Atopic dermatitis, strict definition with reimbursement

ATOPIC_STRICT_REIMB

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

KELA reimbursements: KELA codes 134|395|317

1479

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Check pre-conditions, main-only, mode, ICD version None

1479

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Check minimum number of events None

1479

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Include endpoints

8540

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ATOPIC_STRICT_REIMB

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 8281 5719 2562
Unadjusted prevalence (%) 2.68 3.30 1.90
Mean age at first event (years) 27.31 27.29 27.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.83 [1.29, 2.60] 7.7e-4 191
15 years 0.01 1.30 [0.93, 1.81] 1.3e-1 92
5 years 0.00 2.05 [1.38, 3.04] 3.5e-4 37
1 year 0.00 4.01 [2.23, 7.21] 3.6e-6 13

Correlations

Index endpoint: ATOPIC_STRICT_REIMB – Atopic dermatitis, strict definition with reimbursement
GWS hits: 27

Survival analyses between endpoints

Plot

before Atopic dermatitis, strict definition with reimbursement
after Atopic dermatitis, strict definition with reimbursement

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Drugs most likely to be purchased after Atopic dermatitis, strict definition with reimbursement