Age-related macular degeneration (whether dry or wet)

H7_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

10014

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Remove individuals based on genotype QC

8913

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H7_AMD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 8913 4607 4306
Unadjusted prevalence (%) 2.36 2.19 2.59
Mean age at first event (years) 75.18 75.30 75.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.17 [1.68, 2.80] 2.7e-9 1790
15 years 0.01 1.15 [0.93, 1.41] 1.9e-1 788
5 years 0.00 2.32 [2.01, 2.67] 2.6e-30 720
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_AMD – Age-related macular degeneration (whether dry or wet)
GWS hits: 23

Survival analyses between endpoints

Plot

before Age-related macular degeneration (whether dry or wet)
after Age-related macular degeneration (whether dry or wet)

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Drugs most likely to be purchased after Age-related macular degeneration (whether dry or wet)