byssinosis: An occupational lung disorder caused by exposure to cotton dust. It occurs more commonly in workers in the textile industry. Signs and symptoms include chest tightness, cough and wheezing. The symptoms tend to get worse at the beginning of the week and subside by the end of the week.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
92 |
4. Check minimum number of eventsNone |
92 |
5. Include endpointsNone |
92 |
6. Filter based on genotype QC (FinnGen only) |
92 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Morbus viarum respiratoriarum e pulvere organico specifico
Similar endpoints
↥List of similar endpoints to
Airway disease due to specific organic dust
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 675 | 305 | 364 |
| Only index persons | 584 | 272 | 312 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 45.30 | 44.90 | 45.45 |
| Only index persons | 44.00 | 44.43 | 43.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 92 | 49 | 43 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 45.22 | 41.06 | 49.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 80
- Matched controls
- 800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J66.8
ICD-10 Finland
Airway disease due to other specific organic dusts
+∞
78.6
62
*
J45.9
ICD-10 Finland
Asthma, unspecified
5.9
10.5
34
89
J45.0
ICD-10 Finland
Predominantly allergic asthma
8.8
10.4
23
35
J67.0
ICD-10 Finland
Farmer lung
+∞
8.5
8
*
J66.0
ICD-10 Finland
Byssinosis
+∞
7.4
7
*
R03AC02
ATC
salbutamol; inhalant
3.7
7.1
56
310
XG410
NOMESCO Finland
Flow-volume spirometry
14.0
6.3
10
8
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
16.6
6.1
9
6
J30.3
ICD-10 Finland
Other allergic rhinitis
16.6
6.1
9
6
Mortality – FinRegistry
↥Association
Association between endpoint J10_AIRWDISDUST and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have J10_AIRWDISDUST.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: J10_AIRWDISDUST – Airway disease due to specific organic dust
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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