rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1280 |
6. Filter based on genotype QC (FinnGen only) |
1280 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever incl heart disease
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20505 | 10490 | 9486 |
| Only index persons | 9214 | 4842 | 4372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.30 | 0.27 |
| Only index persons | 0.17 | 0.18 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 61.81 | 65.18 | 57.95 |
| Only index persons | 51.22 | 55.20 | 46.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1280 | 586 | 694 |
| Unadjusted period prevalence (%) | 0.26 | 0.20 | 0.31 |
| Median age at first event (years) | 51.77 | 47.21 | 55.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1169
- Matched controls
- 11689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I06.9
ICD-10 Finland
Rheumatic aortic valve disease, unspecified
+∞
205.4
191
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
22.4
135.2
201
107
B01AA03
ATC
warfarin; systemic
4.2
105.4
567
2160
201
Kela drug reimbursment
Chronic cardiac insufficiency
6.2
88.5
265
527
C01AA05
ATC
digoxin; systemic
4.4
78.2
333
966
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.7
76.4
242
508
5273
FHL
Repair with flap prosthesis or graft
120.9
73.9
79
7
I05.0
ICD-10 Finland
Mitral stenosis
+∞
73.7
70
*
I06.0
ICD-10 Finland
Rheumatic aortic stenosis
+∞
70.5
67
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
66.8
366
1301
I01.0
ICD-10 Finland
Acute rheumatic pericarditis
+∞
64.1
61
*
I08.0
ICD-10 Finland
Disorders of both mitral and aortic valves
+∞
62.0
59
*
3950A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis
+∞
62.0
59
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
8.9
61.7
138
174
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
6.5
60.9
169
295
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
12.0
53.4
100
90
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.7
51.5
490
2456
C03CA01
ATC
furosemide; systemic
2.6
50.8
598
3381
39501
ICD-8 Finland
Diseases of aortic valve, Cum insufficientia (febris rheumatica inactiva)
+∞
49.3
47
*
I05.1
ICD-10 Finland
Rheumatic mitral insufficiency
+∞
48.3
46
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.9
48.1
361
1548
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
49.8
47.4
57
12
I05.2
ICD-10 Finland
Mitral stenosis with insufficiency
+∞
47.2
45
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
6.3
46.9
131
228
I06.1
ICD-10 Finland
Rheumatic aortic insufficiency
+∞
46.1
44
*
3951A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic insufficiency
+∞
46.1
44
*
3952A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis with insufficiency
+∞
45.1
43
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
13.4
44.6
79
63
I50.0
ICD-10 Finland
Congestive heart failure
3.6
44.4
229
746
5253
FHL
Cardiac lung machine
13.7
43.4
76
59
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.0
41.2
140
307
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
53.1
38.8
46
9
39097
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Suspecta
+∞
37.7
36
*
I06.2
ICD-10 Finland
Rheumatic aortic stenosis with insufficiency
+∞
36.6
35
*
39500
ICD-8 Finland
Diseases of aortic valve, Cum stenosi (febris rheumatica inactiva)
+∞
36.6
35
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
5.8
36.0
106
196
I05.9
ICD-10 Finland
Mitral valve disease, unspecified
+∞
35.6
34
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
21.7
35.5
52
25
C03DA01
ATC
spironolactone; oral
3.0
34.1
224
855
81
HP
Angiography of the heart and coronary arteries
3.5
32.8
170
547
XF640
NOMESCO Finland
NA
5.7
31.9
95
178
I34.1
ICD-10 Finland
Mitral (valve) prolapse
7.1
31.2
78
116
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.4
31.0
335
1696
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
5.4
30.8
97
194
K83
ICPC
Heart valve disease NOS
11.7
30.6
57
51
39502
ICD-8 Finland
Diseases of aortic valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
30.3
29
*
C07AA07
ATC
sotalol; systemic
4.0
30.2
128
347
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
60.0
30.2
35
6
39401
ICD-8 Finland
Diseases of mitral valve, Cum insufficientia (febris rheumatica inactiva)
+∞
28.2
27
*
207
Kela drug reimbursment
Chronic arrhythmias
2.4
27.2
267
1276
3941A
ICD-9 Finland
Diseases of mitral valve, Rheumatic mitral insufficiency
+∞
26.1
25
*
62
HP
Catheterization and pressure measurement of the right side of the heart
23.2
25.3
36
16
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
25.2
293
1514
39099
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Unspecified
+∞
25.1
24
*
I50.1
ICD-10 Finland
Left ventricular failure
3.3
24.8
134
442
C07AB07
ATC
bisoprolol; oral
1.9
24.5
632
4473
AN1
HP
Coronary angiography
2.5
24.1
206
909
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
55.2
23.1
27
5
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.5
22.8
111
338
21
HP
Aortic Valve Replacement (AVR)
27.9
22.3
30
11
3940A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis
+∞
21.9
21
*
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
63.8
21.9
25
*
C07AB02
ATC
metoprolol; systemic
2.0
21.8
350
2055
39199
ICD-8 Finland
Rheumatic fever with heart involvement, Other active rheumatic heart disease
+∞
20.9
20
*
39197
ICD-8 Finland
Rheumatic fever with heart involvement, Suspecta
+∞
20.9
20
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
21.9
20.9
30
14
TFP20
NOMESCO Finland
Cardiodefibrillation
2.9
20.8
133
491
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
8.7
20.5
44
52
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.0
20.4
126
455
61
HP
Catheterization and pressure measurement of the left side of the heart
5.4
20.1
61
118
I07.1
ICD-10 Finland
Tricuspid insufficiency
+∞
19.8
19
*
39400
ICD-8 Finland
Diseases of mitral valve, Cum stenosi (febris rheumatica inactiva)
+∞
19.8
19
*
I00
ICD-10 Finland
Rheumatic fever without mention of heart involvement
74.8
19.7
22
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
19.7
512
3533
4240A
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]
40.8
19.5
24
6
J01DA01
ATC
[U] cefalexin; systemic
1.8
19.5
717
5519
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
12.0
19.3
35
30
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
5.7
19.1
55
100
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
17.9
18.3
28
16
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
5.1
18.0
57
116
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
17.9
211
1077
3960A
ICD-9 Finland
Diseases of mitral and aortic valves, Mitral valve stenosis and aortic valve stenosis
+∞
17.7
17
*
5284
FHL
Mitral defect correction with flap prosthesis or graft
96.5
17.6
19
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.8
17.6
122
474
B01AB05
ATC
enoxaparin; parenteral
1.8
17.3
358
2268
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
17.0
357
2272
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
6.4
16.8
44
71
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
16.7
245
1369
3942A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis with insufficiency
+∞
16.7
16
*
R06.0
ICD-10 Finland
Dyspnoea
1.8
16.2
315
1948
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.2
15.9
85
278
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
33.9
15.8
20
6
39409
ICD-8 Finland
Diseases of mitral valve, Unspecified
+∞
15.7
15
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
15.5
314
1960
R50.9
ICD-10 Finland
Fever, unspecified
2.1
15.4
182
925
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.0
15.2
92
327
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
6.4
14.9
39
63
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
14.9
332
2136
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.3
14.8
142
655
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.9
14.6
91
331
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
5.7
14.4
41
74
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
9.3
14.2
29
32
M04AA01
ATC
allopurinol; systemic
2.0
14.0
207
1153
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
5.1
13.8
43
87
39509
ICD-8 Finland
Diseases of aortic valve, Unspecified
+∞
13.6
13
*
39403
ICD-8 Finland
Diseases of mitral valve, Operata (febris rheumatica inactiva)
+∞
13.6
13
*
AC2
HP
MVR bio
34.4
13.5
17
5
C01DA14
ATC
isosorbide mononitrate; oral
1.8
13.5
282
1768
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
21.4
13.3
19
9
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
40.5
13.2
16
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
13.1
360
2449
K78
ICPC
Atrial fibrillation/flutter
2.3
13.0
129
606
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
22.8
12.9
18
8
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
12.7
363
2496
I07.2
ICD-10 Finland
Tricuspid stenosis with insufficiency
+∞
12.5
12
*
39402
ICD-8 Finland
Diseases of mitral valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
12.5
12
*
39503
ICD-8 Finland
Diseases of aortic valve, Operata (febris rheumatica inactiva)
+∞
12.5
12
*
A12BA01
ATC
potassium chloride; oral
2.4
12.5
107
466
J01FF01
ATC
clindamycin; systemic
1.7
12.5
290
1875
AP2
HP
Catheterization of the right side of the heart
13.3
12.4
21
16
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
3.8
12.3
52
142
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.2
12.3
124
586
AB2
HP
AVR bio, stent
6.5
12.2
31
49
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
2.9
12.2
76
278
C02EA02
ATC
NA
2.5
12.0
96
406
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
11.9
209
1231
25
HP
Valve and coronary artery bypass surgery
30.3
11.7
15
5
XF404
NOMESCO Finland
Ambulatory ECG
2.2
11.6
122
590
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.7
11.5
302
2018
I01.9
ICD-10 Finland
Acute rheumatic heart disease, unspecified
+∞
11.5
11
*
I08.1
ICD-10 Finland
Disorders of both mitral and tricuspid valves
+∞
11.5
11
*
I08.3
ICD-10 Finland
Combined disorders of mitral, aortic and tricuspid valves
+∞
11.5
11
*
C01BD01
ATC
amiodarone; systemic
3.3
11.5
56
173
XFE00
NOMESCO Finland
Epicardial ultrasonography
3.6
11.4
50
142
WX872
NOMESCO Finland
Intensive care
2.8
11.3
71
260
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.9
11.3
36
75
22
HP
Mitral valve Replacement (MVR)
35.4
11.3
14
*
K84
ICPC
Heart disease other
3.7
11.3
48
133
J01CA04
ATC
amoxicillin; systemic
1.6
11.2
810
6905
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.3
10.7
53
166
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
10.1
10.5
20
20
I01.1
ICD-10 Finland
Acute rheumatic endocarditis
+∞
10.4
10
*
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
8.3
10.3
22
27
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
23.6
10.2
14
6
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
10.2
334
2350
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
10.2
53
172
C08DA01
ATC
verapamil; systemic
2.6
10.2
76
310
H02AB06
ATC
prednisolone; systemic
1.5
10.0
496
3840
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
9.9
148
823
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
8.2
9.8
21
26
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
9.8
76
316
J01FA06
ATC
roxithromycin; oral
1.5
9.7
414
3098
C09AA02
ATC
enalapril; systemic
1.6
9.6
267
1799
L04AA01
ATC
[U] ciclosporin; systemic
5.1
9.6
29
58
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
9.5
125
662
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
9.5
85
381
39604
ICD-8 Finland
Diseases of mitral and aortic valves, Non operata
+∞
9.4
9
*
24
HP
Multi-valve repair or other valve surgery
+∞
9.4
9
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
9.4
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
9.3
182
1108
J01FA10
ATC
azithromycin; systemic
1.5
9.3
499
3915
R04.0
ICD-10 Finland
Epistaxis
2.1
9.2
100
489
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
5.0
9.1
28
57
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.1
9.1
48
159
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.2
9.0
45
143
I50
ICD-10 Finland
Heart failure
2.6
9.0
65
261
4289X
ICD-9 Finland
Heart failure, unspecified
4.6
8.8
29
64
N05BA01
ATC
diazepam; systemic, rectal
1.8
8.7
154
905
42410
ICD-8 Finland
Chronic disease of endocardium, Aortae, non operata
50.3
8.7
10
*
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
50.3
8.7
10
*
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
8.5
668
7708
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.0
8.5
112
592
J01MA12
ATC
levofloxacin; systemic
1.6
8.4
218
1435
L54.0*I00
ICD-10 Finland
Erythema marginatum in acute rheumatic fever
+∞
8.3
8
*
I01.8
ICD-10 Finland
Other acute rheumatic heart disease
+∞
8.3
8
*
3910A
ICD-9 Finland
Rheumatic fever with heart involvement, Acute rheumatic pericarditis
+∞
8.3
8
*
42411
ICD-8 Finland
Chronic disease of endocardium, Aortae, operata
+∞
8.3
8
*
39601
ICD-8 Finland
Diseases of mitral and aortic valves, Mitralium operata
+∞
8.3
8
*
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
4.4
8.2
28
65
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
9.0
8.0
16
18
5311
FHL
Bypass surgery in one vein
22.2
8.0
11
5
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
7.9
182
1159
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
13.1
7.9
13
10
L04AX01
ATC
azathioprine; systemic
2.8
7.9
50
186
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.1
7.9
40
130
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.5
7.8
34
98
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.7
7.8
175
1108
AC4
HP
MVP
10.9
7.8
14
13
R03AK08
ATC
formoterol and beclometasone; inhalant
3.4
7.8
36
109
4240X
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[ALIUD VITIUM VALVULAE MITRALIS (NON RHEUMATICUM)]
45.3
7.7
9
*
40299
ICD-8 Finland
Hypertensive heart disease
5.6
7.7
21
38
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.0
7.7
41
138
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.7
341
2549
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.0
7.6
93
479
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
7.6
235
1615
5312
FHL
Bypass surgery for two vessels
11.9
7.6
13
11
R07.3
ICD-10 Finland
Other chest pain
1.9
7.4
100
537
I09.9
ICD-10 Finland
Rheumatic heart disease, unspecified
+∞
7.3
7
*
3900A
ICD-9 Finland
Rheumatic fever without mention of heart involvement[FEBRIS RHEUMATICA, MORBO CORDIS NON INDICATO]
+∞
7.3
7
*
C01BA03
ATC
disopyramide; systemic
5.0
7.3
22
45
L04AA06
ATC
mycophenolic acid; systemic
4.5
7.3
24
54
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
4.5
7.3
24
54
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.3
257
1822
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.5
7.2
53
216
N05CD07
ATC
temazepam; oral
1.6
7.2
176
1140
UJF32
NOMESCO Finland
Coloscopy
1.5
7.1
261
1862
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.1
215
1469
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.5
7.1
31
90
A41.9
ICD-10 Finland
Sepsis, unspecified
2.5
7.1
54
225
C01BA01
ATC
quinidine; oral
5.1
7.1
21
42
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.1
7.1
74
357
I40.9
ICD-10 Finland
Acute myocarditis, unspecified
8.8
7.1
14
16
N05CF01
ATC
zopiclone; oral
1.4
7.1
372
2865
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
10.1
7.0
13
13
R51.80
ICD-10 Finland
Headache
1.8
7.0
122
713
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.9
7.0
40
139
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
13.9
6.9
11
8
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.0
6.9
37
126
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.8
110
627
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
8.3
6.8
14
17
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.9
6.8
93
501
42100
ICD-8 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
40.3
6.8
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.7
331
2512
R03BA05
ATC
fluticasone; inhalant
1.6
6.7
175
1153
A02BC03
ATC
lansoprazole; oral
1.5
6.7
308
2305
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.2
6.7
62
286
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
6.6
254
1829
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.1
6.6
67
322
A46
ICD-10 Finland
Erysipelas
1.6
6.6
160
1033
J00
ICD-10 Finland
Acute nasopharyngitis [common cold]
4.4
6.5
22
51
P01BA02
ATC
hydroxychloroquine; oral
2.0
6.5
79
407
ZX120
NOMESCO Finland
Intravenous
1.9
6.5
99
556
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
2.6
6.5
43
166
FPD00
NOMESCO Finland
Maze procedure for atrial fibrillation
70.2
6.4
7
*
5342
FHL
Reoperation due to leakage
70.2
6.4
7
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
6.4
86
460
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.8
6.4
38
138
2720X
ICD-9 Finland
Disorders of lipoid metabolism, Pure hypercholesterolaemia[HYPERCHOLESTEROLAEMIA ALIA]
14.4
6.4
10
7
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
6.4
108
625
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
3.8
6.4
25
67
N18.8
ICD-10 Finland
Other chronic renal failure
2.7
6.4
42
162
J01AA02
ATC
doxycycline; systemic
1.4
6.3
795
7072
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
6.3
133
827
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.3
425
3406
M01AH02
ATC
rofecoxib; oral
1.7
6.3
142
898
73
HP
Initial pacemaker installation
4.6
6.3
20
44
127
Kela drug reimbursment
Transplant complication
4.6
6.3
20
44
I97.0
ICD-10 Finland
Postcardiotomy syndrome
9.3
6.3
12
13
AB1
HP
AVR mechanical
9.3
6.3
12
13
I38
ICD-10 Finland
Endocarditis, valve unspecified
18.1
6.3
9
5
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
18.1
6.3
9
5
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
6.3
6
*
39899
ICD-8 Finland
Other heart disease, specified as rheumatic
+∞
6.3
6
*
I02.9
ICD-10 Finland
Rheumatic chorea without heart involvement
+∞
6.3
6
*
26
HP
Aortic root """"composite graft""""
+∞
6.3
6
*
39609
ICD-8 Finland
Diseases of mitral and aortic valves, Unspecified
+∞
6.3
6
*
I02.0
ICD-10 Finland
Rheumatic chorea with heart involvement
+∞
6.3
6
*
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
6.3
6
*
I09.0
ICD-10 Finland
Rheumatic myocarditis
+∞
6.3
6
*
39602
ICD-8 Finland
Diseases of mitral and aortic valves, Aortae operata
+∞
6.3
6
*
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.3
235
1686
H02AB07
ATC
prednisone; oral
1.6
6.2
164
1081
I49.5
ICD-10 Finland
Sick sinus syndrome
2.2
6.2
61
287
42400
ICD-8 Finland
Chronic disease of endocardium, Mitralis, non-operata
26.8
6.2
8
*
4210A
ICD-9 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
26.8
6.2
8
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
6.1
258
1896
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.7
6.1
111
663
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
4.4
6.1
20
46
L04AD01
ATC
ciclosporin; systemic
4.2
6.0
21
51
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 2.108 [1.91, 2.33] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 1814 out of 3349 females with I9_RHEUFEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 1.918 [1.69, 2.18] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1381 out of 2720 males with I9_RHEUFEV died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.234% |
| 5 | 0.939% | 1.818% |
| 10 | 2.767% | 4.92% |
| 15 | 5.439% | 8.981% |
| 20 | 9.551% | 15.703% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data