Type 2 diabetes, definitions combined

T2D

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

not E4_DM1

402463

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

64935

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Remove individuals based on genotype QC

57698

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T2D

Control definitions

Control exclude DIABETES_FG
Control conditions not E4_DM1

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 57698 25433 32265
Unadjusted prevalence (%) 15.30 12.06 19.40
Mean age at first event (years) 60.06 58.82 61.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.36 [2.15, 2.59] 1.1e-71 9934
15 years 0.01 1.67 [1.54, 1.81] 3.4e-36 5117
5 years 0.00 2.38 [2.21, 2.56] <1e-100 2406
1 year 0.00 4.47 [4.00, 4.99] <1e-100 845

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T2D – Type 2 diabetes, definitions combined
GWS hits: 221

Survival analyses between endpoints

Plot

before Type 2 diabetes, definitions combined
after Type 2 diabetes, definitions combined

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Drugs most likely to be purchased after Type 2 diabetes, definitions combined