Meningitis, viral

G6_MENINGVIR

viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G02.0, G02.0A87.0, G02.0A87.1, G02.0B00.3, G02.0B01.0, G02.0B02.1, G02.0B05.1, G02.0B06.0, G02.0B26.1, G02.0B27.9 Cause of death: ICD-10 — G02.0, G02.0A87.0, G02.0A87.1, G02.0B00.3, G02.0B01.0, G02.0B02.1, G02.0B05.1, G02.0B06.0, G02.0B26.1, G02.0B27.9 2 out of 7 registries used, show all original rules.	159
4. Check minimum number of events None	159
5. Include endpoints None	159
6. Filter based on genotype QC (FinnGen only)	159

Control definitions (FinnGen only)

Control exclude: G6_NEUINFL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF12

NAME	G6_MENINGVIR
CONTROL_EXCLUDE	G6_NEUINFL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G020
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G020
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Meningitis, viral based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1037	609	424
Only index persons	980	583	397
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	36.25	39.74	31.18
Only index persons	36.97	39.99	32.53

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	159	112	47
Unadjusted period prevalence (%)	0.03	0.04	0.02
Median age at first event (years)	43.09	39.73	51.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
144: Matched controls
1440

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G02.0*B00.3

ICD-10 Finland

Herpesviral meningitis

+∞

87.7

A87.9

ICD-10 Finland

Viral meningitis, unspecified

568.5

70.0

J05AB11

ATC

valaciclovir; oral

11.7

31.3

R51.80

ICD-10 Finland

Headache

9.6

28.7

122

TAB00

NOMESCO Finland

Lumbar puncture

27.6

28.5

G02.0*B02.1

ICD-10 Finland

Zoster meningitis

+∞

26.9

G02.0

ICD-10 Finland

Meningitis in viral diseases classified elsewhere

+∞

25.8

G02.0*B01.0

ICD-10 Finland

Varicella meningitis

+∞

21.4

G02.0*A87.0

ICD-10 Finland

Enteroviral meningitis

+∞

19.2

G03.9

ICD-10 Finland

Meningitis, unspecified

+∞

19.2

J05AB01

ATC

aciclovir; systemic

6.1

18.9

154

A86

ICD-10 Finland

Unspecified viral encephalitis

141.8

12.6

AA1AD

NOMESCO Finland

CT of head and brain

4.5

12.3

152

B00.3

ICD-10 Finland

Herpesviral meningitis

+∞

11.6

A87.8

ICD-10 Finland

Other viral meningitis

+∞

11.6

5AB01

NOMESCO Finland

+∞

10.5

N01

ICPC

Headache

4.6

9.4

B02.9

ICD-10 Finland

Zoster without complication

8.4

7.6

N02BE01

ATC

paracetamol; systemic, rectal

3.9

7.6

129

990

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

16.9

7.4

N71

ICPC

Meningitis/encephalitis

+∞

7.3

G04.9

ICD-10 Finland

Encephalitis, myelitis and encephalomyelitis, unspecified

+∞

7.3

B02.1

ICD-10 Finland

Zoster meningitis

+∞

7.3

ZX120

NOMESCO Finland

Intravenous

4.5

6.7

XF400

NOMESCO Finland

ECG with 12 standard connections

3.6

6.6

H02AB06

ATC

prednisolone; systemic

2.5

6.5

438

B00.19

ICD-10 Finland

Other vesicular dermatitis caused by the herper simplex virus

72.9

6.5

B00.4

ICD-10 Finland

Herpesviral encephalitis

+∞

6.3

A87.0

ICD-10 Finland

Enteroviral meningitis

+∞

6.3

G05.1*B00.4

ICD-10 Finland

Herpesviral meningoencephalitis

+∞

6.3

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.5

6.2

339

N03AX16

ATC

pregabalin; oral

2.8

6.0

191

Mortality – FinRegistry

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Association

Association between endpoint G6_MENINGVIR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_MENINGVIR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: G6_MENINGVIR – Meningitis, viral

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Meningitis, viral

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints