Inguinal hernia, bilateral

HERING_BILATERAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

3758

4. Check minimum number of events

None

3758

5. Include endpoints

None

3758

6. Filter based on genotype QC (FinnGen only)

3625

Control definitions (FinnGen only)

Control exclude
K11_HERNIA

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 32945 3598 29171
Only index persons 30071 3207 26864
Unadjusted period prevalence (%)
Whole population 0.73 0.10 0.82
Only index persons 0.93 0.12 1.03
Median age at first event (years)
Whole population 60.00 58.80 60.10
Only index persons 59.60 58.64 59.71

-FinnGen-

Key figures

All Female Male
Number of individuals 3625 362 3263
Unadjusted period prevalence (%) 1.49 0.14 1.64
Median age at first event (years) 62.20 55.30 62.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3758
Matched controls
37575
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
1290.2
323.0
1100
12
JAB12
NOMESCO Finland
Laparoscopic repair of inguinal hernia, TEP
+∞
323.0
443
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
194.4
323.0
1796
176
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
1087.4
323.0
1662
27
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
9663.9
323.0
3300
25
K40.0
ICD-10 Finland
Bilateral inguinal hernia, with obstruction, without gangrene
+∞
323.0
418
*
ZXA10
NOMESCO Finland
Bilateral
4.2
255.7
1197
3774
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
52.3
237.1
286
59
K40
ICD-10 Finland
Inguinal hernia
32.2
234.6
314
106
D89
ICPC
Inguinal hernia
43.1
199.7
250
62
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
98.9
170.8
188
20
6123
FHL
Radical surgery
113.1
168.7
183
17
55099
ICD-8 Finland
Inguinal hernia without mention of obstruction
+∞
166.9
159
*
JAB10
NOMESCO Finland
Repair of inguinal hernia
180.1
165.1
172
10
JAB97
NOMESCO Finland
Other laparoscopic repair of inguinal hernia
+∞
154.2
147
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
40.3
139.6
177
46
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
26.5
138.0
194
77
JAF30
NOMESCO Finland
Repair of umbilical hernia using prosthetic material
180.0
117.1
122
7
JAF10
NOMESCO Finland
Repair of umbilical hernia
30.6
111.1
150
51
5509B
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,LATERALIS (SCROT]
+∞
105.7
101
*
K40.1
ICD-10 Finland
Bilateral inguinal hernia, with gangrene
+∞
104.6
100
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
96.6
1453
8487
5509A
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,MEDIALIS]
+∞
92.0
88
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
74.7
728
3388
N02BE01
ATC
paracetamol; systemic, rectal
2.1
72.9
3058
25382
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
69.2
1413
8992
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
123.9
57.0
61
5
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
290.9
56.4
57
*
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
192.8
55.1
57
*
K42.0
ICD-10 Finland
Umbilical hernia with obstruction, without gangrene
494.0
49.5
49
*
JAB91
NOMESCO Finland
Repair of recurrent inguinal hernia, endoscopy
+∞
48.0
46
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
47.7
993
6176
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.3
47.1
503
2402
103
Kela drug reimbursment
Diabetes, insulin-treated
0.5
46.3
503
8682
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
+∞
43.8
42
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
42.9
1035
6711
5509D
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,RECIDIVANS]
+∞
42.8
41
*
6124
FHL
Radical cutting and plastic with foreign material
422.1
42.2
42
*
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
5.6
42.1
127
234
A10BA02
ATC
metformin; oral
0.5
41.1
545
8945
JAB93
NOMESCO Finland
Repair of recurrent inguinal hernia, implantation
+∞
40.7
39
*
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
+∞
36.5
35
*
ZXA00
NOMESCO Finland
Right side
1.7
34.8
916
6026
G04CA02
ATC
tamsulosin; oral
1.6
34.5
1388
10207
WX402
NOMESCO Finland
General anaesthesia
1.9
34.1
557
3141
ZXE00
NOMESCO Finland
One hour or less
1.6
34.0
1277
9227
JAB96
NOMESCO Finland
Other repair of inguinal hernia
340.1
34.0
34
*
A98
ICPC
Health maint/preventive medicine
1.8
33.8
3329
30368
WX320
NOMESCO Finland
Spinalanesthesy
1.7
33.6
755
4732
N40
ICD-10 Finland
Hyperplasia of prostate
1.6
33.6
1329
9715
ZXD20
NOMESCO Finland
Day surgery
2.1
33.0
412
2090
WX110
NOMESCO Finland
Local anesthesy
1.5
31.0
2142
17642
M01AE01
ATC
ibuprofen; systemic, rectal
1.6
31.0
2947
26104
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
29.8
1458
11108
215
Kela drug reimbursment
Diabetes, non-insulin-treated
0.6
29.0
464
7364
D91
ICPC
Abdominal hernia other
11.2
27.0
51
46
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
0.6
25.5
473
7279
A02BC02
ATC
pantoprazole; systemic
1.4
25.4
2069
17285
ZXA05
NOMESCO Finland
Left side
1.6
24.7
830
5744
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
24.6
674
4427
Z2221
NOMESCO Finland
Medical doctor
1.6
24.0
844
5900
J01MA02
ATC
ciprofloxacin; systemic
1.4
23.9
1380
10737
G04CA01
ATC
alfuzosin; oral
1.6
23.0
683
4572
JAF11
NOMESCO Finland
Laparoscopic repair of umbilical hernia
+∞
22.9
22
*
S18
ICPC
Laceration/cut
1.4
22.6
1408
11085
J01CA04
ATC
amoxicillin; systemic
1.4
22.0
2501
21926
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
21.4
849
6076
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
21.0
292
1539
WX002
NOMESCO Finland
Sedation and analgesia
1.6
20.9
601
3984
J01AA02
ATC
doxycycline; systemic
1.4
20.6
2497
21988
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
0.4
20.6
72
1883
6125
FHL
Residual surgery, can be reported as a side effect
211.0
20.6
21
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
20.4
210
976
T90
ICPC
Diabetes non-insulin dependent
0.6
20.3
471
6940
A10BB12
ATC
glimepiride; oral
0.4
20.2
89
2122
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
20.1
523
3370
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
20.1
697
4830
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
19.6
1534
12477
XKD00
NOMESCO Finland
Uroflowmetry
1.5
19.6
858
6256
A02BC05
ATC
esomeprazole; systemic
1.4
19.1
1136
8794
K40.4
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with gangrene
+∞
18.8
18
*
N02AX02
ATC
tramadol; systemic, rectal
1.4
18.7
1392
11200
A10AE04
ATC
insulin glargine; parenteral
0.5
18.4
119
2474
J01DB01
ATC
cefalexin; oral
1.4
18.4
2683
24109
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
18.0
430
2703
UKC02
NOMESCO Finland
Cystoscopy
1.5
17.9
687
4858
WX704
NOMESCO Finland
Intubation
2.0
17.8
230
1178
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
17.7
17
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
17.3
1074
8348
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.5
17.1
600
4149
ZXC86
NOMESCO Finland
Use of endoscopic device
8.5
17.1
37
44
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
17.1
848
6314
J01FA10
ATC
azithromycin; systemic
1.4
16.6
1474
12135
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.6
16.1
458
3013
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
0.4
16.0
57
1480
5509X
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,ALIA SEU NUD]
+∞
15.6
15
*
UJF32
NOMESCO Finland
Coloscopy
1.4
15.3
783
5850
M79.6
ICD-10 Finland
Pain in limb
1.4
15.1
944
7308
JAD10
NOMESCO Finland
Repair of incisional hernia
23.4
15.1
21
9
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
4.8
14.8
49
104
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
31.8
14.8
19
6
R01AD12
ATC
fluticasone furoate; nasal
1.5
14.8
639
4615
JAB40
NOMESCO Finland
Repair of inguinal hernia by laparotomy and reconstruction of abdominal wall
80.4
14.6
16
*
B01AB05
ATC
enoxaparin; parenteral
1.4
14.6
919
7122
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.5
14.5
116
477
SPAT1153
SPAT
Removal of sutures
1.4
13.6
1017
8089
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
0.3
13.4
29
941
K42
ICD-10 Finland
Umbilical hernia
7.7
13.3
30
39
A10BB01
ATC
glibenclamide; oral
0.4
13.1
42
1137
XJH00
NOMESCO Finland
Transanal ultrasonography
1.6
13.1
329
2093
M01AC06
ATC
meloxicam; systemic, rectal
1.3
13.0
965
7654
Z3231
NOMESCO Finland
Registered nurse
1.4
13.0
856
6661
A10AE05
ATC
insulin detemir; parenteral
0.4
12.9
48
1224
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
12.6
691
5205
R42
ICD-10 Finland
Dizziness and giddiness
1.4
12.4
596
4380
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.8
12.2
51
137
M25.5
ICD-10 Finland
Pain in joint
1.4
12.2
658
4944
R03DC03
ATC
montelukast; oral
1.6
12.1
330
2141
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
12.1
1418
11997
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
0.6
12.0
157
2656
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
11.9
652
4907
E11
ICD-10 Finland
Type 2 diabetes mellitus
0.7
11.9
297
4354
R06AX27
ATC
desloratadine; oral
1.4
11.8
543
3958
R51.80
ICD-10 Finland
Headache
1.6
11.8
291
1842
R4110
NOMESCO Finland
Physiotherapy
1.4
11.6
783
6105
M01AE02
ATC
naproxen; oral, rectal
1.3
11.5
1558
13395
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
11.5
360
2420
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
11.3
601
4495
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
11.2
510
3703
AA1AD
NOMESCO Finland
CT of head and brain
1.4
11.2
764
5961
H02AB06
ATC
prednisolone; systemic
1.3
11.2
1405
11953
R03AC02
ATC
salbutamol; inhalant
1.3
11.1
1383
11748
Z3226
NOMESCO Finland
Physiotherapist
1.4
11.1
530
3890
J45
ICD-10 Finland
Asthma
1.7
11.0
212
1251
R01AD09
ATC
mometasone; nasal
1.3
10.9
1072
8819
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
0.3
10.9
29
850
R35
ICD-10 Finland
Polyuria
1.7
10.9
238
1458
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
10.8
196
1136
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
0.5
10.6
93
1760
K44.0
ICD-10 Finland
Diaphragmatic hernia with obstruction, without gangrene
60.1
10.6
12
*
M03BX02
ATC
tizanidine; oral
1.3
10.6
1680
14679
R20.2
ICD-10 Finland
Paraesthesia of skin
1.9
10.6
149
791
J01FA09
ATC
clarithromycin; systemic
1.3
10.6
759
5962
D01
ICPC
Abdominal pain/cramps general
1.7
10.5
225
1370
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
10.5
206
1222
D06
ICPC
Abdominal pain localized other
1.8
10.5
168
934
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
10.5
520
3839
55120
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Hernia epigastrica
+∞
10.4
10
*
A10AA02
ATC
NA
0.3
10.3
17
628
J01FA06
ATC
roxithromycin; oral
1.3
10.3
1072
8876
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
10.3
600
4558
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
10.3
302
1997
M01AB05
ATC
diclofenac; systemic, rectal
1.3
10.2
1993
17817
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.7
10.1
197
1168
M01AH05
ATC
etoricoxib; oral
1.3
10.1
1612
14069
WZC30
NOMESCO Finland
Teaching
1.5
10.0
393
2772
N06AX11
ATC
mirtazapine; oral
1.3
10.0
796
6342
WX290
NOMESCO Finland
Other blockade of nerve
1.3
9.8
1094
9127
A10BK03
ATC
empagliflozin; oral
0.5
9.7
92
1702
ZXD05
NOMESCO Finland
Urgent procedure
1.3
9.6
941
7714
R05
ICD-10 Finland
Cough
1.4
9.6
477
3523
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
9.6
1109
9297
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
2.1
9.6
100
474
JBB01
NOMESCO Finland
Laparoscopic repair of paraoesophageal hernia
100.2
9.4
10
*
JAC30
NOMESCO Finland
Repair of femoral hernia using prosthetic material
+∞
9.4
9
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
9.4
696
5487
R10.2
ICD-10 Finland
Pelvic and perineal pain
2.8
9.3
56
200
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
9.2
722
5736
L82
ICD-10 Finland
Seborrhoeic keratosis
1.4
9.1
407
2942
R53
ICD-10 Finland
Malaise and fatigue
1.4
9.0
521
3946
JA1AE
SPAT
NA
9.0
9.0
18
20
SPAT1262
SPAT
Handing over of treatment supplies
0.7
9.0
381
5102
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
9.0
400
2892
A02BC03
ATC
lansoprazole; oral
1.3
9.0
790
6377
M02AA07
ATC
piroxicam; topical
1.3
9.0
1008
8398
I49.3
ICD-10 Finland
Ventricular premature depolarization
1.7
9.0
193
1179
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
8.9
443
3264
KED22
NOMESCO Finland
Transurethral resection of prostate
1.5
8.9
294
1999
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
8.8
969
8047
J45.9
ICD-10 Finland
Asthma, unspecified
1.4
8.8
419
3067
A10BJ06
ATC
semaglutide; parenteral
0.3
8.8
16
565
H02AB04
ATC
methylprednisolone; systemic
1.5
8.8
355
2515
A10BH01
ATC
sitagliptin; oral
0.6
8.8
160
2508
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.6
8.8
219
1393
R33
ICD-10 Finland
Retention of urine
1.5
8.7
346
2444
R55
ICD-10 Finland
Syncope and collapse
1.5
8.7
347
2452
XF404
NOMESCO Finland
Ambulatory ECG
1.5
8.7
295
2019
Z02.4
ICD-10 Finland
Examination for driving licence
1.3
8.7
972
8089
JAC10
NOMESCO Finland
Repair of femoral hernia
50.1
8.7
10
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.6
8.6
204
1283
A10BG03
ATC
pioglitazone; oral
0.3
8.6
16
554
M79.1
ICD-10 Finland
Myalgia
1.5
8.5
260
1740
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
1.8
8.4
128
703
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.3
8.4
1122
9536
F51.0
ICD-10 Finland
Nonorganic insomnia
1.5
8.4
248
1645
5530A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Femoral hernia
+∞
8.3
8
*
R31
ICD-10 Finland
Unspecified haematuria
1.4
8.3
401
2944
N41.1
ICD-10 Finland
Chronic prostatitis
1.9
8.2
112
593
A02BC04
ATC
rabeprazole; oral
1.7
8.2
175
1068
L02
ICPC
Back symptom/complaint
1.7
8.1
180
1111
K59.09
ICD-10 Finland
Constipation, unspecified
1.7
8.1
173
1053
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.6
8.1
183
1136
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
8.1
267
1816
Z01.7
ICD-10 Finland
Laboratory examination
1.5
8.1
281
1932
R07.3
ICD-10 Finland
Other chest pain
1.5
8.1
240
1595
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
0.3
8.0
14
499
R03BA08
ATC
ciclesonide; inhalant
1.7
7.9
166
1008
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
7.9
1927
17427
D01BA02
ATC
terbinafine; oral; topical
1.3
7.9
808
6642
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
7.8
443
3344
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
1.8
7.8
132
755
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
0.3
7.8
22
626
H25.1
ICD-10 Finland
Senile nuclear cataract
1.3
7.8
778
6376
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.7
7.7
151
900
KMAK
NOMESCO Finland
NA
1.2
7.7
1320
11501
WX702
NOMESCO Finland
Supraglottic ventilation device
1.9
7.7
108
577
R03BA01
ATC
beclometasone; inhalant
1.4
7.7
324
2319
XF402
NOMESCO Finland
ECG with work load test
1.4
7.6
346
2514
J01DA01
ATC
[U] cefalexin; systemic
1.2
7.6
1841
16618
6129
FHL
Other measure in this category
11.8
7.6
13
11
A10BB07
ATC
glipizide; oral
0.1
7.6
*
298
U02
ICPC
Urinary frequency/urgency
1.5
7.5
222
1471
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
0.4
7.5
36
829
I34.1
ICD-10 Finland
Mitral (valve) prolapse
2.0
7.5
94
482
TKE00
NOMESCO Finland
Needle biopsy of prostate
1.6
7.5
202
1314
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.5
7.4
226
1514
J01MA06
ATC
norfloxacin; oral
1.5
7.4
268
1862
J31.0
ICD-10 Finland
Chronic rhinitis
1.6
7.3
167
1039
N01
ICPC
Headache
1.7
7.3
159
978
R63.4
ICD-10 Finland
Abnormal weight loss
1.9
7.3
103
553
JAH01
NOMESCO Finland
Laparoscopy
2.1
7.3
77
370
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
7.3
7
*
55121
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Alia hernia ventralis (incisionalis, in cicactrice)
+∞
7.3
7
*
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.0
7.3
90
460
A02BC01
ATC
omeprazole; systemic
1.3
7.3
764
6293
I73.0
ICD-10 Finland
Raynaud syndrome
2.9
7.3
40
137
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
2.0
7.2
81
400
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.5
7.1
210
1395
A98
ICD-10 Finland
Other viral haemorrhagic fevers, not elsewhere classified
2.3
7.1
60
262
WX220
NOMESCO Finland
Ilioinguinal plexus blockade
10.0
7.0
13
13
J01EA01
ATC
trimethoprim; systemic
1.3
7.0
445
3421
R06AE09
ATC
levocetirizine; oral
1.5
7.0
269
1890
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.3
7.0
443
3404
PHD99
NOMESCO Finland
Resection of other vein
1.8
6.9
115
652
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.7
6.9
148
906
R21
ICPC
Throat symptom/complaint
1.4
6.9
339
2495
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
6.9
1239
10821
A01AB09
ATC
miconazole; local oral
1.6
6.9
186
1209
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
0.4
6.9
24
625
N43.3
ICD-10 Finland
Hydrocele, unspecified
1.9
6.9
91
477
L12
ICPC
Hand/finger symptom/complaint
1.4
6.9
313
2275
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
6.9
379
2849
H02AB07
ATC
prednisone; oral
1.4
6.9
362
2701
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.3
6.8
495
3878
A10BD07
ATC
metformin and sitagliptin; systemic
0.5
6.8
58
1101
N17
ICPC
Vertigo/dizziness
1.5
6.8
255
1788
N43.4
ICD-10 Finland
Spermatocele
2.0
6.8
84
432
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
6.8
644
5235
N30.0
ICD-10 Finland
Acute cystitis
1.5
6.7
229
1573
A02BA02
ATC
ranitidine; systemic
1.3
6.7
533
4228
WX720
NOMESCO Finland
Own respiration
1.8
6.7
109
615
J20
ICD-10 Finland
Acute bronchitis
1.5
6.7
211
1426
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.5
6.6
201
1345
P07.3
ICD-10 Finland
Other preterm infants
7.8
6.6
14
18
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.4
6.6
261
1848
R74
ICPC
Upper respiratory infection acute
1.3
6.6
500
3945
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
6.6
692
5694
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.7
6.5
40
147
D03
ICPC
Heartburn
2.1
6.5
66
310
XF400
NOMESCO Finland
ECG with 12 standard connections
1.3
6.5
530
4220
R03BA05
ATC
fluticasone; inhalant
1.3
6.5
406
3110
N03AX16
ATC
pregabalin; oral
1.3
6.5
585
4720
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.4
6.5
268
1912
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
1.6
6.4
164
1053
B01AA03
ATC
warfarin; systemic
1.3
6.4
745
6200
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
6.4
654
5358
UJH02
NOMESCO Finland
Anoscopy
1.8
6.4
101
565
C05AA08
ATC
fluocortolone; rectal, topical
1.4
6.4
355
2669
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.4
1471
13132
R06AE07
ATC
cetirizine; oral
1.2
6.4
949
8118
R13
ICD-10 Finland
Dysphagia
1.6
6.4
170
1106
H01.0
ICD-10 Finland
Blepharitis
1.8
6.3
106
606
G04BD12
ATC
mirabegron; oral
1.4
6.3
271
1950
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.6
6.3
158
1014
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.3
6.3
407
3138
R01AD08
ATC
fluticasone; nasal
1.3
6.3
622
5079
J05AB01
ATC
aciclovir; systemic
1.3
6.3
453
3545
L17
ICPC
Foot/toe symptom/complaint
1.3
6.3
631
5165
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
6.2
240
1688
55110
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Umbilical
+∞
6.2
6
*
JAB95
NOMESCO Finland
Operation of inguinal hernia, removal of mesh due to complication
+∞
6.2
6
*
5531A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Umbilical hernia
+∞
6.2
6
*
D11
ICPC
Diarrhoea
1.5
6.2
207
1415
K43.2
ICD-10 Finland
Incisional hernia without obstruction or gangrene
26.7
6.2
8
*
H3603, E113
ICD-10 Finland
NA
0.1
6.2
*
187
M20.1
ICD-10 Finland
Hallux valgus (acquired)
1.7
6.2
112
654
A10BX02
ATC
repaglinide; oral
0.1
6.2
*
233
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
1.8
6.2
92
507
R03DC01
ATC
zafirlukast; oral
2.6
6.2
41
158
WX725
NOMESCO Finland
Noninvasive ventilation
1.7
6.2
127
770
R03BB04
ATC
tiotropium bromide; inhalant
1.4
6.1
329
2458
J02AC01
ATC
fluconazole; systemic
1.3
6.1
608
4966
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
6.1
857
7287
M01AX17
ATC
nimesulide; oral
1.3
6.1
647
5333
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.5
6.1
229
1606

Mortality – FinRegistry

Association

Association between endpoint HERING_BILATERAL and mortality.

Females

Parameter HR [95% CI] p-value
HERING_BILATERAL 1.146 [1.01, 1.3] 0.038
Birth year 0.993 [0.98, 1.0] 0.095

During the follow-up period (1.1.1998 — 31.12.2019), 657 out of 3063 females with HERING_BILATERAL died.

Males

Parameter HR [95% CI] p-value
HERING_BILATERAL 0.986 [0.91, 1.07] 0.741
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 5117 out of 25068 males with HERING_BILATERAL died.

Mortality risk

Mortality risk for people of age

years, who have HERING_BILATERAL.

N-year risk Females Males
1 0.08% 0.224%
5 0.647% 1.255%
10 1.526% 3.107%
15 2.9% 5.815%
20 5.48% 9.394%

Relationships between endpoints

Index endpoint: HERING_BILATERAL – Inguinal hernia, bilateral

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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