Other diseases of appendix

K11_OTHAPPEND

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K38
  • Hospital discharge: ICD-9 543
  • Hospital discharge: ICD-8 543
  • Cause of death: ICD-10 K38
  • Cause of death: ICD-9 543
  • Cause of death: ICD-8 543

2 out of 7 registries used, show all original rules.

377

4. Check minimum number of events

None

377

5. Include endpoints

None

377

6. Filter based on genotype QC (FinnGen only)

365

Control definitions (FinnGen only)

Control exclude
K11_APPENDIX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K35-K38
Name in latin
Alii morbi appendicis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3360 2099 1235
Only index persons 2823 1812 1011
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.06 0.07 0.04
Median age at first event (years)
Whole population 37.74 37.44 37.89
Only index persons 33.98 34.08 33.82

-FinnGen-

Key figures

All Female Male
Number of individuals 365 250 115
Unadjusted period prevalence (%) 0.09 0.10 0.06
Median age at first event (years) 36.32 34.38 40.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
377
Matched controls
3772
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
54301
ICD-8 Finland
Other diseases of appendix, Stercolithium appendicis
+∞
74.5
69
*
K38.9
ICD-10 Finland
Disease of appendix, unspecified
+∞
73.4
68
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
76.7
57.4
64
10
K38.8
ICD-10 Finland
Other specified diseases of appendix
+∞
53.4
50
*
54309
ICD-8 Finland
Other diseases of appendix, Unspecified
+∞
52.3
49
*
54308
ICD-8 Finland
Other diseases of appendix, Alii definiti
+∞
41.4
39
*
5439X
ICD-9 Finland
Other diseases of appendix, Other and unspecified diseases of appendix
+∞
40.3
38
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
+∞
25.3
24
*
K38.1
ICD-10 Finland
Appendicular concretions
+∞
24.2
23
*
6421
FHL
Appendicectomy
9.2
19.0
40
48
54300
ICD-8 Finland
Other diseases of appendix, Mucocele appendicis
+∞
16.8
16
*
JEA00
NOMESCO Finland
Appendectomy
8.8
15.9
34
42
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
+∞
13.6
13
*
54003
ICD-8 Finland
Acute appendicitis, Cum abscessu
+∞
12.6
12
*
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
31.1
11.7
15
5
K38.0
ICD-10 Finland
Hyperplasia of appendix
+∞
11.5
11
*
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
45.9
7.7
9
*
JAH01
NOMESCO Finland
Laparoscopy
4.2
7.6
28
71
K37
ICD-10 Finland
Unspecified appendicitis
81.6
7.4
8
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
30.6
7.2
9
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.8
166
1146
54399
ICD-8 Finland
NA
+∞
6.3
6
*
K36
ICD-10 Finland
Other appendicitis
+∞
6.3
6
*
8480/3-C18.1
ICD-O-3
Mucinous adenocarcinoma of appendix
+∞
6.3
6
*
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
27.2
6.2
8
*

Mortality – FinRegistry

Association

Association between endpoint K11_OTHAPPEND and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHAPPEND 1.183 [0.87, 1.6] 0.277
Birth year 0.996 [0.99, 1.0] 0.385

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 525 females with K11_OTHAPPEND died.

Males

Parameter HR [95% CI] p-value
K11_OTHAPPEND 1.303 [0.91, 1.86] 0.142
Birth year 0.989 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 371 males with K11_OTHAPPEND died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHAPPEND.

N-year risk Females Males
1 0.09% 0.251%
5 0.711% 1.634%
10 1.591% 4.017%
15 3.205% 7.607%
20 6.275% 13.089%

Relationships between endpoints

Index endpoint: K11_OTHAPPEND – Other diseases of appendix

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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