3
8.1
29
71
L28.1
ICD-10 Finland
Prurigo nodularis
17.5
8.1
12
7
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
17.5
8.1
12
7
Z49.0
ICD-10 Finland
Preparatory care for dialysis
33.9
8.1
10
*
B01AB10
ATC
tinzaparin; parenteral
3.4
8.1
38
118
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
10.3
8.1
15
15
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
5.3
7.9
23
45
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.0
7.9
17
22
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
7.9
49
182
WW200
NOMESCO Finland
Immunization
6.3
7.9
20
33
J01DA01
ATC
[U] cefalexin; systemic
1.7
7.9
284
2172
UDC00
NOMESCO Finland
Ear microscopy
3.0
7.8
44
154
C01CA24
ATC
epinephrine; parenteral
3.8
7.8
32
89
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.5
7.8
35
105
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.4
7.8
36
111
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
7.7
152
964
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
7.7
134
814
J42
ICD-10 Finland
Unspecified chronic bronchitis
45.7
7.7
9
*
T78.4
ICD-10 Finland
Allergy, unspecified
4.3
7.7
27
65
J01FA15
ATC
telithromycin; oral
2.7
7.7
50
194
N02BE01
ATC
paracetamol; systemic, rectal
1.9
7.7
401
3418
L28
ICPC
Limited function/disability (L)
2.4
7.7
64
285
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.8
7.7
48
181
L50.3
ICD-10 Finland
Dermatographic urticaria
8.2
7.6
16
20
J37.0
ICD-10 Finland
Chronic laryngitis
18.7
7.6
11
6
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
18.7
7.6
11
6
R07
ICPC
Sneezing/nasal congestion
3.6
7.6
33
97
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
3.2
7.5
38
125
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
7.5
39
131
H03AA01
ATC
levothyroxine sodium; systemic
2.0
7.5
99
544
WX892
NOMESCO Finland
Monitored bed care
3.2
7.5
37
120
M81.4
ICD-10 Finland
Drug-induced osteoporosis
81.2
7.4
8
*
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
81.2
7.4
8
*
127
Kela drug reimbursment
Transplant complication
13.6
7.4
12
9
WX110
NOMESCO Finland
Local anesthesy
1.7
7.3
328
2640
M04AA01
ATC
allopurinol; systemic
2.5
7.3
59
257
3027
Kela drug reimbursment
Benralizumab
+∞
7.3
7
*
JN4AD
NOMESCO Finland
Body CT examination
3.0
7.3
41
143
N18.0
ICD-10 Finland
End-stage renal disease
16.0
7.3
11
7
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.9
7.2
22
46
R05
ICPC
Cough
2.0
7.2
97
535
AA1AD
NOMESCO Finland
CT of head and brain
2.0
7.2
107
611
G47.3
ICD-10 Finland
Sleep apnoea
2.0
7.2
91
490
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
30.5
7.2
9
*
J34.3
ICD-10 Finland
Hypertrophy of nasal turbinates
30.5
7.2
9
*
J35.0
ICD-10 Finland
Chronic tonsillitis
20.3
7.2
10
5
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
20.3
7.2
10
5
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
20.3
7.2
10
5
N18.8
ICD-10 Finland
Other chronic renal failure
5.4
7.1
20
38
R06AX26
ATC
fexofenadine; oral
3.4
7.1
33
102
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
12.2
7.1
12
10
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.2
7.1
12
10
ZX120
NOMESCO Finland
Intravenous
2.9
7.1
42
154
A01AB09
ATC
miconazole; local oral
2.9
7.1
42
154
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
10.2
7.1
13
13
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
7.1
52
217
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.9
7.0
42
155
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
5.0
7.0
21
43
SPAT1262
SPAT
Handing over of treatment supplies
2.1
7.0
88
471
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
6.9
64
297
R11
ICD-10 Finland
Nausea and vomiting
2.9
6.9
40
144
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
6.9
102
583
A02BA02
ATC
ranitidine; systemic
2.1
6.9
85
452
R75
ICPC
Sinusitis acute/chronic
4.1
6.9
25
63
SPAT1058
SPAT
PEF monitoring instruction
3.1
6.8
35
117
J02AC01
ATC
fluconazole; systemic
1.7
6.8
173
1179
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
9.5
6.8
13
14
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.5
6.8
13
14
N02AA05
ATC
oxycodone; systemic
2.4
6.8
56
248
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.9
6.8
39
140
H05AA02
ATC
teriparatide; parenteral
40.6
6.8
8
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
40.6
6.8
8
*
318
Kela drug reimbursment
Teriparatide
40.6
6.8
8
*
V03AE01
ATC
polystyrene sulfonate; oral
17.0
6.8
10
6
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.6
6.7
16
25
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
6.7
133
841
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.7
6.7
21
46
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.8
6.6
40
149
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
6.6
31
97
S18
ICPC
Laceration/cut
1.7
6.6
194
1377
I50.0
ICD-10 Finland
Congestive heart failure
3.7
6.6
27
76
N05CF01
ATC
zopiclone; oral
1.8
6.6
129
810
SPAT1260
SPAT
Consultation of another employee
2.0
6.6
87
478
N03AX16
ATC
pregabalin; oral
1.9
6.5
97
557
J36
ICD-10 Finland
Peritonsillar abscess
70.7
6.4
7
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
14.5
6.4
10
7
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
6.4
49
210
R20.2
ICD-10 Finland
Paraesthesia of skin
3.0
6.4
34
117
A03
ICPC
Fever
2.1
6.4
70
355
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
6.7
6.4
15
23
D02AE01
ATC
carbamide; topical
2.7
6.3
41
159
L04AA01
ATC
[U] ciclosporin; systemic
9.4
6.3
12
13
R06.5
ICD-10 Finland
Mouth breathing
2.7
6.3
41
160
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
18.3
6.3
9
5
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
+∞
6.3
6
*
I42.3
ICD-10 Finland
Endomyocardial (eosinophilic) disease
+∞
6.3
6
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
+∞
6.3
6
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
+∞
6.3
6
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
6.3
6
*
J20.5
ICD-10 Finland
Acute bronchitis due to respiratory syncytial virus
+∞
6.3
6
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
6.3
6
*
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
6.3
6
*
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
27.0
6.2
8
*
RK110
NOMESCO Finland
NA
27.0
6.2
8
*
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
27.0
6.2
8
*
J01.1
ICD-10 Finland
Acute frontal sinusitis
27.0
6.2
8
*
A11CC03
ATC
alfacalcidol; systemic
6.4
6.2
15
24
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
5.5
6.2
17
32
P01AB01
ATC
metronidazole; oral, rectal
1.7
6.1
172
1201
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.6
6.1
43
175
R13
ICD-10 Finland
Dysphagia
3.2
6.1
29
93
XF600
NOMESCO Finland
Bloodpressure measurement
3.1
6.0
31
105
Mortality – FinRegistry
↥Association
Association between endpoint ESOSINOPHIL_DISEASE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ESOSINOPHIL_DISEASE | 1.584 [1.31, 1.92] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.321 |
During the follow-up period (1.1.1998 — 31.12.2019), 216 out of 1475 females with ESOSINOPHIL_DISEASE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ESOSINOPHIL_DISEASE | 1.733 [1.41, 2.13] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 271 out of 1353 males with ESOSINOPHIL_DISEASE died.
Mortality risk
Mortality risk for people of age
years, who have ESOSINOPHIL_DISEASE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.352% |
| 5 | 1.08% | 1.952% |
| 10 | 2.6% | 4.925% |
| 15 | 4.718% | 9.169% |
| 20 | 8.017% | 15.241% |
Relationships between endpoints
↥Index endpoint: ESOSINOPHIL_DISEASE – Eosinophilic disease (BM)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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