extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.
Hypersensitivity pneumonitis due to organic dust
DOID EFO Endpoint Browser PheWeb
J10_HYPERSPNEUMONI
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
582 |
4. Check minimum number of eventsNone |
582 |
5. Include endpointsNone |
582 |
6. Filter based on genotype QC (FinnGen only) |
582 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Pneumonitis/alveolitis hypersensitiva e pulvere organico
Similar endpoints
↥List of similar endpoints to
Hypersensitivity pneumonitis due to organic dust
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5824 | 2873 | 2887 |
| Only index persons | 4602 | 2341 | 2261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 52.93 | 53.15 | 52.37 |
| Only index persons | 49.96 | 50.96 | 48.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 582 | 301 | 281 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 49.81 | 47.62 | 52.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 533
- Matched controls
- 5329
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J67.0
ICD-10 Finland
Farmer lung
+∞
192.7
173
*
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
+∞
170.2
154
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
114.8
106
*
4959X
ICD-9 Finland
Extrinsic allergic alveolitis, Unspecified allergic alveolitis and pneumonitis
+∞
90.2
84
*
H02AB06
ATC
prednisolone; systemic
3.6
43.3
343
1772
TGC00
NOMESCO Finland
Bronchial lavation
13.3
42.3
76
66
J67.8
ICD-10 Finland
Hypersensitivity pneumonitis due to other organic dusts
+∞
40.1
38
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.5
33.6
108
235
J45.9
ICD-10 Finland
Asthma, unspecified
3.6
29.1
155
543
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.3
28.1
60
72
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
13.1
26.0
46
38
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
25.2
24
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.5
25.2
68
117
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.3
25.0
102
280
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
11.6
24.1
45
42
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.5
22.9
71
145
J45.1
ICD-10 Finland
Nonallergic asthma
4.6
21.5
80
199
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.9
21.4
153
644
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
52.3
21.3
25
5
R03AC02
ATC
salbutamol; inhalant
2.2
17.7
309
2036
R06.0
ICD-10 Finland
Dyspnoea
2.5
17.7
175
874
XG410
NOMESCO Finland
Flow-volume spirometry
5.1
16.7
54
116
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.4
16.6
44
74
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
16.1
79
251
1240
FHL
Bronchoscopy
15.1
16.0
26
18
J01FA06
ATC
roxithromycin; oral
2.2
16.0
248
1523
4958X
ICD-9 Finland
Extrinsic allergic alveolitis, Other specified allergic alveolitis and pneumonitis
+∞
15.7
15
*
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
11.3
15.2
28
26
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
15.0
163
841
R03BA01
ATC
beclometasone; inhalant
2.7
14.6
107
446
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
11.4
13.1
24
22
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
13.1
99
420
J67.2
ICD-10 Finland
Bird fancier lung
+∞
12.5
12
*
J67.1
ICD-10 Finland
Bagassosis
+∞
12.5
12
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
13.8
12.0
20
15
4779A
ICD-9 Finland
Allergic rhinitis, Cause unspecified
19.5
11.7
17
9
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
23.5
11.6
16
7
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
9.9
11.3
22
23
J47
ICD-10 Finland
Bronchiectasis
7.9
11.3
25
33
J66.8
ICD-10 Finland
Airway disease due to other specific organic dusts
+∞
10.4
10
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
10.1
65
247
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
12.5
9.9
17
14
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
9.7
248
1732
L04AX01
ATC
azathioprine; systemic
4.0
9.7
38
100
R03BA02
ATC
budesonide; inhalant
2.2
9.6
110
570
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
5.4
9.3
27
52
R03AC12
ATC
salmeterol; inhalant
3.5
9.3
42
126
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
9.2
61
238
7860A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Dyspnoea and respiratory abnormalities[DYSPNOEA]
12.8
8.9
15
12
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
14.3
8.7
14
10
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
8.5
37
108
Z94.2
ICD-10 Finland
Lung transplant status
91.5
8.4
9
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.9
8.1
32
86
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.0
8.0
45
158
R50.9
ICD-10 Finland
Fever, unspecified
2.2
7.9
84
420
GDA10
NOMESCO Finland
Biopsy of lung
45.7
7.7
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.3
120
708
J67.7
ICD-10 Finland
Air-conditioner and humidifier lung
+∞
7.3
7
*
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
7.3
7
*
R03BB04
ATC
tiotropium bromide; inhalant
2.3
7.1
68
322
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
7.0
36
120
R03AC03
ATC
terbutaline; inhalant
2.1
7.0
82
425
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
5.8
6.8
18
32
R03DA04
ATC
theophylline; systemic, rectal
3.0
6.7
36
124
J45.8
ICD-10 Finland
Mixed asthma
3.5
6.6
29
86
GDG10
NOMESCO Finland
Bilateral transplantation of lung
70.7
6.4
7
*
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
10.2
6.1
11
11
J01MA14
ATC
moxifloxacin; systemic
2.2
6.0
59
284
R05
ICD-10 Finland
Cough
1.8
6.0
100
593
Mortality – FinRegistry
↥Association
Association between endpoint J10_HYPERSPNEUMONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.979 [1.7, 2.31] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 1173 females with J10_HYPERSPNEUMONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.516 [1.31, 1.76] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1282 males with J10_HYPERSPNEUMONI died.
Mortality risk
Mortality risk for people of age
years, who have J10_HYPERSPNEUMONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.299% |
| 5 | 1.17% | 1.727% |
| 10 | 2.856% | 4.114% |
| 15 | 5.534% | 7.983% |
| 20 | 9.455% | 13.086% |
Relationships between endpoints
↥Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data