Atrial fibrillation and flutter with reimbursement

I9_AF_REIMB

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

I9_AF

50713

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes 207|351

1 out of 7 registries used, show all original rules.

23965

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Check minimum number of events None

23965

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Include endpoints None

23965

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Remove individuals based on genotype QC

21700

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I9_AF_REIMB

Control definitions

Control exclude FG_CVD
Control conditions not I9_AF

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 21700 8820 12880
Unadjusted prevalence (%) 5.75 4.18 7.75
Mean age at first event (years) 69.92 71.64 68.74

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.96 [1.61, 2.38] 1.1e-11 3074
15 years 0.01 0.94 [0.81, 1.09] 3.8e-1 1016
5 years 0.00 2.21 [1.97, 2.48] 7.7e-42 1053
1 year 0.00 6.34 [5.54, 7.25] <1e-100 609

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_AF_REIMB – Atrial fibrillation and flutter with reimbursement
GWS hits: 79

Survival analyses between endpoints

Plot

before Atrial fibrillation and flutter with reimbursement
after Atrial fibrillation and flutter with reimbursement

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atrial fibrillation and flutter with reimbursement

Not a core endpoint, no data to show.