ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
5718 |
4. Check minimum number of eventsNone |
5718 |
5. Include endpointsNone |
5718 |
6. Filter based on genotype QC (FinnGen only) |
5718 |
Control definitions (FinnGen only)
- Control exclude
- K11_ENERCOLNONINF
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K51
- Name in latin
- Proctocolitis mucosalis
Similar endpoints
↥List of similar endpoints to
Mucosal proctocolitis
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30958 | 13651 | 17191 |
| Only index persons | 29989 | 13348 | 16641 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.44 | 0.39 | 0.48 |
| Only index persons | 0.57 | 0.49 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 41.81 | 41.20 | 42.30 |
| Only index persons | 41.49 | 41.03 | 41.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5718 | 2878 | 2840 |
| Unadjusted period prevalence (%) | 1.12 | 0.98 | 1.25 |
| Median age at first event (years) | 43.75 | 41.05 | 46.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 5150
- Matched controls
- 51498
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K51.5
ICD-10 Finland
Left sided colitis
4503599627370496.0
323.0
5149
5
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
8913.8
323.0
772
*
A07EA06
ATC
budesonide; oral, local oral
249.3
323.0
1905
121
H02AB06
ATC
prednisolone; systemic
11.0
323.0
4216
14980
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
41.1
323.0
671
187
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
323.0
537
*
UJF32
NOMESCO Finland
Coloscopy
28.8
323.0
4013
5624
K50.8
ICD-10 Finland
Other Crohn disease
+∞
323.0
593
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
14971.4
323.0
1927
*
L01BB02
ATC
mercaptopurine; oral
264.1
323.0
746
33
K50.1
ICD-10 Finland
Crohn disease of large intestine
6253.0
323.0
569
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.9
323.0
2510
7190
A07EC01
ATC
sulfasalazine; oral, rectal
9.4
323.0
1266
1730
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
5242.1
323.0
3074
15
K51
ICD-10 Finland
Ulcerative colitis
1049.6
323.0
874
10
UJF30
NOMESCO Finland
Ileoscopy through colon
25.3
323.0
2302
1595
ZX120
NOMESCO Finland
Intravenous
6.7
323.0
1074
1958
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
323.0
1215
*
A07EA02
ATC
hydrocortisone; rectal
425.6
323.0
1989
76
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
14.0
323.0
1434
1384
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
4663
*
A07EA01
ATC
prednisolone; rectal
623.6
323.0
404
7
D94
ICPC
Chronic enteritis/ulcerative colitis
379.2
323.0
422
12
K50.9
ICD-10 Finland
Crohn disease, unspecified
935.0
323.0
507
6
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
77.7
323.0
389
54
P01AB01
ATC
metronidazole; oral, rectal
3.2
323.0
2653
12724
H02AB07
ATC
prednisone; oral
8.1
323.0
1796
3204
J01MA02
ATC
ciprofloxacin; systemic
3.6
323.0
2596
11440
A07EC02
ATC
mesalazine; oral, rectal
2795.6
323.0
4682
184
L04AX01
ATC
azathioprine; systemic
115.5
323.0
2556
437
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
515.7
323.0
514
11
K51.8
ICD-10 Finland
Other ulcerative colitis
5551.9
323.0
1299
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
1966.4
323.0
349
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
1296.4
323.0
953
9
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
57.8
291.6
346
64
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
290.4
276
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
1483.5
288.0
278
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
365.3
278.9
279
8
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
278.7
265
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
274.2
1828
7416
K83.0
ICD-10 Finland
Cholangitis
29.1
260.3
358
132
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
241.6
230
*
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
236.3
225
*
4AA12
NOMESCO Finland
NA
184.2
220.0
229
13
A05AA02
ATC
ursodeoxycholic acid; oral
15.3
207.8
354
247
4AB02
NOMESCO Finland
NA
91.8
205.1
228
26
L04AB04
ATC
adalimumab; parenteral
12.8
203.9
376
315
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
201.2
1397
5602
WX002
NOMESCO Finland
Sedation and analgesia
3.1
193.8
1259
4803
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
49.6
187.1
228
48
A07EC03
ATC
olsalazine; oral
466.4
182.2
181
*
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
173.9
166
*
A02BC02
ATC
pantoprazole; systemic
2.3
169.2
3325
22835
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
167.1
1216
4941
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.3
165.9
275
178
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
165.6
2226
12714
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.5
152.5
484
952
L04AD01
ATC
ciclosporin; systemic
9.6
147.0
312
342
A06AC01
ATC
ispaghula (psylla seeds); oral
2.6
141.1
1274
5808
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
128.7
704
2302
UJF92
NOMESCO Finland
Capsular endoscopy
11.5
127.8
246
223
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.5
125.7
652
2044
Z93.2
ICD-10 Finland
Ileostomy status
72.3
123.2
141
20
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.6
119.0
366
688
JFH10
NOMESCO Finland
Total colectomy and ileostomy
77.1
118.9
135
18
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
7.7
117.4
284
385
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.4
116.0
450
1089
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
1143.4
115.1
112
*
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
107.7
103
*
4AA33
NOMESCO Finland
NA
+∞
106.6
102
*
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
105.6
101
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
36.2
103.4
134
38
3042
Kela drug reimbursment
NA
+∞
101.4
97
*
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
101.4
97
*
253
Kela drug reimbursment
NA
+∞
101.4
97
*
1370
FHL
Colonoscopy, whole colon
36.0
100.3
130
37
JFF10
NOMESCO Finland
Loop enterostomy
26.3
93.4
131
51
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.7
91.4
332
748
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
91.1
675
2674
A07DA03
ATC
loperamide; oral
5.7
90.7
274
502
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
6.3
89.4
249
411
3AC01
NOMESCO Finland
NA
11.4
88.8
171
155
3005
Kela drug reimbursment
Tofacitinib
49.6
88.2
107
22
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
9.3
87.8
189
211
C10AC01
ATC
colestyramine; oral
7.3
86.4
216
307
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.7
85.4
227
352
L04AC05
ATC
ustekinumab; parenteral
32.7
84.6
112
35
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
7.3
82.7
206
291
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
9.6
77.0
162
174
K92.1
ICD-10 Finland
Melaena
4.1
75.4
313
801
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
377.8
74.9
75
*
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
9.3
74.3
159
176
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.7
74.2
559
2219
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
74.1
71
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
73.9
719
3285
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
44.0
73.5
91
21
H02AB04
ATC
methylprednisolone; systemic
2.3
72.5
761
3609
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
72.4
692
3132
H02AB09
ATC
hydrocortisone; systemic
5.7
70.9
214
391
L04AA29
ATC
tofacitinib; oral
37.0
70.9
91
25
L04AB06
ATC
golimumab; parenteral
10.6
69.5
138
133
C05AA08
ATC
fluocortolone; rectal, topical
2.3
68.5
729
3471
A07AA09
ATC
vancomycin; oral
10.4
68.2
137
135
K50
ICD-10 Finland
Crohn disease [regional enteritis]
179.9
68.2
71
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
67.8
1757
11745
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.1
65.1
121
102
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
6.7
65.1
171
261
WVA20
NOMESCO Finland
Medicine administration
5.5
65.0
201
378
UJK12
NOMESCO Finland
Peroral cholangioscopy
37.9
64.2
82
22
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
+∞
63.7
61
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.8
63.6
187
331
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.5
62.5
539
2301
N02AX02
ATC
tramadol; systemic, rectal
1.7
62.1
1902
13272
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
61.6
59
*
JF1BD
NOMESCO Finland
Very extensive small bowel CT
28.4
61.5
84
30
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.5
61.2
304
905
N02BE01
ATC
paracetamol; systemic, rectal
1.8
60.7
4129
35795
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
60.7
1312
8216
R50.9
ICD-10 Finland
Fever, unspecified
2.2
60.7
732
3678
K56.7
ICD-10 Finland
Ileus, unspecified
8.7
59.9
133
157
UJK02
NOMESCO Finland
ERCP
5.7
59.0
177
321
WX402
NOMESCO Finland
General anaesthesia
2.0
56.2
870
4830
B01AB05
ATC
enoxaparin; parenteral
1.8
54.7
1278
8158
L04AA01
ATC
[U] ciclosporin; systemic
6.7
54.2
143
220
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
19.8
54.0
82
42
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
53.2
51
*
J01MA12
ATC
levofloxacin; systemic
1.9
52.2
821
4572
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
16.4
51.7
84
52
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
12.3
51.1
94
78
L04AA33
ATC
vedolizumab; parenteral
+∞
51.1
49
*
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
50.1
48
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
49.1
380
1520
A02BC01
ATC
omeprazole; systemic
1.7
48.6
1163
7433
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
23.7
47.5
68
29
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
46.8
972
5934
1490
FHL
Sigmoideoscopy (fiberscope)
55.6
46.5
55
10
A02BC03
ATC
lansoprazole; oral
1.7
46.2
1209
7915
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
45.0
329
1273
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
7.5
44.7
108
147
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
43.5
974
6076
UJG02
NOMESCO Finland
Proctoscopy
5.0
43.3
144
295
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.3
43.2
229
715
TJF80
NOMESCO Finland
Ostomy education
9.0
43.2
93
105
JHA00
NOMESCO Finland
Anal or perianal incision
5.6
42.1
127
233
UJF34
NOMESCO Finland
Left colonoscopy
12.2
42.0
77
64
M45
ICD-10 Finland
Ankylosing spondylitis
4.2
41.8
164
398
K60.3
ICD-10 Finland
Anal fistula
4.7
41.6
147
322
JFF13
NOMESCO Finland
Terminal enterostomy
28.3
41.2
56
20
K59.1
ICD-10 Finland
Functional diarrhoea
3.0
40.1
246
850
D11
ICPC
Diarrhoea
1.9
40.0
602
3274
K76.9
ICD-10 Finland
Liver disease, unspecified
6.1
39.3
110
184
6419
FHL
Other measure in this category
58.0
39.3
46
8
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.9
39.1
606
3327
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
38.6
37
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
3.3
38.5
206
649
Z93
ICD-10 Finland
Artificial opening status
23.1
38.3
55
24
JF2AB
NOMESCO Finland
Colongraphy with X-ray
19.5
38.3
58
30
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
19.9
37.8
57
29
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
37.6
276
1069
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
37.5
313
1304
M05BA04
ATC
alendronic acid; oral
2.7
37.1
267
1023
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
30.9
36.9
49
16
E0000UV
ATC
NA
1.5
36.9
1788
13493
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
36.0
785
4827
UJF02
NOMESCO Finland
Peroral enteroscopy
11.7
35.9
67
58
A02BC05
ATC
esomeprazole; systemic
1.5
35.9
1705
12788
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
35.7
390
1853
JFB00
NOMESCO Finland
Partial resection of small intestine
6.3
35.0
95
153
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
8.5
34.7
77
92
JAH00
NOMESCO Finland
Laparotomy
3.9
34.6
149
395
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.0
34.4
203
685
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.6
34.3
158
443
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
21.0
33.9
50
24
K61.0
ICD-10 Finland
Anal abscess
4.2
33.5
131
318
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
+∞
33.4
32
*
Z94.4
ICD-10 Finland
Liver transplant status
14.5
33.1
56
39
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.7
33.1
148
405
UJF30
SPAT
NA
10.4
33.0
65
63
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.0
32.8
135
344
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
319.0
31.9
32
*
D16
ICPC
Rectal bleeding
4.1
31.8
129
324
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
31.8
405
2054
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
+∞
31.3
30
*
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
+∞
31.3
30
*
J01DB01
ATC
cefalexin; oral
1.5
30.8
3943
35462
JJC00
NOMESCO Finland
Allogenic transplantation of liver
22.2
30.4
44
20
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
30.4
1698
13057
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
24.9
30.0
42
17
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
12.1
29.6
54
45
D07AC01
ATC
betamethasone; topical
1.5
29.3
1428
10659
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
28.8
467
2596
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.0
28.7
118
301
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.7
28.5
203
773
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
28.2
322
1560
A06AC51
ATC
ispaghula, combinations; systemic
2.6
28.0
217
865
JF1AD
NOMESCO Finland
Small bowel CT
11.1
28.0
53
48
E86
ICD-10 Finland
Volume depletion
4.0
27.9
114
289
D18
ICPC
Change in faeces/bowel movements
3.8
27.9
122
329
A03CA02
ATC
clidinium and psycholeptics; oral
2.5
27.8
227
935
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
28.6
27.5
37
13
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
27.3
2049
16552
K56.0
ICD-10 Finland
Paralytic ileus
7.6
27.2
64
85
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
27.2
332
1653
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
27.1
26
*
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
5.2
26.5
83
161
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
26.5
263
1194
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
26.1
302
1472
JHD00
NOMESCO Finland
Anal dilatation
6.9
25.9
65
95
R4110
NOMESCO Finland
Physiotherapy
1.5
25.9
1084
7805
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
73.0
25.8
29
*
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
5.3
25.7
80
154
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
25.3
602
3772
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
22.6
25.2
36
16
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
25.0
24
*
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
24.8
391
2145
UJH02
NOMESCO Finland
Anoscopy
2.5
24.4
195
792
WW200
NOMESCO Finland
Immunization
2.8
24.4
166
615
ZXC86
NOMESCO Finland
Use of endoscopic device
7.7
24.2
56
73
K74.3
ICD-10 Finland
Primary biliary cirrhosis
9.2
23.9
50
55
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.1
23.9
277
1352
6525
FHL
Enterostomy occlusion
87.1
23.7
26
*
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
13.9
23.5
40
29
D06BX01
ATC
metronidazole; topical
1.8
23.2
425
2453
B03BA03
ATC
hydroxocobalamin; parenteral
2.5
23.0
192
799
Z43.2
ICD-10 Finland
Attention to ileostomy
18.5
23.0
35
19
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
18.5
23.0
35
19
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
10.3
23.0
45
44
SPAT1262
SPAT
Handing over of treatment supplies
1.6
22.9
686
4560
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
230.9
22.6
23
*
K83.1
ICD-10 Finland
Obstruction of bile duct
5.3
22.6
69
131
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.6
22.5
66
119
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.8
22.4
150
551
1380
FHL
Colonoscopy, left side
45.2
22.3
27
6
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
5.5
22.1
66
122
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
7.9
21.9
50
64
R4190
NOMESCO Finland
Nutritional therapy
2.5
21.8
170
684
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
3.6
21.5
99
280
C05AA01
ATC
hydrocortisone; rectal, topical
2.3
21.4
197
863
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
13.3
21.4
37
28
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
4.1
21.3
84
208
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
21.3
788
5500
L88
ICD-10 Finland
Pyoderma gangrenosum
18.9
21.2
32
17
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.7
21.2
95
263
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
6.3
20.7
55
88
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
20.3
3917
42007
J01FA10
ATC
azithromycin; systemic
1.3
20.2
2740
23862
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
11.6
20.2
37
32
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
32.6
20.2
26
8
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
8.4
20.1
44
53
M13.9
ICD-10 Finland
Arthritis, unspecified
1.9
19.9
303
1643
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
11.7
19.7
36
31
JJ5AT
NOMESCO Finland
NA
29.0
19.6
26
9
A07AA02
ATC
nystatin; oral
2.1
19.6
222
1071
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
4.3
19.5
72
168
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.3
19.2
174
759
D07AD01
ATC
clobetasol; topical
1.6
18.8
594
3986
J05AB11
ATC
valaciclovir; oral
1.6
18.7
517
3357
A02BA02
ATC
ranitidine; systemic
1.5
18.7
657
4525
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
30.1
18.3
24
8
J02AC01
ATC
fluconazole; systemic
1.3
18.3
1609
13093
B01AB10
ATC
tinzaparin; parenteral
1.9
18.1
257
1360
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.8
18.1
120
441
UJD02
NOMESCO Finland
Gastroscopy
2.3
18.1
174
780
WX892
NOMESCO Finland
Monitored bed care
1.9
17.9
285
1571
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
4.8
17.9
59
123
SPAT1255
SPAT
Intravenous administration of medicine
2.0
17.8
246
1288
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
2.5
17.8
137
549
K62.4
ICD-10 Finland
Stenosis of anus and rectum
13.7
17.7
30
22
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
4.0
17.6
71
181
RD210
NOMESCO Finland
NA
3.0
17.5
103
351
E000001
ATC
NA
1.4
17.5
860
6338
R2110
NOMESCO Finland
Giving the first information
1.8
17.2
292
1643
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.9
17.2
271
1486
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
6.3
16.8
44
70
M25.5
ICD-10 Finland
Pain in joint
1.4
16.8
1165
9114
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
+∞
16.7
16
*
5563A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctosigmoiditis
+∞
16.7
16
*
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.3
16.6
159
711
JFA76
NOMESCO Finland
Closure of fistula of small intestine
170.5
16.5
17
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
7.9
16.5
37
47
A98
ICPC
Health maint/preventive medicine
1.7
16.5
4877
47104
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
18.5
16.0
24
13
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
16.0
264
1473
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.6
15.8
118
467
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
15.8
363
2245
ZX112
NOMESCO Finland
Subcutaneous
3.0
15.7
92
314
R01AD08
ATC
fluticasone; nasal
1.3
15.7
1226
9752
D07XC01
ATC
betamethasone, combinations; topical
1.6
15.7
450
2950
5589X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis, Other and unspecified non-infectious gastro-enteritis and colitis
+∞
15.6
15
*
6408
FHL
Colectomy and ileostomy
+∞
15.6
15
*
JGB61
NOMESCO Finland
Laparoscopic excision of rectum and ileoanal anastomosis
+∞
15.6
15
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
15.6
1376
11141
JHD20
NOMESCO Finland
Incision of fistula-in-ano
3.9
15.5
64
167
UJF32
SPAT
NA
3.2
15.5
80
250
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.8
15.4
101
370
D07AC13
ATC
mometasone; topical
1.3
15.4
1160
9170
A07AA11
ATC
rifaximin; oral
10.8
15.4
29
27
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
15.4
187
932
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
9.4
15.4
31
33
K75.4
ICD-10 Finland
Autoimmune hepatitis
14.8
15.3
25
17
B02.9
ICD-10 Finland
Zoster without complication
2.0
15.3
188
941
WW500
NOMESCO Finland
Blood transfusion
2.2
15.2
148
670
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
15.1
1107
8714
J05AB01
ATC
aciclovir; systemic
1.4
15.0
800
5970
S18
ICPC
Laceration/cut
1.3
15.0
1570
13012
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
14.9
662
4769
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.2
14.7
154
720
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
14.7
261
1494
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
14.6
14
*
4AC05
NOMESCO Finland
NA
+∞
14.6
14
*
6410
FHL
Panprococolectomy and ileostomy
+∞
14.6
14
*
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
4.4
14.6
52
119
J01FA06
ATC
roxithromycin; oral
1.3
14.5
1612
13451
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
14.5
1769
14943
D99
ICPC
Disease digestive system other
4.2
14.5
54
129
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
150.4
14.5
15
*
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
10.8
14.5
27
25
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
4.3
14.4
53
125
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
36.1
14.4
18
5
B81
ICPC
Anaemia vit B12/folate deficiency
2.4
14.4
117
486
Z98.8
ICD-10 Finland
Other specified postsurgical states
3.6
14.4
64
179
D01
ICPC
Abdominal pain/cramps general
1.6
14.2
423
2794
WZC30
NOMESCO Finland
Teaching
1.5
14.2
483
3293
Z71.8
ICD-10 Finland
Other specified counselling
1.3
14.1
1006
7872
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.3
14.1
131
580
Y0599
ICD-8 Finland
Investigation of digestive system
3.3
14.0
69
209
N05CF01
ATC
zopiclone; oral
1.3
13.9
1108
8817
K85
ICD-10 Finland
Acute pancreatitis
3.2
13.9
73
233
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
8.1
13.7
30
37
D07BC01
ATC
betamethasone and antiseptics; topical
1.5
13.7
447
3019
5550A
ICD-9 Finland
Regional enteritis, Small intestine
+∞
13.5
13
*
JFH31
NOMESCO Finland
Laparoscopic total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
13.5
13
*
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
13.5
13
*
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
10.9
13.5
25
23
L04AB02
ATC
infliximab; parenteral
140.3
13.4
14
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.2
13.4
133
610
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
13.1
336
2142
WX600
NOMESCO Finland
Single shot through catheter
2.5
12.9
103
422
K91.8
ICD-10 Finland
Other postprocedural disorders of digestive system, not elsewhere classified
28.4
12.9
17
6
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
12.9
323
2042
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
2.9
12.9
78
274
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
4.9
12.9
41
84
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
12.9
1346
11109
K52.1
ICD-10 Finland
Toxic gastroenteritis and colitis
50.1
12.8
15
*
WX110
NOMESCO Finland
Local anesthesy
1.2
12.7
3204
29314
WX419
NOMESCO Finland
Other general anesthesy
3.6
12.7
56
157
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.6
12.6
334
2145
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
8.2
12.5
27
33
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
6.6
12.5
31
47
Z90.4
ICD-10 Finland
Acquired absence of other parts of digestive tract
130.3
12.4
13
*
TQW40
NOMESCO Finland
Remowal of suture of skin
1.7
12.4
264
1595
B80
ICPC
Iron deficiency anaemia
2.8
12.4
81
297
D29
ICPC
Digestive symptom/complaint other
2.7
12.3
85
323
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
2.6
12.3
90
355
N03AX16
ATC
pregabalin; oral
1.3
12.2
837
6494
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
12.4
12.1
21
17
Z93.3
ICD-10 Finland
Colostomy status
4.5
12.0
41
91
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.0
12.0
159
824
R11
ICD-10 Finland
Nausea and vomiting
1.6
12.0
286
1787
JFA70
NOMESCO Finland
Suture of small intestine
7.5
11.9
27
36
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
2.7
11.8
78
290
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
6.6
11.7
29
44
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
11.7
586
4316
K61.1
ICD-10 Finland
Rectal abscess
6.3
11.6
30
48
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
11.6
623
4638
5604
FHL
Vascular preparation or cannulation in the operating room
7.7
11.6
26
34
JGB96
NOMESCO Finland
Other proctectomy or excision of rectum
18.9
11.6
17
9
J01CA04
ATC
amoxicillin; systemic
1.3
11.5
3847
36101
JGB60
NOMESCO Finland
Excision of rectum and ileoanal anastomosis
+∞
11.5
11
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.2
11.4
118
551
127
Kela drug reimbursment
Transplant complication
2.7
11.4
76
284
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
15.0
11.3
18
12
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
11.2
565
4162
L40.0
ICD-10 Finland
Psoriasis vulgaris
1.9
11.2
167
903
K60.4
ICD-10 Finland
Rectal fistula
8.9
11.2
23
26
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
11.2
2057
18070
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
5.1
11.2
34
67
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
7.6
11.1
25
33
D95
ICPC
Anal fissure/perianal abscess
4.0
11.0
43
109
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
2.8
11.0
69
249
JWW96
NOMESCO Finland
Other reoperation in gastroenterological surgery
10.0
11.0
21
21
-
ICD-10 Finland
NA
2.4
10.9
90
377
TDM10
NOMESCO Finland
Puncture of maxillary antrum
1.9
10.9
157
841
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
2.9
10.9
63
216
J45.9
ICD-10 Finland
Asthma, unspecified
1.4
10.8
610
4580
JF1DM
NOMESCO Finland
Very extensive MRI of small bowel (more than 1.5 T)
28.1
10.7
14
5
M01AH01
ATC
celecoxib; oral (coxibs)
1.4
10.6
581
4339
1CB02
NOMESCO Finland
NA
60.1
10.6
12
*
K90.0
ICD-10 Finland
Coeliac disease
2.1
10.5
112
533
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.4
10.5
492
3575
WX320
NOMESCO Finland
Spinalanesthesy
1.3
10.5
757
5915
M81.4
ICD-10 Finland
Drug-induced osteoporosis
6.5
10.5
26
40
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
3.3
10.4
51
157
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.6
10.3
266
1699
D07AB08
ATC
desonide; topical
1.5
10.3
397
2777
J01DA01
ATC
[U] cefalexin; systemic
1.2
10.3
2715
24674
H20.1
ICD-10 Finland
Chronic iridocyclitis
3.1
10.2
53
170
J01AA02
ATC
doxycycline; systemic
1.2
10.2
3319
30787
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
3.3
10.2
49
149
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
10.1
351
2404
R53
ICD-10 Finland
Malaise and fatigue
1.3
10.1
713
5551
E000002
ATC
NA
1.4
10.0
445
3201
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
2.4
10.0
79
327
M81.8
ICD-10 Finland
Other osteoporosis
5.1
10.0
30
59
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
1.9
10.0
133
695
JFG96
NOMESCO Finland
Other operation on intestinal stoma or pouch
40.1
10.0
12
*
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
2.0
9.9
121
607
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
9.9
845
6755
L52
ICD-10 Finland
Erythema nodosum
4.0
9.9
38
96
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
9.8
1538
13233
1280
FHL
Endoscopic retrograde cholangiography and pancreaticography
20.0
9.8
14
7
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
9.8
395
2793
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.1
9.7
109
531
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.6
9.7
281
1846
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
4.0
9.7
37
93
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.0
9.7
117
586
JJA20
NOMESCO Finland
Open biopsy of liver
7.4
9.7
22
30
R15
ICD-10 Finland
Faecal incontinence
2.5
9.7
73
295
SPAT1125
SPAT
Stoma care and guidance
3.3
9.7
46
139
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
7.8
9.6
21
27
JN1CM
NOMESCO Finland
Upper part of abdomen extensive MRI examination with 3 Tesla magnet
7.8
9.6
21
27
D02AX
ATC
Other emollients and protectives
2.0
9.6
117
591
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.8
9.6
173
999
R01AD12
ATC
fluticasone furoate; nasal
1.2
9.5
1275
10774
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
9.5
1118
9302
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
9.5
194
1163
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.0
9.5
112
558
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
1.7
9.5
175
1020
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
15.0
9.5
15
10
K83
ICD-10 Finland
Other diseases of biliary tract
100.2
9.4
10
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.7
9.4
179
1052
JD1AB
NOMESCO Finland
Gastro-duodenography with X-ray
17.5
9.4
14
8
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.6
9.4
253
1637
JFG53
NOMESCO Finland
Revision of ileal pelvic pouch
+∞
9.4
9
*
M075, K515
ICD-10 Finland
NA
+∞
9.4
9
*
R01AD09
ATC
mometasone; nasal
1.2
9.4
1908
16846
5781B
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[HAEMORRHAGIA EX ANO]
10.7
9.3
17
16
K85.8
ICD-10 Finland
Other acute pancreatitis
3.7
9.3
38
102
L04AA06
ATC
mycophenolic acid; systemic
2.4
9.2
76
320
B02
ICD-10 Finland
Zoster [herpes zoster]
2.0
9.2
112
566
RS224
NOMESCO Finland
NA
4.6
9.2
30
65
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
2.9
9.1
53
184
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
9.1
1110
9277
TGC00
NOMESCO Finland
Bronchial lavation
2.2
9.0
87
398
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
15.6
9.0
14
9
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.7
9.0
192
1168
E87.6
ICD-10 Finland
Hypokalaemia
2.2
9.0
89
413
E000003
ATC
NA
1.7
8.9
175
1040
JL5AM
NOMESCO Finland
Bile and pancreas ducts simple MRI examination with 3 Tesla magnet
18.6
8.9
13
7
K83.3
ICD-10 Finland
Fistula of bile duct
24.0
8.9
12
5
1470
FHL
Rectoscopy
4.3
8.8
31
73
A02BA03
ATC
famotidine; systemic
2.0
8.8
113
585
A41.9
ICD-10 Finland
Sepsis, unspecified
2.0
8.7
101
498
71240
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Spondylitis ankylopoietica
7.2
8.7
20
28
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
4.4
8.7
30
69
H26.3
ICD-10 Finland
Drug-induced cataract
4.2
8.7
31
74
J01MA14
ATC
moxifloxacin; systemic
1.5
8.6
298
2040
XJW99
NOMESCO Finland
Other investigative procedure on digestive system
5.2
8.6
25
48
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
8.6
430
3164
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
2.5
8.5
63
253
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
8.5
379
2731
RS221
NOMESCO Finland
NA
2.5
8.4
62
248
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
3.5
8.4
37
106
UKC02
NOMESCO Finland
Cystoscopy
1.4
8.4
445
3305
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.5
8.4
243
1602
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.3
8.3
566
4372
M05BB03
ATC
alendronic acid and colecalciferol; oral
2.7
8.3
53
194
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
8.3
449
3346
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
1.9
8.3
119
638
R03AC02
ATC
salbutamol; inhalant
1.2
8.3
2171
19558
A01AB09
ATC
miconazole; local oral
1.5
8.1
270
1834
A03BA03
ATC
hyoscyamine; oral
3.6
8.1
35
99
J01FA09
ATC
clarithromycin; systemic
1.2
8.1
1249
10687
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.8
8.1
140
801
JAG41
NOMESCO Finland
Repair of stomal hernia, laparoscopic
17.2
8.1
12
7
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
1.6
8.0
202
1285
W0X00
NOMESCO Finland
Estimation of continuous need for medical therapy
22.0
8.0
11
5
N02AA05
ATC
oxycodone; systemic
1.4
8.0
387
2831
A03
ICPC
Fever
1.3
8.0
665
5293
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
8.0
818
6683
7200A
ICD-9 Finland
Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis
5.9
8.0
21
36
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.9
7.9
44
150
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.4
7.9
477
3619
TKC20
NOMESCO Finland
Catheterisation of bladder
1.6
7.9
197
1252
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
2.3
7.8
67
289
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
1.7
7.8
145
848
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
3.3
7.8
37
113
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
1.7
7.8
150
887
JN4BD
NOMESCO Finland
Extensive body CT
1.4
7.8
323
2296
L04AA10
ATC
sirolimus; oral
45.0
7.7
9
*
K52.2
ICD-10 Finland
Allergic and dietetic gastroenteritis and colitis
15.0
7.7
12
8
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
3.0
7.7
42
142
JFA42
NOMESCO Finland
Endoscopic injection in colon
6.4
7.7
19
30
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.2
7.6
1209
10366
JG1JB
NOMESCO Finland
Defekography with X-ray
3.8
7.6
30
79
M79.6
ICD-10 Finland
Pain in limb
1.2
7.6
1296
11191
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
2.9
7.6
44
153
K52
ICD-10 Finland
Other noninfective gastroenteritis and colitis
8.0
7.6
16
20
SPAT1325
SPAT
Vaccination
1.2
7.6
1128
9610
K85.3
ICD-10 Finland
Drug-induced acute pancreatitis
25.0
7.6
10
*
N82.4
ICD-10 Finland
Other female intestinal-genital tract fistulae
25.0
7.6
10
*
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
5.1
7.5
22
43
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
7.5
277
1924
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
2.2
7.5
74
345
RS223
NOMESCO Finland
NA
5.7
7.5
20
35
ZXA00
NOMESCO Finland
Right side
1.2
7.5
866
7171
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
7.5
2980
27721
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.0
7.5
85
419
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
2.3
7.5
62
266
J01FA15
ATC
telithromycin; oral
1.4
7.4
368
2706
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
2.8
7.4
44
157
6611
FHL
Needle biopsy in the operating room
13.4
7.4
12
9
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.5
7.4
245
1667
6455
FHL
Perianal fistula surgery
5.3
7.4
21
40
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
6.0
7.4
19
32
J01MA01
ATC
ofloxacin; systemic
1.5
7.4
255
1750
R51.80
ICD-10 Finland
Headache
1.3
7.4
563
4425
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
2.7
7.4
47
173
5BA08
NOMESCO Finland
NA
4.0
7.4
27
67
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
1.8
7.3
111
610
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
8.4
7.3
15
18
4AA17
NOMESCO Finland
NA
+∞
7.3
7
*
JFH40
NOMESCO Finland
Proctocolectomy and continent ileostomy
+∞
7.3
7
*
56398
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Alia definita
+∞
7.3
7
*
5559X
ICD-9 Finland
Regional enteritis, Unspecified site
+∞
7.3
7
*
K52.8
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
+∞
7.3
7
*
5761A
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SUPPURATIVA]
+∞
7.3
7
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
+∞
7.3
7
*
R35
ICD-10 Finland
Polyuria
1.6
7.3
172
1081
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.2
7.3
854
7087
S97
ICPC
Chronic ulcer skin
1.7
7.2
150
908
H15.1
ICD-10 Finland
Episcleritis
2.4
7.2
57
237
K43.5
ICD-10 Finland
Parastomal hernia without obstruction or gangrene
15.7
7.2
11
7
XF600
NOMESCO Finland
Bloodpressure measurement
1.6
7.2
201
1312
TQW99
NOMESCO Finland
Other minor procedure on skin
1.7
7.2
136
803
JKA20
NOMESCO Finland
Cholecystectomy
2.2
7.2
71
330
ZX121
NOMESCO Finland
Central venous catheter
4.6
7.2
23
50
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
2.2
7.2
71
332
JFB96
NOMESCO Finland
Other partial excision of intestine
20.0
7.1
10
5
K63.3
ICD-10 Finland
Ulcer of intestine
12.0
7.1
12
10
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
5.3
7.1
20
38
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
8.8
7.0
14
16
JFA56
NOMESCO Finland
Faecal microbiota transplantation
10.0
7.0
13
13
K63.2
ICD-10 Finland
Fistula of intestine
10.0
7.0
13
13
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
3.3
7.0
32
96
R52.0
ICD-10 Finland
Acute pain
1.8
7.0
116
659
SPAT1131
SPAT
Colonoscopy
1.9
7.0
96
509
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.4
7.0
384
2874
WX610
NOMESCO Finland
Patient controlled analgesia
3.1
6.9
35
113
S29
ICPC
Skin symptom/complaint other
1.3
6.9
536
4222
S10
ICPC
Boil/carbuncle
1.6
6.9
187
1212
D07CC01
ATC
betamethasone and antibiotics; topical
1.3
6.9
444
3402
E000006
ATC
NA
1.5
6.9
226
1531
D50.8
ICD-10 Finland
Other iron deficiency anaemias
2.4
6.9
56
239
N05AH03
ATC
olanzapine; systemic
0.6
6.9
109
1768
WX400
NOMESCO Finland
Inhalation anesthesy
1.6
6.9
161
1010
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
2.3
6.8
61
272
NH3EA
NOMESCO Finland
Feet X-ray examination with load
2.0
6.8
76
374
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
4.4
6.8
23
53
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
5.0
6.8
20
40
K56.2
ICD-10 Finland
Volvulus
4.0
6.8
25
63
JF1CD
NOMESCO Finland
Extensive small bowel CT
40.1
6.8
8
*
J01AA04
ATC
lymecycline; systemic
1.3
6.7
520
4094
R05
ICPC
Cough
1.2
6.7
781
6470
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
2.6
6.7
47
184
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
6.7
2326
21321
JFH01
NOMESCO Finland
Laparoscopic colectomy with ileorectal anastomosis
22.5
6.7
9
*
M01AX17
ATC
nimesulide; oral
1.2
6.6
749
6185
A02BC04
ATC
rabeprazole; oral
1.4
6.6
281
2011
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
1.8
6.6
99
544
SPAT1153
SPAT
Removal of sutures
1.2
6.6
1070
9182
TAB24
NOMESCO Finland
Implantation of epidural injection gate
12.2
6.6
11
9
B01AA03
ATC
warfarin; systemic
1.3
6.6
461
3583
D62
ICPC
Digestive, Administrative procedure
4.0
6.6
24
60
L88
ICPC
Rheumatoid/seropositive arthritis
1.7
6.5
119
695
K29.8
ICD-10 Finland
Duodenitis
3.3
6.5
30
91
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
1.6
6.5
144
889
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
2.2
6.5
59
267
C07AA05
ATC
propranolol; systemic
1.2
6.4
720
5937
Z93.8
ICD-10 Finland
Other artificial opening status
69.9
6.4
7
*
A07EB01
ATC
cromoglicic acid; oral
14.3
6.4
10
7
A07AA12
ATC
fidaxomicin; oral
14.3
6.4
10
7
R05
ICD-10 Finland
Cough
1.3
6.4
630
5118
H25.1
ICD-10 Finland
Senile nuclear cataract
1.3
6.4
460
3587
R06AX27
ATC
desloratadine; oral
1.2
6.4
1114
9623
L73.8
ICD-10 Finland
Other specified follicular disorders
2.7
6.4
39
144
R06.0
ICD-10 Finland
Dyspnoea
1.2
6.3
753
6253
-44
ICPC
Preventive immunization/medic
1.4
6.3
238
1666
WD315
NOMESCO Finland
Multiple therapy of methastized malignancy with biomodifiers
6.5
6.3
15
23
A28
ICPC
Limited function/disability NOS
1.4
6.3
318
2347
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.3
2191
20052
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
6.2
6
*
M07.6
ICD-10 Finland
Other enteropathic arthropathies
+∞
6.2
6
*
JFG70
NOMESCO Finland
Conversion of continent ileostomy to conventional ileostomy
+∞
6.2
6
*
O996, K515
ICD-10 Finland
NA
+∞
6.2
6
*
6437
FHL
Rectum resection and sphincter-sparing through-anastomosis
+∞
6.2
6
*
A01AB04
ATC
amphotericin B; local oral
1.7
6.2
118
698
K60.2
ICD-10 Finland
Anal fissure, unspecified
2.1
6.2
64
303
JFA05
NOMESCO Finland
Endoscopic polypectomy in small intestine
26.7
6.2
8
*
N82.2
ICD-10 Finland
Fistula of vagina to small intestine
26.7
6.2
8
*
XQ848
NOMESCO Finland
Dermatological photography
1.9
6.2
80
417
Z01.2
ICD-10 Finland
Dental examination
1.2
6.2
1723
15483
JFK00
NOMESCO Finland
Division of adhesive band in intestinal obstruction
7.0
6.2
14
20
N82.3
ICD-10 Finland
Fistula of vagina to large intestine
7.0
6.2
14
20
SPAT1263
SPAT
Sampling
1.2
6.2
1660
14877
H04.10
ICD-10 Finland
Dry eye syndrome
1.4
6.2
302
2214
SFA00
NOMESCO Finland
Small filling
1.3
6.2
444
3460
N06AA09
ATC
amitriptyline; systemic
1.4
6.2
283
2056
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
1.8
6.1
103
589
L30.3
ICD-10 Finland
Infective dermatitis
1.7
6.1
110
642
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.2
6.1
789
6606
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
7.7
6.1
13
17
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.2
6.1
1017
8739
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
4.2
6.1
21
50
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
4.6
6.1
19
41
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.5
6.1
206
1412
R10.0
ICD-10 Finland
Acute abdomen
1.7
6.1
111
649
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.5
6.1
210
1444
D07AA02
ATC
hydrocortisone; topical
1.3
6.1
520
4154
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
8.6
6.0
12
14
K45.0
ICD-10 Finland
Other specified abdominal hernia with obstruction, without gangrene
8.6
6.0
12
14
6402
FHL
Small bowel resection
8.6
6.0
12
14
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
1.9
6.0
81
431
K63.9
ICD-10 Finland
Disease of intestine, unspecified
4.9
6.0
18
37
S21
ICPC
Skin texture symptom/complaint
1.3
6.0
378
2889
Mortality – FinRegistry
↥Association
Association between endpoint MUCOPROCT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MUCOPROCT | 1.349 [1.19, 1.53] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.093 |
During the follow-up period (1.1.1998 — 31.12.2019), 877 out of 12049 females with MUCOPROCT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MUCOPROCT | 1.159 [1.05, 1.28] | 0.004 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 1600 out of 15193 males with MUCOPROCT died.
Mortality risk
Mortality risk for people of age
years, who have MUCOPROCT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.238% |
| 5 | 0.73% | 1.521% |
| 10 | 1.83% | 3.939% |
| 15 | 3.382% | 7.108% |
| 20 | 6.115% | 11.594% |
Relationships between endpoints
↥Index endpoint: MUCOPROCT – Mucosal proctocolitis
GWS hits: 48
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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