Acute appendicitis, with complications

APPENDACUT_COMPLIC

appendicitis: Acute inflammation of the vermiform appendix.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 K35.0, K35.1
Hospital discharge: ICD-9 540[0-1]
Hospital discharge: ICD-8 540
Hospital discharge: excluded ICD-8 54090|54099
Cause of death: ICD-10 K35.0, K35.1
Cause of death: ICD-9 540[0-1]
Cause of death: ICD-8 540
Cause of death: excluded ICD-8 54090|54099

9423

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5560

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Check minimum number of events None

5560

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Include endpoints None

5560

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APPENDACUT_COMPLIC

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 5409 2586 2823
Unadjusted prevalence (%) 1.75 1.49 2.09
Mean age at first event (years) 35.94 33.92 37.80

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.41 [1.09, 1.82] 7.8e-3 484
15 years 0.01 0.99 [0.79, 1.25] 9.5e-1 220
5 years 0.00 1.42 [1.08, 1.85] 1.1e-2 80
1 year 0.00 2.50 [1.64, 3.80] 1.9e-5 26

Correlations

Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications
GWS hits: 1

Survival analyses between endpoints

Plot

before Acute appendicitis, with complications
after Acute appendicitis, with complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acute appendicitis, with complications