Risteys · G6_MENINGOTH

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G02, G03 Hospital discharge:* ICD-9 — 322 Hospital discharge: excluded ICD-10 — G02.0, G02.0A87.0, G02.0A87.1, G02.0B00.3, G02.0B01.0, G02.0B02.1, G02.0B05.1, G02.0B06.0, G02.0B26.1, G02.0B27.9 Cause of death: ICD-10 — G02, G03 Cause of death:* ICD-9 — 322 Cause of death: excluded ICD-10 — G02.0, G02.0A87.0, G02.0A87.1, G02.0B00.3, G02.0B01.0, G02.0B02.1, G02.0B05.1, G02.0B06.0, G02.0B26.1, G02.0B27.9 2 out of 7 registries used, show all original rules.	581
4. Check minimum number of events None	581
5. Include endpoints None	581
6. Filter based on genotype QC (FinnGen only)	581

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4841	2409	2393
Only index persons	4163	2151	2012
Unadjusted period prevalence (%)
Whole population	0.07	0.07	0.07
Only index persons	0.08	0.08	0.08
Median age at first event (years)
Whole population	40.27	41.58	38.59
Only index persons	37.69	39.51	35.74

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	581	367	214
Unadjusted period prevalence (%)	0.11	0.13	0.09
Median age at first event (years)	43.35	42.06	45.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
516: Matched controls
5158

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G03.9

ICD-10 Finland

Meningitis, unspecified

+∞

323.0

361

3229X

ICD-9 Finland

Meningitis of unspecified cause, Meningitis, unspecified

+∞

84.8

A87.9

ICD-10 Finland

Viral meningitis, unspecified

99.0

83.2

TAB00

NOMESCO Finland

Lumbar puncture

16.8

74.7

124

R51.80

ICD-10 Finland

Headache

4.9

42.5

163

444

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

7.2

41.9

110

188

G03.0

ICD-10 Finland

Nonpyogenic meningitis

+∞

40.1

AA1AD

NOMESCO Finland

CT of head and brain

4.1

38.0

179

587

G03.8

ICD-10 Finland

Meningitis due to other specified causes

+∞

36.9

G00.9

ICD-10 Finland

Bacterial meningitis, unspecified

+∞

32.6

G03.1

ICD-10 Finland

Chronic meningitis

+∞

29.5

A86

ICD-10 Finland

Unspecified viral encephalitis

109.3

19.7

R50.9

ICD-10 Finland

Fever, unspecified

3.2

19.7

116

426

G02.0*B00.3

ICD-10 Finland

Herpesviral meningitis

+∞

18.9

G04.9

ICD-10 Finland

Encephalitis, myelitis and encephalomyelitis, unspecified

+∞

18.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.3

17.1

225

1302

G03.2

ICD-10 Finland

Benign recurrent meningitis [Mollaret]

+∞

16.8

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

49.2

16.1

AAF00

NOMESCO Finland

Ventriculostomy

87.8

15.7

0499X

ICD-9 Finland

Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system

164.8

15.6

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

17.1

14.9

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

7.4

14.8

H02AB06

ATC

prednisolone; systemic

2.0

13.6

250

1624

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.9

13.6

328

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.4

13.4

216

TPH04

NOMESCO Finland

Cathetrisation of vein

2.4

13.1

123

588

N03AX14

ATC

levetiracetam; systemic

7.9

12.6

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

16.9

11.7

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

66.5

11.7

R51

ICD-10 Finland

Headache

4.0

11.6

127

L04AX01

ATC

azathioprine; systemic

4.7

11.5

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

122.6

11.5

N02AX02

ATC

tramadol; systemic, rectal

1.9

11.1

212

1363

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.5

11.1

443

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

4.2

11.0

103

H47.1

ICD-10 Finland

Papilloedema, unspecified

28.7

10.8

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.7

10.7

317

G96.0

ICD-10 Finland

Cerebrospinal fluid leak

61.3

10.7

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

4.6

10.7

N71

ICPC

Meningitis/encephalitis

112.2

10.5

WX408

NOMESCO Finland

General anesthesy, balanced

2.1

10.4

149

850

I60.2

ICD-10 Finland

Subarachnoid haemorrhage from anterior communicating artery

33.3

10.4

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

9.9

10.3

G91.0

ICD-10 Finland

Communicating hydrocephalus

23.9

10.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.8

10.1

263

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

15.0

10.1

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.0

9.8

199

H02AB07

ATC

prednisone; oral

2.5

9.6

362

XF400

NOMESCO Finland

ECG with 12 standard connections

2.4

9.6

411

XA800

NOMESCO Finland

Neuropsychological investigation

4.4

9.6

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.4

9.5

392

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

101.8

9.4

G00.1

ICD-10 Finland

Pneumococcal meningitis

+∞

9.4

A87.8

ICD-10 Finland

Other viral meningitis

+∞

9.4

N03AX16

ATC

pregabalin; oral

2.1

9.4

123

676

G97.0

ICD-10 Finland

Cerebrospinal fluid leak from spinal puncture

8.9

9.4

R42

ICD-10 Finland

Dizziness and giddiness

2.1

9.3

111

585

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

8.0

9.2

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.9

9.2

189

1227

PA2BC

NOMESCO Finland

Cerebral extensive angiography with X-ray

15.9

9.1

G51.0

ICD-10 Finland

Bell palsy

5.8

8.9

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

7.1

8.6

ZXC95

NOMESCO Finland

Use of surgical navigator

9.2

8.6

TAA40

NOMESCO Finland

Cathetrisation of cerebrospinal fluid through skin

28.0

8.5

5AB01

NOMESCO Finland

91.5

8.4

G40.9

ICD-10 Finland

Epilepsy, unspecified

4.6

8.4

N06AA09

ATC

amitriptyline; systemic

2.7

8.4

220

G05.1*B00.4

ICD-10 Finland

Herpesviral meningoencephalitis

+∞

8.4

G01*A69.2

ICD-10 Finland

Meningitis (in) Lyme disease

+∞

8.4

AAF15

NOMESCO Finland

Ventriculoatrial shunt

+∞

8.4

G91.1

ICD-10 Finland

Obstructive hydrocephalus

33.9

8.1

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

9.1

8.1

WX882

NOMESCO Finland

High dependency care

4.7

8.0

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.2

8.0

412

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.7

7.9

216

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

5.0

7.9

SPAT1255

SPAT

Intravenous administration of medicine

3.2

7.8

127

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.3

7.8

360

P01BA02

ATC

hydroxychloroquine; oral

2.9

7.7

179

TKC20

NOMESCO Finland

Catheterisation of bladder

3.2

7.7

129

AAK40

NOMESCO Finland

Closure of cerebrospinal fluid fistula

81.2

7.4

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

81.2

7.4

G02.0

ICD-10 Finland

Meningitis in viral diseases classified elsewhere

81.2

7.4

ABE50

NOMESCO Finland

Occipitocervical decompression

+∞

7.3

J01EA01

ATC

trimethoprim; systemic

1.9

7.2

130

794

N03AX12

ATC

gabapentin; oral

2.1

7.2

413

R56.8

ICD-10 Finland

Other and unspecified convulsions

3.3

7.2

107

G44.2

ICD-10 Finland

Tension-type headache

2.2

7.1

388

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.3

7.1

302

G43.9

ICD-10 Finland

Migraine, unspecified

2.9

7.1

148

J05AB11

ATC

valaciclovir; oral

2.1

7.0

396

N01

ICPC

Headache

2.3

7.0

320

H53.2

ICD-10 Finland

Diplopia

4.8

6.8

M32.8

ICD-10 Finland

Other forms of systemic lupus erythematosus

40.6

6.8

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

7.3

6.7

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

7.3

6.7

AA1AA

NOMESCO Finland

Head X-ray examination

22.9

6.7

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.0

6.7

518

M01AE02

ATC

naproxen; oral, rectal

1.6

6.6

285

2235

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.4

6.6

232

H02AB09

ATC

hydrocortisone; systemic

4.6

6.5

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

3.0

6.5

131

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.5

6.4

203

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

8.3

6.4

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

11.2

6.3

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

4.9

6.3

B34.9

ICD-10 Finland

Viral infection, unspecified

3.9

6.3

G00.2

ICD-10 Finland

Streptococcal meningitis

+∞

6.3

G44.8

ICD-10 Finland

Other specified headache syndromes

7.2

6.3

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.7

6.2

144

949

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

5.1

6.2

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.3

6.2

264

N02BE01

ATC

paracetamol; systemic, rectal

1.7

6.2

417

3647

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.7

6.1

158

1075

N02AJ06

ATC

codeine and paracetamol; systemic

1.6

6.1

181

1278

ZX120

NOMESCO Finland

Intravenous

2.4

6.0

217

Mortality – FinRegistry

↥

Association

Association between endpoint G6_MENINGOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_MENINGOTH	2.298 [1.88, 2.8]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.112

During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1695 females with G6_MENINGOTH died.

Males

Parameter	HR [95% CI]	p-value
G6_MENINGOTH	2.392 [1.93, 2.96]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.026

During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1631 males with G6_MENINGOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_MENINGOTH.

N-year risk	Females	Males
1	0.192%	0.399%
5	1.228%	2.535%
10	3.051%	6.679%
15	5.931%	12.873%
20	10.511%	21.46%

Relationships between endpoints

↥

Index endpoint: G6_MENINGOTH – Other meningitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_MENINGOTH
CONTROL_EXCLUDE	G6_NEUINFL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G0[2-3]
HD_ICD_9	322
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL	G020
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G0[2-3]
COD_ICD_9	322
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL	G020
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other meningitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints