Dementia in Alzheimer disease

F5_ALZHDEMENT

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F00*
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*
Cause of death: ICD-8 29010

2 out of 7 registries used, show all original rules.

6140

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Check minimum number of events None

6140

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Include endpoints None

6140

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Remove individuals based on genotype QC

5422

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F5_ALZHDEMENT

Control definitions

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 5422 2405 3017
Unadjusted prevalence (%) 1.44 1.14 1.81
Mean age at first event (years) 79.62 79.72 79.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 9.05 [7.81, 10.48] <1e-100 3159
15 years 0.02 2.60 [2.24, 3.03] 1.8e-35 847
5 years 0.01 6.79 [6.08, 7.57] <1e-100 1540
1 year 0.00 12.35 [10.90, 14.00] <1e-100 760

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease
GWS hits: 6

Survival analyses between endpoints

Plot

before Dementia in Alzheimer disease
after Dementia in Alzheimer disease

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Drugs most likely to be purchased after Dementia in Alzheimer disease

Not a core endpoint, no data to show.