Chronic lower respiratory diseases

J10_LOWCHRON

lung disease: A disease involving the lung.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J40-J47
Cause of death: ICD-10 J40-J47

2 out of 7 registries used, show all original rules.

56649

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Check minimum number of events None

56649

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Remove individuals based on genotype QC

65991

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J10_LOWCHRON

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 65991 35259 30732
Unadjusted prevalence (%) 17.50 16.73 18.48
Mean age at first event (years) 47.13 42.74 52.16

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.56 [2.32, 2.83] 3.8e-78 11151
15 years 0.01 1.64 [1.51, 1.79] 1.5e-29 4363
5 years 0.00 3.53 [3.28, 3.79] <1e-100 3091
1 year 0.00 10.91 [9.87, 12.05] <1e-100 1954

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: J10_LOWCHRON – Chronic lower respiratory diseases
GWS hits: 59

Survival analyses between endpoints

Plot

before Chronic lower respiratory diseases
after Chronic lower respiratory diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chronic lower respiratory diseases

Not a core endpoint, no data to show.