Polyglandular dysfunction

E4_DYSPOLYGL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E31
  • Cause of death: ICD-10 E31

2 out of 7 registries used, show all original rules.

64

4. Check minimum number of events

None

64

5. Include endpoints

73

6. Filter based on genotype QC (FinnGen only)

73

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Dysfunctio polyglandularis (endocrina)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 523 320 196
Only index persons 419 270 149
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 38.73 38.37 38.89
Only index persons 35.72 35.52 36.08

-FinnGen-

Key figures

All Female Male
Number of individuals 73 47 26
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 33.77 36.42 28.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
73
Matched controls
730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
175.3
31.6
31
*
H02AA02
ATC
fludrocortisone; oral
+∞
30.3
27
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
29.1
26
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
25.5
23
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
32.5
23.5
31
16
E31.00
ICD-10 Finland
APECED syndrome
+∞
23.1
21
*
A11CC03
ATC
alfacalcidol; systemic
69.8
21.8
24
5
A10AE05
ATC
insulin detemir; parenteral
27.5
20.3
28
16
106
Kela drug reimbursment
Hypoparathyroidism
+∞
19.7
18
*
A12AA04
ATC
calcium carbonate; oral
126.1
18.5
19
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
18.1
17.5
28
24
H03AA01
ATC
levothyroxine sodium; systemic
8.9
16.4
45
111
E31.08
ICD-10 Finland
Autoimmune polyglandular failure
+∞
16.2
15
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
18.3
15.9
25
20
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
29.9
15.2
20
9
103
Kela drug reimbursment
Diabetes, insulin-treated
8.3
15.0
41
97
T89
ICPC
Diabetes insulin dependent
22.1
14.5
21
13
A10AE04
ATC
insulin glargine; parenteral
11.9
14.4
28
36
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.9
14.1
39
92
E31.9
ICD-10 Finland
Polyglandular dysfunction, unspecified
+∞
14.0
13
*
E83.51
ICD-10 Finland
Hypocalcemia
155.7
12.9
13
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
21.2
12.4
18
11
A11CC02
ATC
dihydrotachysterol; oral
+∞
11.8
11
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
42.5
11.7
14
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.3
11.1
36
98
H04AA01
ATC
glucagon; nasal, parenteral
20.0
11.0
16
10
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
38.9
10.7
13
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
9.6
9
*
25810
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Polyglandular dysfunction
+∞
9.6
9
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
9.6
9
*
E31.1
ICD-10 Finland
Polyglandular hyperfunction
+∞
9.6
9
*
104
Kela drug reimbursment
Thyroid insufficiency
11.0
9.5
18
21
A07AA02
ATC
nystatin; oral
11.9
9.4
17
18
XCK10
NOMESCO Finland
Photography of fundus of eye
8.5
9.4
21
33
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
22.2
9.3
13
7
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
19.4
8.9
13
8
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
57.1
8.9
10
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
31.8
8.8
11
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
8.5
8
*
E31.01
ICD-10 Finland
Schmidt's syndrome
+∞
8.5
8
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
20.1
8.4
12
7
E87.6
ICD-10 Finland
Hypokalaemia
38.0
8.3
10
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
38.0
8.3
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.5
8.3
37
135
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
6.5
8.2
22
45
A10AA01
ATC
NA
21.2
7.9
11
6
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.3
7.9
38
147
A09AA02
ATC
multienzymes (lipase, protease etc.)
28.5
7.8
10
*
C03CA01
ATC
furosemide; systemic
4.8
7.6
28
83
E31.0
ICD-10 Finland
Autoimmune polyglandular failure
+∞
7.4
7
*
E31.8
ICD-10 Finland
Other polyglandular dysfunction
+∞
7.4
7
*
25510
ICD-8 Finland
Diseases of adrenal glands, Adrenal cortical hypofunction
+∞
7.4
7
*
2581B
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[AUTOIMMUNE-POLYENDOCRINOPATHY-CANDIDOSIS-ECTOD DYST]
+∞
7.4
7
*
2581A
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[SYNDROMA SCHMIDT]
+∞
7.4
7
*
SPAT1262
SPAT
Handing over of treatment supplies
5.1
7.4
25
67
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
33.7
7.3
9
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
12.8
7.1
12
11
J01MA12
ATC
levofloxacin; systemic
5.4
7.0
22
54
A10AA02
ATC
NA
19.0
7.0
10
6
E83.50
ICD-10 Finland
Hypercalcemia
44.2
6.9
8
*
H3601, E103
ICD-10 Finland
NA
44.2
6.9
8
*
A10AE06
ATC
insulin degludec; parenteral
16.3
6.6
10
7
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
76.2
6.5
7
*
107
Kela drug reimbursment
Pernicious anaemia
20.2
6.4
9
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.7
6.4
23
65
Z01.8
ICD-10 Finland
Other specified special examinations
4.2
6.3
26
84
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
6.3
6
*
L03.0
ICD-10 Finland
Cellulitis of finger and toe
7.6
6.2
14
22
121
Kela drug reimbursment
Severe hypofunction of sexual glands
16.8
6.1
9
6
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
8.1
6.1
13
19

Mortality – FinRegistry

Association

Association between endpoint E4_DYSPOLYGL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_DYSPOLYGL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_DYSPOLYGL – Polyglandular dysfunction

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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