lactic acidosis: Metabolic disease characterized by the accumulation of lactate in the body. It is caused by tissue hypoxia
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
688 |
4. Check minimum number of eventsNone |
688 |
5. Include endpointsNone |
688 |
6. Filter based on genotype QC (FinnGen only) |
688 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Acidosis
Similar endpoints
↥List of similar endpoints to
Acidosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5856 | 2122 | 3700 |
| Only index persons | 5240 | 1915 | 3325 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.06 | 0.10 |
| Only index persons | 0.11 | 0.07 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 65.37 | 68.63 | 63.47 |
| Only index persons | 65.67 | 68.69 | 63.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 688 | 240 | 448 |
| Unadjusted period prevalence (%) | 0.16 | 0.08 | 0.20 |
| Median age at first event (years) | 64.91 | 63.72 | 65.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 610
- Matched controls
- 6100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.2
ICD-10 Finland
Acidosis
+∞
323.0
607
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
45.0
156.2
193
62
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
8.8
125.9
356
838
103
Kela drug reimbursment
Diabetes, insulin-treated
8.0
119.5
378
1031
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
9.1
113.4
288
547
A10BA02
ATC
metformin; oral
7.3
110.0
375
1095
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.0
101.9
335
901
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
13.3
97.5
183
190
T90
ICPC
Diabetes non-insulin dependent
6.4
90.9
312
853
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
10.5
89.8
193
258
A10AE04
ATC
insulin glargine; parenteral
9.7
83.8
188
268
E86
ICD-10 Finland
Volume depletion
236.3
81.5
82
*
A10BH01
ATC
sitagliptin; oral
8.4
78.3
193
318
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
155.3
78.1
81
6
C03CA01
ATC
furosemide; systemic
5.2
75.8
324
1084
E87.5
ICD-10 Finland
Hyperkalaemia
140.0
70.6
74
6
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
9.8
66.4
144
186
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.6
60.1
206
508
A10BB12
ATC
glimepiride; oral
7.7
55.1
139
225
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
9.8
55.1
118
146
C07AB07
ATC
bisoprolol; oral
3.8
52.2
398
2026
F10.25
ICD-10 Finland
Alcohol dependence continuous use
20.5
52.2
79
44
AA1AD
NOMESCO Finland
CT of head and brain
4.2
51.3
251
871
TK800
NOMESCO Finland
Hemodialysis
18.6
51.2
80
49
E87.6
ICD-10 Finland
Hypokalaemia
33.9
49.1
64
21
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.3
48.5
168
406
I10
ICD-10 Finland
Essential (primary) hypertension
3.7
46.6
453
2683
SPAT1262
SPAT
Handing over of treatment supplies
4.2
45.0
205
650
N17.8
ICD-10 Finland
Other acute renal failure
43.0
44.6
55
14
A10AE05
ATC
insulin detemir; parenteral
9.3
44.4
97
122
TPH07
NOMESCO Finland
Cathetrisation of artery
5.3
41.3
139
319
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.4
41.1
95
131
205
Kela drug reimbursment
Chronic hypertension
3.4
40.8
274
1180
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
39.9
353
1845
A10BH05
ATC
linagliptin; oral
8.7
38.7
87
114
T36
ICD-10 Finland
Poisoning by systemic antibiotics
10.1
38.0
78
87
JN3AD
NOMESCO Finland
Abdominal CT examination
5.9
37.0
111
220
N18.8
ICD-10 Finland
Other chronic renal failure
13.1
36.3
65
55
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
6.4
35.9
101
184
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
11.3
35.9
69
68
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
11.0
35.8
70
71
I50.9
ICD-10 Finland
Heart failure, unspecified
4.3
35.6
151
435
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.9
35.4
173
566
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.6
34.6
135
358
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
34.1
239
1029
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
34.1
128
326
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
25.3
33.7
47
20
F10.09
ICD-10 Finland
Alcohol intoxication UNS
13.5
33.5
59
48
R11
ICD-10 Finland
Nausea and vomiting
6.2
33.4
95
175
WX872
NOMESCO Finland
Intensive care
7.1
32.8
84
134
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
32.5
216
890
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.0
32.2
253
1167
N07BB01
ATC
disulfiram; oral
7.4
32.2
80
122
N05AH04
ATC
quetiapine; oral
4.0
32.0
148
457
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.3
31.9
90
164
N19
ICD-10 Finland
Unspecified kidney failure
10.5
31.7
63
66
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
11.0
31.4
61
61
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
4.4
30.8
125
341
A41.9
ICD-10 Finland
Sepsis, unspecified
8.6
30.4
68
88
C08CA01
ATC
amlodipine; oral
2.8
30.0
288
1492
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
13.8
29.4
51
40
M04AA01
ATC
allopurinol; systemic
3.7
29.1
146
480
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.6
28.9
149
500
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.9
28.9
234
1083
ZXD05
NOMESCO Finland
Urgent procedure
2.8
28.3
248
1201
F10.24
ICD-10 Finland
Alcohol depence active use
16.7
28.1
45
29
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
17.5
28.0
44
27
TK810
NOMESCO Finland
Hemofiltration
37.0
27.7
35
10
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
12.0
27.6
51
46
C03DA01
ATC
spironolactone; oral
4.2
27.4
114
316
A28
ICPC
Limited function/disability NOS
3.4
26.9
147
514
R53
ICD-10 Finland
Malaise and fatigue
3.1
26.4
170
667
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
14.2
26.4
45
34
N06AX11
ATC
mirtazapine; oral
2.7
26.4
232
1117
D64.9
ICD-10 Finland
Anaemia, unspecified
4.0
25.9
114
332
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.1
25.9
86
189
C10AA01
ATC
simvastatin; oral
2.5
25.7
316
1828
TKC20
NOMESCO Finland
Catheterisation of bladder
4.7
25.4
92
222
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
13.5
25.3
44
35
WX892
NOMESCO Finland
Monitored bed care
4.5
25.0
95
241
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.7
24.6
44
37
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.2
23.7
66
117
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
20.6
23.7
35
18
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.1
23.4
98
272
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.0
23.2
100
285
WX730
NOMESCO Finland
Conventional respirator
12.8
23.1
41
34
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.5
22.9
61
102
I50.0
ICD-10 Finland
Congestive heart failure
4.8
22.9
81
190
A10BK03
ATC
empagliflozin; oral
4.7
22.9
82
195
P15
ICPC
Chronic alcohol abuse
7.6
22.7
54
77
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
22.2
78
182
L28
ICPC
Limited function/disability (L)
3.1
22.1
138
523
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
10.9
21.4
41
40
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.5
20.9
108
356
T89
ICPC
Diabetes insulin dependent
7.9
20.8
48
65
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
43.3
20.6
25
6
G72.8
ICD-10 Finland
Other specified myopathies
12.2
20.5
37
32
F10.20
ICD-10 Finland
Alcohol dependence currently independent
9.2
20.5
43
50
WX882
NOMESCO Finland
High dependency care
7.7
20.4
48
67
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.6
20.4
174
799
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
20.2
170
774
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
16.0
19.9
32
21
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.0
19.9
66
144
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
19.9
85
239
K92.0
ICD-10 Finland
Haematemesis
8.6
19.8
43
53
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
19.6
219
1161
N05BA01
ATC
diazepam; systemic, rectal
3.1
19.6
118
435
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
12.3
19.5
35
30
C09AA05
ATC
ramipril; oral
2.4
19.5
200
1014
N05CF01
ATC
zopiclone; oral
2.3
19.4
230
1251
XCK10
NOMESCO Finland
Photography of fundus of eye
3.5
19.1
97
315
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
6.3
18.9
51
87
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
9.6
18.6
38
42
P16
ICPC
Acute alcohol abuse
10.9
18.4
35
34
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
26.0
18.3
25
10
A02BC02
ATC
pantoprazole; systemic
2.2
18.3
410
2952
A06AD11
ATC
lactulose; oral
2.9
18.2
121
473
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
12.4
18.0
32
27
SPAT1254
SPAT
Administration of medicine
2.9
17.9
124
500
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.8
17.7
45
71
M10.9
ICD-10 Finland
Gout, unspecified
4.0
17.7
74
204
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
16.2
17.6
28
18
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.0
17.5
57
122
A46
ICD-10 Finland
Erysipelas
2.8
17.4
121
488
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
17.4
162
774
C09AA02
ATC
enalapril; systemic
2.5
17.2
159
755
K29.2
ICD-10 Finland
Alcoholic gastritis
51.6
17.1
20
*
JAH00
NOMESCO Finland
Laparotomy
6.6
17.0
44
71
Z49.1
ICD-10 Finland
Extracorporeal dialysis
11.6
16.9
31
28
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
16.9
183
942
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.5
16.8
50
97
N05BA04
ATC
oxazepam; oral
2.4
16.7
168
833
A10AE06
ATC
insulin degludec; parenteral
7.9
16.7
38
51
ZX120
NOMESCO Finland
Intravenous
3.4
16.7
85
276
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.9
16.5
55
121
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.4
16.5
36
45
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
16.4
139
626
A10BJ06
ATC
semaglutide; parenteral
6.6
16.2
42
68
R06.0
ICD-10 Finland
Dyspnoea
2.3
15.9
173
887
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
17.8
15.7
24
14
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
17.8
15.7
24
14
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.7
15.6
122
523
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
14.2
15.6
26
19
E66.00
ICD-10 Finland
Metabolic syndrome
4.8
15.6
53
119
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
15.5
117
494
J96.0
ICD-10 Finland
Acute respiratory failure
11.7
15.4
28
25
A11CC03
ATC
alfacalcidol; systemic
7.8
15.4
35
47
A10BG03
ATC
pioglitazone; oral
7.1
15.2
37
55
N05BA02
ATC
chlordiazepoxide; systemic
6.0
14.9
41
72
C10AA05
ATC
atorvastatin; oral
2.0
14.8
255
1593
A12BA01
ATC
potassium chloride; oral
4.7
14.7
51
117
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
8.4
14.7
32
40
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.2
14.5
82
286
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
8.5
14.4
31
38
A10BD07
ATC
metformin and sitagliptin; systemic
4.5
14.3
51
121
N05AH03
ATC
olanzapine; systemic
4.3
14.2
53
131
B03XA02
ATC
darbepoetin alfa; parenteral
8.3
14.2
31
39
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
7.5
14.2
33
46
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.4
14.2
37
61
K70.1
ICD-10 Finland
Alcoholic hepatitis
14.9
14.2
23
16
N05CD07
ATC
temazepam; oral
2.7
14.2
105
435
B03BA03
ATC
hydroxocobalamin; parenteral
3.7
14.0
62
179
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.6
13.8
64
192
N05AA02
ATC
levomepromazine; systemic
4.7
13.8
47
106
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
7.2
13.8
33
48
N06AX16
ATC
venlafaxine; oral
2.9
13.7
87
329
N02AA05
ATC
oxycodone; systemic
2.5
13.5
116
523
E66.01
ICD-10 Finland
Obesity due to excess calories
3.9
13.5
56
153
N06AB10
ATC
escitalopram; oral
2.5
13.5
120
550
K70.4
ICD-10 Finland
Alcoholic hepatic failure
26.4
13.4
18
7
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.4
13.4
40
78
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
6.1
13.4
36
62
SPAT1229
SPAT
Assessment of need for aid
3.3
13.1
69
229
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
13.1
99
414
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
17.2
13.1
20
12
N02AX02
ATC
tramadol; systemic, rectal
1.9
13.0
269
1773
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.8
13.0
32
49
A04
ICPC
Weakness/tiredness general
2.8
12.7
86
338
S06.0
ICD-10 Finland
Concussion
3.0
12.6
77
283
S97
ICPC
Chronic ulcer skin
3.8
12.6
54
152
E83.51
ICD-10 Finland
Hypocalcemia
+∞
12.5
12
*
C07AB02
ATC
metoprolol; systemic
2.2
12.5
148
779
B01AC04
ATC
clopidogrel; oral
2.5
12.5
109
492
177
Kela drug reimbursment
Insulin glargine 300 U / ml
8.7
12.4
26
31
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
9.9
12.3
24
25
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
12.3
127
628
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
12.3
64
211
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
12.2
73
262
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
8.0
12.2
27
35
N06AB04
ATC
citalopram; systemic
2.2
12.2
138
711
UJF32
NOMESCO Finland
Coloscopy
2.1
12.2
175
997
C02AC05
ATC
moxonidine; oral
4.4
12.1
44
107
R33
ICD-10 Finland
Retention of urine
3.0
12.0
73
267
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
12.0
122
597
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
7.3
11.9
28
40
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.5
11.8
55
166
A10BB01
ATC
glibenclamide; oral
4.0
11.7
47
125
B01AA03
ATC
warfarin; systemic
2.1
11.7
155
853
AN1
HP
Coronary angiography
2.6
11.7
91
386
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
5.9
11.6
32
57
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.0
11.6
70
254
R40.2
ICD-10 Finland
Coma, unspecified
14.0
11.5
19
14
JN4AD
NOMESCO Finland
Body CT examination
3.0
11.4
69
251
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
12.1
11.4
20
17
I50.1
ICD-10 Finland
Left ventricular failure
4.5
11.4
40
94
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.6
11.3
39
90
TQW11
NOMESCO Finland
Vacuum treatment of wound
7.0
11.3
27
40
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
11.2
116
572
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.2
11.1
123
625
A10BJ02
ATC
liraglutide; parenteral
5.9
11.0
30
53
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.1
11.0
34
70
J01DB01
ATC
cefalexin; oral
2.0
10.9
488
4089
K70.0
ICD-10 Finland
Alcoholic fatty liver
10.8
10.8
20
19
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.4
10.8
38
90
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
28.6
10.8
14
5
Z3231
NOMESCO Finland
Registered nurse
1.9
10.7
184
1115
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.7
10.7
30
55
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
10.6
83
355
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.1
10.6
142
783
N05AX08
ATC
risperidone; systemic
3.1
10.6
60
210
F05.9
ICD-10 Finland
Delirium, unspecified
6.1
10.5
28
48
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.5
10.5
84
360
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
10.5
145
807
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
10.5
204
1290
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
7.0
10.5
25
37
J01MA12
ATC
levofloxacin; systemic
2.1
10.5
130
691
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.9
10.4
33
70
S01.0
ICD-10 Finland
Open wound of scalp
2.8
10.3
68
263
N03AG01
ATC
valproic acid; systemic, rectal
3.4
10.3
50
157
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
7.7
10.3
23
31
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
4.0
10.2
40
105
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
10.2
130
698
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
10.1
108
536
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.2
10.1
53
176
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.7
10.1
21
25
J01MA02
ATC
ciprofloxacin; systemic
1.8
10.1
242
1640
J01FF01
ATC
clindamycin; systemic
1.9
10.1
165
979
K56.7
ICD-10 Finland
Ileus, unspecified
7.4
10.1
23
32
K85
ICD-10 Finland
Acute pancreatitis
7.4
10.1
23
32
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.1
10.0
38
97
D10
ICPC
Vomiting
3.9
9.9
40
108
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.0
9.9
39
103
C09CA01
ATC
losartan; oral
1.9
9.9
162
963
T51.0
ICD-10 Finland
Toxic effect: Ethanol
26.5
9.8
13
5
N02BE01
ATC
paracetamol; systemic, rectal
2.0
9.8
504
4321
E16.19
ICD-10 Finland
Other specified hypoglycaemia
20.4
9.8
14
7
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.3
9.8
29
57
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
6.7
9.8
24
37
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.2
9.8
36
89
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.8
9.8
62
234
V03AA01
ATC
NA
5.7
9.8
27
49
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.0
9.7
55
192
SPAT1216
SPAT
Assessment of functional ability
2.2
9.7
107
540
207
Kela drug reimbursment
Chronic arrhythmias
2.2
9.6
107
543
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.0
9.6
56
201
V03AE01
ATC
polystyrene sulfonate; oral
10.3
9.6
18
18
Y94.0
ICD-10 Finland
Accident at home
6.8
9.5
23
35
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
5.3
9.5
28
55
SPAT1125
SPAT
Stoma care and guidance
7.7
9.5
21
28
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
30.5
9.4
12
*
A02BC01
ATC
omeprazole; systemic
1.9
9.4
175
1083
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
9.4
77
336
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.8
9.3
38
104
Z2446
NOMESCO Finland
Social worker
3.1
9.3
52
179
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
9.3
186
1183
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
3.3
9.2
45
142
F34.1
ICD-10 Finland
Dysthymia
4.9
9.1
29
62
N06AA12
ATC
doxepin; systemic
3.3
9.1
46
149
K08.3
ICD-10 Finland
Retained dental root
2.9
9.1
54
196
B01AB05
ATC
enoxaparin; parenteral
1.8
9.1
186
1188
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
9.2
9.1
18
20
5CM18
NOMESCO Finland
NA
15.9
9.1
14
9
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.3
9.0
44
139
EBA30
NOMESCO Finland
Excision of root of tooth
3.2
9.0
46
151
W19
ICD-10 Finland
Unspecified fall
2.6
9.0
67
279
WX704
NOMESCO Finland
Intubation
2.9
9.0
53
192
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
7.0
8.9
21
31
JFB00
NOMESCO Finland
Partial resection of small intestine
7.0
8.9
21
31
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
8.7
73
321
A10BK01
ATC
dapagliflozin; oral
3.4
8.7
41
127
R50.9
ICD-10 Finland
Fever, unspecified
2.2
8.6
94
473
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.8
8.6
54
203
N06AX03
ATC
mianserin; oral
3.4
8.6
41
128
T68
ICD-10 Finland
Hypothermia
16.6
8.6
13
8
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.9
8.6
34
91
B01AB10
ATC
tinzaparin; parenteral
2.9
8.6
53
196
UJD02
NOMESCO Finland
Gastroscopy
3.2
8.5
44
146
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
8.2
51
188
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
7.7
8.2
18
24
I95.9
ICD-10 Finland
Hypotension, unspecified
7.7
8.2
18
24
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.0
8.2
31
80
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
8.1
65
281
H36.01
ICD-10 Finland
Diabetic maculopathy
8.3
8.1
17
21
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
7.0
8.1
19
28
A10BG02
ATC
rosiglitazone; oral
7.0
8.1
19
28
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
17.5
8.1
12
7
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
9.1
8.1
16
18
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.1
8.0
94
485
WX722
NOMESCO Finland
PEEP
3.1
8.0
42
141
N06AA09
ATC
amitriptyline; systemic
2.5
8.0
64
277
N03AX16
ATC
pregabalin; oral
1.9
7.9
139
837
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.3
7.9
23
45
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.9
7.9
31
83
C08CA13
ATC
lercanidipine; oral
2.2
7.9
85
426
SPAT1301
SPAT
No procedures
1.7
7.8
192
1286
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.0
7.8
14
13
EBA00
NOMESCO Finland
Extraction of tooth
1.7
7.8
192
1289
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
9.6
7.8
15
16
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
7.8
158
1000
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.4
7.8
22
42
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.3
7.8
37
116
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.5
7.7
60
256
NF1AA
NOMESCO Finland
Hip X-ray examination
2.5
7.7
60
257
S76
ICPC
Skin infection other
3.2
7.7
39
128
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
6.8
7.6
18
27
J01MA14
ATC
moxifloxacin; systemic
2.4
7.6
64
283
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.9
7.6
44
157
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
7.6
224
1580
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.5
7.6
61
263
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
25.4
7.6
10
*
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
25.4
7.6
10
*
N03AF01
ATC
carbamazepine; oral, rectal
3.0
7.5
43
152
SPAT1255
SPAT
Intravenous administration of medicine
2.8
7.5
47
175
SPAT1263
SPAT
Sampling
1.6
7.5
239
1720
P76
ICPC
Depressive disorder
3.6
7.5
32
92
N06AB03
ATC
fluoxetine; oral
2.2
7.5
73
348
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.6
7.5
54
220
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
6.6
7.5
18
28
JFF13
NOMESCO Finland
Terminal enterostomy
81.0
7.4
8
*
E13.1
ICD-10 Finland
Other specified diabetes mellitus, with ketoacidosis
81.0
7.4
8
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
81.0
7.4
8
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.9
7.4
43
154
H36.00
ICD-10 Finland
Diabetic background retinopathy
7.8
7.4
16
21
J96.1
ICD-10 Finland
Chronic respiratory failure
4.8
7.4
23
49
B81
ICPC
Anaemia vit B12/folate deficiency
3.3
7.4
36
115
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
3.3
7.4
36
115
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
7.4
95
510
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.9
7.4
29
78
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
8.5
7.4
15
18
N30.9
ICD-10 Finland
Cystitis, unspecified
3.5
7.4
33
99
R55
ICD-10 Finland
Syncope and collapse
2.2
7.3
72
343
A07AA09
ATC
vancomycin; oral
7.0
7.3
17
25
C03AA03
ATC
hydrochlorothiazide; oral
2.3
7.3
68
318
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
9.5
7.3
14
15
Z49.0
ICD-10 Finland
Preparatory care for dialysis
9.5
7.3
14
15
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
7.3
7
*
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.4
7.3
34
105
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
6.4
7.3
18
29
H04AA01
ATC
glucagon; nasal, parenteral
5.6
7.3
20
37
C09BA02
ATC
enalapril and diuretics; systemic
2.5
7.3
57
245
Z3226
NOMESCO Finland
Physiotherapist
1.9
7.3
114
660
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
7.4
7.2
16
22
K92.1
ICD-10 Finland
Melaena
3.0
7.2
41
144
I20.00
ICD-10 Finland
Unstable angina
4.5
7.2
24
55
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.1
7.2
84
431
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.1
7.2
88
461
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
7.2
84
434
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.1
7.2
21
42
E83.50
ICD-10 Finland
Hypercalcemia
30.4
7.2
9
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.4
7.1
24
56
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
7.1
259
1924
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
7.1
159
1032
C01DA14
ATC
isosorbide mononitrate; oral
2.0
7.1
93
502
137
Kela drug reimbursment
Uraemia requiring dialysis
10.2
7.1
13
13
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
10.2
7.1
13
13
R60.0
ICD-10 Finland
Localized oedema
2.2
7.1
70
335
H02AB09
ATC
hydrocortisone; systemic
5.0
7.0
21
43
SPAT1211
SPAT
Application of soft bandage
2.4
7.0
60
267
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.7
7.0
46
179
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.7
7.0
29
82
A12AA04
ATC
calcium carbonate; oral
5.9
7.0
18
31
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
14.0
6.9
11
8
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
3.7
6.9
28
78
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.1
6.9
20
40
I25.2
ICD-10 Finland
Old myocardial infarction
2.6
6.8
48
194
SPAT1252
SPAT
Overall medication plan or its review
2.5
6.8
51
213
F10.01
ICD-10 Finland
Alcohol-related acute intoxication with permanent or other somatic damage
11.1
6.8
12
11
NGJ60
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified
11.1
6.8
12
11
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.2
6.8
17
28
F10.4
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium
40.5
6.8
8
*
PG1AE
NOMESCO Finland
Ultrasound examination of artery not elsewher classified
40.5
6.8
8
*
SPAT1247
SPAT
Outpatient detoxication and monitoring
16.9
6.8
10
6
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.8
6.7
40
147
A02BC03
ATC
lansoprazole; oral
1.7
6.7
164
1092
GD2SN
NOMESCO Finland
Lung ventilation SPECT
22.8
6.7
9
*
GD1UN
NOMESCO Finland
Lung circulation SPECT
22.8
6.7
9
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
6.5
6.7
16
25
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
6.0
6.6
17
29
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
6.0
6.6
17
29
Z72.0
ICD-10 Finland
Tobacco use
4.7
6.6
21
46
SPAT1279
SPAT
Preparation of immediate hospitalisation
7.9
6.6
14
18
R4110
NOMESCO Finland
Physiotherapy
1.7
6.6
152
994
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.9
6.6
20
42
K85.2
ICD-10 Finland
Alcohol-induced acute pancreatitis
8.8
6.6
13
15
SPAT1234
SPAT
Support of social functional capacity
3.0
6.5
37
130
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
5.4
6.5
18
34
N05AB01
ATC
dixyrazine; systemic
6.3
6.5
16
26
XG466
NOMESCO Finland
Sleep oxymetry
3.5
6.5
28
82
E66.9
ICD-10 Finland
Obesity, unspecified
4.2
6.5
23
57
IAB10
NOMESCO Finland
Psychiatric consultation concerning substance abuse
70.6
6.4
7
*
H02AB06
ATC
prednisolone; systemic
1.6
6.4
266
2027
Z94.0
ICD-10 Finland
Kidney transplant status
6.7
6.4
15
23
L04AX01
ATC
azathioprine; systemic
3.2
6.4
31
100
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
6.4
36
126
H3601, E113
ICD-10 Finland
NA
5.3
6.4
18
35
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.1
6.3
23
58
A10AA02
ATC
NA
3.9
6.3
24
63
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
6.1
6.3
16
27
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.3
6.3
30
95
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
6.3
178
1231
T30
ICPC
Metabolic, Medical examin/health eval complete
+∞
6.3
6
*
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
+∞
6.3
6
*
M10.0
ICD-10 Finland
Idiopathic gout
3.7
6.3
25
69
A10AB06
ATC
insulin glulisine; parenteral
7.1
6.2
14
20
P99
ICPC
Psychological disorders other
4.6
6.2
20
45
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.2
209
1510
Z72.1
ICD-10 Finland
Alcohol use
5.4
6.2
17
32
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.6
6.2
43
171
SPAT1260
SPAT
Consultation of another employee
1.8
6.2
107
637
S82.2
ICD-10 Finland
Fracture of shaft of tibia
5.8
6.2
16
28
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
5.8
6.2
16
28
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.1
6.1
22
55
C09AA03
ATC
lisinopril; oral
2.8
6.1
37
138
C07AG02
ATC
carvedilol; oral
2.5
6.1
44
182
SPAT1227
SPAT
Substance abuse rehabilitation
10.2
6.1
11
11
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.0
269
2072
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
5.3
6.0
17
33
R31
ICD-10 Finland
Unspecified haematuria
2.0
6.0
74
390
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.0
6.0
32
110
Mortality – FinRegistry
↥Association
Association between endpoint E4_ACIDOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ACIDOSIS | 4.343 [3.3, 5.71] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.601 |
During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 1194 females with E4_ACIDOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ACIDOSIS | 5.206 [4.09, 6.63] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 864 out of 2128 males with E4_ACIDOSIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ACIDOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.48% | 0.771% |
| 5 | 2.92% | 5.339% |
| 10 | 6.434% | 13.916% |
| 15 | 12.782% | 25.455% |
| 20 | 22.326% | 39.972% |
Relationships between endpoints
↥Index endpoint: E4_ACIDOSIS – Acidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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