Parkinson's disease

G6_PARKINSON

Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G20
Hospital discharge: ICD-9 3320A
Hospital discharge: ICD-8 34200
Cause of death: ICD-10 G20
Cause of death: ICD-9 3320A
Cause of death: ICD-8 34200
KELA reimbursements: KELA codes 110

3 out of 7 registries used, show all original rules.

4703

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Check minimum number of events None

4703

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Include endpoints None

4703

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Remove individuals based on genotype QC

4235

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G6_PARKINSON

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Similar endpoints

List of similar endpoints to Parkinson's disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 4235 1658 2577
Unadjusted prevalence (%) 1.12 0.79 1.55
Mean age at first event (years) 65.57 63.87 66.66

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.39 [2.48, 4.65] 2.7e-14 1174
15 years 0.01 2.09 [1.65, 2.63] 5.7e-10 568
5 years 0.00 3.50 [2.93, 4.18] 1.8e-43 418
1 year 0.00 3.67 [2.86, 4.72] 3.1e-24 90

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 2

Survival analyses between endpoints

Plot

before Parkinson's disease
after Parkinson's disease

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Drugs most likely to be purchased after Parkinson's disease