Risteys · E4_CONGEIOD

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E00, E03.0, E03.1 Hospital discharge: ICD-9 — 243 Hospital discharge: ICD-8 — 243 Cause of death: ICD-10 — E00, E03.0, E03.1 Cause of death: ICD-9 — 243 Cause of death: ICD-8 — 243 2 out of 7 registries used, show all original rules.	1139
4. Check minimum number of events None	1139
5. Include endpoints None	1139
6. Filter based on genotype QC (FinnGen only)	1139

	All	Female	Male
Number of individuals
Whole population	11024	8810	2178
Only index persons	10110	8174	1936
Unadjusted period prevalence (%)
Whole population	0.21	0.25	0.06
Only index persons	0.26	0.30	0.07
Median age at first event (years)
Whole population	67.75	68.82	63.38
Only index persons	67.54	68.52	63.45

	All	Female	Male
Number of individuals	1139	913	226
Unadjusted period prevalence (%)	0.27	0.31	0.10
Median age at first event (years)	60.54	59.01	66.75

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1047: Matched controls
10470

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

871.9

323.0

681

104

Kela drug reimbursment

Thyroid insufficiency

4014.9

323.0

431

E03.0

ICD-10 Finland

Congenital hypothyroidism with diffuse goitre

+∞

323.0

848

H03AA01

ATC

levothyroxine sodium; systemic

2362.3

323.0

1007

110

E03

ICD-10 Finland

Other hypothyroidism

232.6

205.5

206

E03.89

ICD-10 Finland

Other specified hypothyroidism

2252.2

189.5

178

E03.1

ICD-10 Finland

Congenital hypothyroidism without goitre

+∞

185.0

172

E03.80

ICD-10 Finland

Hypothyroidism caused by autoimmune thyroiditis

1102.8

104.1

100

T86

ICPC

Hypothyroidism/myxoedema

147.2

101.1

106

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

48.0

65.9

H03BB01

ATC

carbimazole; oral

108.7

65.7

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

+∞

53.6

E05.9

ICD-10 Finland

Thyrotoxicosis, unspecified

185.8

51.4

M14.5*E03.9

ICD-10 Finland

Arthropathy in hypothyroidism (E00-E03+)

+∞

37.7

E04.2

ICD-10 Finland

Nontoxic multinodular goitre

46.9

37.2

E89.01

ICD-10 Finland

Postsurgical hypothyroidism

348.0

34.1

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

6.3

33.2

158

BAA60

NOMESCO Finland

Total thyroidectomy

337.3

33.1

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

4.1

30.8

128

343

A10AE04

ATC

insulin glargine; parenteral

3.6

28.5

137

416

C03CA01

ATC

furosemide; systemic

2.2

28.0

381

2160

E78.00

ICD-10 Finland

Familial hypercholesterolaemia

4.9

27.9

209

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

6.0

27.7

141

J01MA12

ATC

levofloxacin; systemic

2.6

26.6

233

1053

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.3

25.9

285

1451

N05AH04

ATC

quetiapine; oral

2.7

25.9

200

842

SPAT1254

SPAT

Administration of medicine

2.6

25.5

222

999

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

5.9

25.5

131

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.5

25.3

226

1033

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

25.2

490

3186

A10AE05

ATC

insulin detemir; parenteral

4.2

24.9

249

T89

ICPC

Diabetes insulin dependent

5.8

24.6

129

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

8.2

24.0

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

3.4

23.9

123

393

E89.00

ICD-10 Finland

Postirradiation hypothyroidism

127.9

23.7

103

Kela drug reimbursment

Diabetes, insulin-treated

2.1

23.1

311

1723

E03.8

ICD-10 Finland

Other specified hypothyroidism

+∞

23.0

AA1AD

NOMESCO Finland

CT of head and brain

2.2

22.9

303

1664

A02BC02

ATC

pantoprazole; systemic

2.0

22.9

695

5265

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

6.6

22.6

N03AX16

ATC

pregabalin; oral

2.2

21.8

283

1533

SPAT1263

SPAT

Sampling

1.9

21.7

491

3314

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.0

21.7

404

2541

N02BE01

ATC

paracetamol; systemic, rectal

2.4

21.5

919

7875

N05CF01

ATC

zopiclone; oral

2.0

20.9

377

2332

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.0

20.8

326

1908

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

2.0

20.5

316

1835

I10

ICD-10 Finland

Essential (primary) hypertension

1.9

20.4

623

4634

H04AA01

ATC

glucagon; nasal, parenteral

7.8

20.0

A10AA01

ATC

6.4

19.9

24199

ICD-8 Finland

Non-toxic nodular goitre, Unspecified

+∞

19.9

R53

ICD-10 Finland

Malaise and fatigue

2.1

19.2

257

1404

BAA40

NOMESCO Finland

Unilateral lobectomy of thyroid gland

20.5

19.1

SPAT1301

SPAT

No procedures

1.9

18.9

376

2390

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.2

18.9

234

1234

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.4

18.9

184

867

J01DB01

ATC

cefalexin; oral

2.0

18.5

843

7067

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.2

18.5

206

1035

N06AX11

ATC

mirtazapine; oral

1.9

18.4

351

2192

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.6

18.3

147

624

E66.00

ICD-10 Finland

Metabolic syndrome

4.2

18.2

174

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

7.0

18.2

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

3.8

17.9

213

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.0

17.8

259

1454

R06.0

ICD-10 Finland

Dyspnoea

2.0

17.6

289

1701

24409

ICD-8 Finland

Myxoedema, (hypothyreosis) NUD

183.0

17.6

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.0

17.5

279

1626

SPAT1262

SPAT

Handing over of treatment supplies

2.1

17.1

208

1083

C07AB07

ATC

bisoprolol; oral

1.8

16.8

491

3506

N03AX09

ATC

lamotrigine; oral

4.1

16.6

170

E03.3

ICD-10 Finland

Postinfectious hypothyroidism

172.6

16.5

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.1

16.5

212

1128

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.8

16.5

349

2244

G47.3

ICD-10 Finland

Sleep apnoea

2.2

16.4

188

952

N05AA02

ATC

levomepromazine; systemic

4.3

16.2

149

N30.0

ICD-10 Finland

Acute cystitis

2.1

16.0

201

1057

N06AX16

ATC

venlafaxine; oral

2.4

16.0

152

703

E10.4

ICD-10 Finland

Type 1 diabetes mellitus, With neurological complications

21.3

16.0

N05BA04

ATC

oxazepam; oral

1.9

15.8

282

1702

J01FF01

ATC

clindamycin; systemic

1.9

15.8

277

1660

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.2

15.8

173

856

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

+∞

15.7

24399

ICD-8 Finland

Cretinism of congenital origin

+∞

15.7

A10AA02

ATC

4.1

15.6

155

2500B

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]

7.2

15.4

N06AA09

ATC

amitriptyline; systemic

2.5

15.4

130

564

A06AD11

ATC

lactulose; oral

2.2

15.4

181

923

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.8

15.4

105

404

J45.9

ICD-10 Finland

Asthma, unspecified

2.1

15.3

207

1122

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

9.9

15.2

SPAT1249

SPAT

Treatment-related counselling outside office

1.7

15.2

423

2946

T90

ICPC

Diabetes non-insulin dependent

2.0

15.1

236

1354

H02AB09

ATC

hydrocortisone; systemic

6.1

15.1

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.7

15.0

438

3093

N06AB04

ATC

citalopram; systemic

1.9

14.9

241

1399

TPH04

NOMESCO Finland

Cathetrisation of vein

2.0

14.8

225

1275

E10.00

ICD-10 Finland

Insulin-dependent diabetes diabetic hypoglycemic coma

9.9

14.7

E66.8

ICD-10 Finland

Other obesity

3.6

14.7

190

E04.0

ICD-10 Finland

Nontoxic diffuse goitre

36.6

14.5

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.0

14.4

192

1035

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.7

14.4

407

2837

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.0

14.4

195

1056

N03AX12

ATC

gabapentin; oral

2.1

14.4

174

900

SPAT1153

SPAT

Removal of sutures

1.8

14.2

333

2188

N03AG01

ATC

valproic acid; systemic, rectal

3.2

14.2

245

R42

ICD-10 Finland

Dizziness and giddiness

1.9

14.1

262

1597

Z01.8

ICD-10 Finland

Other specified special examinations

1.9

14.1

231

1345

H02AB06

ATC

prednisolone; systemic

1.7

14.1

473

3459

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.7

13.8

393

2730

J01DA01

ATC

[U] cefalexin; systemic

1.7

13.8

635

5050

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.7

13.8

340

2267

E04.9

ICD-10 Finland

Nontoxic goitre, unspecified

13.8

A28

ICPC

Limited function/disability NOS

2.0

13.8

200

1114

B03BA03

ATC

hydroxocobalamin; parenteral

3.2

13.7

245

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.4

13.7

120

533

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

2.9

13.6

311

A02BC05

ATC

esomeprazole; systemic

1.7

13.6

411

2903

M79.0

ICD-10 Finland

Rheumatism, unspecified

3.7

13.6

165

E06.3

ICD-10 Finland

Autoimmune thyroiditis

76.1

13.6

A10AE06

ATC

insulin degludec; parenteral

5.4

13.6

L28

ICPC

Limited function/disability (L)

2.0

13.5

200

1120

N05CD07

ATC

temazepam; oral

2.2

13.5

147

726

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.8

13.4

315

2065

R03AC02

ATC

salbutamol; inhalant

1.6

13.3

536

4091

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.1

13.3

158

808

E10.1

ICD-10 Finland

Type 1 diabetes mellitus, With ketoacidosis

9.8

13.3

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.2

13.2

235

N02AX02

ATC

tramadol; systemic, rectal

1.7

13.1

421

3017

N05AN01

ATC

lithium; oral

6.1

13.1

N06AX21

ATC

duloxetine; oral

2.3

13.1

124

573

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.0

13.0

189

1050

SPAT1255

SPAT

Intravenous administration of medicine

2.8

13.0

321

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

2.1

12.8

163

858

SPAT1216

SPAT

Assessment of functional ability

2.0

12.8

192

1079

J38.0

ICD-10 Finland

Paralysis of vocal cords and larynx

7.6

12.7

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.2

12.6

132

637

R07.4

ICD-10 Finland

Chest pain, unspecified

1.8

12.5

276

1768

2430A

ICD-9 Finland

Congenital hypothyroidism[HYPOTHYREOSIS CONGENITA]

+∞

12.5

E00.9

ICD-10 Finland

Congenital iodine-deficiency syndrome, unspecified

+∞

12.5

E05.2

ICD-10 Finland

Thyrotoxicosis with toxic multinodular goitre

+∞

12.5

J45.0

ICD-10 Finland

Predominantly allergic asthma

2.4

12.5

105

457

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

4.1

12.5

121

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

3.0

12.4

245

M25.5

ICD-10 Finland

Pain in joint

1.7

12.4

289

1882

P29

ICPC

Psychological sympt/compl other

3.0

12.4

252

N06AB03

ATC

fluoxetine; oral

2.1

12.2

145

741

N02AA05

ATC

oxycodone; systemic

2.0

12.2

165

890

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

2.9

12.2

272

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

2.3

12.1

112

509

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

1.9

12.0

209

1237

K29.4

ICD-10 Finland

Chronic atrophic gastritis

5.1

11.9

M79.6

ICD-10 Finland

Pain in limb

1.6

11.9

374

2645

N05AX08

ATC

risperidone; systemic

2.4

11.8

100

435

C10AA01

ATC

simvastatin; oral

1.6

11.8

439

3242

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

2.3

11.8

110

500

T36

ICD-10 Finland

Poisoning by systemic antibiotics

3.4

11.8

169

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.7

11.8

284

1862

2449X

ICD-9 Finland

Acquired hypothyroidism, Unspecified hypothyroidism

+∞

11.5

I50.9

ICD-10 Finland

Heart failure, unspecified

2.0

11.4

164

901

N06AB06

ATC

sertraline; oral

2.2

11.4

115

546

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.1

11.4

141

733

R60.0

ICD-10 Finland

Localized oedema

2.1

11.4

133

676

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

4.5

11.3

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.6

11.3

493

3782

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.9

11.2

182

1049

E0000UV

ATC

1.6

11.2

398

2900

SPAT1260

SPAT

Consultation of another employee

1.9

11.1

191

1125

SPAT1097

SPAT

Recording of ECG

1.9

11.0

165

923

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.0

11.0

148

793

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

2.4

11.0

399

8260/3-C73.9

ICD-O-3

Papillary adenocarcinoma, NOS, of thyroid gland

43.8

10.9

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.5

10.8

356

107

Kela drug reimbursment

Pernicious anaemia

5.3

10.8

R50.9

ICD-10 Finland

Fever, unspecified

2.0

10.8

148

799

H3600, E103

ICD-10 Finland

9.0

10.8

E66.01

ICD-10 Finland

Obesity due to excess calories

2.5

10.7

359

A10BA02

ATC

metformin; oral

1.7

10.7

271

1795

P01AB01

ATC

metronidazole; oral, rectal

1.6

10.7

399

2933

C73.91

ICD-10 Finland

Papillary carcinoma of the thyroid gland (thyroid gland)

60.6

10.6

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

1.9

10.6

158

881

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

1.7

10.6

237

1512

B81

ICPC

Anaemia vit B12/folate deficiency

3.7

10.6

130

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

9.3

10.5

WX110

NOMESCO Finland

Local anesthesy

1.6

10.5

659

5468

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.4

10.5

409

R03BA05

ATC

fluticasone; inhalant

1.8

10.5

191

1143

C10AA05

ATC

atorvastatin; oral

1.6

10.4

362

2605

J01MA02

ATC

ciprofloxacin; systemic

1.6

10.4

377

2745

SPAT1240

SPAT

Therapeutic discussion

2.2

10.4

113

554

E06.1

ICD-10 Finland

Subacute thyroiditis

+∞

10.4

A06AC01

ATC

ispaghula (psylla seeds); oral

1.7

10.4

267

1773

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.6

10.4

451

3433

B01AB05

ATC

enoxaparin; parenteral

1.6

10.4

310

2148

C09AA05

ATC

ramipril; oral

1.7

10.3

245

1593

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

2.1

10.3

123

630

N05BA01

ATC

diazepam; systemic, rectal

1.9

10.3

148

816

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

1.8

10.3

208

1287

R03AK06

ATC

salmeterol and fluticasone; inhalant

2.0

10.2

144

786

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.4

10.2

402

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.8

10.2

192

1163

N03AE01

ATC

clonazepam; systemic

2.7

10.1

279

H02AB04

ATC

methylprednisolone; systemic

1.9

10.1

157

888

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

1.9

10.0

150

838

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.6

10.0

410

3067

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.0

10.0

144

790

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.0

10.0

125

651

E04.1

ICD-10 Finland

Nontoxic single thyroid nodule

40.5

10.0

A02BC01

ATC

omeprazole; systemic

1.6

9.9

294

2029

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.6

9.9

272

1837

N05BA06

ATC

lorazepam; systemic, sublingual

2.7

9.9

259

E27.1

ICD-10 Finland

Primary adrenocortical insufficiency

16.9

9.9

N05AH03

ATC

olanzapine; systemic

2.8

9.8

237

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.6

9.8

322

2281

N06AX03

ATC

mianserin; oral

2.8

9.7

225

K02.1

ICD-10 Finland

Caries of dentine

1.5

9.7

516

4091

XF400

NOMESCO Finland

ECG with 12 standard connections

1.8

9.7

166

970

M54.5

ICD-10 Finland

Low back pain

1.6

9.6

321

2278

AN1

Coronary angiography

2.0

9.6

122

643

H36.09*E10.3

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic retinopathy

10.2

9.5

UJF32

NOMESCO Finland

Coloscopy

1.6

9.5

264

1785

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

2.0

9.5

117

607

E89.09

ICD-10 Finland

Postprocedural hypothyroidism, other or several procedures

100.9

9.4

R11

ICD-10 Finland

Nausea and vomiting

2.1

9.4

106

529

F60.31

ICD-10 Finland

Emotionally unstable personality disorder, borderline condition

6.3

9.4

K59.1

ICD-10 Finland

Functional diarrhoea

2.6

9.4

274

E03.2

ICD-10 Finland

Hypothyroidism due to medicaments and other exogenous substances

+∞

9.4

2419X

ICD-9 Finland

Non-toxic nodular goitre, Unspecified non-toxic nodular goitre

+∞

9.4

ZX120

NOMESCO Finland

Intravenous

2.1

9.4

103

508

XF404

NOMESCO Finland

Ambulatory ECG

2.2

9.3

484

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.7

9.2

220

1429

M04AA01

ATC

allopurinol; systemic

2.0

9.2

123

659

A46

ICD-10 Finland

Erysipelas

1.9

9.2

141

795

C08CA01

ATC

amlodipine; oral

1.5

9.1

356

2621

Z01.0

ICD-10 Finland

Examination of eyes and vision

1.8

9.1

170

1024

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.3

9.1

389

A41.9

ICD-10 Finland

Sepsis, unspecified

3.3

9.1

142

E66.9

ICD-10 Finland

Obesity, unspecified

3.4

9.1

126

P99

ICPC

Psychological disorders other

3.9

9.1

106

Kela drug reimbursment

Hypoparathyroidism

37.0

9.0

F32.00

ICD-10 Finland

Mild depressive episode without somatic syndrome

3.1

8.9

161

105

Kela drug reimbursment

Adrenal cortical hypofunction

18.8

8.9

SPAT1325

SPAT

Vaccination

1.5

8.9

361

2675

177

Kela drug reimbursment

Insulin glargine 300 U / ml

5.5

8.9

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.8

8.9

207

E000001

ATC

1.7

8.8

209

1352

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

2.1

8.8

100

503

G44.2

ICD-10 Finland

Tension-type headache

1.8

8.7

145

840

R52.2

ICD-10 Finland

Other chronic pain

3.4

8.7

125

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.2

8.7

398

J01AA02

ATC

doxycycline; systemic

1.5

8.7

757

6609

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

2.9

8.7

188

I25.1

ICD-10 Finland

Atherosclerotic heart disease

1.7

8.6

206

1335

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.3

8.6

359

XCK10

NOMESCO Finland

Photography of fundus of eye

2.0

8.6

116

624

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.5

8.5

429

3328

EBA00

NOMESCO Finland

Extraction of tooth

1.6

8.5

297

2124

UKC02

NOMESCO Finland

Cystoscopy

1.8

8.4

142

824

SPAT1229

SPAT

Assessment of need for aid

2.1

8.4

504

SPAT1251

SPAT

Organisation of medication

2.8

8.4

197

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

2.7

8.4

204

A29

ICPC

General symptom/complaint other

1.9

8.4

122

673

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.1

8.4

469

E06.9

ICD-10 Finland

Thyroiditis, unspecified

+∞

8.3

E89.0

ICD-10 Finland

Postprocedural hypothyroidism

+∞

8.3

E05.4

ICD-10 Finland

Thyrotoxicosis factitia

+∞

8.3

R51.80

ICD-10 Finland

Headache

1.8

8.3

152

909

I25.0

ICD-10 Finland

Atherosclerotic cardiovascular disease, so described

2.4

8.3

308

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.5

8.2

430

3356

D07AC01

ATC

betamethasone; topical

1.5

8.2

313

2280

P28

ICPC

Limited function/disability (P)

7.6

8.2

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

2.4

8.2

294

C03DA01

ATC

spironolactone; oral

1.9

8.1

115

631

P03

ICPC

Feeling depressed

2.1

8.1

460

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

2.0

8.1

103

542

E11.6

ICD-10 Finland

Type 2 diabetes mellitus, with other specified complications

4.5

8.1

F31.20

ICD-10 Finland

Bipolar disorder, manic episode with mood-congruent psychotic symptoms

10.1

8.0

2505

FHL

Bilateral resection (also used if total removal has been performed on the other side)

22.2

8.0

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

2.9

8.0

168

J45.1

ICD-10 Finland

Nonallergic asthma

2.2

8.0

354

JN3AD

NOMESCO Finland

Abdominal CT examination

2.2

8.0

367

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.5

8.0

500

4041

CL2S4

NOMESCO Finland

Ocular fundus photography for diabetic retinopathy screening

5.0

7.9

A10BB12

ATC

glimepiride; oral

2.2

7.9

348

WX408

NOMESCO Finland

General anesthesy, balanced

1.6

7.9

252

1759

H02AB07

ATC

prednisone; oral

1.8

7.9

146

874

R02

ICPC

Shortness of breath/dyspnoea

1.8

7.9

129

742

F60.8

ICD-10 Finland

Other specific personality disorders

13.1

7.9

F31.30

ICD-10 Finland

Bipolar disorder Depressive episode without somatic syndrome

5.2

7.9

SPAT1104

SPAT

Monitoring of emergency patient

2.2

7.9

349

SPAT1100

SPAT

Long-term monitoring of blood pressure

2.2

7.9

374

A02BA02

ATC

ranitidine; systemic

1.6

7.9

210

1401

M01AH01

ATC

celecoxib; oral (coxibs)

1.7

7.8

185

1194

285

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

2.8

7.8

171

SPAT1211

SPAT

Application of soft bandage

2.0

7.8

521

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

4.3

7.7

N05AB03

ATC

perphenazine; systemic, rectal

3.1

7.7

132

2504

FHL

Unilateral resection or enucleation

45.3

7.7

R39.1

ICD-10 Finland

Other difficulties with micturition

3.7

7.7

A02BC03

ATC

lansoprazole; oral

1.5

7.7

290

2102

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

2.5

7.7

234

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.6

7.6

205

1369

D02AE01

ATC

carbamide; topical

2.2

7.6

328

SPAT1149

SPAT

Suture or treatment of traumatic wound

1.8

7.6

123

704

D07AB02

ATC

hydrocortisone butyrate; topical

1.5

7.6

267

1906

BEF00

NOMESCO Finland

Continuous subcutaneous glucose monitoring

8.9

7.6

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.0

7.6

484

SPAT1310

SPAT

Counselling related to known health issue

1.5

7.5

311

2299

C01DA02

ATC

glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal

1.6

7.5

211

1425

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

2.2

7.5

357

WX722

NOMESCO Finland

PEEP

2.7

7.5

181

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.4

7.5

480

3879

E10

ICD-10 Finland

Type 1 diabetes mellitus

4.9

7.5

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.9

7.5

104

566

T82

ICPC

Obesity

3.0

7.5

141

D64.9

ICD-10 Finland

Anaemia, unspecified

1.9

7.5

106

582

L03

ICPC

Low back symptom/complaint

1.6

7.5

239

1667

A04

ICPC

Weakness/tiredness general

1.7

7.4

144

877

N05AF03

ATC

chlorprothixene; systemic

3.8

7.4

K90

ICPC

Stroke/cerebrovascular accident

3.2

7.4

114

SPAT1252

SPAT

Overall medication plan or its review

2.2

7.4

367

SAA01

NOMESCO Finland

Simple examination of mouth

1.4

7.3

647

5545

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

2.0

7.3

445

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

2.0

7.3

488

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

1.8

7.3

131

777

F31.7

ICD-10 Finland

Bipolar affective disorder, currently in remission

5.0

7.3

UJD02

NOMESCO Finland

Gastroscopy

2.5

7.3

221

2448A

ICD-9 Finland

Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]

+∞

7.3

2506

FHL

Thyroidectomy

+∞

7.3

D11

ICPC

Diarrhoea

1.9

7.3

112

632

F20.00

ICD-10 Finland

Paranoid schizophrenia continuous

4.5

7.3

M17.1

ICD-10 Finland

Other primary gonarthrosis

1.6

7.3

211

1433

E78.9

ICD-10 Finland

Disorder of lipoprotein metabolism, unspecified

2.8

7.3

155

SPAT1215

SPAT

Assessment of need for medical rehabilitation

2.5

7.2

223

J01EA01

ATC

trimethoprim; systemic

1.5

7.2

301

2227

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

2.6

7.2

198

C07AA05

ATC

propranolol; systemic

1.6

7.2

180

1178

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

2.1

7.2

404

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

1.9

7.2

109

613

A05

ICPC

Feeling ill

2.2

7.1

309

RJ210

NOMESCO Finland

20.2

7.1

A10BK01

ATC

dapagliflozin; oral

2.9

7.1

144

N05AC02

ATC

thioridazine; oral

4.2

7.1

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.6

7.1

184

1216

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.6

7.1

182

1196

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

2.0

7.1

494

BA1AE

NOMESCO Finland

Thyroiid ultrasound examination

5.7

7.1

M70.6

ICD-10 Finland

Trochanteric bursitis

1.7

7.1

137

832

346

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

2.9

7.0

146

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

2.1

7.0

361

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.1

7.0

388

N06AB05

ATC

paroxetine; oral

2.3

7.0

260

ZXA00

NOMESCO Finland

Right side

1.5

7.0

277

2021

E11.3

ICD-10 Finland

Type 2 diabetes mellitus, with ophthalmic complications

3.4

7.0

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

4.3

6.9

SPAT1266

SPAT

Separate instruction to prepare for procedure

3.2

6.9

109

UJF30

NOMESCO Finland

Ileoscopy through colon

1.9

6.9

494

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

2.2

6.9

334

A01

ICPC

Pain general/multiple sites

2.0

6.9

422

L16

ICPC

Ankle symptom/complaint

1.9

6.9

105

592

P72

ICPC

Schizophrenia

4.8

6.9

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

2.7

6.9

166

H25.8

ICD-10 Finland

Other senile cataract

1.8

6.8

127

762

S06.0

ICD-10 Finland

Concussion

1.8

6.8

108

615

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

6.8

J01CA08

ATC

pivmecillinam; oral

1.4

6.8

479

3915

N30.9

ICD-10 Finland

Cystitis, unspecified

2.1

6.8

364

N05BA12

ATC

alprazolam; oral

1.9

6.8

549

SPAT1226

SPAT

Implementation of occupational therapy rehabilitation plan

2.8

6.8

144

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

2.4

6.8

238

J09

ICD-10 Finland

Influenza due to identified zoonotic or pandemic influenza virus

3.4

6.8

N06AX26

ATC

vortioxetine; oral

2.4

6.8

219

E10.8

ICD-10 Finland

Type 1 diabetes mellitus, With unspecified complications

5.7

6.8

C81.9

ICD-10 Finland

Hodgkin lymphoma, unspecified

40.3

6.8

RJ630

NOMESCO Finland

40.3

6.8

A11CC02

ATC

dihydrotachysterol; oral

40.3

6.8

E05

ICD-10 Finland

Thyrotoxicosis [hyperthyroidism]

16.8

6.7

WX882

NOMESCO Finland

High dependency care

3.1

6.7

117

XX9LA

NOMESCO Finland

Complementary kinetic X-ray examination without contrast

7.2

6.7

S97

ICPC

Chronic ulcer skin

2.3

6.7

265

SAA02

NOMESCO Finland

Basic examination of mouth

1.4

6.7

583

4946

SPAT1312

SPAT

General health counselling

1.5

6.7

312

2356

N06AB10

ATC

escitalopram; oral

1.6

6.7

181

1210

N06AX12

ATC

bupropion; oral

2.6

6.7

188

M01AE02

ATC

naproxen; oral, rectal

1.4

6.7

525

4373

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

2.2

6.6

322

R05

ICD-10 Finland

Cough

1.6

6.6

186

1254

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.0

6.6

391

A08

ICPC

Swelling

2.4

6.6

228

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.0

6.6

405

N04AA02

ATC

biperiden; systemic

4.4

6.6

R4110

SPAT

2.9

6.6

125

S18

ICPC

Laceration/cut

1.4

6.5

381

3001

WX290

NOMESCO Finland

Other blockade of nerve

1.4

6.5

360

2805

160

Kela drug reimbursment

exenatide

4.2

6.5

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.1

6.5

331

J01CA04

ATC

amoxicillin; systemic

1.5

6.5

786

7059

M19.0

ICD-10 Finland

Primary arthrosis of other joints

1.9

6.5

468

E16.2

ICD-10 Finland

Hypoglycaemia, unspecified

5.1

6.5

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

1.9

6.5

100

565

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

2.7

6.5

150

R5140

NOMESCO Finland

Monitoring the use of the aid

2.0

6.5

430

E89.2

ICD-10 Finland

Postprocedural hypoparathyroidism

70.3

6.4

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

3.6

6.4

P73

ICPC

Affective psychosis

14.4

6.4

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.0

6.4

405

Z00.0

ICD-10 Finland

General medical examination

1.6

6.4

172

1145

O10.0

ICD-10 Finland

Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium

4.9

6.4

N05AH02

ATC

clozapine; systemic

4.9

6.4

-50

ICPC

Medication/prescr/renewal

2.5

6.4

188

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.2

6.4

280

SPAT1281

SPAT

Other administrative function

1.9

6.3

451

O99.5

ICD-10 Finland

Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium

8.2

6.3

F31.4

ICD-10 Finland

Bipolar affective disorder, current episode severe depression without psychotic symptoms

5.2

6.3

WX306

NOMESCO Finland

Lumbar epidural anesthesy

2.1

6.3

343

C07AB02

ATC

metoprolol; systemic

1.5

6.3

213

1496

F31.0

ICD-10 Finland

Bipolar affective disorder, current episode hypomanic

5.6

6.3

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

2.7

6.3

157

RJ411

NOMESCO Finland

11.1

6.3

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

2.3

6.3

261

F31.5

ICD-10 Finland

Bipolar affective disorder, current episode severe depression with psychotic symptoms

18.1

6.3

XX7CT

NOMESCO Finland

Radioiodine therapy of thydoid tissue

+∞

6.3

2440A

ICD-9 Finland

Acquired hypothyroidism, Postsurgical hypothyroidism

+∞

6.3

E27.2

ICD-10 Finland

Addisonian crisis

+∞

6.3

E05.1

ICD-10 Finland

Thyrotoxicosis with toxic single thyroid nodule

+∞

6.3

24209

ICD-8 Finland

Thyrotoxicosis with or without goitre, Cum struma diffuse NUD

+∞

6.3

E00.0

ICD-10 Finland

Congenital iodine-deficiency syndrome, neurological type

+∞

6.3

A10BH01

ATC

sitagliptin; oral

1.9

6.2

476

RK112

NOMESCO Finland

26.8

6.2

R32

ICD-10 Finland

Unspecified urinary incontinence

2.8

6.2

135

XF600

NOMESCO Finland

Bloodpressure measurement

2.1

6.2

325

M01AH02

ATC

rofecoxib; oral

1.7

6.2

134

839

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

2.0

6.2

381

K43.9

ICD-10 Finland

Other and unspecified ventral hernia without obstruction or gangrene

2.5

6.2

197

Z09.0

ICD-10 Finland

Follow-up examination after surgery for other conditions

1.9

6.1

502

RS221

NOMESCO Finland

4.1

6.1

F32.3

ICD-10 Finland

Severe depressive episode with psychotic symptoms

3.8

6.1

R52.9

ICD-10 Finland

Pain, unspecified

1.9

6.1

443

Z25.1

ICD-10 Finland

Need for immunization against influenza

2.3

6.1

239

R96

ICPC

Asthma

1.9

6.1

479

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.8

6.1

105

616

X44

ICD-10 Finland

Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances

4.4

6.1

XCW99

NOMESCO Finland

Other investigative procedure of eye

1.7

6.1

115

694

SPAT1234

SPAT

Support of social functional capacity

2.1

6.0

299

E10.6

ICD-10 Finland

Type 1 diabetes mellitus, With other specified complications

10.1

6.0

C03AA03

ATC

hydrochlorothiazide; oral

1.8

6.0

103

602

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.4

6.0

332

2581

H02AA02

ATC

fludrocortisone; oral

5.6

6.0

NAME	E4_CONGEIOD
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E00\|E03[0-1]
HD_ICD_9	243
HD_ICD_8	243
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E00\|E03[0-1]
COD_ICD_9	243
COD_ICD_8	243
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
E4_CONGEIOD	1.653 [1.47, 1.86]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.007

Parameter	HR [95% CI]	p-value
E4_CONGEIOD	2.094 [1.67, 2.62]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

N-year risk	Females	Males
1	0.098%	0.386%
5	0.745%	2.472%
10	1.882%	5.762%
15	3.749%	10.868%
20	6.505%	17.926%

Congenital iodine-deficiency syndrome/hypothyroidism

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints