bacterial meningitis: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1304 |
4. Check minimum number of eventsNone |
1304 |
5. Include endpointsNone |
1304 |
6. Filter based on genotype QC (FinnGen only) |
1304 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Bacterial meningitis
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13164 | 5855 | 7210 |
| Only index persons | 10528 | 4917 | 5611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.17 | 0.20 |
| Only index persons | 0.20 | 0.18 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 26.64 | 28.04 | 25.10 |
| Only index persons | 22.93 | 25.96 | 20.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1304 | 680 | 624 |
| Unadjusted period prevalence (%) | 0.25 | 0.23 | 0.28 |
| Median age at first event (years) | 28.16 | 27.13 | 29.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1180
- Matched controls
- 11799
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
+∞
323.0
335
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
3082.4
277.2
257
*
32088
ICD-8 Finland
Meningitis, Alia definita
+∞
193.1
180
*
32000
ICD-8 Finland
Meningitis, H. influenzae
+∞
106.9
101
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
96.2
91
*
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
82.3
78
*
TAB00
NOMESCO Finland
Lumbar puncture
7.6
62.1
154
229
G03.9
ICD-10 Finland
Meningitis, unspecified
596.2
58.2
57
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
40.9
39
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
28.6
38.4
52
19
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
28.2
27
*
AA1AD
NOMESCO Finland
CT of head and brain
2.3
27.0
305
1559
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
25.1
24
*
G00.3
ICD-10 Finland
Staphylococcal meningitis
+∞
25.1
24
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
17.5
25.0
39
23
3209X
ICD-9 Finland
Bacterial meningitis, Meningitis due to unspecified bacterium
+∞
23.0
22
*
AAF00
NOMESCO Finland
Ventriculostomy
16.9
21.0
33
20
R51.80
ICD-10 Finland
Headache
2.4
21.0
203
948
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
20.9
128
460
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
20.1
193
899
G01
ICD-10 Finland
Meningitis in bacterial diseases classified elsewhere
+∞
19.8
19
*
G01*A32.1
ICD-10 Finland
Listerial meningitis
+∞
19.8
19
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
30.6
18.4
24
8
A69.2
ICD-10 Finland
Lyme disease
3.6
18.3
86
255
32010
ICD-8 Finland
Meningitis, Pneumococcus
+∞
16.7
16
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
9.4
15.7
32
35
G91.0
ICD-10 Finland
Communicating hydrocephalus
20.3
15.1
22
11
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
14.6
14
*
3200A
ICD-9 Finland
Bacterial meningitis, Haemophilus meningitis
+∞
14.6
14
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
14.6
14
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
14.0
164
830
G00.0
ICD-10 Finland
Haemophilus meningitis
+∞
13.6
13
*
A86
ICD-10 Finland
Unspecified viral encephalitis
18.5
13.4
20
11
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
13.4
77
266
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
50.6
12.9
15
*
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
32.4
12.6
16
5
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
19.1
11.6
17
9
N71
ICPC
Meningitis/encephalitis
+∞
11.5
11
*
3201A
ICD-9 Finland
Bacterial meningitis, Pneumococcal meningitis
+∞
11.5
11
*
G51.0
ICD-10 Finland
Bell palsy
4.1
11.4
43
107
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.5
11.2
52
155
N03AF01
ATC
carbamazepine; oral, rectal
2.8
10.3
66
246
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
10.0
440
3315
N03AX14
ATC
levetiracetam; systemic
3.8
9.9
40
107
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.3
9.8
49
155
R50.9
ICD-10 Finland
Fever, unspecified
1.9
9.6
156
896
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
21.9
9.4
13
6
R51
ICD-10 Finland
Headache
2.6
9.1
66
266
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
5.7
9.1
25
45
N03AX16
ATC
pregabalin; oral
1.6
9.0
250
1680
N05CF01
ATC
zopiclone; oral
1.5
9.0
324
2323
N03AX12
ATC
gabapentin; oral
1.8
8.8
165
990
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.7
549
4426
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
8.7
172
1049
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.1
8.7
32
79
N03AF02
ATC
oxcarbazepine; oral
3.2
8.6
43
137
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
8.5
204
1320
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.9
8.4
33
87
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
7.1
8.3
19
27
A41.9
ICD-10 Finland
Sepsis, unspecified
3.0
8.1
44
149
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.7
8.1
53
202
G63.0*A69.2
ICD-10 Finland
Polyneuropathy (in) Lyme disease
33.6
8.1
10
*
N03AB02
ATC
phenytoin; systemic
5.6
8.0
22
40
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
45.3
7.7
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.7
212
1420
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.6
91
465
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.6
227
1551
G91.1
ICD-10 Finland
Obstructive hydrocephalus
11.9
7.6
13
11
N02AA05
ATC
oxycodone; systemic
1.8
7.4
131
771
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
6.0
7.4
19
32
H02AB06
ATC
prednisolone; systemic
1.4
7.4
470
3756
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.2
7.4
72
339
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
7.4
83
415
J01DA01
ATC
[U] cefalexin; systemic
1.4
7.4
667
5681
N06AA09
ATC
amitriptyline; systemic
1.9
7.3
105
574
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.3
204
1365
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
7.2
54
222
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
10.1
7.0
13
13
G44.2
ICD-10 Finland
Tension-type headache
1.7
7.0
136
824
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.0
431
3414
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.0
267
1927
N03AG01
ATC
valproic acid; systemic, rectal
2.1
6.9
76
377
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.9
278
2027
AA1AA
NOMESCO Finland
Head X-ray examination
6.7
6.8
16
24
WX882
NOMESCO Finland
High dependency care
3.2
6.8
34
110
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.8
217
1500
A32.7
ICD-10 Finland
Listerial sepsis
40.3
6.8
8
*
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
40.3
6.8
8
*
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
16.8
6.7
10
6
SPAT1255
SPAT
Intravenous administration of medicine
2.1
6.6
69
335
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
5.5
6.6
18
33
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
6.6
94
516
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
6.6
112
653
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.4
6.6
22
51
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
6.5
66
317
XA800
NOMESCO Finland
Neuropsychological investigation
2.4
6.5
52
221
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.6
6.5
27
76
B94.80
ICD-10 Finland
Late effects of bacterial meningitis
70.2
6.4
7
*
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
70.2
6.4
7
*
G50.0
ICD-10 Finland
Trigeminal neuralgia
4.2
6.3
22
53
WX730
NOMESCO Finland
Conventional respirator
3.9
6.3
24
63
J01FF01
ATC
clindamycin; systemic
1.5
6.3
283
2104
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
6.3
132
819
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.5
6.3
45
183
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
6.3
6
*
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
+∞
6.3
6
*
N73
ICPC
Neurological infection other
26.8
6.2
8
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
26.8
6.2
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.2
174
1167
TKC20
NOMESCO Finland
Catheterisation of bladder
2.1
6.2
66
324
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
5.8
6.2
16
28
J01DB01
ATC
cefalexin; oral
1.4
6.1
898
8172
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
6.0
102
594
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGBACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGBACT | 2.439 [2.05, 2.9] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 366 out of 1921 females with G6_MENINGBACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGBACT | 2.511 [2.12, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 2305 males with G6_MENINGBACT died.
Mortality risk
Mortality risk for people of age
years, who have G6_MENINGBACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.462% |
| 5 | 1.41% | 3.008% |
| 10 | 3.352% | 7.395% |
| 15 | 6.994% | 13.678% |
| 20 | 12.009% | 22.485% |
Relationships between endpoints
↥Index endpoint: G6_MENINGBACT – Bacterial meningitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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