Hypothyroidism, drug reimbursement

HYPOTHY_REIMB

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes 104

1 out of 7 registries used, show all original rules.

13223

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Check minimum number of events None

13223

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Include endpoints None

13223

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Remove individuals based on genotype QC

12040

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HYPOTHY_REIMB

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 12040 9977 2063
Unadjusted prevalence (%) 3.19 4.73 1.24
Mean age at first event (years) 46.84 45.95 51.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.41 [1.16, 1.70] 4.8e-4 1192
15 years 0.01 1.01 [0.86, 1.18] 9.2e-1 520
5 years 0.00 1.00 [0.82, 1.22] 9.7e-1 137
1 year 0.00 1.33 [0.92, 1.93] 1.3e-1 32

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: HYPOTHY_REIMB – Hypothyroidism, drug reimbursement
GWS hits: 23

Survival analyses between endpoints

Plot

before Hypothyroidism, drug reimbursement
after Hypothyroidism, drug reimbursement

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Drugs most likely to be purchased after Hypothyroidism, drug reimbursement

Not a core endpoint, no data to show.