Other/unspecified seropositive rheumatoid arthritis

RHEUMA_SEROPOS_OTH

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M05.8, M05.9
Hospital discharge: ICD-9 7140A
Cause of death: ICD-10 M05.8, M05.9
Cause of death: ICD-9 7140A

2 out of 7 registries used, show all original rules.

9916

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Check minimum number of events None

9916

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Include endpoints None

9916

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Remove individuals based on genotype QC

9139

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RHEUMA_SEROPOS_OTH

Control definitions

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 9139 6262 2877
Unadjusted prevalence (%) 2.42 2.97 1.73
Mean age at first event (years) 54.39 52.59 58.31

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.65 [2.14, 3.29] 1.1e-18 1209
15 years 0.01 1.91 [1.63, 2.24] 1.2e-15 595
5 years 0.00 2.43 [2.07, 2.85] 6.9e-28 267
1 year 0.00 3.32 [2.55, 4.33] 7.3e-19 70

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: RHEUMA_SEROPOS_OTH – Other/unspecified seropositive rheumatoid arthritis
GWS hits: 30

Survival analyses between endpoints

Plot

before Other/unspecified seropositive rheumatoid arthritis
after Other/unspecified seropositive rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other/unspecified seropositive rheumatoid arthritis

Not a core endpoint, no data to show.