Alzheimer’s disease, wide definition

G6_AD_WIDE

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F00*, G30
Hospital discharge: ICD-9 3310
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*, G30
Cause of death: ICD-9 3310
Cause of death: ICD-8 29010
KELA reimbursements: KELA codes 307
KELA reimbursements: ICD-10 F00*, G30
Medicine purchases: ATC N06D

4 out of 7 registries used, show all original rules.

15244

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Check minimum number of events

Min. number of events 3

15244

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Include endpoints

15244

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Remove individuals based on genotype QC

13393

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G6_AD_WIDE

Control definitions

Control exclude G6_ALZHEIMER

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 13393 5830 7563
Unadjusted prevalence (%) 3.55 2.77 4.55
Mean age at first event (years) 78.21 78.32 78.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 7.30 [6.62, 8.06] <1e-100 5899
15 years 0.02 2.81 [2.55, 3.09] 5.7e-100 2013
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition
GWS hits: 21

Survival analyses between endpoints

Plot

before Alzheimer’s disease, wide definition
after Alzheimer’s disease, wide definition

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Drugs most likely to be purchased after Alzheimer’s disease, wide definition