Gout, strict definition

GOUT_STRICT

gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

GOUT_IDIOP_NOS

7300

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Check pre-conditions, main-only, mode, registry filters

Medicine purchases: ATC M04AA01|M04AA03|M04AB01|M04AB03

1 out of 7 registries used, show all original rules.

4933

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Check minimum number of events

Min. number of events 3

4933

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Include endpoints None

4933

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Remove individuals based on genotype QC

4429

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GOUT_STRICT

Control definitions

Control conditions not GOUT_IDIOP_NOS

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 4429 874 3555
Unadjusted prevalence (%) 1.17 0.41 2.14
Mean age at first event (years) 62.21 65.39 61.43

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.60 [1.16, 2.20] 3.7e-3 1057
15 years 0.01 1.27 [1.00, 1.62] 5.2e-2 549
5 years 0.00 2.06 [1.69, 2.50] 5.0e-13 270
1 year 0.00 1.42 [0.98, 2.05] 6.6e-2 34

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: GOUT_STRICT – Gout, strict definition
GWS hits: 11

Survival analyses between endpoints

Plot

before Gout, strict definition
after Gout, strict definition

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Drugs most likely to be purchased after Gout, strict definition