No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
288 |
4. Check minimum number of eventsNone |
288 |
5. Include endpointsNone |
288 |
6. Filter based on genotype QC (FinnGen only) |
278 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E23
- Name in latin
- Diabetes insipidus
Similar endpoints
↥List of similar endpoints to
Diabetes insipidus
based on the number of shared cases.
Similar with more cases:
- Exclusions for E4_PCOS_BROAD
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of other endocrine glands
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1936 | 1022 | 905 |
| Only index persons | 1614 | 884 | 730 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.88 | 45.33 | 42.11 |
| Only index persons | 42.57 | 44.24 | 40.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 278 | 171 | 107 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 46.20 | 45.67 | 47.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 288
- Matched controls
- 2878
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
323.0
259
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
311.8
236.4
216
27
102
Kela drug reimbursment
Diabetes insipidus
+∞
224.4
185
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
74.2
68
*
H02AB09
ATC
hydrocortisone; systemic
84.5
73.1
80
13
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
71.9
66
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
65.1
60
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
160.5
61.7
63
5
2535A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Diabetes insipidus
+∞
37.3
35
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
36.2
34
*
H03AA01
ATC
levothyroxine sodium; systemic
5.1
32.4
130
400
R63.1
ICD-10 Finland
Polydipsia
+∞
30.8
29
*
25390
ICD-8 Finland
Diseases of pituitary gland, Diabetes insipidus
+∞
30.8
29
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
15.4
28.1
47
36
R35
ICD-10 Finland
Polyuria
9.2
23.2
50
64
H01AC01
ATC
somatropin; parenteral
+∞
22.2
21
*
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
56.4
18.2
21
*
N05AN01
ATC
lithium; oral
18.9
17.3
26
15
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.6
17.2
53
112
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
+∞
16.8
16
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
11.4
16.7
31
30
H53.4
ICD-10 Finland
Visual field defects
14.0
16.5
28
22
XCK00
NOMESCO Finland
Perimetry
6.7
16.2
42
71
301
Kela drug reimbursment
Growth hormone
+∞
15.8
15
*
N25.1
ICD-10 Finland
Nephrogenic diabetes insipidus
+∞
15.8
15
*
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
15.8
15
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.0
15.3
29
29
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
14.7
14
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
6.6
13.9
36
61
AA1AD
NOMESCO Finland
CT of head and brain
3.2
13.8
86
342
E23.05
ICD-10 Finland
Lack of TSH
+∞
13.6
13
*
TAB00
NOMESCO Finland
Lumbar puncture
7.2
13.6
33
51
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
12.6
12
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
11.5
11
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
11.5
11
*
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
11.5
11
*
E23.0
ICD-10 Finland
Hypopituitarism
+∞
11.5
11
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
11.5
66
242
R51.80
ICD-10 Finland
Headache
3.3
11.3
63
228
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
114.0
10.5
11
*
E23.03
ICD-10 Finland
Lack of ACTH
+∞
10.5
10
*
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
10.5
10
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
24.4
10.3
14
6
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
13.8
10.3
17
13
N05BA01
ATC
diazepam; systemic, rectal
3.2
9.9
55
197
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
9.7
51
176
N03AG01
ATC
valproic acid; systemic, rectal
4.6
9.7
33
78
N05AA02
ATC
levomepromazine; systemic
6.0
9.6
26
47
ZXC86
NOMESCO Finland
Use of endoscopic device
31.2
9.5
12
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
9.4
9
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.0
9.0
36
100
N91.1
ICD-10 Finland
Secondary amenorrhoea
14.6
8.8
14
10
E22.1
ICD-10 Finland
Hyperprolactinaemia
92.7
8.5
9
*
N05AH03
ATC
olanzapine; systemic
4.1
8.4
32
85
2542
FHL
Transasal hypophysectomy
+∞
8.4
8
*
E23.3
ICD-10 Finland
Hypothalamic dysfunction, not elsewhere classified
+∞
8.4
8
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
8.4
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
8.2
62
267
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
8.2
74
355
R50.9
ICD-10 Finland
Fever, unspecified
3.0
8.2
50
191
A06AD11
ATC
lactulose; oral
3.0
8.0
46
169
R42
ICD-10 Finland
Dizziness and giddiness
2.5
7.9
70
330
R60.0
ICD-10 Finland
Localized oedema
3.2
7.8
41
142
N04BC06
ATC
cabergoline; oral (dopamine agonists)
46.3
7.8
9
*
G04BD04
ATC
oxybutynin; oral, transdermal
4.7
7.7
25
57
A12BA01
ATC
potassium chloride; oral
5.6
7.5
21
40
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
82.1
7.5
8
*
N05AH04
ATC
quetiapine; oral
2.5
7.4
60
271
R33
ICD-10 Finland
Retention of urine
3.9
7.3
29
80
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
7.3
7
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
7.3
7
*
25310
ICD-8 Finland
Diseases of pituitary gland, Panhypopituitarismus
+∞
7.3
7
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.3
7.3
36
119
N03AX14
ATC
levetiracetam; systemic
6.3
7.2
18
30
H47.2
ICD-10 Finland
Optic atrophy
30.9
7.2
9
*
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
20.6
7.2
10
5
R53
ICD-10 Finland
Malaise and fatigue
2.4
7.0
67
327
L28
ICPC
Limited function/disability (L)
2.6
7.0
51
217
N05CD07
ATC
temazepam; oral
2.9
7.0
44
171
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
7.0
39
140
ZXC95
NOMESCO Finland
Use of surgical navigator
14.2
6.9
11
8
WX882
NOMESCO Finland
High dependency care
7.0
6.9
16
24
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.7
87
489
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.7
121
777
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
6.5
45
186
N05BA04
ATC
oxazepam; oral
2.1
6.5
81
448
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
7.7
6.5
14
19
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
6.4
44
180
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.5
6.4
21
49
E23.06
ICD-10 Finland
Empty sella
+∞
6.3
6
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
6.3
6
*
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
+∞
6.3
6
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.5
6.2
15
24
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.5
6.2
15
24
UKC02
NOMESCO Finland
Cystoscopy
2.5
6.1
48
212
N06AA09
ATC
amitriptyline; systemic
2.9
6.1
35
129
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.8
6.1
16
29
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
6.0
67
350
C02AC05
ATC
moxonidine; oral
5.0
6.0
18
38
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.0
53
250
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
6.0
34
123
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.0
65
337
Mortality – FinRegistry
↥Association
Association between endpoint E4_DIABINSIPIDUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DIABINSIPIDUS | 3.239 [2.46, 4.27] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.864 |
During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 716 females with E4_DIABINSIPIDUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DIABINSIPIDUS | 2.412 [1.78, 3.27] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 595 males with E4_DIABINSIPIDUS died.
Mortality risk
Mortality risk for people of age
years, who have E4_DIABINSIPIDUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.39% | 0.489% |
| 5 | 2.107% | 3.104% |
| 10 | 5.629% | 7.422% |
| 15 | 10.58% | 13.857% |
| 20 | 18.654% | 22.663% |
Relationships between endpoints
↥Index endpoint: E4_DIABINSIPIDUS – Diabetes insipidus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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