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Crohn disease (strict definition, require KELA)

K11_CD_STRICT

ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_KELACROHN
2490

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K50
  • Hospital discharge: ICD-9 555
  • Hospital discharge: ICD-8 5630
  • Cause of death: ICD-10 K50
  • Cause of death: ICD-9 555
  • Cause of death: ICD-8 5630

2 out of 7 registries used, show all original rules.

2313

4. Check minimum number of events

None

2313

5. Include endpoints

None

2313

6. Filter based on genotype QC (FinnGen only)

2227

Control definitions (FinnGen only)

Control exclude
K11_CD_STRICT_PSC
Control conditions
not K11_KELACROHN

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
K50-K52
Name in latin
Morbus Crohn

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 2227 1278 949
Unadjusted period prevalence (%) 0.49 0.50 0.48
Median age at first event (years) 38.40 37.38 39.77

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2313
Matched controls
23130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJF30
NOMESCO Finland
Ileoscopy through colon
24.1
323.0
1183
961
A07EA06
ATC
budesonide; oral, local oral
120.4
323.0
1380
280
L01BB02
ATC
mercaptopurine; oral
51.9
323.0
397
92
K50.0
ICD-10 Finland
Crohn disease of small intestine
904.0
323.0
1549
51
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
8.0
323.0
1345
3410
UJF32
NOMESCO Finland
Coloscopy
23.2
323.0
1759
2787
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
177.5
323.0
523
38
L04AX01
ATC
azathioprine; systemic
84.1
323.0
1421
429
A07EC02
ATC
mesalazine; oral, rectal
75.3
323.0
1536
591
K50.1
ICD-10 Finland
Crohn disease of large intestine
342.2
323.0
1066
57
L04AB04
ATC
adalimumab; parenteral
33.3
323.0
440
162
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
114.2
323.0
413
44
H02AB06
ATC
prednisolone; systemic
5.9
323.0
1655
6897
UJF92
NOMESCO Finland
Capsular endoscopy
57.2
323.0
623
148
K50.9
ICD-10 Finland
Crohn disease, unspecified
445.3
323.0
1259
61
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
2313
461
K50.8
ICD-10 Finland
Other Crohn disease
691.9
323.0
1545
68
K50
ICD-10 Finland
Crohn disease [regional enteritis]
305.9
294.6
294
11
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
140.0
268.3
283
23
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.0
254.4
1081
3429
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
15.3
238.6
412
322
P01AB01
ATC
metronidazole; oral, rectal
4.3
232.3
1383
5960
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
15.1
218.6
379
296
ZX120
NOMESCO Finland
Intravenous
7.5
209.6
550
925
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
6.7
193.2
552
1036
J01MA02
ATC
ciprofloxacin; systemic
3.5
166.9
1163
5192
C10AC01
ATC
colestyramine; oral
16.0
163.3
274
192
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
288.8
159.7
161
6
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
156.9
1196
5629
JF1BD
NOMESCO Finland
Very extensive small bowel CT
54.8
156.7
187
37
A07EC01
ATC
sulfasalazine; oral, rectal
6.3
155.5
458
873
H02AB07
ATC
prednisone; oral
4.6
139.4
565
1531
D94
ICPC
Chronic enteritis/ulcerative colitis
39.8
133.9
170
46
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
132.0
1129
5535
L04AC05
ATC
ustekinumab; parenteral
86.0
129.9
145
18
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.1
129.1
459
1076
K51.5
ICD-10 Finland
Left sided colitis
9.7
126.6
271
313
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
9.2
125.1
276
336
JFB20
NOMESCO Finland
Ileocaecal resection
49.2
125.0
152
33
A07EA02
ATC
hydrocortisone; rectal
12.6
122.2
227
198
4AA12
NOMESCO Finland
NA
67.6
121.4
140
22
WX002
NOMESCO Finland
Sedation and analgesia
3.6
115.9
624
2139
4AB02
NOMESCO Finland
NA
52.9
108.4
130
26
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
23.8
106.4
154
69
A02BC02
ATC
pantoprazole; systemic
2.7
105.2
1554
10060
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
98.1
640
2491
JF1AD
NOMESCO Finland
Small bowel CT
36.6
96.9
125
36
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
18.0
93.9
149
88
K51.8
ICD-10 Finland
Other ulcerative colitis
13.0
93.1
169
139
JFB00
NOMESCO Finland
Partial resection of small intestine
19.7
91.7
141
76
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
10.0
90.9
189
204
B03BA03
ATC
hydroxocobalamin; parenteral
7.0
89.6
234
365
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.5
82.3
445
1483
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
4.6
81.6
308
745
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
46.4
79.9
98
22
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
78.9
588
2449
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
18.1
75.4
119
69
K60.3
ICD-10 Finland
Anal fistula
10.6
74.5
149
149
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
741.1
73.6
72
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
19.6
72.9
112
60
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.8
68.9
246
558
N02AX02
ATC
tramadol; systemic, rectal
2.2
63.7
970
5763
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
+∞
62.8
60
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.6
62.4
568
2613
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
10.8
60.7
120
117
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
70.9
60.5
69
10
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
60.4
239
599
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
59.9
296
903
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
9.2
59.3
128
147
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
57.6
399
1550
K56.7
ICD-10 Finland
Ileus, unspecified
15.1
57.5
97
67
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
57.4
56.9
67
12
JHA00
NOMESCO Finland
Anal or perianal incision
10.3
56.4
114
116
UJF02
NOMESCO Finland
Peroral enteroscopy
28.0
55.5
76
28
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
191.2
54.2
56
*
B81
ICPC
Anaemia vit B12/folate deficiency
6.8
53.4
140
217
N02BE01
ATC
paracetamol; systemic, rectal
2.3
52.5
1942
16071
A02BC03
ATC
lansoprazole; oral
2.2
52.0
652
3474
A02BC01
ATC
omeprazole; systemic
2.2
50.1
628
3335
3042
Kela drug reimbursment
NA
108.4
49.0
53
5
M45
ICD-10 Finland
Ankylosing spondylitis
6.6
48.2
128
202
253
Kela drug reimbursment
NA
106.4
48.0
52
5
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
45.8
541
2779
K61.0
ICD-10 Finland
Anal abscess
7.3
45.6
113
162
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
45.4
673
3816
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.9
45.4
156
337
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.2
44.3
178
450
107
Kela drug reimbursment
Pernicious anaemia
10.0
42.7
87
90
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
10.7
42.3
83
80
4AA33
NOMESCO Finland
NA
62.5
42.3
49
8
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.6
41.8
333
1388
3AC01
NOMESCO Finland
NA
11.7
41.5
78
69
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
61.2
41.3
48
8
WW200
NOMESCO Finland
Immunization
5.2
41.0
132
265
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
74.8
39.0
44
6
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
198.2
37.9
39
*
5550A
ICD-9 Finland
Regional enteritis, Small intestine
135.6
37.8
40
*
K83.0
ICD-10 Finland
Cholangitis
9.0
37.6
81
93
A02BC05
ATC
esomeprazole; systemic
1.8
37.0
853
5608
JF1DM
NOMESCO Finland
Very extensive MRI of small bowel (more than 1.5 T)
101.7
36.8
40
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
36.7
219
759
R50.9
ICD-10 Finland
Fever, unspecified
2.3
36.5
368
1730
UJD02
NOMESCO Finland
Gastroscopy
4.2
36.4
146
368
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
31.9
35.8
47
15
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.6
35.2
285
1194
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.3
34.8
184
585
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.1
34.1
139
356
WVA20
NOMESCO Finland
Medicine administration
6.2
33.9
94
158
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
25.2
33.6
47
19
ZXE00
NOMESCO Finland
One hour or less
1.8
33.4
907
6222
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
33.0
208
746
J01DB01
ATC
cefalexin; oral
1.9
32.8
1883
16166
L04AA33
ATC
vedolizumab; parenteral
172.4
32.8
34
*
JFB30
NOMESCO Finland
Right hemicolectomy
11.1
32.5
62
57
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
11.1
32.5
62
57
K59.1
ICD-10 Finland
Functional diarrhoea
3.7
32.4
151
434
JAH00
NOMESCO Finland
Laparotomy
5.5
32.2
97
181
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.7
32.1
242
972
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.0
31.0
128
331
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
7.6
30.7
73
99
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
35.1
29.7
38
11
A02BA02
ATC
ranitidine; systemic
2.1
29.5
371
1917
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
29.0
165
552
Z93.2
ICD-10 Finland
Ileostomy status
25.4
28.8
40
16
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
49.2
28.4
34
7
A05AA02
ATC
ursodeoxycholic acid; oral
5.6
27.9
83
153
J01MA12
ATC
levofloxacin; systemic
2.1
27.7
374
1988
ZXD05
NOMESCO Finland
Urgent procedure
1.7
27.4
706
4698
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.9
27.2
179
659
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
27.1
803
5564
C05AA08
ATC
fluocortolone; rectal, topical
2.2
26.6
307
1522
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
26.4
835
5880
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
26.1
542
3361
5551A
ICD-9 Finland
Regional enteritis, Large intestine
73.5
25.8
29
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.7
25.8
89
194
ZX112
NOMESCO Finland
Subcutaneous
5.5
25.6
77
144
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
25.4
739
5066
K92.1
ICD-10 Finland
Melaena
3.6
25.1
119
347
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
25.0
24
*
H02AB09
ATC
hydrocortisone; systemic
4.4
24.5
90
209
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
24.1
464
2796
D01
ICPC
Abdominal pain/cramps general
2.1
23.9
286
1439
WX402
NOMESCO Finland
General anaesthesia
1.9
23.9
398
2284
JHD20
NOMESCO Finland
Incision of fistula-in-ano
7.6
23.9
56
75
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.8
23.7
81
175
4AC05
NOMESCO Finland
NA
126.3
23.6
25
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
23.6
202
867
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
54.6
23.1
27
5
XJW99
NOMESCO Finland
Other investigative procedure on digestive system
17.7
22.6
35
20
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.6
22.6
80
180
A07DA03
ATC
loperamide; oral
4.0
22.5
93
242
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
22.4
947
7098
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
22.4
363
2058
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.3
21.7
114
361
K63.1
ICD-10 Finland
Perforation of intestine (nontraumatic)
9.9
21.6
43
44
E0000UV
ATC
NA
1.6
21.6
856
6301
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
21.4
964
7308
K29.7
ICD-10 Finland
Gastritis, unspecified
3.8
21.2
91
245
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.5
21.2
76
173
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.5
21.1
175
737
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.3
21.1
79
188
UJH02
NOMESCO Finland
Anoscopy
3.2
20.9
111
355
A06AC51
ATC
ispaghula, combinations; systemic
3.0
20.7
123
423
Z2221
NOMESCO Finland
Medical doctor
1.6
20.5
605
4115
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
4.3
20.2
75
177
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.2
20.1
78
192
H02AB04
ATC
methylprednisolone; systemic
1.9
19.5
290
1587
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
19.6
19.5
29
15
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.8
19.5
65
138
K29.8
ICD-10 Finland
Duodenitis
8.5
19.4
42
50
M05BA04
ATC
alendronic acid; oral
2.9
19.4
124
450
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.3
19.2
190
875
J05AB11
ATC
valaciclovir; oral
1.9
19.2
283
1543
A03CA02
ATC
clidinium and psycholeptics; oral
3.0
19.1
111
378
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
19.0
280
1527
Z3231
NOMESCO Finland
Registered nurse
1.6
18.9
553
3742
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
18.7
381
2323
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
18.3
824
6180
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
6.3
18.2
48
77
JFF13
NOMESCO Finland
Terminal enterostomy
21.9
18.2
26
12
JAH01
NOMESCO Finland
Laparoscopy
2.8
18.1
123
462
K61.1
ICD-10 Finland
Rectal abscess
14.5
18.1
30
21
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
7.3
18.0
43
60
D07AC01
ATC
betamethasone; topical
1.5
17.7
665
4777
1370
FHL
Colonoscopy, whole colon
9.9
17.6
35
36
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.4
17.6
159
702
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
10.8
17.4
33
31
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
17.2
221
1142
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
17.1
1080
8668
WZC30
NOMESCO Finland
Teaching
1.9
17.0
262
1449
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
3.2
17.0
89
283
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.7
16.9
75
209
K63.2
ICD-10 Finland
Fistula of intestine
35.3
16.7
21
6
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
16.5
199
1000
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
16.5
109
402
JFA60
NOMESCO Finland
Stricturoplasty in small intestine
171.2
16.5
17
*
D11
ICPC
Diarrhoea
1.8
16.4
279
1598
K56.0
ICD-10 Finland
Paralytic ileus
7.4
16.2
38
52
K60.2
ICD-10 Finland
Anal fissure, unspecified
4.5
16.2
57
129
J02AC01
ATC
fluconazole; systemic
1.5
16.1
828
6344
B02.9
ICD-10 Finland
Zoster without complication
2.7
16.0
108
406
D07XC01
ATC
betamethasone, combinations; topical
1.9
15.9
231
1252
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
60.4
15.8
18
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.6
15.6
36
48
E000001
ATC
NA
1.6
15.6
445
2976
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
15.5
567
4029
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.0
15.5
220
1182
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
3.6
15.4
70
200
A07AA09
ATC
vancomycin; oral
5.7
15.3
43
76
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.5
15.1
71
208
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
15.0
123
517
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
8.1
15.0
33
41
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
7.4
15.0
35
48
K60.0
ICD-10 Finland
Acute anal fissure
5.7
14.8
42
75
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
14.7
260
1509
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
5.8
14.7
41
72
WX110
NOMESCO Finland
Local anesthesy
1.4
14.6
1545
13504
JEA00
NOMESCO Finland
Appendectomy
2.1
14.6
163
794
JF1CD
NOMESCO Finland
Extensive small bowel CT
150.9
14.5
15
*
D07AC13
ATC
mometasone; topical
1.5
14.5
558
3999
S18
ICPC
Laceration/cut
1.5
14.4
759
5809
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
4.3
14.4
53
126
B01AB05
ATC
enoxaparin; parenteral
1.5
14.4
504
3535
M01AH01
ATC
celecoxib; oral (coxibs)
1.7
14.3
306
1883
K60.4
ICD-10 Finland
Rectal fistula
19.2
14.2
21
11
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
22.4
14.2
20
9
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.5
14.2
67
198
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
4.0
14.0
56
144
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
13.9
692
5229
J01DA01
ATC
[U] cefalexin; systemic
1.4
13.8
1288
10936
M81.4
ICD-10 Finland
Drug-induced osteoporosis
17.6
13.8
21
12
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
13.8
652
4876
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.0
13.7
186
982
J01AA02
ATC
doxycycline; systemic
1.4
13.5
1540
13527
K30
ICD-10 Finland
Functional dyspepsia
1.9
13.5
212
1178
K65.0
ICD-10 Finland
Acute peritonitis
5.4
13.3
39
73
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.5
13.2
101
409
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
4.0
13.1
52
133
R11
ICD-10 Finland
Nausea and vomiting
2.0
13.1
172
898
K60.1
ICD-10 Finland
Chronic anal fissure
3.3
12.9
64
197
5559X
ICD-9 Finland
Regional enteritis, Unspecified site
50.3
12.8
15
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.9
12.8
77
271
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
4.2
12.8
48
117
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
12.6
265
1620
JFA96
NOMESCO Finland
Other local operation on intestine
70.2
12.6
14
*
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.4
12.5
44
101
JFB96
NOMESCO Finland
Other partial excision of intestine
130.7
12.4
13
*
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.1
12.3
47
117
J05AB01
ATC
aciclovir; systemic
1.5
12.2
409
2827
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
7.4
12.2
28
38
D06BX01
ATC
metronidazole; topical
1.9
12.2
197
1105
D07AD01
ATC
clobetasol; topical
1.7
12.1
284
1791
Z01.2
ICD-10 Finland
Dental examination
1.4
11.8
904
7346
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.7
11.8
78
292
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
30.2
11.6
15
5
A07EC03
ATC
olsalazine; oral
19.0
11.6
17
9
E86
ICD-10 Finland
Volume depletion
4.0
11.6
45
114
JFB46
NOMESCO Finland
Resection of sigmoid colon
6.2
11.5
30
49
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
4.1
11.5
44
110
6455
FHL
Perianal fistula surgery
13.7
11.4
19
14
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.5
11.4
414
2910
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.8
11.4
75
278
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
11.4
166
899
Z93
ICD-10 Finland
Artificial opening status
11.9
11.3
20
17
L04AD01
ATC
ciclosporin; systemic
3.3
11.2
56
175
WW500
NOMESCO Finland
Blood transfusion
2.6
11.1
82
328
TQW99
NOMESCO Finland
Other minor procedure on skin
2.5
10.9
84
343
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
10.9
134
678
K29.9
ICD-10 Finland
Gastroduodenitis, unspecified
6.0
10.9
29
49
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
10.8
334
2263
K02.1
ICD-10 Finland
Caries of dentine
1.3
10.7
1297
11276
UJF30
SPAT
NA
7.6
10.7
24
32
4AA17
NOMESCO Finland
NA
60.3
10.6
12
*
K51
ICD-10 Finland
Ulcerative colitis
4.7
10.6
35
76
UJG02
NOMESCO Finland
Proctoscopy
3.4
10.6
50
150
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
8.5
10.5
22
26
D99
ICPC
Disease digestive system other
4.9
10.5
33
68
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
4.2
10.4
38
91
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
4.7
10.4
34
73
K59.9
ICD-10 Finland
Functional intestinal disorder, unspecified
4.1
10.4
39
96
K85
ICD-10 Finland
Acute pancreatitis
4.0
10.4
40
101
M03BX02
ATC
tizanidine; oral
1.3
10.4
1272
11053
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
4.5
10.4
35
78
QBA10
NOMESCO Finland
Incision of skin of trunk
4.5
10.4
35
78
L88
ICD-10 Finland
Pyoderma gangrenosum
16.1
10.3
16
10
JGB30
NOMESCO Finland
Abdominoperineal excision of rectum
23.5
10.2
14
6
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
10.2
184
1073
M25.5
ICD-10 Finland
Pain in joint
1.4
10.2
536
4053
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
10.1
130
675
7200A
ICD-9 Finland
Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis
11.3
10.0
18
16
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
7.2
10.0
23
32
A03FA02
ATC
cisapride; oral, rectal
2.0
10.0
123
628
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
9.9
1162
9996
N03AX16
ATC
pregabalin; oral
1.5
9.9
392
2801
ZYC01
NOMESCO Finland
Remote contact by phone
2.2
9.9
102
482
B07.9
ICD-10 Finland
Verruca simplex
2.4
9.9
84
363
UJK02
NOMESCO Finland
ERCP
3.2
9.8
49
154
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
20.1
9.8
14
7
JFB43
NOMESCO Finland
Left hemicolectomy
8.8
9.8
20
23
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
9.8
540
4120
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
9.7
162
922
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
9.7
1476
13181
SPAT1263
SPAT
Sampling
1.3
9.7
855
7043
UJF34
NOMESCO Finland
Left colonoscopy
6.4
9.5
24
38
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.7
9.5
64
244
A07AA02
ATC
nystatin; oral
2.2
9.5
97
459
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.1
9.4
99
473
R10.0
ICD-10 Finland
Acute abdomen
2.5
9.4
71
288
K63.8
ICD-10 Finland
Other specified diseases of intestine
17.6
9.4
14
8
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
9.4
210
1309
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
12.4
9.4
16
13
6403
FHL
Ileocal resection
21.8
9.3
13
6
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
8.1
9.3
20
25
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
9.3
348
2453
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
10.7
9.3
17
16
Z94.4
ICD-10 Finland
Liver transplant status
9.5
9.3
18
19
H20.1
ICD-10 Finland
Chronic iridocyclitis
4.4
9.2
32
74
RD210
NOMESCO Finland
NA
2.8
9.2
55
196
A01AB09
ATC
miconazole; local oral
1.8
9.2
150
847
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
9.2
308
2123
56510
ICD-8 Finland
Anal fissure and fistula, Anal fistula
13.7
9.2
15
11
R51.80
ICD-10 Finland
Headache
1.5
9.1
306
2105
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.1
9.1
104
515
R4190
NOMESCO Finland
Nutritional therapy
2.3
9.1
82
366
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.6
9.1
253
1669
JFH10
NOMESCO Finland
Total colectomy and ileostomy
11.5
9.1
16
14
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.9
9.0
124
660
D82
ICPC
Teeth/gum disease
1.3
8.9
764
6241
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.7
8.9
58
218
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.7
8.9
197
1221
M54.5
ICD-10 Finland
Low back pain
1.4
8.9
633
5025
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.7
8.9
187
1142
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
8.8
1775
18955
S01FA02
ATC
scopolamine; ophthalmic
5.6
8.7
24
43
M13.9
ICD-10 Finland
Arthritis, unspecified
1.9
8.7
133
735
6402
FHL
Small bowel resection
14.1
8.7
14
10
N06AX21
ATC
duloxetine; oral
1.6
8.6
204
1286
H15.1
ICD-10 Finland
Episcleritis
3.6
8.6
37
104
SPAT1153
SPAT
Removal of sutures
1.4
8.6
536
4161
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
8.6
145
827
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
8.6
75
329
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
6.2
8.6
22
36
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
8.6
1089
9400
K61.2
ICD-10 Finland
Anorectal abscess
16.3
8.5
13
8
JFB01
NOMESCO Finland
Laparoscopic partial resection of small intestine
16.3
8.5
13
8
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
10.1
8.5
16
16
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
8.5
1231
10812
J01FA06
ATC
roxithromycin; oral
1.3
8.5
733
5989
6404
FHL
Hemicolectomy on the right
27.6
8.5
11
*
E000002
ATC
NA
1.6
8.5
230
1505
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
5.1
8.5
25
49
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
90.4
8.4
9
*
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
4.5
8.3
28
63
WX610
NOMESCO Finland
Patient controlled analgesia
4.5
8.3
28
63
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.0
8.3
100
506
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
3.6
8.3
35
97
J01FF01
ATC
clindamycin; systemic
1.4
8.3
502
3872
B01AB10
ATC
tinzaparin; parenteral
1.9
8.3
112
593
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
10.8
8.3
15
14
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
8.2
149
870
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
6.5
8.2
20
31
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.4
8.2
69
298
L73.8
ICD-10 Finland
Other specified follicular disorders
4.0
8.1
31
79
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.3
8.1
70
307
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
2.8
8.1
49
177
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
8.1
151
892
JK3MN
NOMESCO Finland
Bile absorbtion isotope examination
17.2
8.1
12
7
JJC00
NOMESCO Finland
Allogenic transplantation of liver
11.7
8.1
14
12
Z93.3
ICD-10 Finland
Colostomy status
5.3
8.0
23
44
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.2
8.0
81
383
UKC02
NOMESCO Finland
Cystoscopy
1.6
8.0
211
1373
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.1
7.9
90
447
JFA70
NOMESCO Finland
Suture of small intestine
7.8
7.9
17
22
L40.8
ICD-10 Finland
Other psoriasis
4.5
7.9
26
58
K03.66
ICD-10 Finland
Tooth plaque
1.8
7.8
128
726
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
7.8
749
6198
M79.7
ICD-10 Finland
Fibromyalgia
2.3
7.8
70
313
R06AE07
ATC
cetirizine; oral
1.3
7.8
910
7732
SPAT1255
SPAT
Intravenous administration of medicine
1.9
7.8
110
593
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
2.9
7.8
45
157
S10
ICPC
Boil/carbuncle
1.9
7.7
108
582
N07BA03
ATC
varenicline; oral
1.9
7.7
113
615
L82
ICD-10 Finland
Seborrhoeic keratosis
1.6
7.7
210
1379
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
7.7
248
1692
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
7.7
279
1955
JKA20
NOMESCO Finland
Cholecystectomy
3.1
7.6
40
132
UJK12
NOMESCO Finland
Peroral cholangioscopy
8.9
7.5
15
17
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
8.9
7.5
15
17
J01FA10
ATC
azithromycin; systemic
1.3
7.5
1281
11408
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
5.4
7.5
21
39
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.5
622
5035
TJF80
NOMESCO Finland
Ostomy education
4.3
7.5
26
61
L20.0
ICD-10 Finland
Besnier prurigo
1.7
7.4
157
964
B80
ICPC
Iron deficiency anaemia
2.8
7.4
45
164
D05AX52
ATC
calcipotriol, combinations; topical
1.9
7.4
97
510
JFF10
NOMESCO Finland
Loop enterostomy
5.3
7.4
21
40
M79.6
ICD-10 Finland
Pain in limb
1.3
7.4
632
5138
K76.9
ICD-10 Finland
Liver disease, unspecified
3.6
7.4
31
87
L52
ICD-10 Finland
Erythema nodosum
3.9
7.4
28
72
ZX114
NOMESCO Finland
Intramuscular
2.9
7.3
42
145
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
7.3
527
4175
N06AX11
ATC
mirtazapine; oral
1.3
7.3
567
4541
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.9
7.3
42
146
4AB04
NOMESCO Finland
NA
+∞
7.3
7
*
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
9.4
7.3
14
15
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
3.0
7.3
40
137
A02BA03
ATC
famotidine; systemic
2.4
7.3
57
237
M01AX17
ATC
nimesulide; oral
1.4
7.2
351
2602
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
7.2
319
2324
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
7.2
456
3539
L73.2
ICD-10 Finland
Hidradenitis suppurativa
3.3
7.2
34
105
M01AH02
ATC
rofecoxib; oral
1.6
7.1
181
1164
K85.3
ICD-10 Finland
Drug-induced acute pancreatitis
20.1
7.1
10
5
D07AB08
ATC
desonide; topical
1.6
7.1
190
1243
A02BA04
ATC
nizatidine; systemic
1.9
7.1
101
549
R03AC02
ATC
salbutamol; inhalant
1.3
7.1
1035
9019
A02BX02
ATC
sucralfate; oral
2.3
7.1
59
255
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
3.7
7.1
29
80
SPAT1325
SPAT
Vaccination
1.3
7.0
556
4466
R2110
NOMESCO Finland
Giving the first information
1.7
7.0
136
817
NA6CG
NOMESCO Finland
Sacro-iliac joint extensive MRI examination with high intensity magnet
4.9
7.0
21
43
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
4.6
6.9
22
48
WX290
NOMESCO Finland
Other blockade of nerve
1.3
6.9
1010
8796
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.8
446
3476
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
6.8
115
659
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
11.0
6.8
12
11
JN2DM
NOMESCO Finland
Lower part of abdomen very extensive MRI examination with Tesla magnet
9.3
6.8
13
14
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
6.8
90
476
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.2
6.7
66
310
A06AD11
ATC
lactulose; oral
1.6
6.7
177
1152
R07.0
ICD-10 Finland
Pain in throat
1.7
6.7
123
722
SDA02
NOMESCO Finland
Parodonthologic therapy
1.3
6.7
645
5313
A02BB01
ATC
misoprostol; oral
7.2
6.7
15
21
D06
ICPC
Abdominal pain localized other
1.6
6.7
156
984
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.0
6.6
79
402
J01CA04
ATC
amoxicillin; systemic
1.3
6.6
1792
16773
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
7.8
6.6
14
18
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
6.6
139
855
S01FA04
ATC
cyclopentolate; ophthalmic
4.0
6.6
24
60
K62.4
ICD-10 Finland
Stenosis of anus and rectum
10.0
6.5
12
12
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
6.5
1134
10051
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
6.9
6.5
15
22
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
3.7
6.5
26
71
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.4
6.5
50
210
1380
FHL
Colonoscopy, left side
14.3
6.4
10
7
L04AB06
ATC
golimumab; parenteral
3.5
6.4
27
77
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
6.3
1152
10244
K13.78
ICD-10 Finland
Other change in the oral mucosa
2.7
6.3
39
145
K62.1
ICD-10 Finland
Rectal polyp
5.2
6.3
18
35
JN2CM
NOMESCO Finland
Lower part of abdomen extensive MRI examination with Tesla magnet
5.5
6.3
17
31
6451
FHL
Dilatation
5.5
6.3
17
31
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.3
1544
14218
Z43.2
ICD-10 Finland
Attention to ileostomy
18.1
6.3
9
5
JFC20
NOMESCO Finland
Other enterocolostomy
18.1
6.3
9
5
L88
ICPC
Rheumatoid/seropositive arthritis
2.1
6.2
64
306
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
1.9
6.2
80
420
A03
ICPC
Fever
1.4
6.2
347
2634
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
2.7
6.2
38
141
M50.8
ICD-10 Finland
Other cervical disc disorders
5.0
6.2
18
36
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
6.2
114
1770
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
4.5
6.2
20
45
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.2
6.1
56
256
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.1
6.1
61
290
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.8
6.1
92
509
5660A
ICD-9 Finland
Abscess of anal and rectal regions[ABSCESSUS ANI ET ANORECTALIS]
12.5
6.1
10
8
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.1
6.1
63
304
JF2AB
NOMESCO Finland
Colongraphy with X-ray
8.6
6.1
12
14
R35
ICD-10 Finland
Polyuria
1.9
6.0
86
467
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
10.0
6.0
11
11
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.5
6.0
210
1459

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: K11_CD_STRICT – Crohn disease (strict definition, require KELA)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).