Psoriasis (vulgaris), strict definition

PSORI_STRICT

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

L12_PSORI_VULG

6319

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes 319|377|134

1 out of 7 registries used, show all original rules.

748

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Check minimum number of events None

748

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Include endpoints None

748

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Remove individuals based on genotype QC

679

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PSORI_STRICT

Control definitions

Control exclude L12_PAPULOSQUAMOUS
Control conditions not L12_PSORI_VULG

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 679 254 425
Unadjusted prevalence (%) 0.18 0.12 0.26
Mean age at first event (years) 50.92 51.36 50.66

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.94 [1.76, 8.79] 8.2e-4 50
15 years 0.02 2.43 [1.30, 4.54] 5.4e-3 21
5 years 0.00 3.61 [1.83, 7.12] 2.1e-4 10
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: PSORI_STRICT – Psoriasis (vulgaris), strict definition
GWS hits: 3

Survival analyses between endpoints

Plot

before Psoriasis (vulgaris), strict definition
after Psoriasis (vulgaris), strict definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Psoriasis (vulgaris), strict definition

Not a core endpoint, no data to show.