Acute appendicitis, with complications

APPENDACUT_COMPLIC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K35.0, K35.1
  • Hospital discharge: ICD-9 540[0-1]
  • Hospital discharge: ICD-8 540
  • Hospital discharge: excluded ICD-8 54090|54099
  • Cause of death: ICD-10 K35.0, K35.1
  • Cause of death: ICD-9 540[0-1]
  • Cause of death: ICD-8 540
  • Cause of death: excluded ICD-8 54090|54099

2 out of 7 registries used, show all original rules.

8367

4. Check minimum number of events

None

8367

5. Include endpoints

None

8367

6. Filter based on genotype QC (FinnGen only)

8104

Control definitions (FinnGen only)

Control exclude
K11_APPENDIX

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 84045 36878 46560
Only index persons 72602 32822 39780
Unadjusted period prevalence (%)
Whole population 1.19 1.06 1.30
Only index persons 1.38 1.21 1.52
Median age at first event (years)
Whole population 33.29 33.34 32.99
Only index persons 30.31 30.74 29.95

-FinnGen-

Key figures

All Female Male
Number of individuals 8104 3893 4211
Unadjusted period prevalence (%) 1.83 1.53 2.11
Median age at first event (years) 33.63 30.79 36.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
8367
Matched controls
83666
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
54000
ICD-8 Finland
Acute appendicitis, Perforans
+∞
323.0
611
*
JEA00
NOMESCO Finland
Appendectomy
28.5
323.0
1723
754
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
526.0
323.0
1521
35
6421
FHL
Appendicectomy
19.7
323.0
1227
724
5401A
ICD-9 Finland
Acute appendicitis, With peritoneal abscess
+∞
323.0
426
*
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
16384.0
323.0
1597
*
K35.0
ICD-10 Finland
Acute appendicitis with generalized peritonitis
13334.6
323.0
2050
*
54001
ICD-8 Finland
Acute appendicitis, Cum peritonitide diffusa
+∞
323.0
421
*
54003
ICD-8 Finland
Acute appendicitis, Cum abscessu
+∞
323.0
412
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
75.4
323.0
1275
199
54002
ICD-8 Finland
Acute appendicitis, Cum peritonitide circumscripta
+∞
323.0
329
*
5400B
ICD-9 Finland
Acute appendicitis, With generalised peritonitis[APPENDICITIS ACUTA CUM PERITONITIDE CIRCUMSCRIPTA]
+∞
323.0
477
*
54091
ICD-8 Finland
Acute appendicitis, Gangraenosa, peritonitide non indicata
+∞
323.0
1841
*
5400A
ICD-9 Finland
Acute appendicitis, With generalised peritonitis[APPENDICITIS ACUTA CUM PERITONITIDE DIFFUSA]
+∞
319.8
305
*
ZXD05
NOMESCO Finland
Urgent procedure
2.3
234.6
2908
15663
P01AB01
ATC
metronidazole; oral, rectal
2.0
182.5
3415
21383
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
160.0
1113
4237
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
113.1
2745
17984
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
78.0
2080
13692
K36
ICD-10 Finland
Other appendicitis
694.1
70.2
69
*
K37
ICD-10 Finland
Unspecified appendicitis
39.1
70.1
89
23
54099
ICD-8 Finland
Acute appendicitis, Without mention of peritonitis
+∞
67.8
65
*
D88
ICPC
Appendicitis
304.6
59.4
60
*
5409X
ICD-9 Finland
Acute appendicitis, Without mention of peritonitis
+∞
54.2
52
*
R10.0
ICD-10 Finland
Acute abdomen
3.1
45.4
266
885
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
45.3
1397
9363
K35
ICD-10 Finland
Acute appendicitis
22.9
39.6
57
25
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
38.3
541
2838
JFB20
NOMESCO Finland
Ileocaecal resection
8.2
37.2
84
103
JAH01
NOMESCO Finland
Laparoscopy
2.3
34.8
335
1489
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
34.5
2500
19793
99850
ICD-8 Finland
Other complications of surgical procedures, Postoperative wound infection
7.2
33.6
83
117
JAH00
NOMESCO Finland
Laparotomy
2.8
33.0
217
780
J01DB01
ATC
cefalexin; oral
1.4
32.7
6201
56707
54009
ICD-8 Finland
NA
+∞
30.2
29
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
27.2
866
5794
J01MA12
ATC
levofloxacin; systemic
1.4
26.2
1234
8976
ZXE00
NOMESCO Finland
One hour or less
1.3
24.5
2631
21838
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.0
23.5
305
1547
54200
ICD-8 Finland
Other appendicitis, Appendicitis chronica
+∞
21.9
21
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
8.7
21.0
45
52
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
20.2
671
4523
54208
ICD-8 Finland
Other appendicitis
+∞
18.8
18
*
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
10.0
17.8
35
35
JFB30
NOMESCO Finland
Right hemicolectomy
2.9
17.6
108
377
JEA10
NOMESCO Finland
Appendectomy with drainage
42.1
17.3
21
5
54199
ICD-8 Finland
Appendicitis, unqualified
+∞
16.7
16
*
J01MA02
ATC
ciprofloxacin; systemic
1.2
15.0
2522
21780
K65.0
ICD-10 Finland
Acute peritonitis
2.9
14.6
86
294
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.7
14.2
271
1580
N02BE01
ATC
paracetamol; systemic, rectal
1.2
13.7
6306
59783
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
3.4
13.2
63
187
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
13.0
1276
10327
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
3.0
13.0
73
244
J01DA01
ATC
[U] cefalexin; systemic
1.2
12.8
4409
40541
UJF32
NOMESCO Finland
Coloscopy
1.2
12.1
1544
12888
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
11.7
2728
24179
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.5
10.9
419
2918
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
2.2
10.6
108
501
JEW96
NOMESCO Finland
Other operation on appendix
+∞
10.4
10
*
5420A
ICD-9 Finland
Other appendicitis[APPENDICITIS CHRONICA]
+∞
10.4
10
*
Z3226
NOMESCO Finland
Physiotherapist
1.3
9.8
1074
8795
8140/3-C18.1
ICD-O-3
Adenocarcinoma, NOS, of appendix
30.0
9.4
12
*
5410X
ICD-9 Finland
Appendicitis, unqualified[APPENDICITIS NUD]
+∞
9.4
9
*
5428X
ICD-9 Finland
Other appendicitis[APPENDICITIS ALIA DEFINITA]
+∞
9.4
9
*
54308
ICD-8 Finland
Other diseases of appendix, Alii definiti
+∞
9.4
9
*
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
4.3
9.1
32
75
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.2
9.0
1186
9915
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
2.3
8.8
76
328
WX110
NOMESCO Finland
Local anesthesy
1.1
8.6
4732
44468
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
6.2
8.3
21
34
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
1.7
8.2
167
1000
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
2.4
8.1
64
266
6429
FHL
Other measure in this category
33.4
8.1
10
*
B01AB05
ATC
enoxaparin; parenteral
1.2
7.9
1781
15632
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
2.1
7.8
85
411
6565
FHL
Sewerage the other way
80.2
7.4
8
*
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
2.0
7.4
89
450
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.2
7.3
898
7442
54090
ICD-8 Finland
Acute appendicitis, Phlegmonosa, peritonitide non indicata
+∞
7.3
7
*
K56.7
ICD-10 Finland
Ileus, unspecified
2.0
7.0
84
422
D06
ICPC
Abdominal pain localized other
1.4
7.0
391
2917
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
1.7
7.0
146
887
F20.9
ICD-10 Finland
Schizophrenia, unspecified
1.8
6.9
119
682
JAK00
NOMESCO Finland
Laparotomy and drainage of peritoneal cavity
5.3
6.7
19
36
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
4.5
6.7
22
49
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
3.7
6.6
27
74
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
2.2
6.6
60
270
8240/3-C18.2
ICD-O-3
Neuroendocrine tumor, NOS, of ascending colon
8.7
6.5
13
15
WX402
NOMESCO Finland
General anaesthesia
1.2
6.5
925
7784
JAD10
NOMESCO Finland
Repair of incisional hernia
2.5
6.5
49
200
S18
ICPC
Laceration/cut
1.1
6.3
2528
23098
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.2
6.3
891
7494
K50.0
ICD-10 Finland
Crohn disease of small intestine
2.0
6.3
77
395
R4110
NOMESCO Finland
Physiotherapy
1.2
6.3
1550
13684
54093
ICD-8 Finland
NA
+∞
6.2
6
*
K38.8
ICD-10 Finland
Other specified diseases of appendix
+∞
6.2
6
*
J01FF01
ATC
clindamycin; systemic
1.2
6.2
1646
14604
SPAT1153
SPAT
Removal of sutures
1.1
6.2
1866
16715
N05AH02
ATC
clozapine; systemic
1.8
6.1
105
603
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
2.0
6.1
75
385
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
10.0
6.0
11
11

Mortality – FinRegistry

Association

Association between endpoint APPENDACUT_COMPLIC and mortality.

Females

Parameter HR [95% CI] p-value
APPENDACUT_COMPLIC 1.249 [1.12, 1.4] < 0.001
Birth year 0.992 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 1325 out of 13079 females with APPENDACUT_COMPLIC died.

Males

Parameter HR [95% CI] p-value
APPENDACUT_COMPLIC 1.119 [1.01, 1.25] 0.04
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1714 out of 14440 males with APPENDACUT_COMPLIC died.

Mortality risk

Mortality risk for people of age

years, who have APPENDACUT_COMPLIC.

N-year risk Females Males
1 0.088% 0.216%
5 0.567% 1.277%
10 1.541% 3.117%
15 2.994% 5.806%
20 5.332% 10.039%

Relationships between endpoints

Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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