Psoriasis

L12_PSORIASIS

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L40
Cause of death: ICD-10 L40

2 out of 7 registries used, show all original rules.

9729

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Check minimum number of events None

9729

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Remove individuals based on genotype QC

9267

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L12_PSORIASIS

Control definitions

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L40-L45
Name in latin Psoriasis

Summary Statistics

Key figures

All Female Male
Number of individuals 9267 4843 4424
Unadjusted prevalence (%) 2.46 2.30 2.66
Mean age at first event (years) 49.82 48.65 51.10

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.90 [1.49, 2.42] 2.4e-7 829
15 years 0.01 1.48 [1.22, 1.80] 7.8e-5 425
5 years 0.00 2.11 [1.72, 2.59] 1.2e-12 176
1 year 0.00 3.02 [2.19, 4.17] 1.8e-11 46

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_PSORIASIS – Psoriasis
GWS hits: 33

Survival analyses between endpoints

Plot

before Psoriasis
after Psoriasis

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