Alzheimer disease

G6_ALZHEIMER

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G30
  • Hospital discharge: ICD-9 3310
  • Cause of death: ICD-10 G30
  • Cause of death: ICD-9 3310

2 out of 7 registries used, show all original rules.

12198

4. Check minimum number of events

None

12198

5. Include endpoints

None

12198

6. Filter based on genotype QC (FinnGen only)

11755

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G30-G32
Name in latin
Morbus Alzheimer

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 227475 144794 80971
Only index persons 189864 122913 66951
Unadjusted period prevalence (%)
Whole population 3.46 4.15 2.26
Only index persons 3.83 4.52 2.56
Median age at first event (years)
Whole population 82.31 83.07 81.01
Only index persons 82.76 83.50 81.40

-FinnGen-

Key figures

All Female Male
Number of individuals 11755 5354 6401
Unadjusted period prevalence (%) 2.71 2.10 3.21
Median age at first event (years) 80.28 80.25 80.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
9844
Matched controls
79845
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N06DA02
ATC
donepezil; oral
43.5
323.0
4692
1637
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
273.7
323.0
3421
155
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
209.0
323.0
490
20
N06DA03
ATC
rivastigmine; oral, transdermal
30.4
323.0
2810
1037
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
88.4
323.0
4142
651
P70
ICPC
Dementia
17.4
323.0
1158
606
P20
ICPC
Memory disturbance
6.5
323.0
4288
8495
N05AX08
ATC
risperidone; systemic
10.8
323.0
2669
2648
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
30.5
323.0
1277
388
G30.1
ICD-10 Finland
Alzheimer disease with late onset
123.3
323.0
5812
919
F0019, G301
ICD-10 Finland
NA
+∞
323.0
483
*
A28
ICPC
Limited function/disability NOS
2.9
323.0
3233
11508
N05AH04
ATC
quetiapine; oral
4.8
323.0
2140
4378
F03
ICD-10 Finland
Unspecified dementia
7.9
323.0
1951
2415
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.4
323.0
2581
4185
G30.8
ICD-10 Finland
Other Alzheimer disease
54.4
323.0
1700
305
SPAT1053
SPAT
Memory test
3.6
323.0
3770
11844
N06DX01
ATC
memantine; oral
56.7
323.0
5608
1821
G30.0
ICD-10 Finland
Alzheimer disease with early onset
442.4
323.0
851
17
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
60.2
323.0
2465
440
G30
ICD-10 Finland
Alzheimer disease
64.9
323.0
855
117
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
32.3
323.0
930
257
N06DA04
ATC
galantamine; oral
19.8
323.0
1265
590
F009, G309
ICD-10 Finland
NA
1455.7
319.0
335
*
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
17.5
292.8
498
242
R41.3
ICD-10 Finland
Other amnesia
6.4
285.5
834
1139
SPAT1245
SPAT
Provision of support and information to patient’s family members
4.2
278.1
1191
2507
R53
ICD-10 Finland
Malaise and fatigue
2.5
267.1
2828
11246
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
30.7
261.6
376
103
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.9
238.9
1705
5330
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
236.4
3825
18379
SPAT1216
SPAT
Assessment of functional ability
2.3
221.6
2524
10244
N05BA04
ATC
oxazepam; oral
2.2
213.3
2769
11929
F06.7
ICD-10 Finland
Mild cognitive disorder
5.0
208.5
746
1291
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
202.4
1306
3780
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
191.2
3794
19321
SPAT1234
SPAT
Support of social functional capacity
3.4
186.3
1031
2657
WYA20
NOMESCO Finland
Home visit
7.5
181.3
466
523
TAB00
NOMESCO Finland
Lumbar puncture
5.7
178.2
565
846
N06AX11
ATC
mirtazapine; oral
2.0
171.5
3018
14520
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
170.5
2553
11503
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
163.1
2006
8265
AA1AD
NOMESCO Finland
CT of head and brain
1.9
158.8
3071
15215
F0009, G300
ICD-10 Finland
NA
+∞
155.9
162
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
13.0
149.4
285
183
R41.0
ICD-10 Finland
Disorientation, unspecified
3.8
148.8
696
1552
N06AB10
ATC
escitalopram; oral
2.5
147.8
1390
4988
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
70.8
146.2
180
21
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.1
141.0
881
2459
SPAT1254
SPAT
Administration of medicine
2.1
136.3
1959
8554
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
135.2
2148
9763
N03AG01
ATC
valproic acid; systemic, rectal
3.8
133.8
628
1402
F0029, G308
ICD-10 Finland
NA
+∞
123.1
128
*
N02BE01
ATC
paracetamol; systemic, rectal
1.8
119.3
7851
54850
A06AD11
ATC
lactulose; oral
1.9
118.3
2248
10841
N05AH03
ATC
olanzapine; systemic
4.3
116.3
480
951
L28
ICPC
Limited function/disability (L)
1.9
114.3
2172
10454
A04
ICPC
Weakness/tiredness general
2.1
111.1
1571
6747
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
108.1
1227
17205
F0014, G301
ICD-10 Finland
NA
917.9
105.7
112
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
103.9
720
2139
N05BA06
ATC
lorazepam; systemic, sublingual
2.8
101.2
720
2173
XA800
NOMESCO Finland
Neuropsychological investigation
4.6
96.4
367
670
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
95.0
1695
7910
F00.14
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms of mixed type
49.6
93.4
121
20
Z75.5
ICD-10 Finland
Holiday relief care
5.7
91.1
285
417
130
Kela drug reimbursment
Malignant tumour
0.3
88.3
206
5285
N05AD01
ATC
haloperidol; systemic
3.1
87.8
523
1398
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
4.7
87.2
322
569
S72.0
ICD-10 Finland
Fracture of neck of femur
2.5
85.1
743
2521
F001, G301
ICD-10 Finland
NA
52.5
85.0
109
17
N06AB04
ATC
citalopram; systemic
1.8
83.9
1859
9283
U04
ICPC
Incontinence urine
2.5
80.5
679
2257
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
4.8
80.4
290
500
F00.1
ICD-10 Finland
Dementia in Alzheimer disease with late onset
63.1
80.2
100
13
F00
ICD-10 Finland
Dementia in Alzheimer disease
15.2
80.0
142
77
N06AX26
ATC
vortioxetine; oral
3.6
79.6
396
923
SPAT1360
SPAT
Extensive global examination
2.2
77.8
918
3609
S01.0
ICD-10 Finland
Open wound of scalp
2.2
74.8
875
3423
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.9
73.8
487
1395
R55
ICD-10 Finland
Syncope and collapse
1.8
72.8
1405
6676
N02AA05
ATC
oxycodone; systemic
1.7
71.1
1806
9343
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
71.0
1345
6345
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
70.9
1592
7936
SPAT1301
SPAT
No procedures
1.5
70.2
3188
19117
SPAT1101
SPAT
Orthostatic test
2.3
67.6
719
2687
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
65.0
649
2351
F21
ICPC
NA
5.2
62.3
208
330
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
29.3
59.8
86
24
SPAT1246
SPAT
Screening of depression or other psychiatric problem
3.5
57.9
290
680
S06.0
ICD-10 Finland
Concussion
1.9
56.9
919
4078
S70.0
ICD-10 Finland
Contusion of hip
2.5
56.8
486
1623
F05.9
ICD-10 Finland
Delirium, unspecified
3.0
56.1
346
945
I95.1
ICD-10 Finland
Orthostatic hypotension
2.3
55.3
581
2153
SPAT1252
SPAT
Overall medication plan or its review
1.9
54.4
867
3825
SPAT1229
SPAT
Assessment of need for aid
1.8
53.4
1028
4844
SPAT1172
SPAT
Guidance concerning hydration
2.7
53.2
396
1221
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.8
52.5
373
1118
H02AB02
ATC
dexamethasone; systemic
0.4
50.9
221
4367
F0011, G301
ICD-10 Finland
NA
+∞
50.9
53
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
50.7
1304
6701
W19
ICD-10 Finland
Unspecified fall
1.8
50.0
926
4303
G04CA02
ATC
tamsulosin; oral
1.4
48.6
3265
20788
SPAT1304
SPAT
Counselling and guidance related to ageing
1.7
48.3
1076
5298
Z01.9
ICD-10 Finland
Special examination, unspecified
2.2
47.7
525
1988
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
4.0
47.5
206
428
SPAT1251
SPAT
Organisation of medication
2.3
47.4
485
1774
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.8
47.2
975
4691
N05AD03
ATC
melperone; systemic
3.5
47.0
235
551
N02AJ06
ATC
codeine and paracetamol; systemic
0.7
46.8
1383
15923
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
46.7
626
2578
3310A
ICD-9 Finland
Other cerebral degenerations, Alzheimer's disease
+∞
46.1
48
*
SPAT1153
SPAT
Removal of sutures
0.7
45.7
1709
18847
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.2
44.7
511
1967
N07AA05
ATC
NA
381.6
43.5
47
*
E86
ICD-10 Finland
Volume depletion
2.5
43.0
361
1193
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.9
43.0
710
3164
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.7
42.8
1106
5671
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.6
42.4
1137
13386
R42
ICD-10 Finland
Dizziness and giddiness
1.4
42.1
2246
13613
A29
ICPC
General symptom/complaint other
1.7
42.0
1092
5611
B03BA03
ATC
hydroxocobalamin; parenteral
1.8
41.9
774
3584
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
1.7
41.8
961
4765
F0024, G308
ICD-10 Finland
NA
+∞
40.3
42
*
Z02.7
ICD-10 Finland
Issue of medical certificate
2.0
39.6
567
2394
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.2
39.4
423
1583
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.6
38.8
313
1013
C10AA01
ATC
simvastatin; oral
1.3
37.8
5050
35425
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
6.1
37.7
109
146
R41
ICD-10 Finland
Other symptoms and signs involving cognitive functions and awareness
4.6
37.0
137
245
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.5
36.7
1765
10438
R33
ICD-10 Finland
Retention of urine
1.6
35.9
1132
6094
N06AB06
ATC
sertraline; oral
1.9
35.8
566
2480
J01DB01
ATC
cefalexin; oral
1.3
35.5
6463
47195
Z29
ICPC
Social problem NOS
3.1
34.2
199
524
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
34.1
1237
6880
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
34.1
2943
19251
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.0
33.8
473
1981
N30.0
ICD-10 Finland
Acute cystitis
1.5
33.3
1200
6663
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.8
33.3
652
3071
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
32.3
1708
10257
SPAT1139
SPAT
Nutrition survey
2.2
32.1
339
1260
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.9
31.8
538
2414
Z2445
NOMESCO Finland
Psychologist
3.2
31.7
180
467
WZC30
NOMESCO Finland
Teaching
0.6
31.6
387
5484
F00.24
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type other additional symptoms of mixed type
28.2
31.4
45
13
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.0
31.2
188
507
G31.0
ICD-10 Finland
Circumscribed brain atrophy
5.9
30.7
90
124
A03FA01
ATC
metoclopramide; systemic, rectal
0.7
29.9
893
10371
A04AA02
ATC
granisetron; systemic, transdermal
0.3
29.7
87
2026
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.4
29.7
1579
9482
SPAT1167
SPAT
Insertion of urinary catheter
1.9
28.9
456
1994
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.4
28.9
256
874
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.7
28.7
630
3070
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.2
28.7
308
1154
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
28.5
3072
20621
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
0.3
28.3
51
1499
WX402
NOMESCO Finland
General anaesthesia
0.6
28.2
387
5331
F00.11
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms, mainly paranoidism
21.9
28.0
43
16
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
1.9
28.0
443
1941
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
3.7
27.8
128
283
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.4
27.7
142
343
F01.2
ICD-10 Finland
Subcortical vascular dementia
4.5
27.6
102
184
S18
ICPC
Laceration/cut
0.8
27.2
2555
24970
F002, G308
ICD-10 Finland
NA
30.9
27.2
38
10
A69
ICPC
General and Unspecified, Other reason for encounter NEC
2.2
27.1
282
1041
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.6
27.0
639
7779
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.4
26.7
244
846
F00.09
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset information on additional symptoms is lacking
40.7
26.5
35
7
J01EA01
ATC
trimethoprim; systemic
1.3
26.5
2193
14140
-2
ICPC
NA
4.2
26.3
106
208
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.4
26.3
1415
8495
SPAT1231
SPAT
Assessment of adjustments needed in living environment
2.2
26.1
279
1042
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
0.2
25.9
35
1195
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.3
25.4
55
1474
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
5.2
25.4
82
128
A10AE04
ATC
insulin glargine; parenteral
1.6
25.3
802
4312
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.5
25.1
1106
6385
SPAT1276
SPAT
Outlining of treatment with patient or their family members
2.2
25.1
258
949
F0012, G301
ICD-10 Finland
NA
+∞
25.0
26
*
Z51.88
ICD-10 Finland
Other specified medical care
2.5
24.6
205
678
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.6
24.5
743
3945
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.0
24.4
321
1313
F00.13
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms, mainly depression
30.7
24.3
34
9
J01CA08
ATC
pivmecillinam; oral
1.3
24.3
2558
17030
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
25.9
24.0
35
11
L82
ICD-10 Finland
Seborrhoeic keratosis
0.7
23.6
664
7823
N28
ICPC
Limited function/disability (N)
2.6
23.5
175
544
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
1.8
23.4
461
2176
R1250
NOMESCO Finland
Evaluation of functional capability
2.7
22.7
163
497
Z28
ICPC
Limited function/disability (Z)
4.4
22.6
86
161
G04BD08
ATC
solifenacin; oral
1.6
22.1
697
3737
F0021, G308
ICD-10 Finland
NA
+∞
22.1
23
*
AXX01
SPAT
NA
2.6
21.9
171
545
E000001
ATC
NA
1.4
21.5
1459
9084
F00.2
ICD-10 Finland
Dementia in Alzheimer disease, atypical or mixed type
33.7
21.3
29
7
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.0
21.1
292
1218
Z13.3
ICD-10 Finland
Special screening examination for mental and behavioural disorders
12.1
21.1
40
27
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.8
21.1
1650
16610
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.5
20.8
899
5163
J01MA02
ATC
ciprofloxacin; systemic
1.2
20.8
3511
24661
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
0.2
20.7
24
894
F00.01
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly paranoidism
52.8
20.7
26
*
RD211
NOMESCO Finland
NA
0.4
20.7
66
1479
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
0.2
20.7
18
795
SPAT1050
SPAT
Extensive neurological examination
2.2
20.5
227
864
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.7
20.3
439
2131
F0013, G301
ICD-10 Finland
NA
+∞
20.2
21
*
N07AA06
ATC
NA
+∞
20.2
21
*
F0022, G308
ICD-10 Finland
NA
+∞
20.2
21
*
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.4
19.8
99
1857
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.6
19.8
585
3086
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.7
19.7
1041
11068
F00.12
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset, other additional symptoms, mainly hallucinations
17.4
19.6
32
15
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.5
19.4
817
4663
SPAT1307
SPAT
Psychosocial counselling and guidance
2.2
19.2
194
709
F0004, G300
ICD-10 Finland
NA
+∞
19.2
20
*
F0023, G308
ICD-10 Finland
NA
+∞
19.2
20
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.4
19.1
169
579
F22.0
ICD-10 Finland
Delusional disorder
2.8
18.8
127
374
R11
ICD-10 Finland
Nausea and vomiting
1.5
18.7
622
3377
N29
ICPC
Neurological sympt/complt other
2.3
18.6
176
623
WX212
NOMESCO Finland
Femoral plexus blockade
2.1
18.6
207
793
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
0.7
18.4
565
6564
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.2
18.3
3062
21402
UGC12
NOMESCO Finland
Flexible bronchoscopy
0.6
18.2
414
5096
F0024, G301
ICD-10 Finland
NA
+∞
18.2
19
*
F009, G301
ICD-10 Finland
NA
+∞
18.2
19
*
E0000UV
ATC
NA
1.2
18.2
2804
19421
N30.9
ICD-10 Finland
Cystitis, unspecified
1.6
18.2
469
2392
XX3DW
NOMESCO Finland
Time consuming IT work
0.6
18.1
348
4438
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
4.3
17.9
68
128
N06AX16
ATC
venlafaxine; oral
1.6
17.9
543
2883
SPAT1284
SPAT
Extensive health certificate
2.1
17.9
206
798
A04AA01
ATC
ondansetron; systemic, rectal
0.5
17.8
156
2432
F01.9
ICD-10 Finland
Vascular dementia, unspecified
2.0
17.6
235
967
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.4
17.6
755
4325
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
0.5
17.5
194
2828
4289X
ICD-9 Finland
Heart failure, unspecified
0.1
17.5
*
438
SPAT1263
SPAT
Sampling
1.2
17.4
3334
23606
L01BC06
ATC
capecitabine; oral
0.4
17.3
62
1322
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
6.5
17.1
46
58
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.4
17.1
1099
6766
SPAT1058
SPAT
PEF monitoring instruction
0.6
17.0
266
3553
F00.04
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms of mixed type
81.3
16.9
20
*
SPAT1279
SPAT
Preparation of immediate hospitalisation
2.4
16.9
148
505
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
2.1
16.9
204
811
JN4AD
NOMESCO Finland
Body CT examination
0.6
16.8
280
3686
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
5.4
16.8
52
79
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.2
16.6
2610
18076
K59.0
ICD-10 Finland
Constipation
1.5
16.5
551
2992
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
0.7
16.5
612
6889
N05AB03
ATC
perphenazine; systemic, rectal
2.0
16.5
205
822
Z51.5
ICD-10 Finland
Palliative care
1.5
16.5
636
3566
S00.0
ICD-10 Finland
Superficial injury of scalp
2.1
16.5
184
705
SAD02
NOMESCO Finland
Assessment of need for oral health care, extensive
2.3
16.4
159
572
P05
ICPC
Senility, feeling/behaving old
3.3
16.4
86
215
C04AE01
ATC
ergoloid mesylates; systemic
2.7
16.3
116
354
H02AA02
ATC
fludrocortisone; oral
2.7
16.3
115
348
A01
ICPC
Pain general/multiple sites
1.5
16.3
590
3263
F00.23
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type of other additional symptoms, mainly depression
42.6
16.2
21
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.4
16.2
883
5287
WF049
NOMESCO Finland
Radiotherapy of metastasis
0.4
16.2
72
1410
LAITO
NOMESCO Finland
NA
13.1
16.1
29
18
H02AB06
ATC
prednisolone; systemic
0.8
15.9
3143
28850
U13
ICPC
Bladder symptom/complaint other
1.9
15.8
253
1118
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
2.0
15.8
207
850
G91.0
ICD-10 Finland
Communicating hydrocephalus
4.0
15.8
65
133
C03CA01
ATC
furosemide; systemic
1.2
15.8
3957
28681
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
4.1
15.7
62
122
N06AX21
ATC
duloxetine; oral
1.5
15.7
538
2943
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.3
15.6
1288
8234
L08
ICPC
Shoulder symptom/complaint
0.7
15.6
803
8589
Y94.1
ICD-10 Finland
Accident in connection with service housing
10.5
15.5
31
24
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
0.5
15.5
106
1780
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
4.9
15.5
52
87
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
0.4
15.3
74
1403
N03AX14
ATC
levetiracetam; systemic
2.1
15.3
183
726
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.2
15.2
2530
17595
F05.0
ICD-10 Finland
Delirium not superimposed on dementia, so described
4.3
15.2
58
111
SPAT1262
SPAT
Handing over of treatment supplies
1.3
15.1
1553
10218
WF002
NOMESCO Finland
Radical radiotherapy
0.5
15.1
148
2229
L15
ICPC
Knee symptom/complaint
0.8
15.0
927
9669
Z60.8
ICD-10 Finland
Other problems related to social environment
5.0
14.9
49
80
W06
ICD-10 Finland
Fall involving bed
2.7
14.9
101
301
Y94.0
ICD-10 Finland
Accident at home
2.1
14.8
172
673
R03AC02
ATC
salbutamol; inhalant
0.8
14.7
2959
27172
M01AH05
ATC
etoricoxib; oral
0.8
14.7
2699
24989
S01
ICD-10 Finland
Open wound of head
2.5
14.7
116
376
H25.1
ICD-10 Finland
Senile nuclear cataract
1.2
14.6
3453
24839
S15
ICPC
Foreign body in skin
0.6
14.6
176
2504
F009, F03
ICD-10 Finland
NA
12.2
14.6
27
18
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
2.3
14.4
132
461
R00.1
ICD-10 Finland
Bradycardia, unspecified
1.6
14.4
379
1945
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.3
14.4
938
5783
F000, G300
ICD-10 Finland
NA
+∞
14.4
15
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.4
14.4
624
3583
P29
ICPC
Psychological sympt/compl other
2.0
14.4
178
715
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
0.7
14.4
526
5932
F00.0
ICD-10 Finland
Dementia in Alzheimer disease with early onset
48.7
14.3
18
*
K08.3
ICD-10 Finland
Retained dental root
1.5
14.2
485
2648
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
9.0
14.0
30
27
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
1.9
13.9
206
887
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
5.8
13.9
40
56
N05CD07
ATC
temazepam; oral
1.3
13.9
1374
8987
PJA12
NOMESCO Finland
Sentinel node biopsy
0.6
13.9
179
2507
ZXD05
NOMESCO Finland
Urgent procedure
1.2
13.9
2486
17391
ZXD35
NOMESCO Finland
Usual procedure
1.7
13.9
272
1285
DFF00
NOMESCO Finland
Pure tone audiometry
0.7
13.8
385
4559
HMAK
NOMESCO Finland
NA
0.6
13.8
289
3620
Z51.0
ICD-10 Finland
Radiotherapy session
0.2
13.8
11
509
G04CA01
ATC
alfuzosin; oral
1.3
13.8
1204
7748
XF606
NOMESCO Finland
Ortostatic test
2.8
13.8
90
263
S28
ICPC
Limited function/disability (S)
3.3
13.7
69
168
G04CB02
ATC
dutasteride; oral
1.4
13.7
780
4703
A10AE05
ATC
insulin detemir; parenteral
1.6
13.7
397
2086
A06AC01
ATC
ispaghula (psylla seeds); oral
1.2
13.7
2041
14010
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
6.5
13.6
36
45
N17
ICPC
Vertigo/dizziness
1.3
13.6
964
6017
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
0.8
13.4
1524
14810
F0019, G309
ICD-10 Finland
NA
+∞
13.4
14
*
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
0.3
13.4
31
798
J96.1
ICD-10 Finland
Chronic respiratory failure
0.5
13.4
82
1430
R32
ICD-10 Finland
Unspecified urinary incontinence
1.8
13.3
249
1160
SPAT1111
SPAT
Planning of analgesia
2.5
13.2
108
359
R06.0
ICD-10 Finland
Dyspnoea
0.8
13.2
1669
16043
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
2.0
13.1
177
735
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
0.6
13.1
217
2861
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
1.9
13.0
181
763
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
2.8
13.0
85
248
P04
ICPC
Feeling/behaving irritable/angry
6.6
13.0
34
42
F00.21
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type of other additional symptoms, mainly paranoidism
17.1
13.0
21
10
A78
ICPC
Infectious disease other/NOS
2.7
13.0
89
268
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
0.6
13.0
219
2872
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
0.5
13.0
104
1658
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
0.4
12.9
41
917
SPAT1125
SPAT
Stoma care and guidance
1.9
12.8
181
768
R50.9
ICD-10 Finland
Fever, unspecified
1.3
12.8
1052
6709
F00, F03
ICD-10 Finland
NA
8.1
12.8
29
29
P28
ICPC
Limited function/disability (P)
3.7
12.7
56
123
N99
ICPC
Neurological disease other
2.5
12.7
98
316
N05CF01
ATC
zopiclone; oral
1.2
12.6
2995
21483
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.2
12.5
132
497
N02AX02
ATC
tramadol; systemic, rectal
0.8
12.4
2774
25344
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.4
12.4
514
2925
S01.8
ICD-10 Finland
Open wound of other parts of head
2.4
12.4
110
380
F05.8
ICD-10 Finland
Other delirium
2.6
12.4
89
276
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.8
12.4
78
224
X59
ICD-10 Finland
Exposure to unspecified factor
1.3
12.3
1132
7330
EBA15
NOMESCO Finland
Extraction of large number of teeth
1.7
12.3
267
1302
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.5
12.1
419
2297
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
0.7
12.1
418
4760
WW500
NOMESCO Finland
Blood transfusion
0.5
12.0
121
1806
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
0.7
12.0
422
4796
S82
ICPC
Naevus/mole
0.7
12.0
434
4907
M70.6
ICD-10 Finland
Trochanteric bursitis
0.7
11.9
509
5607
KMAK
NOMESCO Finland
NA
1.2
11.9
2786
19929
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
0.8
11.9
1230
12087
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
0.3
11.8
18
570
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
0.4
11.5
44
910
N27
ICPC
Fear of neurological disease other
2.1
11.5
128
494
F0001, G300
ICD-10 Finland
NA
+∞
11.5
12
*
N05AH02
ATC
clozapine; systemic
3.7
11.4
50
110
F00.29
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without information on additional symptoms
13.5
11.4
20
12
F00.22
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type other additional symptoms, mainly hallucinations
15.4
11.4
19
10
C34.11
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary epidermoid carcinoma
0.3
11.4
17
545
I95.9
ICD-10 Finland
Hypotension, unspecified
2.0
11.4
147
604
T05
ICPC
Feeding problem of adult
3.5
11.4
53
123
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
0.6
11.4
205
2650
WX111
NOMESCO Finland
Local infiltration anesthesia
0.5
11.4
70
1214
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
0.2
11.3
13
483
115
Kela drug reimbursment
Breast cancer
0.6
11.2
211
2702
L75
ICPC
Fracture: femur
2.0
11.2
141
571
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
0.6
11.2
131
1877
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
0.6
11.2
145
2025
SPAT1014
SPAT
Treatment of eyes
1.9
11.2
170
743
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
2.5
11.1
85
274
N18
ICPC
Paralysis/weakness
1.8
11.1
179
798
G04BD07
ATC
tolterodine; oral
1.4
11.1
515
2998
S42.2
ICD-10 Finland
Fracture of upper end of humerus
1.5
11.1
363
1967
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
0.4
11.1
54
1017
L57.0
ICD-10 Finland
Actinic keratosis
0.8
11.1
705
7337
S01BC05
ATC
ketorolac; ophthalmic
1.4
11.1
484
2785
JN4BD
NOMESCO Finland
Extensive body CT
0.7
11.1
553
5948
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
0.4
11.0
38
818
Z75.0
ICD-10 Finland
Medical services not available in home
4.3
11.0
41
78
R29.6
ICD-10 Finland
Tendency to fall, not elsewhere classified
3.3
11.0
55
135
D12
ICPC
Constipation
1.6
10.9
305
1590
AA1AD
SPAT
NA
5.4
10.9
33
50
ZX120
NOMESCO Finland
Intravenous
0.7
10.8
399
4500
S22.3
ICD-10 Finland
Fracture of rib
1.4
10.8
486
2810
WF003
NOMESCO Finland
Adjuvant radiotherapy
0.5
10.7
71
1201
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
1.6
10.7
303
1588
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.8
10.7
45
96
A10BB12
ATC
glimepiride; oral
1.3
10.7
839
5315
C34.31
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung epidermoid carcinoma
0.2
10.7
10
420
R01AD12
ATC
fluticasone furoate; nasal
0.8
10.7
785
8027
L03AA13
ATC
pegfilgrastim; parenteral
0.4
10.6
59
1059
J01.0
ICD-10 Finland
Acute maxillary sinusitis
0.7
10.6
582
6176
F0009, G309
ICD-10 Finland
NA
+∞
10.6
11
*
F009, G308
ICD-10 Finland
NA
+∞
10.6
11
*
F0021, G301
ICD-10 Finland
NA
+∞
10.6
11
*
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
1.7
10.5
220
1063
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
4.9
10.5
34
56
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
3.3
10.5
52
127
4148X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Other specified forms of chronic ischaemic heart disease[MORBUS CORDIS ISCHAEMICUS ALIA,MÄÄRITTELEMÄT]
0.3
10.5
26
646
L90
ICPC
Osteoarthrosis of knee
0.7
10.5
241
2959
K86
ICPC
Hypertension uncomplicated
0.8
10.5
674
7006
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
0.4
10.5
43
862
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
2.0
10.4
129
523
R2110
NOMESCO Finland
Giving the first information
1.5
10.4
362
1990
SPAT1043
SPAT
Audiometry
0.8
10.4
648
6765
N39.9
ICD-10 Finland
Disorder of urinary system, unspecified
2.0
10.4
139
580
A05
ICPC
Feeling ill
1.6
10.4
258
1309
K80
ICPC
Cardiac arrhythmia NOS
0.7
10.4
294
3466
NF1AA
NOMESCO Finland
Hip X-ray examination
1.3
10.3
777
4896
L01
ICPC
Neck symptom/complaint
0.7
10.3
472
5142
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.9
10.2
42
88
D19
ICPC
Teeth/gum symptom/complaint
0.8
10.2
791
8041
R03BA08
ATC
ciclesonide; inhalant
0.6
10.2
202
2558
KED22
NOMESCO Finland
Transurethral resection of prostate
1.3
10.2
797
5046
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
1.8
10.2
182
841
A10BK03
ATC
empagliflozin; oral
0.6
10.2
168
2213
TPX10
NOMESCO Finland
Implantation of vascular injection port
0.4
10.2
53
972
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
0.8
10.1
2200
20219
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
1.5
10.1
330
1792
A23
ICPC
Risk factor NOS
1.6
10.0
278
1449
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
1.7
10.0
225
1110
XCH00
NOMESCO Finland
Eye pressure measurement
0.6
10.0
145
1966
C03DA01
ATC
spironolactone; oral
0.8
10.0
711
7299
8041/3-C34.9
ICD-O-3
Small cell carcinoma, NOS, of lung, NOS
0.2
10.0
11
418
AA1AA
NOMESCO Finland
Head X-ray examination
2.4
10.0
81
271
F09
ICD-10 Finland
Unspecified organic or symptomatic mental disorder
7.2
10.0
24
27
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
0.7
9.9
280
3305
G72.8
ICD-10 Finland
Other specified myopathies
1.9
9.9
147
636
L03AA02
ATC
filgrastim; parenteral
0.4
9.9
45
867
R45.5
ICD-10 Finland
Hostility
12.2
9.9
18
12
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
4.0
9.9
39
79
Z11
ICPC
Compliance/being ill problem
2.9
9.9
61
173
R40.2
ICD-10 Finland
Coma, unspecified
2.3
9.8
88
308
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
0.7
9.8
265
3150
C10AA07
ATC
rosuvastatin; oral
0.8
9.8
1311
12573
L03
ICPC
Low back symptom/complaint
0.8
9.8
1089
10633
K59.09
ICD-10 Finland
Constipation, unspecified
1.4
9.8
537
3222
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
0.5
9.7
62
1060
EB1AA
NOMESCO Finland
Tooth X-ray examination
0.9
9.7
2447
22251
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.5
9.7
320
1738
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
1.7
9.7
213
1047
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
4.1
9.5
37
74
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
0.5
9.5
57
997
A04AA55
ATC
palonosetron, combinations; systemic
0.2
9.5
12
418
U28
ICPC
Limited function/disability (U)
2.0
9.5
111
442
Z20.8
ICD-10 Finland
Contact with and exposure to other communicable diseases
1.8
9.4
171
793
EBA30
NOMESCO Finland
Excision of root of tooth
1.5
9.4
369
2083
HA1RA
SPAT
NA
0.2
9.3
10
387
N95.1
ICD-10 Finland
Menopausal and female climacteric states
0.5
9.3
59
1014
SPAT1098
SPAT
Exercise ECG
0.4
9.3
36
738
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
0.6
9.3
121
1686
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
0.8
9.3
942
9295
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.8
9.3
775
7808
S32.8
ICD-10 Finland
Fracture of other and unspecified parts of lumbar spine and pelvis
2.1
9.3
100
384
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.2
9.3
3389
25002
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
1.3
9.2
978
6439
R1250
SPAT
NA
3.0
9.2
52
139
SPAT1157
SPAT
Guidance concerning treatment of mouth and mucous membranes
2.1
9.2
106
418
N05AX12
ATC
aripiprazole; systemic
2.6
9.1
68
216
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
0.5
9.1
89
1334
SPAT1285
SPAT
Provision of consultation response
1.4
9.1
403
2330
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
0.7
9.1
290
3344
G40
ICD-10 Finland
Epilepsy
3.1
9.0
51
136
R44.3
ICD-10 Finland
Hallucinations, unspecified
3.1
9.0
51
136
M04AA01
ATC
allopurinol; systemic
0.8
9.0
1031
10049
WX199
NOMESCO Finland
Other local analgesia
0.5
9.0
77
1200
Z43.5
ICD-10 Finland
Attention to cystostomy
2.4
9.0
74
250
D07AA02
ATC
hydrocortisone; topical
1.3
9.0
816
5273
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
3.3
9.0
44
108
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.8
9.0
56
161
N05AA02
ATC
levomepromazine; systemic
1.6
8.9
249
1302
S42.0
ICD-10 Finland
Fracture of clavicle
1.8
8.9
156
717
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
1.2
8.9
1223
8287
S06.3
ICD-10 Finland
Focal brain injury
2.0
8.9
113
466
SPAT1042
SPAT
Guidance concerning balance maintenance
2.6
8.9
64
202
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
0.3
8.9
18
490
SPAT1236
SPAT
Informing family of child’s disability
1.7
8.8
164
768
T03
ICPC
Loss of appetite
3.9
8.8
36
76
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
0.5
8.8
59
991
R45.1
ICD-10 Finland
Restlessness and agitation
4.9
8.8
28
46
ZXY02
NOMESCO Finland
Neuropsychologist
4.4
8.8
31
57
F00.02
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly illusions
44.6
8.8
11
*
SPAT1104
SPAT
Monitoring of emergency patient
1.4
8.7
516
3134
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.2
8.7
1257
8561
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.8
8.7
143
646
I48.1
ICD-10 Finland
Persistent atrial fibrillation
0.6
8.7
106
1496
ZXA00
NOMESCO Finland
Right side
1.2
8.7
2346
16902
IAB14
NOMESCO Finland
Geriatric psychiatry consultation
4.3
8.6
31
58
R63.4
ICD-10 Finland
Abnormal weight loss
1.5
8.6
282
1534
M75.1
ICD-10 Finland
Rotator cuff syndrome
0.8
8.6
1082
10449
C10AX09
ATC
ezetimibe; oral
0.8
8.6
480
5084
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
0.8
8.6
1214
11596
DAX08
NOMESCO Finland
Fitting of hearing aid
0.7
8.6
227
2707
C10AA02
ATC
lovastatin; oral
1.4
8.6
499
3024
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
1.5
8.6
266
1430
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
1.9
8.5
122
525
NFB10
NOMESCO Finland
Primary partial prosthetic replacement of hip joint not using cement, other or unspecified
2.8
8.5
53
153
SPAT1215
SPAT
Assessment of need for medical rehabilitation
1.5
8.4
290
1594
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
0.6
8.4
174
2179
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
5.6
8.4
24
35
R21
ICPC
Throat symptom/complaint
0.7
8.3
444
4731
K22
ICPC
Risk factor cardiovascular disease
0.7
8.2
221
2631
R05
ICPC
Cough
0.8
8.2
1020
9865
Z73.6
ICD-10 Finland
Limitation of activities due to disability
2.2
8.2
78
284
T08
ICPC
Weight loss
1.9
8.2
112
474
SPAT1138
SPAT
Guidance concerning bowel function
1.8
8.2
127
560
180
Kela drug reimbursment
Interferon alfa
0.0
8.2
*
168
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.4
8.2
382
2230
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
2.2
8.1
79
289
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
2.2
8.1
79
289
C09AA05
ATC
ramipril; oral
1.2
8.1
2522
18347
HA1AA
NOMESCO Finland
X-ray mammography
0.7
8.1
193
2349
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
0.6
8.1
103
1439
G20
ICD-10 Finland
Parkinson disease
1.4
8.1
330
1880
A69.2
ICD-10 Finland
Lyme disease
0.6
8.0
125
1666
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
0.8
8.0
502
5240
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.3
8.0
599
3769
SDA02
NOMESCO Finland
Parodonthologic therapy
0.8
8.0
1283
12127
K90
ICPC
Stroke/cerebrovascular accident
1.5
8.0
276
1519
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
0.6
8.0
111
1518
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
1.5
8.0
302
1694
R26
ICD-10 Finland
Abnormalities of gait and mobility
3.7
8.0
34
75
Z03
ICPC
Housing/neighbourhood problem
2.7
8.0
54
163
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
1.7
8.0
158
757
WX404
NOMESCO Finland
Intravenous generell anesthesy
0.8
8.0
833
8194
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.3
8.0
685
4395
R54
ICD-10 Finland
Senility
2.5
7.9
61
199
F32
ICD-10 Finland
Depressive episode
1.6
7.9
181
901
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.7
7.9
54
165
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
0.8
7.9
1197
11367
R74
ICPC
Upper respiratory infection acute
0.8
7.9
681
6839
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
3.0
7.9
45
123
F00.03
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenil onset other additional symptoms, mainly depression
40.6
7.9
10
*
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
2.4
7.9
62
207
S00.1
ICD-10 Finland
Contusion of eyelid and periocular area
1.9
7.9
113
489
S12
ICPC
Insect bite/sting
0.7
7.8
312
3469
SPAT1244
SPAT
Occupational therapy
2.1
7.8
87
340
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
0.3
7.8
16
435
XA400
NOMESCO Finland
EEG
2.7
7.8
51
153
TK800
NOMESCO Finland
Hemodialysis
0.4
7.8
42
760
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
1.4
7.8
445
2688
Z60.9
ICD-10 Finland
Problem related to social environment, unspecified
3.3
7.8
38
94
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.3
7.8
815
5360
A12AA04
ATC
calcium carbonate; oral
0.4
7.7
32
637
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
0.4
7.7
32
637
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
0.2
7.7
10
344
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
0.6
7.7
165
2050
N03AF02
ATC
oxcarbazepine; oral
1.6
7.7
179
897
L13
ICPC
Hip symptom/complaint
0.8
7.7
880
8581
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
3.0
7.7
44
121
R31
ICD-10 Finland
Unspecified haematuria
1.2
7.7
1057
7165
K91
ICPC
Cerebrovascular disease
1.8
7.6
132
609
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
1.4
7.6
355
2073
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
0.6
7.6
115
1538
L02BG04
ATC
letrozole; oral
0.6
7.5
139
1779
D82
ICPC
Teeth/gum disease
0.8
7.5
1157
10972
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.2
7.5
2223
16103
T90.5
ICD-10 Finland
Sequelae of intracranial injury
2.3
7.5
65
229
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
0.6
7.4
147
1857
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
0.7
7.4
218
2552
R03BB01
ATC
ipratropium bromide; inhalant
0.7
7.4
319
3505
N81.1
ICD-10 Finland
Cystocele
0.7
7.4
207
2443
SPAT1059
SPAT
Spirometry at the office
0.7
7.4
185
2226
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
0.7
7.4
211
2478
M05BA02
ATC
clodronic acid; systemic
0.2
7.4
6
274
G04BD10
ATC
darifenacin; oral
2.3
7.4
67
241
Z49.1
ICD-10 Finland
Extracorporeal dialysis
0.3
7.4
20
472
ZYC01
NOMESCO Finland
Remote contact by phone
0.6
7.4
83
1196
C01DA14
ATC
isosorbide mononitrate; oral
1.2
7.4
2247
16307
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
0.3
7.3
15
405
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
1.7
7.3
160
788
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
0.9
7.3
2362
21188
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
0.4
7.3
35
661
WX302
NOMESCO Finland
Thoracal epidural anesthesy
0.7
7.3
162
1994
F01
ICD-10 Finland
Vascular dementia
2.7
7.3
50
153
A96
ICPC
Death
2.4
7.3
60
205
HAB99
NOMESCO Finland
Other partial excision of mammary gland
0.4
7.2
29
583
A01AB09
ATC
miconazole; local oral
1.3
7.2
686
4457
SDA01
NOMESCO Finland
Simple parodonthologic therapy
0.8
7.2
860
8353
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
2.0
7.2
91
374
R35
ICD-10 Finland
Polyuria
1.3
7.2
523
3281
G04BX04
ATC
NA
1.5
7.2
241
1319
B01AC24
ATC
ticagrelor; oral
0.6
7.2
90
1263
S21
ICPC
Skin texture symptom/complaint
0.8
7.2
597
6017
TGC00
NOMESCO Finland
Bronchial lavation
0.5
7.1
63
970
B01AA03
ATC
warfarin; systemic
1.1
7.1
2601
19114
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
0.5
7.1
50
824
R44.1
ICD-10 Finland
Visual hallucinations
2.6
7.1
49
152
N04AA02
ATC
biperiden; systemic
1.9
7.1
100
429
NFJ52
NOMESCO Finland
Internal fixation of fracture of upper femur with screws and sideplate
1.9
7.1
98
418
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.3
7.0
642
4152
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
0.7
7.0
327
3552
UKC02
NOMESCO Finland
Cystoscopy
1.2
7.0
1717
12253
XJH00
NOMESCO Finland
Transanal ultrasonography
1.2
7.0
749
4938
LCA06
NOMESCO Finland
Biopsy of endometrium
0.7
7.0
226
2599
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
0.6
7.0
81
1159
E87.6
ICD-10 Finland
Hypokalaemia
1.5
7.0
218
1178
L04AX01
ATC
azathioprine; systemic
0.6
7.0
87
1222
S32.4
ICD-10 Finland
Fracture of acetabulum
2.2
7.0
66
240
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.2
7.0
752
4962
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
0.2
7.0
7
277
N05AL01
ATC
sulpiride; systemic
1.9
7.0
98
423
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
0.5
7.0
53
855
P99
ICPC
Psychological disorders other
2.2
7.0
71
268
F99
ICD-10 Finland
Mental disorder, not otherwise specified
2.5
7.0
53
175
NA1AD
NOMESCO Finland
Cervical spine CT examination
1.5
7.0
251
1396
S20.2
ICD-10 Finland
Contusion of thorax
1.4
6.9
306
1772
C34.16
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary microcellular carcinoma
0.1
6.9
*
209
SPAT1281
SPAT
Other administrative function
1.3
6.9
513
3226
S01.41
ICD-10 Finland
Open wound in the temple-jaw region
2.2
6.9
68
252
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
0.7
6.9
312
3404
G04BD11
ATC
fesoterodine; oral
1.4
6.9
269
1520
WVA30
SPAT
NA
0.5
6.9
47
782
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
6.6
6.8
17
21
T68
ICD-10 Finland
Hypothermia
2.7
6.8
44
131
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
0.7
6.8
177
2117
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
3.5
6.8
30
69
G47.3
ICD-10 Finland
Sleep apnoea
0.8
6.8
778
7585
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.2
6.8
1902
13710
G04BD12
ATC
mirabegron; oral
1.2
6.8
887
5980
B01AC07
ATC
dipyridamole; systemic
1.3
6.7
699
4591
Z74.1
ICD-10 Finland
Need for assistance with personal care
8.7
6.7
14
13
R03DA04
ATC
theophylline; systemic, rectal
0.8
6.7
441
4572
F0010, G308
ICD-10 Finland
NA
+∞
6.7
7
*
F0022, G301
ICD-10 Finland
NA
+∞
6.7
7
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.9
6.7
1763
16047
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
0.4
6.7
35
635
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
2.1
6.6
74
292
TQW40
SPAT
NA
0.5
6.6
60
916
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.2
6.6
954
6494
N05BE01
ATC
buspirone; oral
1.7
6.6
126
598
A04AD12
ATC
aprepitant; systemic
0.3
6.6
12
343
H01
ICPC
Ear pain/earache
0.7
6.6
278
3064
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.3
6.6
416
2559
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
0.4
6.6
25
513
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
0.6
6.6
71
1032
128
Kela drug reimbursment
Cancers of female genital organs
0.4
6.6
21
461
C34.19
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung other or unspecified histology
0.3
6.6
13
356
207
Kela drug reimbursment
Chronic arrhythmias
0.9
6.6
1293
12025
SPAT1109
SPAT
Analgesia with portable analgesic pump
2.4
6.6
55
189
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
0.6
6.5
137
1705
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
0.8
6.5
469
4810
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
1.6
6.5
165
847
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
1.6
6.5
168
866
R03AK07
ATC
formoterol and budesonide; inhalant
0.8
6.5
715
7000
G91.1
ICD-10 Finland
Obstructive hydrocephalus
3.2
6.5
33
85
S06.2
ICD-10 Finland
Diffuse brain injury
2.1
6.5
70
271
A11CC03
ATC
alfacalcidol; systemic
0.5
6.5
66
976
HAB40
NOMESCO Finland
Wedge excision of mammary gland
0.6
6.5
122
1552
201
Kela drug reimbursment
Chronic cardiac insufficiency
0.8
6.5
400
4179
T93
ICPC
Lipid disorder
0.7
6.5
193
2248
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
0.8
6.5
644
6367
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.5
6.4
239
1340
G21.0
ICD-10 Finland
Malignant neuroleptic syndrome
7.2
6.4
15
17
SGC00
NOMESCO Finland
Local medication of root channels of tooth
0.7
6.4
192
2234
Z01.2
ICD-10 Finland
Dental examination
0.9
6.4
1605
14668
K03.64
ICD-10 Finland
Dental calculus supragingival
0.8
6.4
824
7946
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.8
6.4
99
443
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
2.7
6.4
41
122
HA1RA
NOMESCO Finland
Combined assessment of mammary gland (mammography and ultrasound)
0.3
6.4
11
325
F16
ICPC
Eyelid symptom/complaint
0.6
6.4
128
1608
P15
ICPC
Chronic alcohol abuse
2.0
6.4
80
330
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
0.6
6.3
78
1094
GD1AA
SPAT
NA
0.5
6.3
60
903
N81.6
ICD-10 Finland
Rectocele
0.7
6.3
193
2237
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
3.7
6.3
26
57
I50.9
ICD-10 Finland
Heart failure, unspecified
1.2
6.3
1841
13302
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.2
6.3
1177
8209
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
0.7
6.3
151
1830
H04AA01
ATC
glucagon; nasal, parenteral
2.1
6.3
71
281
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
0.6
6.3
70
1009
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
1.6
6.3
167
871
EBA00
NOMESCO Finland
Extraction of tooth
1.1
6.3
1885
13648
M19.0
ICD-10 Finland
Primary arthrosis of other joints
0.8
6.3
348
3683
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
0.3
6.3
15
376
IGY99
NOMESCO Finland
Other psychiatric treatment contact
2.8
6.2
37
106
I95.0
ICD-10 Finland
Idiopathic hypotension
3.4
6.2
28
66
F06.0
ICD-10 Finland
Organic hallucinosis
3.4
6.2
28
66
S72.2
ICD-10 Finland
Subtrochanteric fracture
1.9
6.2
86
370
N84.0
ICD-10 Finland
Polyp of corpus uteri
0.7
6.2
168
1989
D17
ICPC
Incontinence of bowel
2.0
6.2
71
284
A77
ICPC
Viral disease other/NOS
0.4
6.2
21
450
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
0.7
6.2
174
2047
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
1.8
6.2
95
421
R12
ICD-10 Finland
Heartburn
0.7
6.2
200
2298
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
1.4
6.2
326
1950
Z02.8
ICD-10 Finland
Other examinations for administrative purposes
3.0
6.2
35
96
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
0.7
6.2
245
2719
ACC51
NOMESCO Finland
Release of median nerve
0.7
6.2
195
2247
Z46.9
ICD-10 Finland
Fitting and adjustment of unspecified device
1.7
6.2
111
519
B01AF01
ATC
rivaroxaban; oral
0.8
6.1
705
6874
G04BD04
ATC
oxybutynin; oral, transdermal
1.3
6.1
517
3315
F0289, G318
ICD-10 Finland
NA
32.4
6.1
8
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
0.4
6.1
19
421
Z08
ICPC
Social welfare problem
2.1
6.1
65
252
ZXC96
NOMESCO Finland
Robot assisted procedure
0.5
6.1
38
648
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
0.7
6.1
138
1687
L01CA04
ATC
vinorelbine; systemic
0.3
6.1
9
285
Z51.4
ICD-10 Finland
Preparatory care for subsequent treatment, not elsewhere classified
1.9
6.1
80
337
F30.1
ICD-10 Finland
Mania without psychotic symptoms
6.4
6.0
15
19
E000003
ATC
NA
1.4
6.0
243
1386

Mortality – FinRegistry

Association

Association between endpoint G6_ALZHEIMER and mortality.

Females

Parameter HR [95% CI] p-value
G6_ALZHEIMER 2.419 [2.2, 2.66] < 0.001
Birth year 0.989 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 74328 out of 110920 females with G6_ALZHEIMER died.

Males

Parameter HR [95% CI] p-value
G6_ALZHEIMER 2.756 [2.43, 3.13] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 42782 out of 61190 males with G6_ALZHEIMER died.

Mortality risk

Mortality risk for people of age

years, who have G6_ALZHEIMER.

N-year risk Females Males
1 0.184% 0.451%
5 1.156% 2.751%
10 2.546% 6.244%
15 4.559% 11.313%
20 8.12% 18.563%

Relationships between endpoints

Index endpoint: G6_ALZHEIMER – Alzheimer disease

GWS hits: 16

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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