No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
1021 |
4. Check minimum number of eventsNone |
1021 |
5. Include endpointsNone |
1021 |
6. Filter based on genotype QC (FinnGen only) |
1021 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 5
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Dronedarone medication
based on the number of shared cases.
Similar with more cases:
- Atrial fibrillation and flutter
- Cardiac arrhythmias
- Other heart diseases
- Other heart diseases, wide
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4159 | 1987 | 2166 |
| Only index persons | 4146 | 1983 | 2163 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.08 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 67.74 | 70.95 | 64.81 |
| Only index persons | 67.74 | 70.93 | 64.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1021 | 473 | 548 |
| Unadjusted period prevalence (%) | 0.20 | 0.16 | 0.24 |
| Median age at first event (years) | 67.53 | 70.21 | 65.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 921
- Matched controls
- 9208
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C01AA05
ATC
digoxin; systemic
192.7
323.0
349
29
C01BD01
ATC
amiodarone; systemic
+∞
323.0
299
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
323.0
537
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1281.5
323.0
331
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3759.8
323.0
622
5
C01BD07
ATC
dronedarone; oral
+∞
323.0
754
*
B01AF02
ATC
apixaban; oral
74.1
323.0
425
105
C01BC04
ATC
flecainide; systemic
1568.8
323.0
375
*
K78
ICPC
Atrial fibrillation/flutter
116.4
323.0
399
60
C07AB07
ATC
bisoprolol; oral
41.5
323.0
867
2566
B01AA03
ATC
warfarin; systemic
99.9
323.0
765
430
207
Kela drug reimbursment
Chronic arrhythmias
16384.0
323.0
886
6
TFP20
NOMESCO Finland
Cardiodefibrillation
3304.1
323.0
634
6
I48
ICD-10 Finland
Atrial fibrillation and flutter
15177.7
323.0
914
53
342
Kela drug reimbursment
Dronedarone
+∞
323.0
921
*
TFP34
NOMESCO Finland
Electrophysiological investigation
+∞
296.3
268
*
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
+∞
288.0
261
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
16.8
286.6
542
723
XF404
NOMESCO Finland
Ambulatory ECG
36.6
280.3
368
164
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
347.7
261.4
253
10
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
13.9
223.1
438
563
I50.9
ICD-10 Finland
Heart failure, unspecified
73.4
209.3
236
43
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
434.5
209.0
202
6
TFP35
NOMESCO Finland
Electroanatomical mapping
+∞
194.9
180
*
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
+∞
187.0
173
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
226.2
181.3
182
10
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
25.2
177.5
257
139
I49.5
ICD-10 Finland
Sick sinus syndrome
1007.7
175.0
166
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
674.7
174.4
167
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
1915.9
165.8
156
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
134.1
663
2783
AR6
HP
Catheter ablation of arrhythmia, target: atrial fibrillation
+∞
127.1
119
*
I48.2
ICD-10 Finland
Chronic atrial fibrillation
692.3
125.4
121
*
C07AA07
ATC
sotalol; systemic
33.0
122.2
162
59
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.4
121.7
394
958
I48.1
ICD-10 Finland
Persistent atrial fibrillation
441.8
119.5
117
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
14.8
118.1
208
178
WX404
NOMESCO Finland
Intravenous generell anesthesy
6.0
116.5
406
1071
C03CA01
ATC
furosemide; systemic
5.8
115.6
421
1169
AQ2
HP
Electrophysiological electroanatomical examination
+∞
108.5
102
*
AQ1
HP
Conventional electrophysiological examination
+∞
103.1
97
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
97.6
95.3
104
12
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
180.3
94.1
97
6
K80
ICPC
Cardiac arrhythmia NOS
11.3
93.1
186
202
C08DA01
ATC
verapamil; systemic
20.3
92.6
142
82
XF400
NOMESCO Finland
ECG with 12 standard connections
5.7
92.4
316
774
AN1
HP
Coronary angiography
6.9
90.2
254
483
C07AB02
ATC
metoprolol; systemic
5.0
88.5
354
1026
XF402
NOMESCO Finland
ECG with work load test
6.5
86.7
256
516
I50.0
ICD-10 Finland
Congestive heart failure
126.0
85.6
91
8
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
76.3
85.2
96
14
B01AE07
ATC
dabigatran etexilate; oral
19.6
75.2
116
67
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.3
73.5
338
1088
I49.3
ICD-10 Finland
Ventricular premature depolarization
25.6
72.9
103
45
AS4
HP
Physiological pacemaker insertion DDD (R)
+∞
72.9
69
*
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
+∞
72.9
69
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
3.5
65.0
421
1777
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
+∞
63.2
60
*
I50.1
ICD-10 Finland
Left ventricular failure
228.8
63.0
64
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.8
60.1
312
1084
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
615.7
59.4
58
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.6
59.2
341
1288
R06.0
ICD-10 Finland
Dyspnoea
3.7
59.2
328
1199
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
+∞
59.0
56
*
B01AF01
ATC
rivaroxaban; oral
5.0
57.8
211
521
B01AF03
ATC
edoxaban; oral
209.7
57.7
59
*
K04
ICPC
Palpitations/awareness of heart
10.7
56.8
114
120
XF640
NOMESCO Finland
NA
20.9
56.0
84
44
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.0
55.2
145
238
C03DA01
ATC
spironolactone; oral
6.0
53.6
160
311
K05
ICPC
Irregular heartbeat other
16.8
51.2
83
54
I35.0
ICD-10 Finland
Aortic (valve) stenosis
35.4
51.2
66
20
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
+∞
49.4
47
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
175.9
48.3
50
*
R07.4
ICD-10 Finland
Chest pain, unspecified
3.1
48.2
353
1543
I49.1
ICD-10 Finland
Atrial premature depolarization
20.4
47.8
72
38
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
3.5
46.3
257
912
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
46.2
44
*
AR5
HP
Catheter ablation of arrhythmia, target: atrial flutter
236.1
44.3
45
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.5
42.4
238
844
SPAT1097
SPAT
Recording of ECG
3.4
41.5
238
856
201
Kela drug reimbursment
Chronic cardiac insufficiency
31.1
40.0
53
18
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
38.8
37
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
38.6
412
2193
C08DB01
ATC
diltiazem; oral
6.3
38.4
107
187
I47.2
ICD-10 Finland
Ventricular tachycardia
203.2
38.1
39
*
PH3AC
NOMESCO Finland
Flebography of internal organs with X-ray
+∞
37.8
36
*
C01DA14
ATC
isosorbide mononitrate; oral
3.5
37.4
200
675
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
51.2
36.9
44
9
TFP40
NOMESCO Finland
Ablation treatment for a-v node re-entry activation
+∞
36.7
35
*
C09AA05
ATC
ramipril; oral
2.7
36.3
312
1455
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
131.9
36.0
38
*
WX892
NOMESCO Finland
Monitored bed care
5.1
35.7
119
258
R00.2
ICD-10 Finland
Palpitations
6.2
35.7
101
180
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
35.6
34
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
35.5
197
681
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
5.9
35.3
104
195
B01AB05
ATC
enoxaparin; parenteral
2.5
35.1
378
1991
C07AB03
ATC
atenolol; systemic
5.1
34.3
114
246
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
7.4
33.4
82
120
K99
ICPC
Cardiovascular disease other
12.0
33.0
61
54
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
+∞
32.5
31
*
I49.8
ICD-10 Finland
Other specified cardiac arrhythmias
14.6
32.0
54
39
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.8
31.9
253
1109
GD1LA
NOMESCO Finland
GD
117.5
31.9
34
*
I50
ICD-10 Finland
Heart failure
20.6
31.6
47
24
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
14.7
31.5
53
38
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
31.2
467
2857
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
30.4
29
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
60.5
30.3
35
6
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.8
28.5
132
391
I20.99
ICD-10 Finland
Angina pectoris, unspecified
4.6
28.3
103
244
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
66.1
28.1
32
5
SPAT1249
SPAT
Treatment-related counselling outside office
2.2
27.8
423
2560
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
48.8
27.6
33
7
N02BE01
ATC
paracetamol; systemic, rectal
3.0
27.5
831
6937
XF600
NOMESCO Finland
Bloodpressure measurement
4.8
27.5
96
218
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
99.7
26.8
29
*
C01BA03
ATC
disopyramide; systemic
144.1
26.8
28
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.2
26.5
652
4827
I20.09
ICD-10 Finland
Unstable angina
4.5
25.8
96
232
81
HP
Angiography of the heart and coronary arteries
4.4
25.1
96
239
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
3.8
24.1
110
321
SPAT1104
SPAT
Monitoring of emergency patient
4.0
23.8
99
266
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
246.0
23.7
24
*
I48.3
ICD-10 Finland
Typical atrial flutter
128.3
23.7
25
*
SPAT1263
SPAT
Sampling
2.1
23.5
432
2767
I48.4
ICD-10 Finland
Atypical atrial flutter
+∞
23.0
22
*
R00.1
ICD-10 Finland
Bradycardia, unspecified
10.0
23.0
46
48
J01DB01
ATC
cefalexin; oral
2.3
22.8
751
6076
G47.3
ICD-10 Finland
Sleep apnoea
2.4
22.8
235
1160
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
123.0
22.7
24
*
R02
ICPC
Shortness of breath/dyspnoea
3.0
22.6
140
513
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
4.1
22.5
92
243
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
8.8
22.3
48
57
H03BB01
ATC
carbimazole; oral
5.7
22.1
65
121
R53
ICD-10 Finland
Malaise and fatigue
2.5
22.0
206
965
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
+∞
22.0
21
*
C01BC03
ATC
propafenone; systemic
+∞
22.0
21
*
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
+∞
22.0
21
*
H02AB06
ATC
prednisolone; systemic
2.0
21.8
447
2959
A02BC02
ATC
pantoprazole; systemic
2.0
20.8
632
4824
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.1
20.5
301
1735
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
20.2
233
1207
K83
ICPC
Heart valve disease NOS
58.8
20.0
23
*
FPB22
NOMESCO Finland
Transvenous radiofrequency ablation of aberrant pathway or focus of heart
+∞
19.9
19
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
19.9
19
*
R00.0
ICD-10 Finland
Tachycardia, unspecified
7.0
19.8
49
73
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
75.1
19.8
22
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
9.7
19.7
40
43
SPAT1260
SPAT
Consultation of another employee
2.3
19.6
213
1068
K84
ICPC
Heart disease other
7.1
19.5
48
71
C10AA05
ATC
atorvastatin; oral
1.9
19.3
438
2966
R04.0
ICD-10 Finland
Epistaxis
3.5
19.0
93
287
SPAT1325
SPAT
Vaccination
1.9
18.8
404
2671
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
11.3
18.8
35
32
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
+∞
18.8
18
*
WX402
NOMESCO Finland
General anaesthesia
2.4
18.3
175
822
R42
ICD-10 Finland
Dizziness and giddiness
2.1
18.1
237
1288
I25.2
ICD-10 Finland
Old myocardial infarction
3.9
18.0
76
207
A98
ICPC
Health maint/preventive medicine
4.2
18.0
895
8199
J01CA04
ATC
amoxicillin; systemic
2.0
18.0
690
5564
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
6.2
17.8
48
81
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
3.9
17.4
74
203
UJF32
NOMESCO Finland
Coloscopy
2.0
17.3
286
1703
C07AG02
ATC
carvedilol; oral
3.5
17.2
82
248
A02BC05
ATC
esomeprazole; systemic
1.9
17.1
400
2698
SPAT1081
SPAT
Cardiorespiratory global assessment
3.4
17.1
85
265
R55
ICD-10 Finland
Syncope and collapse
2.7
17.0
124
499
WX002
NOMESCO Finland
Sedation and analgesia
2.1
17.0
234
1295
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
19.7
16.9
25
13
Z71.8
ICD-10 Finland
Other specified counselling
2.1
16.9
220
1188
FK1BT
NOMESCO Finland
Implantation of cardiac pacemaker with X-ray guidance
+∞
16.7
16
*
WX902
NOMESCO Finland
External defibrillation of heart
+∞
16.7
16
*
AA1AD
NOMESCO Finland
CT of head and brain
2.0
16.7
250
1429
E05.89
ICD-10 Finland
Other thyrotoxicosis
91.7
16.6
18
*
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
3.2
16.6
93
316
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.3
16.6
88
289
R2110
NOMESCO Finland
Giving the first information
3.6
16.4
76
224
R31
ICD-10 Finland
Unspecified haematuria
2.6
16.3
129
544
Z50.0
ICD-10 Finland
Cardiac rehabilitation
11.9
16.1
29
25
C10AA01
ATC
simvastatin; oral
1.8
16.1
500
3680
A12BA01
ATC
potassium chloride; oral
4.6
15.9
56
129
S18
ICPC
Laceration/cut
1.8
15.8
444
3156
71
HP
Electrophysiological Special Examination
+∞
15.7
15
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
+∞
15.7
15
*
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
+∞
15.7
15
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
15.5
168
833
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
4.6
15.5
54
123
M04AA01
ATC
allopurinol; systemic
2.4
15.5
143
657
H11.3
ICD-10 Finland
Conjunctival haemorrhage
4.1
15.4
60
152
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
6.1
15.4
42
72
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.5
15.3
126
545
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
4.3
15.2
56
135
SPAT1310
SPAT
Counselling related to known health issue
1.8
15.1
325
2106
205
Kela drug reimbursment
Chronic hypertension
1.8
14.9
311
1993
FM1CD
NOMESCO Finland
Very extensive CT of heart
57.6
14.8
17
*
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
4.1
14.7
58
149
-34
ICPC
Blood test
5.4
14.7
44
85
PD5BD
NOMESCO Finland
Extensive CT of aorta
7.2
14.7
35
50
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
152.2
14.5
15
*
J01AA02
ATC
doxycycline; systemic
1.8
14.5
707
5901
N05BA04
ATC
oxazepam; oral
2.0
14.5
227
1312
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
3.2
14.4
78
260
R07.3
ICD-10 Finland
Other chest pain
2.7
14.3
105
423
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
14.1
208
1172
M10.9
ICD-10 Finland
Gout, unspecified
3.1
14.1
79
268
C03AA03
ATC
hydrochlorothiazide; oral
2.5
14.0
121
535
AP1
HP
Catheterization of the left side of the heart
9.6
14.0
28
30
J01FA06
ATC
roxithromycin; oral
1.8
13.9
352
2390
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
5.2
13.8
42
83
SPAT1153
SPAT
Removal of sutures
1.8
13.7
352
2396
K22
ICPC
Risk factor cardiovascular disease
3.2
13.7
74
246
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
13.6
603
7101
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
+∞
13.6
13
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
+∞
13.6
13
*
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
3.3
13.5
68
215
R03AC02
ATC
salbutamol; inhalant
1.7
13.4
433
3157
K77
ICPC
Heart failure
14.0
13.3
22
16
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
40.7
13.2
16
*
XF409
NOMESCO Finland
Other special ECG
40.7
13.2
16
*
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
40.7
13.2
16
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.4
13.0
110
483
I25
ICD-10 Finland
Chronic ischaemic heart disease
3.3
12.9
66
212
K29
ICPC
Cardiovascular sympt/complt other
3.4
12.7
61
186
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
12.7
297
1957
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.5
12.7
60
181
SPAT1251
SPAT
Organisation of medication
4.0
12.6
50
130
I20.90
ICD-10 Finland
Angina pectoris, unspecified
4.2
12.5
47
116
72
HP
Catheter ablation of arrhythmia
+∞
12.5
12
*
73
HP
Initial pacemaker installation
+∞
12.5
12
*
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
+∞
12.5
12
*
TFP33
NOMESCO Finland
Simple electrophysiological investigation (e.g. ventricular stimulation)
+∞
12.5
12
*
FFM10
NOMESCO Finland
Occlusion or excision of atrial appendage externally with a closing device
+∞
12.5
12
*
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.0
12.5
73
257
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
12.5
288
1887
C01BA01
ATC
quinidine; oral
131.6
12.5
13
*
C10AA03
ATC
pravastatin; oral
2.5
12.4
100
426
C08CA01
ATC
amlodipine; oral
1.7
12.2
379
2703
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
12.1
282
1847
B01AC04
ATC
clopidogrel; oral
2.0
12.1
173
959
N05CF01
ATC
zopiclone; oral
1.7
12.0
310
2095
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
11.9
231
1426
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
11.9
81
313
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.0
11.9
179
1012
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
11.9
241
1511
C10AA07
ATC
rosuvastatin; oral
1.8
11.8
264
1704
M25.5
ICD-10 Finland
Pain in joint
1.8
11.8
244
1540
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.9
11.8
48
128
C07AA05
ATC
propranolol; systemic
2.0
11.7
156
841
K79
ICPC
Paroxysmal tachycardia
30.4
11.7
15
5
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.4
11.6
103
461
C10AX09
ATC
ezetimibe; oral
2.1
11.5
131
662
AC4
HP
MVP
+∞
11.5
11
*
FPE40
NOMESCO Finland
Replacement of transvenous cardiac pacemaker electrode
+∞
11.5
11
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
11.5
11
*
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
+∞
11.5
11
*
FPB10
NOMESCO Finland
Cryoablation of ectopic heart focus
+∞
11.5
11
*
FPD96
NOMESCO Finland
Other operation for atrial fibrillation
+∞
11.5
11
*
R01AD08
ATC
fluticasone; nasal
1.8
11.4
230
1437
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
3.3
11.4
58
186
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.0
11.3
45
118
J01FF01
ATC
clindamycin; systemic
1.8
11.3
239
1515
H26.4
ICD-10 Finland
After-cataract
2.3
11.2
113
538
-69
ICPC
Other reason for encounter NEC
3.3
11.2
56
177
R01AD12
ATC
fluticasone furoate; nasal
1.8
11.2
219
1355
I20.00
ICD-10 Finland
Unstable angina
4.3
10.9
40
97
SPAT1301
SPAT
No procedures
1.7
10.9
311
2153
I49
ICD-10 Finland
Other cardiac arrhythmias
9.7
10.8
21
22
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
10.8
300
2062
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.1
10.8
134
702
J01FA10
ATC
azithromycin; systemic
1.6
10.7
441
3362
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.4
10.7
95
427
A04
ICPC
Weakness/tiredness general
2.2
10.7
116
572
WVA40
NOMESCO Finland
Initiation and monitoring of intravenous hydration
8.1
10.6
23
29
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
10.6
105
497
Q23.11
ICD-10 Finland
Bicuspid aortic valve
111.2
10.4
11
*
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
10.4
10
*
AB1
HP
AVR mechanical
+∞
10.4
10
*
AH2
HP
Treatment of atrial fibrillation by maze surgery or its modification as the only procedure
+∞
10.4
10
*
AS2
HP
Ventricular pacemaker insertion VVI (R)
+∞
10.4
10
*
C01B
ATC
ANTIARRHYTHMICS, CLASS I AND III
+∞
10.4
10
*
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
10.3
60
211
R00.8
ICD-10 Finland
Other and unspecified abnormalities of heart beat
8.9
10.3
21
24
XF405
NOMESCO Finland
Symptom ECG
19.0
10.3
15
8
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
10.3
158
897
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
10.1
396
2964
N02AX02
ATC
tramadol; systemic, rectal
1.6
10.1
387
2881
C07AB04
ATC
acebutolol; systemic
6.2
10.0
26
43
WX722
NOMESCO Finland
PEEP
3.2
10.0
52
170
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
10.0
353
2572
ZX120
NOMESCO Finland
Intravenous
2.3
9.9
95
441
C08CA13
ATC
lercanidipine; oral
1.9
9.8
145
810
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.0
9.6
127
681
C09AA04
ATC
perindopril; oral
2.7
9.5
64
247
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
9.5
146
826
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
9.5
120
631
FN1AD
NOMESCO Finland
CT of coronary arteries
7.6
9.4
21
28
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
7.6
9.4
21
28
AB2
HP
AVR bio, stent
+∞
9.4
9
*
FPD10
NOMESCO Finland
Surgical ablation of atrial fibrillation
+∞
9.4
9
*
FPB32
NOMESCO Finland
Transvenous radiofrequency ablation of pulmonary vein pathway or focus
+∞
9.4
9
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.9
9.4
58
211
AN4
HP
Balloon angioplasty and drug eluding stent
3.2
9.3
47
151
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.1
9.3
113
586
A02BC01
ATC
omeprazole; systemic
1.7
9.2
252
1706
C07AB08
ATC
celiprolol; oral
3.5
9.2
42
125
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
9.2
222
1454
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
9.0
222
1462
E66.00
ICD-10 Finland
Metabolic syndrome
2.9
8.9
52
184
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
8.9
63
249
SPAT1312
SPAT
General health counselling
1.6
8.9
287
2027
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
9.6
8.8
17
18
-60
ICPC
Result test/procedure
2.5
8.8
67
279
C09CA06
ATC
candesartan; oral
1.7
8.7
199
1278
WX872
NOMESCO Finland
Intensive care
3.1
8.7
47
159
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
8.6
50
176
WX110
NOMESCO Finland
Local anesthesy
1.5
8.6
571
4759
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
8.6
98
495
SPAT1255
SPAT
Intravenous administration of medicine
2.4
8.5
71
309
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
10.1
8.5
16
16
SPAT1285
SPAT
Provision of consultation response
2.6
8.5
59
233
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.9
8.5
33
86
-44
ICPC
Preventive immunization/medic
2.1
8.5
97
490
C08CA02
ATC
felodipine; oral
2.1
8.5
99
505
R51.80
ICD-10 Finland
Headache
2.0
8.4
107
564
UKC02
NOMESCO Finland
Cystoscopy
1.7
8.4
174
1086
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
90.8
8.4
9
*
F2680
NOMESCO Finland
NA
90.8
8.4
9
*
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
6.8
8.4
20
30
K60
ICPC
Cardiovascular, Result test/procedure
8.0
8.4
18
23
C09DX04
ATC
valsartan and sacubitril; oral
+∞
8.3
8
*
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
8.3
8
*
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
+∞
8.3
8
*
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
+∞
8.3
8
*
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
+∞
8.3
8
*
FPJ00
NOMESCO Finland
Revision of pacemaker pulse generator or electrode
+∞
8.3
8
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.0
8.3
115
626
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
5.0
8.2
25
51
A02BC03
ATC
lansoprazole; oral
1.6
8.2
271
1921
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
8.1
561
4688
H02AB07
ATC
prednisone; oral
1.9
8.1
125
709
L15
ICPC
Knee symptom/complaint
1.7
8.1
203
1337
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
8.1
75
343
R07.2
ICD-10 Finland
Precordial pain
4.3
8.1
28
66
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
10.1
8.0
15
15
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
2.5
8.0
59
241
Z01.9
ICD-10 Finland
Special examination, unspecified
2.6
8.0
55
216
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.6
8.0
211
1408
C09CA01
ATC
losartan; oral
1.6
8.0
237
1635
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
7.9
43
147
N05BA01
ATC
diazepam; systemic, rectal
1.9
7.8
121
688
M03BX02
ATC
tizanidine; oral
1.5
7.8
496
4059
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
45.3
7.7
9
*
F1246
NOMESCO Finland
NA
45.3
7.7
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
7.7
59
245
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
7.6
105
571
I97.0
ICD-10 Finland
Postcardiotomy syndrome
18.5
7.6
11
6
N17
ICPC
Vertigo/dizziness
1.9
7.6
108
592
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
7.5
132
783
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.5
383
2985
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.5
237
1658
C02AC05
ATC
moxonidine; oral
2.8
7.5
47
174
WX780
NOMESCO Finland
Remote monitoring CPAP
3.2
7.4
36
114
I44.0
ICD-10 Finland
Atrioventricular block, first degree
13.5
7.4
12
9
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
7.4
71
332
AN3
HP
Balloon angioplasty and metallic stent
3.3
7.4
35
109
C07AB12
ATC
nebivolol; oral
3.7
7.3
30
83
I47.0
ICD-10 Finland
Re-entry ventricular arrhythmia
+∞
7.3
7
*
FPD00
NOMESCO Finland
Maze procedure for atrial fibrillation
+∞
7.3
7
*
I30.9
ICD-10 Finland
Acute pericarditis, unspecified
+∞
7.3
7
*
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
+∞
7.3
7
*
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
+∞
7.3
7
*
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
+∞
7.3
7
*
21
HP
Aortic Valve Replacement (AVR)
+∞
7.3
7
*
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
+∞
7.3
7
*
SPAT1254
SPAT
Administration of medicine
1.8
7.3
122
711
R50.9
ICD-10 Finland
Fever, unspecified
1.9
7.3
111
624
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
7.3
403
3186
R05
ICD-10 Finland
Cough
1.7
7.2
169
1089
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.1
7.2
81
405
SPAT1211
SPAT
Application of soft bandage
2.0
7.1
85
437
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
7.0
289
2143
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.3
6.9
24
57
D07AC01
ATC
betamethasone; topical
1.5
6.9
292
2173
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
6.9
211
1457
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
6.9
115
670
M54.5
ICD-10 Finland
Low back pain
1.5
6.9
258
1875
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.8
54
230
SPAT1094
SPAT
Continuous Positive Airway Pressure
5.1
6.8
20
40
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
2.6
6.8
47
184
L13
ICPC
Hip symptom/complaint
1.7
6.8
159
1025
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.8
441
3583
AN2
HP
Balloon angioplasty, including several vessels
3.0
6.8
36
122
AP3
HP
Catheterization of the right and left side of the heart
40.3
6.8
8
*
K34
ICPC
Cardiovascular, Blood test
40.3
6.8
8
*
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
40.3
6.8
8
*
C09CA03
ATC
valsartan; oral
2.0
6.8
86
452
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
6.7
143
895
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
6.7
176
1169
S80.0
ICD-10 Finland
Contusion of knee
2.4
6.7
53
226
PD5AD
NOMESCO Finland
CT of aorta
6.5
6.6
16
25
I95.1
ICD-10 Finland
Orthostatic hypotension
3.2
6.6
33
107
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
6.6
100
562
E0000UV
ATC
NA
1.5
6.6
318
2434
R05FA02
ATC
opium derivatives and expectorants; systemic
1.5
6.6
339
2626
SPAT1262
SPAT
Handing over of treatment supplies
1.6
6.5
171
1137
A13
ICPC
Concern/fear medical treatment
4.5
6.5
21
47
I45.6
ICD-10 Finland
Pre-excitation syndrome
70.3
6.4
7
*
ATX
HP
Other pacemaker replacement or related action, such as cord removal or replacement
70.3
6.4
7
*
Q21.10
ICD-10 Finland
Persistent ostium secundum
70.3
6.4
7
*
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
70.3
6.4
7
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.3
6.4
55
246
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
2.6
6.4
45
180
I95.2
ICD-10 Finland
Hypotension due to drugs
8.2
6.3
13
16
L03
ICPC
Low back symptom/complaint
1.6
6.3
201
1403
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
3.3
6.3
29
89
R01AD09
ATC
mometasone; nasal
1.4
6.3
331
2571
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
6.3
199
1383
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
+∞
6.3
6
*
AR2
HP
Catheter ablation of arrhythmia, target: extra pathway (WPW, AVRT, PJRT)
+∞
6.3
6
*
4276B
ICD-9 Finland
Cardiac dysrhythmias, Premature beats[EXTRASYSTOLIA VENTRICULARIS]
+∞
6.3
6
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
6.3
6
*
AR1
HP
Catheter ablation of arrhythmia, target: AV node reentry activation (AVNRT)
+∞
6.3
6
*
GE1BE
NOMESCO Finland
Mediastinal ultrasound examinaiton through oesophagus
+∞
6.3
6
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
6.3
6
*
4270A
ICD-9 Finland
Cardiac dysrhythmias, Paroxysmal supraventricular tachycardia
+∞
6.3
6
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
+∞
6.3
6
*
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
+∞
6.3
6
*
I35.8
ICD-10 Finland
Other aortic valve disorders
+∞
6.3
6
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
6.3
6
*
I45.9
ICD-10 Finland
Conduction disorder, unspecified
26.8
6.2
8
*
T92
ICPC
Gout
4.0
6.2
23
59
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.0
6.2
33
113
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
6.2
40
153
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.7
6.2
40
153
M25.0
ICD-10 Finland
Haemarthrosis
5.8
6.2
16
28
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.1
486
4070
A11
ICPC
Chest pain NOS
2.0
6.1
73
375
C10AA04
ATC
fluvastatin; oral
1.8
6.1
96
547
M79.6
ICD-10 Finland
Pain in limb
1.5
6.1
287
2177
A10
ICPC
Bleeding/haemorrhage NOS
8.7
6.1
12
14
J20
ICD-10 Finland
Acute bronchitis
2.0
6.0
79
422
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.0
6.0
69
351
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
6.0
144
932
M10
ICD-10 Finland
Gout
2.5
6.0
46
193
Mortality – FinRegistry
↥Association
Association between endpoint I9_E_DRONE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_E_DRONE | 0.927 [0.77, 1.11] | 0.406 |
| Birth year | 0.996 [0.99, 1.0] | 0.387 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 1798 females with I9_E_DRONE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_E_DRONE | 0.704 [0.59, 0.84] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 2019 males with I9_E_DRONE died.
Mortality risk
Mortality risk for people of age
years, who have I9_E_DRONE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.177% |
| 5 | 0.57% | 0.898% |
| 10 | 1.349% | 2.186% |
| 15 | 2.555% | 4.226% |
| 20 | 4.654% | 7.241% |
Relationships between endpoints
↥Index endpoint: I9_E_DRONE – Dronedarone medication
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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