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Simple and mucopurulent chronic bronchitis

DOID EFO Endpoint Browser PheWeb

J10_SIMPLBRONCH

bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J41
  • Hospital discharge: ICD-9 — 491[0-1]
  • Hospital discharge: ICD-8 — 4910[1-2]
  • Cause of death: ICD-10 — J41
  • Cause of death: ICD-9 — 491[0-1]
  • Cause of death: ICD-8 — 4910[1-2]

2 out of 7 registries used, show all original rules.

1762

4. Check minimum number of events

None

1762

5. Include endpoints

None

1762

6. Filter based on genotype QC (FinnGen only)

1762

Control definitions (FinnGen only)

Control exclude
J10_LOWCHRON

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J40-J47
Name in latin
Bronchitis chronica simplex sive mucopurulenta

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19612 7277 11777
Only index persons 9480 4605 4875
Unadjusted period prevalence (%)
Whole population 0.29 0.21 0.33
Only index persons 0.18 0.17 0.19
Median age at first event (years)
Whole population 59.51 57.01 60.88
Only index persons 52.89 52.77 53.00

-FinnGen-

Key figures

All Female Male
Number of individuals 1762 681 1081
Unadjusted period prevalence (%) 0.38 0.23 0.48
Median age at first event (years) 54.66 49.83 57.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1623
Matched controls
16224
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
5612.2
323.0
431
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
+∞
323.0
617
*
J45.9
ICD-10 Finland
Asthma, unspecified
50.2
323.0
499
142
R03BB04
ATC
tiotropium bromide; inhalant
29.3
323.0
455
213
J41.0
ICD-10 Finland
Simple chronic bronchitis
1657.8
323.0
472
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
88.4
323.0
490
79
49101
ICD-8 Finland
Chronic bronchitis, Nonpurulenta (simplex)
+∞
315.1
292
*
R03AC02
ATC
salbutamol; inhalant
7.1
287.2
1079
3543
R03AK06
ATC
salmeterol and fluticasone; inhalant
16.3
250.9
428
348
J45.1
ICD-10 Finland
Nonallergic asthma
298.7
231.9
231
9
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
282.3
219.9
220
9
R03BA02
ATC
budesonide; inhalant
10.3
213.0
461
602
R03DA04
ATC
theophylline; systemic, rectal
19.7
205.7
322
201
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
15.5
195.7
338
271
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
88.5
195.2
216
28
H02AB06
ATC
prednisolone; systemic
4.8
189.0
981
3911
4910A
ICD-9 Finland
Chronic bronchitis, Simple chronic bronchitis
+∞
188.2
177
*
R03BA05
ATC
fluticasone; inhalant
8.4
184.3
453
716
UGC12
NOMESCO Finland
Flexible bronchoscopy
9.9
180.7
394
507
J45.0
ICD-10 Finland
Predominantly allergic asthma
87.2
173.9
193
25
R03BB01
ATC
ipratropium bromide; inhalant
17.6
172.5
281
191
R03AC12
ATC
salmeterol; inhalant
58.6
170.7
201
39
R03BA01
ATC
beclometasone; inhalant
9.6
160.7
356
463
R03AK07
ATC
formoterol and budesonide; inhalant
7.5
149.0
391
661
J47
ICD-10 Finland
Bronchiectasis
275.0
149.0
150
6
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
271.0
146.8
148
6
R03DC03
ATC
montelukast; oral
8.9
145.5
335
460
49102
ICD-8 Finland
Chronic bronchitis, Purulenta
+∞
133.2
126
*
J41.8
ICD-10 Finland
Mixed simple and mucopurulent chronic bronchitis
+∞
124.6
118
*
R03AC13
ATC
formoterol; inhalant
35.5
116.8
152
47
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.6
110.6
448
1235
4911A
ICD-9 Finland
Chronic bronchitis, Mucopurulent chronic bronchitis
+∞
106.4
101
*
J45
ICD-10 Finland
Asthma
16.3
106.1
176
120
R03AC03
ATC
terbutaline; inhalant
6.4
104.6
301
556
J42
ICD-10 Finland
Unspecified chronic bronchitis
98.2
100.4
110
12
49300
ICD-8 Finland
Asthma, bronchiale
+∞
95.8
91
*
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
+∞
93.6
89
*
J01AA02
ATC
doxycycline; systemic
3.3
93.4
1300
8860
J01FA06
ATC
roxithromycin; oral
3.0
90.3
764
3704
R96
ICPC
Asthma
13.5
86.0
154
125
R04.2
ICD-10 Finland
Haemoptysis
11.1
83.4
164
162
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
83.2
640
2868
R03AK08
ATC
formoterol and beclometasone; inhalant
45.2
82.8
102
24
J46
ICD-10 Finland
Status asthmaticus
147.4
79.8
84
6
H02AB04
ATC
methylprednisolone; systemic
4.3
77.2
320
870
J45.8
ICD-10 Finland
Mixed asthma
207.3
76.9
79
*
J01MA14
ATC
moxifloxacin; systemic
5.5
76.0
246
514
R03BA08
ATC
ciclesonide; inhalant
9.4
75.7
163
190
R05
ICD-10 Finland
Cough
3.5
72.2
405
1420
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
+∞
71.4
68
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.4
70.1
161
209
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
185.4
68.6
71
*
R95
ICPC
Chron obstructive pulmonary disease
41.6
66.4
83
21
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
8.1
65.8
155
209
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.2
63.3
264
712
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.5
62.6
780
4437
R06.0
ICD-10 Finland
Dyspnoea
2.9
61.0
467
2004
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.9
60.1
278
821
J96.1
ICD-10 Finland
Chronic respiratory failure
19.4
59.9
92
50
H02AB07
ATC
prednisone; oral
3.6
58.1
300
969
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.9
56.6
111
108
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
+∞
55.5
53
*
J01FA09
ATC
clarithromycin; systemic
2.7
55.2
484
2232
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
19.4
54.1
83
45
49099
ICD-8 Finland
Bronchitis, unspecified
+∞
52.4
50
*
XG474
NOMESCO Finland
Exhalation nntrogen oxide
20.2
52.3
79
41
J01FA10
ATC
azithromycin; systemic
2.2
49.6
789
4863
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
+∞
49.2
47
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
62.0
46.6
54
9
J01MA12
ATC
levofloxacin; systemic
2.6
45.7
386
1712
J43.9
ICD-10 Finland
Emphysema, unspecified
236.4
45.2
46
*
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
+∞
45.0
43
*
1240
FHL
Bronchoscopy
12.3
43.1
79
67
R06.2
ICD-10 Finland
Wheezing
8.1
42.3
98
128
51899
ICD-8 Finland
Bronchiectasis
+∞
40.8
39
*
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
60.4
40.4
47
8
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.8
40.4
142
318
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.6
39.5
105
168
R03AK11
ATC
formoterol and fluticasone; inhalant
26.5
39.1
54
21
R05CB01
ATC
acetylcysteine; inhalant, oral
11.2
39.1
75
70
J01FA15
ATC
telithromycin; oral
3.7
37.9
180
533
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
+∞
37.6
36
*
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
+∞
37.6
36
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
36.7
703
4490
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
17.3
36.0
57
34
XG410
NOMESCO Finland
Flow-volume spirometry
6.2
35.9
100
170
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
35.5
34
*
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
28.4
34.7
47
17
R02
ICPC
Shortness of breath/dyspnoea
3.1
34.7
207
727
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.4
33.8
129
313
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.1
33.2
464
2582
TGC00
NOMESCO Finland
Bronchial lavation
7.6
33.2
79
108
R03DC01
ATC
zafirlukast; oral
21.9
32.3
47
22
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
9.5
32.3
67
73
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
9.5
32.3
67
73
J01DA01
ATC
[U] cefalexin; systemic
1.9
31.3
964
7150
R01AD08
ATC
fluticasone; nasal
2.2
31.0
380
1986
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.5
30.8
267
1174
R01AD09
ATC
mometasone; nasal
1.9
30.0
553
3407
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
5.3
29.9
94
186
J01CA04
ATC
amoxicillin; systemic
1.9
28.8
1134
9012
C03CA01
ATC
furosemide; systemic
1.9
28.6
614
3979
R05FB02
ATC
cough suppressants and expectorants
1.9
28.5
613
3979
R03BB02
ATC
oxitropium bromide; inhalant
26.6
28.4
39
15
N02AX02
ATC
tramadol; systemic, rectal
1.8
28.4
663
4424
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
28.2
500
3022
R06AE07
ATC
cetirizine; oral
1.9
28.0
552
3464
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.5
27.5
73
117
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.1
27.1
385
2125
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.1
27.1
88
181
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
+∞
26.1
25
*
J31.0
ICD-10 Finland
Chronic rhinitis
3.5
25.2
123
371
A02BC01
ATC
omeprazole; systemic
1.9
25.1
468
2859
GD1AD
NOMESCO Finland
Thorax CT examination
4.5
25.1
92
215
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
+∞
25.1
24
*
A02BC03
ATC
lansoprazole; oral
1.9
24.8
470
2882
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.6
24.8
74
138
TDM10
NOMESCO Finland
Puncture of maxillary antrum
6.3
24.5
66
108
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
56.9
24.1
28
5
R05CB03
ATC
carbocisteine; oral
5.7
24.0
70
127
J20
ICD-10 Finland
Acute bronchitis
2.9
24.0
151
546
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
23.9
460
2831
A02BC02
ATC
pantoprazole; systemic
1.7
23.7
930
7145
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.0
23.5
97
254
R05FA02
ATC
opium derivatives and expectorants; systemic
1.8
23.0
574
3839
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
23.3
22.6
32
14
A07AA02
ATC
nystatin; oral
3.2
22.5
123
404
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
22.5
321
1762
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
11.6
22.2
41
36
G47.3
ICD-10 Finland
Sleep apnoea
2.1
22.2
280
1462
R03AC18
ATC
indacaterol; inhalant
52.8
22.1
26
5
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.5
22.1
108
326
A02BC05
ATC
esomeprazole; systemic
1.7
21.6
566
3822
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.7
21.3
97
277
R05CB02
ATC
bromhexine; systemic
5.8
21.1
60
106
N03AX16
ATC
pregabalin; oral
1.9
20.9
336
1925
R01AD01
ATC
beclometasone; nasal
2.3
20.8
210
987
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
6.8
20.7
52
78
XQ800
NOMESCO Finland
Prick test
3.7
20.7
94
268
R01AD12
ATC
fluticasone furoate; nasal
2.0
20.5
317
1786
R03DA05
ATC
aminophylline; systemic, rectal
12.7
20.4
36
29
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.6
20.2
155
629
R29
ICPC
Respiratory symptom/complaint other
3.4
20.1
100
306
J01DA06
ATC
[U] cefuroxime; systemic
2.2
20.1
228
1129
UJF32
NOMESCO Finland
Coloscopy
1.8
20.1
409
2540
4919X
ICD-9 Finland
Chronic bronchitis, Unspecified chronic bronchitis
+∞
19.8
19
*
R03BC03
ATC
nedocromil; inhalant
3.1
19.5
110
368
J01FF01
ATC
clindamycin; systemic
1.8
18.9
378
2331
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
17.3
18.7
29
17
R03AC04
ATC
fenoterol; inhalant
101.2
18.6
20
*
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
192.0
18.6
19
*
R28
ICPC
Limited function/disability (R)
9.7
18.4
37
39
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
25.3
18.2
25
10
SPAT1058
SPAT
PEF monitoring instruction
3.0
18.1
106
366
N05CF01
ATC
zopiclone; oral
1.7
18.0
529
3653
Y0499
ICD-8 Finland
Investigation of respiratory system
7.0
17.5
43
63
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
7.3
17.3
41
57
A01AB09
ATC
miconazole; local oral
2.4
17.2
147
636
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
17.2
387
2465
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
17.1
146
631
R05
ICPC
Cough
1.9
16.9
277
1588
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.7
16.9
380
2417
XG460
NOMESCO Finland
Short time oxymetry
5.9
16.8
47
82
N06AA09
ATC
amitriptyline; systemic
2.3
16.8
163
752
J37.0
ICD-10 Finland
Chronic laryngitis
4.9
16.7
55
116
R81
ICPC
Pneumonia
3.9
16.6
69
183
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
16.6
241
1320
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
16.3
467
3182
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
5.9
16.2
45
78
R01BA52
ATC
pseudoephedrine, combinations; oral
1.7
16.2
358
2262
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
16.1
291
1720
N05BA01
ATC
diazepam; systemic, rectal
2.0
16.1
218
1160
G44.2
ICD-10 Finland
Tension-type headache
2.2
16.0
165
782
R50.9
ICD-10 Finland
Fever, unspecified
2.0
15.8
218
1168
49302
ICD-8 Finland
Asthma, Rhinitis allergica cum asthmate bronchiali
+∞
15.6
15
*
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
7.5
15.5
36
49
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
15.3
116
470
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
15.2
457
3143
J02AC01
ATC
fluconazole; systemic
1.6
15.2
450
3083
R03BB07
ATC
umeclidinium bromide; inhalant
23.6
15.1
21
9
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
15.1
433
2943
P01AB01
ATC
metronidazole; oral, rectal
1.6
14.9
490
3444
J01FA01
ATC
erythromycin; systemic
2.1
14.9
170
840
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.0
14.9
201
1065
M54.5
ICD-10 Finland
Low back pain
1.7
14.9
385
2539
N03AX12
ATC
gabapentin; oral
2.0
14.8
206
1107
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
9.0
14.5
30
34
C01DA14
ATC
isosorbide mononitrate; oral
1.7
14.5
351
2271
SPAT1059
SPAT
Spirometry at the office
3.6
14.4
64
181
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
19.3
14.2
21
11
R05DB20
ATC
other cough suppressants - combinations
2.7
14.1
98
377
A03FA02
ATC
cisapride; oral, rectal
2.2
14.0
146
693
A02BA02
ATC
ranitidine; systemic
1.7
14.0
323
2055
M79.6
ICD-10 Finland
Pain in limb
1.6
14.0
433
2993
R06AX27
ATC
desloratadine; oral
1.8
13.9
274
1663
C07AB07
ATC
bisoprolol; oral
1.5
13.9
725
5662
R51.80
ICD-10 Finland
Headache
2.1
13.7
170
870
N06AX21
ATC
duloxetine; oral
2.3
13.7
132
606
4779A
ICD-9 Finland
Allergic rhinitis, Cause unspecified
16.3
13.5
21
13
N06AX11
ATC
mirtazapine; oral
1.6
13.4
407
2791
N07BA03
ATC
varenicline; oral
3.9
13.4
54
141
N05CD07
ATC
temazepam; oral
1.8
13.3
241
1419
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
21.3
13.3
19
9
A01AB04
ATC
amphotericin B; local oral
2.7
13.1
93
363
46699
ICD-8 Finland
Acute bronchitis and bronchiolitis
8.4
13.0
28
34
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
13.0
102
421
D07AC01
ATC
betamethasone; topical
1.6
12.9
452
3211
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.8
12.8
54
147
R03CC02
ATC
salbutamol; systemic
3.4
12.7
61
184
4660A
ICD-9 Finland
Acute bronchitis and bronchiolitis, Acute bronchitis
6.8
12.7
31
46
J01DA08
ATC
[U] cefaclor; oral
2.3
12.6
124
573
XG466
NOMESCO Finland
Sleep oxymetry
3.8
12.6
53
144
J32.4
ICD-10 Finland
Chronic pansinusitis
8.8
12.5
26
30
R03CC03
ATC
terbutaline; systemic
7.2
12.3
29
41
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
7.2
12.3
29
41
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
6.0
12.3
33
56
C08DB01
ATC
diltiazem; oral
2.2
12.2
126
597
R03DA54
ATC
theophylline, combinations excl. psycholeptics; systemic
5.3
12.1
36
69
XG405
NOMESCO Finland
Education on PEF monitoring
8.2
12.1
26
32
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
12.0
147
749
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
4.5
12.0
41
92
J01MA01
ATC
ofloxacin; systemic
2.0
11.9
165
882
R03BB06
ATC
glycopyrronium bromide; inhalant
47.0
11.9
14
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
47.0
11.9
14
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
11.8
218
1292
C01AA05
ATC
digoxin; systemic
1.8
11.8
204
1182
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.4
11.8
104
459
R01AD05
ATC
budesonide; nasal
2.4
11.7
98
420
R01AD11
ATC
triamcinolone; nasal
2.3
11.7
111
505
N05BA04
ATC
oxazepam; oral
1.6
11.7
337
2272
SPAT1057
SPAT
Peak expiratory flow measurement
5.8
11.6
32
56
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
12.6
11.6
20
16
348
Kela drug reimbursment
Roflumilast
+∞
11.5
11
*
48509
ICD-8 Finland
Bronchopneumonia, unspecified
7.5
11.4
26
35
R09.3
ICD-10 Finland
Abnormal sputum
7.9
11.4
25
32
R78
ICPC
Acute bronchitis/bronchiolitis
4.2
11.2
42
103
R07.3
ICD-10 Finland
Other chest pain
2.1
11.1
130
650
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
11.1
202
1193
N06AX16
ATC
venlafaxine; oral
2.0
11.1
141
733
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
5.0
11.0
34
69
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
10.9
223
1362
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
10.8
558
4280
A02BA03
ATC
famotidine; systemic
2.4
10.7
86
363
48609
ICD-8 Finland
Pneumonia, unspecified
5.2
10.6
32
63
R06.8
ICD-10 Finland
Other and unspecified abnormalities of breathing
5.2
10.6
32
63
SPAT1257
SPAT
Teaching of medicine inhalation technique
3.6
10.5
46
130
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
7.4
10.5
24
33
J01MA02
ATC
ciprofloxacin; systemic
1.4
10.4
573
4443
4939B
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA CUM EXACERBATIONE]
+∞
10.4
10
*
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
10.4
10
*
R03DX07
ATC
roflumilast; oral
+∞
10.4
10
*
7862A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Cough
7.8
10.4
23
30
N06AA12
ATC
doxepin; systemic
2.4
10.4
86
368
J98.1
ICD-10 Finland
Pulmonary collapse
16.1
10.3
16
10
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
12.1
10.3
18
15
R06AX13
ATC
loratadine; oral
1.9
10.3
158
877
M48.0
ICD-10 Finland
Spinal stenosis
1.8
10.2
177
1026
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
10.1
136
721
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
11.4
10.1
18
16
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.0
10.1
137
730
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
9.2
10.0
20
22
C08DA01
ATC
verapamil; systemic
2.6
10.0
74
298
M04AA01
ATC
allopurinol; systemic
1.7
9.9
228
1443
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.5
9.9
77
320
R13
ICD-10 Finland
Dysphagia
2.2
9.8
98
457
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
4.8
9.8
31
65
UDC00
NOMESCO Finland
Ear microscopy
2.1
9.7
107
522
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
9.7
211
1311
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
9.6
210
1309
UDM02
NOMESCO Finland
Sinoscopy
4.3
9.6
34
80
J01DB01
ATC
cefalexin; oral
1.4
9.6
1061
9297
N06AB04
ATC
citalopram; systemic
1.6
9.5
282
1908
J41
ICD-10 Finland
Simple and mucopurulent chronic bronchitis
100.6
9.4
10
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
9.4
310
2146
R06.5
ICD-10 Finland
Mouth breathing
2.1
9.4
105
518
R03BB05
ATC
aclidinium bromide; inhalant
+∞
9.4
9
*
J01GB01
ATC
tobramycin; inhalant, parenteral
+∞
9.4
9
*
49309
ICD-8 Finland
Asthma, Unspecified
+∞
9.4
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.4
223
1421
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
9.4
132
714
R06AX22
ATC
ebastine; oral
1.8
9.3
170
1003
K30
ICD-10 Finland
Functional dyspepsia
2.0
9.3
125
663
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
9.3
144
804
R06AE09
ATC
levocetirizine; oral
1.9
9.2
143
798
R05DA01
ATC
ethylmorphine; oral
2.0
9.1
113
580
A07EC01
ATC
sulfasalazine; oral, rectal
2.1
9.1
105
526
L04AX01
ATC
azathioprine; systemic
2.7
8.9
57
213
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.1
8.8
99
490
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
8.8
428
3221
0
FHL
NA
14.1
8.7
14
10
R79
ICPC
Chronic bronchitis
50.2
8.7
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
8.7
222
1442
7860A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Dyspnoea and respiratory abnormalities[DYSPNOEA]
6.6
8.7
21
32
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
8.7
402
2996
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
3.6
8.7
37
104
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
8.6
180
1106
A06AD11
ATC
lactulose; oral
1.6
8.6
264
1796
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.3
8.6
80
363
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
8.6
324
2311
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
8.6
262
1780
N05AH04
ATC
quetiapine; oral
1.7
8.6
189
1180
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.8
8.5
138
781
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
7.0
8.5
20
29
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.9
8.5
129
715
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
20.1
8.5
12
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
8.4
146
847
B96.5
ICD-10 Finland
Pseudomonas (aeruginosa) as the cause of diseases classified to other chapters
90.5
8.4
9
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
8.4
176
1082
XF402
NOMESCO Finland
ECG with work load test
1.8
8.4
154
909
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.3
8.3
78
355
R05DB05
ATC
pentoxyverine; oral, rectal
2.6
8.2
57
224
J86.9
ICD-10 Finland
Pyothorax without fistula
6.5
8.2
20
31
R06.4
ICD-10 Finland
Hyperventilation
5.2
8.2
24
47
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
8.2
131
739
WW200
NOMESCO Finland
Immunization
3.4
8.1
38
115
N05AF03
ATC
chlorprothixene; systemic
3.4
8.1
37
110
N05BA12
ATC
alprazolam; oral
1.9
8.1
125
696
R11
ICD-10 Finland
Nausea and vomiting
2.0
8.1
106
559
R74
ICPC
Upper respiratory infection acute
1.5
8.1
255
1747
SPAT1263
SPAT
Sampling
1.4
8.0
519
4100
N06AB06
ATC
sertraline; oral
1.9
8.0
113
609
1430
FHL
Laryngoscopy (direct)
22.1
8.0
11
5
WX723
NOMESCO Finland
CPAP therapy
2.9
8.0
46
160
A02BA04
ATC
nizatidine; systemic
1.8
8.0
126
708
D07AD01
ATC
clobetasol; topical
1.7
8.0
183
1156
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
3.2
7.9
39
123
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
3.2
7.9
39
123
UJD02
NOMESCO Finland
Gastroscopy
2.2
7.9
80
377
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
7.9
73
332
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.8
188
1202
M05BA04
ATC
alendronic acid; oral
1.9
7.7
119
665
120
Kela drug reimbursment
Hypogammaglobulinaemia
45.2
7.7
9
*
UGC02
NOMESCO Finland
Rigid bronchoscopy
15.1
7.7
12
8
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.1
7.7
79
378
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
18.4
7.6
11
6
R05CA10
ATC
expectorants - combinations
3.2
7.6
38
122
I50.0
ICD-10 Finland
Congestive heart failure
1.7
7.6
147
884
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.5
7.6
57
235
N02AC04
ATC
dextropropoxyphene; oral
2.1
7.6
83
409
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.3
7.5
65
286
J21.90
ICD-10 Finland
Acute obstructive bronchitis in children
10.1
7.5
14
14
SPAT1262
SPAT
Handing over of treatment supplies
1.5
7.5
250
1732
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.8
7.4
125
717
5861
FHL
Pleural biopsy or removal of local change
80.4
7.4
8
*
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
7.4
225
1526
N06AB10
ATC
escitalopram; oral
1.6
7.4
197
1294
N06AB03
ATC
fluoxetine; oral
1.7
7.3
140
839
WX722
NOMESCO Finland
PEEP
2.3
7.3
66
297
4939A
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA SINE EXACERBATIONE]
+∞
7.3
7
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
7.3
173
1103
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
7.2
270
1917
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
7.2
57
241
M03BX02
ATC
tizanidine; oral
1.3
7.2
671
5602
N05AA02
ATC
levomepromazine; systemic
2.3
7.2
65
293
J01DC02
ATC
cefuroxime; systemic
2.2
7.1
68
315
R03BA07
ATC
mometasone; inhalant
8.0
7.1
15
19
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.3
7.1
62
276
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.9
7.1
27
70
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.4
7.0
54
226
Z50.1
ICD-10 Finland
Other physical therapy
2.1
7.0
79
394
L03
ICPC
Low back symptom/complaint
1.5
7.0
247
1732
M47.9
ICD-10 Finland
Spondylosis, unspecified
2.6
7.0
47
183
Y0599
ICD-8 Finland
Investigation of digestive system
3.3
7.0
33
102
E000001
ATC
NA
1.5
7.0
237
1646
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.9
131
780
N03AF01
ATC
carbamazepine; oral, rectal
2.0
6.9
82
414
A03CA02
ATC
clidinium and psycholeptics; oral
1.9
6.9
93
497
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
6.9
168
1080
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
6.9
78
391
WX780
NOMESCO Finland
Remote monitoring CPAP
2.6
6.8
46
180
Z01.9
ICD-10 Finland
Special examination, unspecified
2.1
6.8
73
358
4289X
ICD-9 Finland
Heart failure, unspecified
4.3
6.7
23
54
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.5
6.7
48
193
N03AE01
ATC
clonazepam; systemic
2.1
6.7
68
325
SPAT1260
SPAT
Consultation of another employee
1.5
6.7
213
1458
S80.0
ICD-10 Finland
Contusion of knee
2.1
6.7
70
339
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.7
117
683
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.1
6.7
74
366
30041
ICD-8 Finland
Neuroses, Depressiva
3.7
6.7
27
74
M79.7
ICD-10 Finland
Fibromyalgia
3.2
6.7
33
106
M01AH02
ATC
rofecoxib; oral
1.6
6.7
176
1152
ZXA10
NOMESCO Finland
Bilateral
1.5
6.6
240
1690
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
6.6
94
510
5188X
ICD-9 Finland
Other diseases of lung
7.8
6.6
14
18
N06AX03
ATC
mianserin; oral
2.2
6.6
66
312
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.9
6.6
94
513
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.9
6.5
88
472
R03BC01
ATC
cromoglicic acid; inhalant
6.9
6.5
15
22
A02BX02
ATC
sucralfate; oral
2.1
6.5
73
364
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
6.5
55
240
C03DA01
ATC
spironolactone; oral
1.6
6.4
151
960
M01AB05
ATC
diclofenac; systemic, rectal
1.3
6.4
821
7133
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.1
6.4
66
318
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
70.1
6.4
7
*
J15.1
ICD-10 Finland
Pneumonia due to Pseudomonas
70.1
6.4
7
*
XG431
NOMESCO Finland
Oscillometric spirometry with exercise provocation
70.1
6.4
7
*
N05BB01
ATC
hydroxyzine; systemic
2.0
6.4
79
409
79399
ICD-8 Finland
Observation, without need for further medical care, Unspecified
4.3
6.4
22
52
R01AD
ATC
Corticosteroids
4.7
6.4
20
43
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.6
6.4
43
168
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.3
344
2622
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
8.2
6.3
13
16
XJC10
NOMESCO Finland
Oesophageal pH monitoring
8.2
6.3
13
16
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
5.5
6.3
17
31
C01CA24
ATC
epinephrine; parenteral
2.3
6.3
55
247
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
6.3
62
294
XW1XT
NOMESCO Finland
Biopsy from other organ close to skin with other quidance
+∞
6.3
6
*
J01XB01
ATC
colistin; inhalant, parenteral
+∞
6.3
6
*
49308
ICD-8 Finland
Asthma, Alia definita
+∞
6.3
6
*
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.8
6.2
37
134
R03DB04
ATC
theophylline and adrenergics; systemic
26.8
6.2
8
*
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.2
6.2
30
95
UDQ22
NOMESCO Finland
Microlaryngoscopy
4.8
6.2
19
40
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.8
6.2
37
135
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.7
6.2
111
655
R01AX03
ATC
ipratropium bromide; nasal
2.6
6.2
41
159
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.5
6.2
44
177
I45.9
ICD-10 Finland
Conduction disorder, unspecified
5.4
6.2
17
32
A03
ICPC
Fever
1.6
6.1
146
932
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.1
317
2396
N06AX12
ATC
bupropion; oral
2.3
6.1
50
217
H02AB09
ATC
hydrocortisone; systemic
2.9
6.1
33
114
E66.00
ICD-10 Finland
Metabolic syndrome
2.1
6.1
61
292

Mortality – FinRegistry

↥

Association

Association between endpoint J10_SIMPLBRONCH and mortality.

Females

Parameter HR [95% CI] p-value
J10_SIMPLBRONCH 2.004 [1.78, 2.25] < 0.001
Birth year 0.993 [0.98, 1.0] 0.111

During the follow-up period (1.1.1998 — 31.12.2019), 1102 out of 3129 females with J10_SIMPLBRONCH died.

Males

Parameter HR [95% CI] p-value
J10_SIMPLBRONCH 2.066 [1.84, 2.32] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 1687 out of 3566 males with J10_SIMPLBRONCH died.

Mortality risk

Mortality risk for people of age

years, who have J10_SIMPLBRONCH.

N-year risk Females Males
1 0.186% 0.437%
5 1.027% 2.415%
10 2.692% 5.921%
15 5.329% 11.176%
20 9.318% 18.593%

Relationships between endpoints

↥

Index endpoint: J10_SIMPLBRONCH – Simple and mucopurulent chronic bronchitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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