info icon

This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Atrophy of thyroid (acquired)

E4_ATROTHY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E03.4
  • Hospital discharge: ICD-9 2448B
  • Cause of death: ICD-10 E03.4
  • Cause of death: ICD-9 2448B

2 out of 7 registries used, show all original rules.

45

4. Check minimum number of events

None

45

5. Include endpoints

None

45

6. Filter based on genotype QC (FinnGen only)

43

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Atrophia glandulae thyreoideae [acquisita]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 551 413 132
Only index persons 364 274 90
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 64.16 64.40 63.12
Only index persons 55.98 56.10 55.62

-FinnGen-

Key figures

All Female Male
Number of individuals 43 37 6
Unadjusted period prevalence (%) 0.01 0.01 0.00
Median age at first event (years) 53.81 51.83 66.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

Association

Association between endpoint E4_ATROTHY and mortality.

Females

Parameter HR [95% CI] p-value
E4_ATROTHY 1.365 [0.88, 2.11] 0.16
Birth year 1.0 [0.99, 1.01] 0.991

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 182 females with E4_ATROTHY died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ATROTHY.

N-year risk Females Males
1 0.137% No data
5 0.83% No data
10 1.972% No data
15 4.112% No data
20 7.823% No data

Relationships between endpoints

Index endpoint: E4_ATROTHY – Atrophy of thyroid (acquired)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data