hypertensive encephalopathy: Encephalopathy resulting from hypertension.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
125 |
4. Check minimum number of eventsNone |
125 |
5. Include endpointsNone |
125 |
6. Filter based on genotype QC (FinnGen only) |
125 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Encephalopathia hypertensiva
Similar endpoints
↥List of similar endpoints to
Hypertensive encephalopathy
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Hypertension
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1060 | 561 | 482 |
| Only index persons | 823 | 460 | 363 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 67.18 | 71.76 | 61.86 |
| Only index persons | 66.77 | 72.24 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 125 | 65 | 60 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 69.14 | 68.82 | 69.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 114
- Matched controls
- 1140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.4
ICD-10 Finland
Hypertensive encephalopathy
+∞
134.5
101
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
+∞
31.8
29
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
142.5
22.5
23
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
13.8
13
*
4372A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Hypertensive encephalopathy
+∞
12.7
12
*
I10
ICD-10 Finland
Essential (primary) hypertension
5.5
12.6
96
563
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.0
12.3
32
60
C08CA01
ATC
amlodipine; oral
4.1
11.8
70
316
AA1AD
NOMESCO Finland
CT of head and brain
4.2
10.7
49
172
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
54.3
8.8
10
*
XA800
NOMESCO Finland
Neuropsychological investigation
22.1
8.7
12
6
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.3
8.3
15
15
C07AB07
ATC
bisoprolol; oral
3.2
8.2
76
435
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.1
8.0
19
31
R56.8
ICD-10 Finland
Other and unspecified convulsions
8.7
7.7
16
21
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
7.4
7
*
205
Kela drug reimbursment
Chronic hypertension
3.1
7.2
55
266
TAB00
NOMESCO Finland
Lumbar puncture
10.3
7.0
13
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
6.7
33
118
Z01.9
ICD-10 Finland
Special examination, unspecified
6.5
6.1
15
26
R4110
NOMESCO Finland
Physiotherapy
3.0
6.1
41
179
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPERTENC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTENC | 1.734 [1.28, 2.34] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.144 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 379 females with I9_HYPERTENC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTENC | 1.693 [1.05, 2.72] | 0.03 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 273 males with I9_HYPERTENC died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPERTENC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.273% |
| 5 | 1.208% | 1.923% |
| 10 | 2.592% | 4.794% |
| 15 | 4.882% | 8.678% |
| 20 | 8.622% | 14.586% |
Relationships between endpoints
↥Index endpoint: I9_HYPERTENC – Hypertensive encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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