MS-disease / Multiple Sclerosis

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109

3 out of 7 registries used, show all original rules.

2395

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Check minimum number of events None

2395

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Include endpoints None

2395

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Remove individuals based on genotype QC

2182

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G6_MS

Control definitions

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Summary Statistics

Key figures

All Female Male
Number of individuals 2182 1648 534
Unadjusted prevalence (%) 0.58 0.78 0.32
Mean age at first event (years) 39.45 38.45 42.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.17 [0.55, 2.50] 6.8e-1 94
15 years 0.01 0.90 [0.46, 1.76] 7.7e-1 42
5 years 0.00 1.99 [1.07, 3.70] 3.1e-2 22
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 5

Survival analyses between endpoints

Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

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Drugs most likely to be purchased after MS-disease / Multiple Sclerosis