Femoral hernia, bilateral

FEMHER_BILATERAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

97

4. Check minimum number of events

None

97

5. Include endpoints

None

97

6. Filter based on genotype QC (FinnGen only)

93

Control definitions (FinnGen only)

Control exclude
K11_HERNIA

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 879 487 390
Only index persons 757 427 330
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 64.25 66.06 61.96
Only index persons 62.17 63.86 59.99

-FinnGen-

Key figures

All Female Male
Number of individuals 93 56 37
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 59.77 60.52 58.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
97
Matched controls
968
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
55.7
48
*
K41.0
ICD-10 Finland
Bilateral femoral hernia, with obstruction, without gangrene
+∞
47.9
42
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
+∞
44.2
39
*
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
+∞
25.1
23
*
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
+∞
18.3
17
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
218.0
18.2
18
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
148.2
12.8
13
*
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
10.6
10
*
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
+∞
10.6
10
*
JAB10
NOMESCO Finland
Repair of inguinal hernia
+∞
9.5
9
*
K41.1
ICD-10 Finland
Bilateral femoral hernia, with gangrene
+∞
8.4
8
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
24.5
8.2
11
5
A06AD11
ATC
lactulose; oral
4.5
7.7
29
83
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
86.3
7.5
8
*
JAC10
NOMESCO Finland
Repair of femoral hernia
+∞
7.4
7
*
R51.80
ICD-10 Finland
Headache
4.8
7.0
24
62
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
28.7
6.3
8
*
D01
ICPC
Abdominal pain/cramps general
5.1
6.2
19
44
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.0
6.0
16
31

Mortality – FinRegistry

Association

Association between endpoint FEMHER_BILATERAL and mortality.

Females

Parameter HR [95% CI] p-value
FEMHER_BILATERAL 1.462 [1.18, 1.81] < 0.001
Birth year 1.0 [0.99, 1.01] 0.999

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 427 females with FEMHER_BILATERAL died.

Males

Parameter HR [95% CI] p-value
FEMHER_BILATERAL 1.338 [1.05, 1.71] 0.021
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 348 males with FEMHER_BILATERAL died.

Mortality risk

Mortality risk for people of age

years, who have FEMHER_BILATERAL.

N-year risk Females Males
1 0.167% 0.245%
5 0.996% 1.493%
10 2.343% 3.873%
15 4.664% 7.459%
20 7.967% 12.692%

Relationships between endpoints

Index endpoint: FEMHER_BILATERAL – Femoral hernia, bilateral

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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