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Chronic lower respiratory diseases

DOID EFO MESH SNOMED PheWeb

J10_LOWCHRON

lung disease: A disease involving the lung.

Endpoint definition

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FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J40-J47
Cause of death: ICD-10 J40-J47

2 out of 7 registries used, show all original rules.

56649

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Check minimum number of events None

56649

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Include endpoints

72219

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Remove individuals based on genotype QC

65991

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J10_LOWCHRON

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 65991 35259 30732
Unadjusted prevalence (%) 17.50 16.73 18.48
Mean age at first event (years) 47.13 42.74 52.16

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.56 [2.32, 2.83] 3.8e-78 11151
15 years 0.01 1.64 [1.51, 1.79] 1.5e-29 4363
5 years 0.00 3.53 [3.28, 3.79] <1e-100 3091
1 year 0.00 10.91 [9.87, 12.05] <1e-100 1954

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_LOWCHRON – Chronic lower respiratory diseases
GWS hits: 59

Survival analyses between endpoints

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Plot

before Chronic lower respiratory diseases
after Chronic lower respiratory diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chronic lower respiratory diseases

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Not a core endpoint, no data to show.