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Psoriasis (vulgaris), strict definition

DOID EFO MESH SNOMED PheWeb

PSORI_STRICT

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Endpoint definition

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FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

L12_PSORI_VULG

6319

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes 319|377|134

1 out of 7 registries used, show all original rules.

748

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Check minimum number of events None

748

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Include endpoints None

748

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Remove individuals based on genotype QC

679

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PSORI_STRICT

Control definitions

Control exclude L12_PAPULOSQUAMOUS
Control conditions not L12_PSORI_VULG

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 679 254 425
Unadjusted prevalence (%) 0.18 0.12 0.26
Mean age at first event (years) 50.92 51.36 50.66

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.94 [1.76, 8.79] 8.2e-4 50
15 years 0.02 2.43 [1.30, 4.54] 5.4e-3 21
5 years 0.00 3.61 [1.83, 7.12] 2.1e-4 10
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: PSORI_STRICT – Psoriasis (vulgaris), strict definition
GWS hits: 3

Survival analyses between endpoints

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Plot

before Psoriasis (vulgaris), strict definition
after Psoriasis (vulgaris), strict definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Psoriasis (vulgaris), strict definition

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Not a core endpoint, no data to show.