Risteys · E4

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E34, E35 Cause of death: ICD-10 — E34, E35 2 out of 7 registries used, show all original rules.	2051
4. Check minimum number of events None	2051
5. Include endpoints E4_CARCISDR E4_HYPERSEC E4_ECTHOR E4_SHORT E4_TALL E4_ANDRORESIST E4_ENDODISNAS E4_ENDINOTH	2167
6. Filter based on genotype QC (FinnGen only)	2167

	All	Female	Male
Number of individuals
Whole population	31129	16403	14689
Only index persons	22605	12208	10397
Unadjusted period prevalence (%)
Whole population	0.44	0.47	0.41
Only index persons	0.42	0.45	0.40
Median age at first event (years)
Whole population	7.81	8.09	7.35
Only index persons	10.77	11.10	10.40

	All	Female	Male
Number of individuals	2167	1294	873
Unadjusted period prevalence (%)	0.42	0.44	0.38
Median age at first event (years)	15.85	15.95	15.70

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1937: Matched controls
18807

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E34.35

ICD-10 Finland

Abnormal growth retardation

1301.2

323.0

421

E34.9

ICD-10 Finland

Endocrine disorder, unspecified

+∞

323.0

558

E34.0

ICD-10 Finland

Carcinoid syndrome

+∞

291.2

275

H01AC01

ATC

somatropin; parenteral

1448.0

269.3

259

E34.39

ICD-10 Finland

Short stature, not elsewhere classified

930.0

258.8

251

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

21.1

217.5

334

184

E34.30

ICD-10 Finland

Short stature NOS

+∞

206.9

197

101

Kela drug reimbursment

Anterior pituitary hypofunction

+∞

189.8

181

E23.01

ICD-10 Finland

Isolated deficiency of growth hormone

+∞

137.7

132

H01CB02

ATC

octreotide; parenteral

170.3

124.5

131

186

Kela drug reimbursment

Growth retardation associated with renal failure (growth hormone)

+∞

110.3

106

E34.40

ICD-10 Finland

Constitutional tall stature

+∞

108.2

104

301

Kela drug reimbursment

Growth hormone

530.7

104.5

104

C17.9

ICD-10 Finland

Malignant neoplasm: Small intestine, unspecified

97.9

102.9

114

H01CB03

ATC

lanreotide; parenteral

195.9

92.1

E34.45

ICD-10 Finland

Abnormal growth increase

428.6

84.8

E34.31

ICD-10 Finland

Short stature, prenatal disorder

829.0

83.2

130

Kela drug reimbursment

Malignant tumour

6.1

82.0

241

428

AA4CG

NOMESCO Finland

Extensive MRI examination of sella turcica with high intensity magnet

49.8

76.2

JN7AQ

NOMESCO Finland

Somatostatin receptor SPET med low dose CT

259.5

75.1

H02AB09

ATC

hydrocortisone; systemic

7.4

69.6

175

249

XX7JT

NOMESCO Finland

Somatostatin isotope ablative therapy

224.3

64.8

D35.2

ICD-10 Finland

Benign neoplasm: Pituitary gland

63.0

64.0

C78.7

ICD-10 Finland

Secondary malignant neoplasm of liver and intrahepatic bile duct

14.1

57.8

101

25898

ICD-8 Finland

Polyglandular dysfunction and other diseases of endocrine glands, Alii definiti

+∞

56.9

R62.8

ICD-10 Finland

Other lack of expected normal physiological development

18.1

56.2

E23.02

ICD-10 Finland

Neurosecretory dysfunction of the growth hormone

+∞

55.9

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

4.8

55.4

197

431

E21.09

ICD-10 Finland

Other primary hyperparathyroidism

+∞

54.8

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

8.1

54.3

127

161

H03AA01

ATC

levothyroxine sodium; systemic

2.6

53.2

451

1936

E23.00

ICD-10 Finland

Panhypopituitarism

+∞

52.8

C17.2

ICD-10 Finland

Malignant neoplasm: Ileum

111.9

51.4

JN4CD

NOMESCO Finland

Very extensive body CT

8.5

50.4

114

137

JN5ER

NOMESCO Finland

PET-CT of receptors in whole body

50.0

49.4

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

4.8

48.2

170

367

25899

ICD-8 Finland

Polyglandular dysfunction and other diseases of endocrine glands, Other and unspecified diseases of endocrine system

+∞

47.6

8240/3-C17.9

ICD-O-3

Neuroendocrine tumor, NOS, of small intestine, NOS

238.6

46.6

WX408

NOMESCO Finland

General anesthesy, balanced

2.2

46.5

626

3360

XX9AN

NOMESCO Finland

Complementary isotope examination or additional picture

101.6

46.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.1

45.3

767

4534

JFB00

NOMESCO Finland

Partial resection of small intestine

11.0

44.6

E34.3

ICD-10 Finland

Short stature, not elsewhere classified

+∞

44.5

JN3BD

NOMESCO Finland

Extensive abdominal CT

3.3

42.4

230

729

G03BA03

ATC

testosterone; systemic, rectal, sublingual, transdermal

5.7

41.9

125

223

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.5

41.0

375

1652

E34.8

ICD-10 Finland

Other specified endocrine disorders

+∞

39.3

JN4BD

NOMESCO Finland

Extensive body CT

3.3

38.7

210

664

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.2

38.1

499

2604

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.3

38.1

411

1962

C79.8

ICD-10 Finland

Secondary malignant neoplasm of other specified sites

7.2

37.6

132

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.3

35.8

195

617

E30.00

ICD-10 Finland

Familial delayed puberty

353.1

35.7

E30.09

ICD-10 Finland

Delayed puberty NOS

353.1

35.7

D77

ICPC

Malignant digestive neopl other/NOS

39.7

34.9

JN4AD

NOMESCO Finland

Body CT examination

3.8

34.2

153

413

Z31.5

ICD-10 Finland

Genetic counselling

3.3

34.2

182

566

L01AX03

ATC

temozolomide; systemic

27.5

34.2

D37.2

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Small intestine

23.2

34.0

XX3DW

NOMESCO Finland

Time consuming IT work

3.0

32.3

199

685

SPAT1262

SPAT

Handing over of treatment supplies

2.4

31.3

308

1391

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

3.4

31.2

161

488

JN7AN

NOMESCO Finland

Somatostatin receptor isotope imaging

+∞

31.0

602

Kela drug reimbursment

Children's severe malnutrition

5.8

30.6

154

WD305

NOMESCO Finland

Simple therapy of methastized malignancy with biomodifiers

16.8

30.5

302

Kela drug reimbursment

Interferon alfa

157.8

30.4

UJF32

NOMESCO Finland

Coloscopy

2.1

29.4

397

2069

AAE10

NOMESCO Finland

Transsphenoidal total or partial excision of intracranial lesion

152.8

29.4

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.0

29.3

466

2595

WD225

NOMESCO Finland

Demanding therapy of methastized malignancy with hormones

16.7

29.2

A11CC03

ATC

alfacalcidol; systemic

6.5

28.6

117

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.8

28.6

757

5016

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

4.0

28.3

120

309

BBA40

NOMESCO Finland

Subtotal parathyroidectomy

277.0

27.5

AA4CM

NOMESCO Finland

Extensive MRI examination of sella turcica with 3 Tesla magnet

142.8

27.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.0

27.3

446

2497

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

2.5

26.9

235

994

A03FA01

ATC

metoclopramide; systemic, rectal

2.1

26.7

332

1664

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.7

26.4

710

4694

JN7SN

NOMESCO Finland

Somatostatin receptor SPECT

+∞

25.8

106

Kela drug reimbursment

Hypoparathyroidism

+∞

25.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.1

25.8

348

1802

E22.1

ICD-10 Finland

Hyperprolactinaemia

71.5

25.5

T73

ICPC

Neoplasm endocrine other/unspecified

91.9

25.4

A09AA02

ATC

multienzymes (lipase, protease etc.)

7.8

24.4

C17.8

ICD-10 Finland

Malignant neoplasm: Overlapping lesion of small intestine

245.8

24.4

E21.0

ICD-10 Finland

Primary hyperparathyroidism

127.8

24.3

105

Kela drug reimbursment

Adrenal cortical hypofunction

+∞

23.7

E22.80

ICD-10 Finland

Central precocious puberty

235.7

23.4

WX302

NOMESCO Finland

Thoracal epidural anesthesy

3.4

23.2

116

343

BF20A

NOMESCO Finland

+∞

22.7

JN3AD

NOMESCO Finland

Abdominal CT examination

3.1

22.5

133

443

D37.7

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Other digestive organs

6.0

22.5

105

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.5

21.9

190

796

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

2.4

21.9

203

881

L03AB05

ATC

interferon alfa-2b; parenteral

23.5

21.8

C25.4

ICD-10 Finland

Malignant neoplasm: Endocrine pancreas

215.8

21.4

8240/3-C17.2

ICD-O-3

Neuroendocrine tumor, NOS, of ileum

215.8

21.4

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.6

21.3

677

4625

JFB30

NOMESCO Finland

Right hemicolectomy

8.9

21.1

C10AC01

ATC

colestyramine; oral

5.2

20.9

127

EP1AE

NOMESCO Finland

Neck ultrasound examination

3.1

20.4

116

377

A02BC01

ATC

omeprazole; systemic

1.8

20.4

406

2406

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

4.5

20.3

162

A12AA04

ATC

calcium carbonate; oral

7.4

20.2

RD210

NOMESCO Finland

3.4

20.1

102

306

J01MA12

ATC

levofloxacin; systemic

2.1

19.9

259

1310

133

Kela drug reimbursment

Severe chronic pancreatic insufficiency

8.2

19.7

R50.9

ICD-10 Finland

Fever, unspecified

1.9

19.6

341

1927

104

Kela drug reimbursment

Thyroid insufficiency

3.0

19.6

114

378

E30.1

ICD-10 Finland

Precocious puberty

196.0

19.3

N02AA05

ATC

oxycodone; systemic

2.3

19.3

184

809

JKA20

NOMESCO Finland

Cholecystectomy

5.8

19.2

R62.0

ICD-10 Finland

Delayed milestone

3.4

19.0

272

A04AA02

ATC

granisetron; systemic, transdermal

3.2

18.7

103

329

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

3.5

18.6

255

E22.0

ICD-10 Finland

Acromegaly and pituitary gigantism

+∞

18.6

NH3EA

NOMESCO Finland

Feet X-ray examination with load

5.5

18.4

100

Z51.80

ICD-10 Finland

Manipulation of puberty development with hormone therapy

186.1

18.3

127

Kela drug reimbursment

Transplant complication

4.7

18.3

130

B03BA03

ATC

hydroxocobalamin; parenteral

3.4

18.2

260

D37.6

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts

7.6

17.9

7834C

ICD-9 Finland

Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]

32.2

17.7

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.5

17.7

147

604

102

Kela drug reimbursment

Diabetes insipidus

+∞

17.5

C03CA01

ATC

furosemide; systemic

1.9

17.5

305

1722

WX723

NOMESCO Finland

CPAP therapy

4.1

17.4

164

D35.0

ICD-10 Finland

Benign neoplasm: Adrenal gland

8.0

17.3

K56.6

ICD-10 Finland

Other and unspecified intestinal obstruction

4.4

17.2

143

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.8

16.7

336

1985

E27.3

ICD-10 Finland

Drug-induced adrenocortical insufficiency

+∞

16.5

E34.1

ICD-10 Finland

Other hypersecretion of intestinal hormones

+∞

16.5

JF1AB

NOMESCO Finland

Passage examination of small bowell with X-ray

5.2

16.5

121

Kela drug reimbursment

Severe hypofunction of sexual glands

5.5

16.5

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

2.9

16.4

100

343

E26.0

ICD-10 Finland

Primary hyperaldosteronism

166.3

16.3

8249/3-C17.9

ICD-O-3

Neuroendocrine tumor, grade 2 of small intestine, NOS

166.3

16.3

XX9AD

NOMESCO Finland

Complementary CT

166.3

16.3

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

4.4

16.3

133

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

4.1

16.1

153

D44.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Adrenal gland

8.8

16.1

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

1.9

16.0

254

1382

L01BC06

ATC

capecitabine; oral

3.9

15.9

164

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.7

15.5

370

2297

E30.9

ICD-10 Finland

Disorder of puberty, unspecified

+∞

15.5

8246/3-C17.9

ICD-O-3

Neuroendocrine carcinoma, NOS, of small intestine, NOS

+∞

15.5

E34.5

ICD-10 Finland

Androgen resistance syndrome

+∞

15.5

XFE00

NOMESCO Finland

Epicardial ultrasonography

4.3

15.4

131

BCA31

NOMESCO Finland

Endoscopic unilateral adrenalectomy

25.7

15.4

JAH00

NOMESCO Finland

Laparotomy

3.9

15.3

165

E27.1

ICD-10 Finland

Primary adrenocortical insufficiency

156.5

15.3

E21.3

ICD-10 Finland

Hyperparathyroidism, unspecified

37.2

15.2

JN1DG

NOMESCO Finland

Very extensive MRI examination of upper part of abdomen with high intensity magnet

5.3

15.1

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.8

15.1

276

1576

UKC02

NOMESCO Finland

Cystoscopy

2.1

15.0

189

941

G02CB01

ATC

bromocriptine; systemic

6.4

15.0

JN3CG

NOMESCO Finland

Extensive MRI examination of abdomen with high intensity magnet

5.5

15.0

E23.04

ICD-10 Finland

Hypogonadotropic hypogonadism

22.9

14.9

WZC30

NOMESCO Finland

Teaching

2.0

14.8

204

1053

T99

ICPC

Endocr/metab/nutrit disease other

5.8

14.6

D44.8

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement

+∞

14.4

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

2.0

14.4

206

1077

C17.0

ICD-10 Finland

Malignant neoplasm: Duodenum

78.3

14.4

SPAT1377

SPAT

Polysomnography

3.7

14.3

170

JN4DD

NOMESCO Finland

Scout CT scan of torso

35.2

14.2

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

2.1

14.1

172

846

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.6

13.9

425

2811

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

6.6

13.9

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

3.7

13.8

161

-50

ICPC

Medication/prescr/renewal

3.0

13.7

273

TPH07

NOMESCO Finland

Cathetrisation of artery

2.0

13.7

189

977

L04AA01

ATC

[U] ciclosporin; systemic

5.4

13.5

A12AA06

ATC

calcium lactate gluconate; oral

136.8

13.3

L04AA06

ATC

mycophenolic acid; systemic

4.0

13.3

132

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

2.1

13.2

148

702

N04BC06

ATC

cabergoline; oral (dopamine agonists)

20.7

13.1

TPH04

NOMESCO Finland

Cathetrisation of vein

1.7

13.0

324

2027

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

2.2

12.9

136

627

F82

ICD-10 Finland

Specific developmental disorder of motor function

3.7

12.8

146

OAB74

NOMESCO Finland

Nutritional guidance related to treatment and rehabilitation for medical condition

6.7

12.8

E83.50

ICD-10 Finland

Hypercalcemia

7.7

12.8

H02AA02

ATC

fludrocortisone; oral

10.7

12.8

E27.0

ICD-10 Finland

Other adrenocortical overactivity

68.2

12.4

XF404

NOMESCO Finland

Ambulatory ECG

2.1

12.4

151

743

2592A

ICD-9 Finland

Other endocrine disorders, Carcinoid syndrome

+∞

12.4

BB1BQ

NOMESCO Finland

Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT

+∞

12.4

E27.4

ICD-10 Finland

Other and unspecified adrenocortical insufficiency

+∞

12.4

2594A

ICD-9 Finland

Other endocrine disorders, Dwarfism, not elsewhere classified

+∞

12.4

E23.6

ICD-10 Finland

Other disorders of pituitary gland

+∞

12.4

UDC00

NOMESCO Finland

Ear microscopy

2.0

12.1

153

763

JN3DE

NOMESCO Finland

Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation

4.5

12.1

-44

ICPC

Preventive immunization/medic

2.1

12.1

140

675

N06AA09

ATC

amitriptyline; systemic

2.2

12.0

126

581

J45.1

ICD-10 Finland

Nonallergic asthma

2.0

12.0

156

785

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

2.1

11.9

143

699

A02BC05

ATC

esomeprazole; systemic

1.5

11.9

511

3645

SPAT1325

SPAT

Vaccination

1.4

11.8

642

4805

R4190

NOMESCO Finland

Nutritional therapy

2.0

11.8

148

735

B81

ICPC

Anaemia vit B12/folate deficiency

3.4

11.8

168

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

4.0

11.6

110

A02BA02

ATC

ranitidine; systemic

1.8

11.5

225

1310

WX780

NOMESCO Finland

Remote monitoring CPAP

3.1

11.5

198

E28.3

ICD-10 Finland

Primary ovarian failure

63.4

11.5

G47.3

ICD-10 Finland

Sleep apnoea

1.7

11.4

244

1460

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.7

11.4

227

1329

E24.0

ICD-10 Finland

Pituitary-dependent Cushing disease

+∞

11.3

8240/3-C34.9

ICD-O-3

Neuroendocrine tumor, NOS, of lung, NOS

+∞

11.3

E35.8

ICD-10 Finland

Disorders of other endocrine glands in diseases classified elsewhere

+∞

11.3

E25.01

ICD-10 Finland

Congenital adrenal hyperplasia

+∞

11.3

321

Kela drug reimbursment

Paricalcitol and cinacalcet

117.1

11.3

E21.1

ICD-10 Finland

Secondary hyperparathyroidism, not elsewhere classified

117.1

11.3

WX402

NOMESCO Finland

General anaesthesia

1.6

11.3

321

2075

R11

ICD-10 Finland

Nausea and vomiting

1.9

11.3

176

953

JN4JR

NOMESCO Finland

Whole body extensive metabolic PET with CT

9.0

11.2

N02AX02

ATC

tramadol; systemic, rectal

1.5

11.2

508

3658

205

Kela drug reimbursment

Chronic hypertension

1.7

11.2

277

1726

C17.1

ICD-10 Finland

Malignant neoplasm: Jejunum

34.2

11.1

BCA30

NOMESCO Finland

Unilateral adrenalectomy

34.2

11.1

R1100

NOMESCO Finland

General evaluation of the need for rehabilitation

2.7

11.1

264

E28.2

ICD-10 Finland

Polycystic ovarian syndrome

6.8

11.1

SPAT1153

SPAT

Removal of sutures

1.5

11.0

419

2899

C18.99

ICD-10 Finland

Malignant tumor in unspecified location in the colon other or unspecified histology

16.6

11.0

R06.0

ICD-10 Finland

Dyspnoea

1.6

11.0

328

2147

C18.09

ICD-10 Finland

Malignant tumor of caecum other or unspecified histology

24.4

11.0

B01AB10

ATC

tinzaparin; parenteral

2.4

10.9

400

E13.9

ICD-10 Finland

Other specified diabetes mellitus, without complications

6.6

10.9

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

5.3

10.9

F83

ICD-10 Finland

Mixed specific developmental disorders

2.9

10.8

233

N06AX16

ATC

venlafaxine; oral

1.8

10.8

207

1200

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.6

10.8

297

1905

JN3DG

NOMESCO Finland

Very extensive MRI examination with high intensity magnet

5.9

10.8

601

Kela drug reimbursment

Severe malabsorption of nutrients, mainly fats

4.3

10.7

TDW99

NOMESCO Finland

Other minor procedure in surgery of ear, nose and larynx

3.0

10.7

207

SPAT1324

SPAT

Screening procedure

0.5

10.6

1429

H02AB06

ATC

prednisolone; systemic

1.4

10.6

645

4907

C18.90

ICD-10 Finland

Malignant tumor in unspecified location in the colon without histology

27.3

10.6

Z56.5

ICD-10 Finland

Uncongenial work

27.3

10.6

OAB73

NOMESCO Finland

Prevention and treatment of malnutrition

10.3

10.6

JF1BD

NOMESCO Finland

Very extensive small bowel CT

8.6

10.5

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

3.7

10.5

121

Z01.9

ICD-10 Finland

Special examination, unspecified

2.4

10.5

371

Z94.0

ICD-10 Finland

Kidney transplant status

4.3

10.5

E29.1

ICD-10 Finland

Testicular hypofunction

12.6

10.4

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

1.8

10.4

181

1018

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

2.9

10.3

202

E23.03

ICD-10 Finland

Lack of ACTH

+∞

10.3

KA1MN

NOMESCO Finland

Glomerular filtration rate (GFR) Isotope mesurement

3.4

10.2

139

Z01.8

ICD-10 Finland

Other specified special examinations

1.6

10.2

328

2181

C18.19

ICD-10 Finland

Malignant tumor in appendix other or unspecified histology

15.6

10.2

RL140

NOMESCO Finland

4.9

10.2

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.0

10.2

132

667

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

2.0

10.1

132

668

E87.6

ICD-10 Finland

Hypokalaemia

3.4

10.1

141

C25.0

ICD-10 Finland

Malignant neoplasm: Head of pancreas

6.9

10.0

H05BX01

ATC

cinacalcet; oral

39.0

9.8

A11CC02

ATC

dihydrotachysterol; oral

39.0

9.8

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.4

9.8

758

5992

SPAT1312

SPAT

General health counselling

1.4

9.8

680

5278

A06AD11

ATC

lactulose; oral

1.8

9.8

165

917

JKA21

NOMESCO Finland

Laparoscopic cholecystectomy

2.0

9.7

127

644

EB1JA

NOMESCO Finland

Double panorama tomography of teeth and jaws or similar X-ray examination

5.9

9.7

K03.66

ICD-10 Finland

Tooth plaque

1.8

9.7

168

938

C25.2

ICD-10 Finland

Malignant neoplasm: Tail of pancreas

25.4

9.7

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.8

9.7

164

912

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

1.9

9.6

134

697

Q87.88

ICD-10 Finland

Other specified congenital malformation syndromes, not elsewhere classified

8.5

9.6

JFB20

NOMESCO Finland

Ileocaecal resection

9.3

9.6

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

1.9

9.5

139

734

158

Kela drug reimbursment

Everolimus

53.6

9.5

E23.2

ICD-10 Finland

Diabetes insipidus

53.6

9.5

Z51.5

ICD-10 Finland

Palliative care

2.6

9.5

261

E16.2

ICD-10 Finland

Hypoglycaemia, unspecified

4.1

9.5

WX110

NOMESCO Finland

Local anesthesy

1.4

9.4

1248

10727

L04AD01

ATC

ciclosporin; systemic

3.1

9.4

154

ZXA10

NOMESCO Finland

Bilateral

1.6

9.3

292

1928

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

2.7

9.3

233

P05.1

ICD-10 Finland

Small for gestational age

6.2

9.3

D44.9

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Endocrine gland, unspecified

97.5

9.3

E27.5

ICD-10 Finland

Adrenomedullary hyperfunction

97.5

9.3

E340, C179

ICD-10 Finland

+∞

9.3

8240/3-C20.9

ICD-O-3

Neuroendocrine tumor, NOS, of rectum, NOS

+∞

9.3

2520A

ICD-9 Finland

Disorders of parathyroid gland, Hyperparathyroidism

+∞

9.3

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

2.8

9.2

212

WX400

NOMESCO Finland

Inhalation anesthesy

2.0

9.2

115

574

A41.9

ICD-10 Finland

Sepsis, unspecified

2.6

9.2

260

NJ3DA

NOMESCO Finland

Long bones of extremities X-ray examination

7.3

9.2

A55

ICPC

General and Unspecified, Local injection/infiltration

6.4

9.2

WZA10

NOMESCO Finland

Long statement of health and health related matters

3.7

9.2

100

ZX120

NOMESCO Finland

Intravenous

1.8

9.2

151

832

C03DA01

ATC

spironolactone; oral

1.9

9.1

130

679

R68.8

ICD-10 Finland

Other specified general symptoms and signs

5.7

9.1

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.1

9.1

107

520

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

2.5

9.0

267

DM1AI

NOMESCO Finland

Cone beam CT of paranasal sinus

3.0

9.0

159

A02BC02

ATC

pantoprazole; systemic

1.3

9.0

828

6702

XKC03

NOMESCO Finland

Water cystometry

3.1

9.0

154

B01AB05

ATC

enoxaparin; parenteral

1.5

9.0

348

2412

SPAT1301

SPAT

No procedures

1.4

8.9

531

3995

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

3.1

8.9

150

E0000UV

ATC

1.4

8.9

704

5561

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.8

8.8

164

938

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.6

8.8

231

1458

JLC10

NOMESCO Finland

Distal pancreatectomy

18.1

8.8

D76

ICPC

Malignant neoplasm pancreas

23.4

8.8

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

1.9

8.8

135

728

SPAT1263

SPAT

Sampling

1.3

8.6

726

5784

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.1

8.6

101

490

N03AX16

ATC

pregabalin; oral

1.6

8.6

265

1742

Z96.6

ICD-10 Finland

Presence of orthopaedic joint implants

3.0

8.6

154

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

2.4

8.6

312

8249/3-C17.2

ICD-O-3

Neuroendocrine tumor, grade 2 of ileum

48.7

8.6

Q87.19

ICD-10 Finland

Congenital malformation syndromes predominantly associated with short stature

48.7

8.6

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.7

8.6

196

1195

L04AX01

ATC

azathioprine; systemic

2.2

8.5

398

137

Kela drug reimbursment

Uraemia requiring dialysis

5.0

8.5

KA2AE

NOMESCO Finland

Ultrasound examination transplanted kidney

4.9

8.4

B03XA01

ATC

erythropoietin; parenteral

5.1

8.4

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

5.3

8.4

SPAT1249

SPAT

Treatment-related counselling outside office

1.3

8.4

695

5520

D37.9

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified

8.7

8.3

J45.9

ICD-10 Finland

Asthma, unspecified

1.5

8.3

275

1834

AA1AD

NOMESCO Finland

CT of head and brain

1.5

8.3

262

1730

C07AB02

ATC

metoprolol; systemic

1.6

8.3

215

1352

BBA30

NOMESCO Finland

Excision of lesion of parathyroid gland

87.8

8.3

E21.2

ICD-10 Finland

Other hyperparathyroidism

87.8

8.3

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.7

8.3

163

952

R5140

NOMESCO Finland

Monitoring the use of the aid

1.9

8.3

120

634

K85

ICD-10 Finland

Acute pancreatitis

4.6

8.3

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

2.5

8.3

257

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

1.9

8.3

125

670

OAB72

NOMESCO Finland

Weight control and weight loss guidance

7.1

8.2

G44.2

ICD-10 Finland

Tension-type headache

1.6

8.2

196

1207

8249/3-C25.9

ICD-O-3

Neuroendocrine tumor, grade 2 of pancreas, NOS

+∞

8.2

E24.9

ICD-10 Finland

Cushing syndrome, unspecified

+∞

8.2

E20.8

ICD-10 Finland

Other hypoparathyroidism

+∞

8.2

E83.51

ICD-10 Finland

Hypocalcemia

12.4

8.2

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

1.6

8.2

206

1288

A07AA02

ATC

nystatin; oral

2.2

8.1

374

BC00A

NOMESCO Finland

9.2

8.1

JAH01

NOMESCO Finland

Laparoscopy

2.3

8.1

303

F59

ICD-10 Finland

Unspecified behavioural syndromes associated with physiological disturbances and physical factors

5.1

8.1

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

1.6

8.1

242

1581

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

2.5

8.1

230

TDM10

NOMESCO Finland

Puncture of maxillary antrum

2.3

8.0

287

XX4AW

NOMESCO Finland

3.3

8.0

113

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

4.3

8.0

E23.05

ICD-10 Finland

Lack of TSH

32.5

8.0

8240/3-C18.2

ICD-O-3

Neuroendocrine tumor, NOS, of ascending colon

32.5

8.0

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.2

8.0

360

XA800

NOMESCO Finland

Neuropsychological investigation

1.9

7.9

105

539

SAA04

NOMESCO Finland

Special inverstigation of mouth

1.7

7.9

150

865

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

4.2

7.9

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

1.6

7.8

215

1375

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

2.9

7.8

151

XKD00

NOMESCO Finland

Uroflowmetry

1.7

7.8

158

929

M81.9

ICD-10 Finland

Osteoporosis, unspecified

2.9

7.8

152

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

2.1

7.7

423

R53

ICD-10 Finland

Malaise and fatigue

1.5

7.7

291

2000

I15.9

ICD-10 Finland

Secondary hypertension, unspecified

6.4

7.7

A06AC01

ATC

ispaghula (psylla seeds); oral

1.5

7.7

280

1910

XF602

NOMESCO Finland

Bloodpressure monitoring

3.7

7.7

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

2.8

7.6

167

L01CB01

ATC

etoposide; systemic

10.5

7.6

C74.9

ICD-10 Finland

Malignant neoplasm: Adrenal gland, unspecified

43.8

7.6

L01XE10

ATC

[U] everolimus; oral

43.8

7.6

340

Kela drug reimbursment

Everolimus

43.8

7.6

H04.10

ICD-10 Finland

Dry eye syndrome

1.8

7.5

121

664

E03.80

ICD-10 Finland

Hypothyroidism caused by autoimmune thyroiditis

2.8

7.5

163

S02.51

ICD-10 Finland

Fracture of tooth, open

1.8

7.5

135

767

E66.2

ICD-10 Finland

Extreme obesity with alveolar hypoventilation

5.8

7.5

T90

ICPC

Diabetes non-insulin dependent

1.6

7.5

221

1437

T10

ICPC

Growth delay

5.4

7.5

318

Kela drug reimbursment

Teriparatide

24.4

7.5

Q87.14

ICD-10 Finland

Noonan's syndrome

24.4

7.5

SPAT1260

SPAT

Consultation of another employee

1.5

7.4

277

1900

Y0099

ICD-8 Finland

Investigation of endocrine system and metabolism

8.6

7.4

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

1.7

7.4

157

938

N03AX09

ATC

lamotrigine; oral

2.0

7.3

434

E21

ICD-10 Finland

Hyperparathyroidism and other disorders of parathyroid gland

78.0

7.3

8240/3-C25.9

ICD-O-3

Neuroendocrine tumor, NOS, of pancreas, NOS

78.0

7.3

E89.6

ICD-10 Finland

Postprocedural adrenocortical(-medullary) hypofunction

78.0

7.3

K65.0

ICD-10 Finland

Acute peritonitis

5.3

7.3

N05BA04

ATC

oxazepam; oral

1.4

7.3

321

2275

F98.2

ICD-10 Finland

Feeding disorder of infancy and childhood

4.2

7.3

M80.4

ICD-10 Finland

Drug-induced osteoporosis with pathological fracture

13.0

7.2

M79.0

ICD-10 Finland

Rheumatism, unspecified

2.6

7.2

179

1522B

ICD-9 Finland

Malignant neoplasm of small intestine, including duodenum, Ileum[NEOPLASMA MALIGNUM ILEI,ALIA DEFINITA SEU NUD]

+∞

7.2

E26.9

ICD-10 Finland

Hyperaldosteronism, unspecified

+∞

7.2

E22.9

ICD-10 Finland

Hyperfunction of pituitary gland, unspecified

+∞

7.2

E34.4

ICD-10 Finland

Constitutional tall stature

+∞

7.2

E21.5

ICD-10 Finland

Disorder of parathyroid gland, unspecified

+∞

7.2

8249/3-C80.9

ICD-O-3

Neuroendocrine tumor, grade 2 of unknown primary site

+∞

7.2

BB1AN

NOMESCO Finland

Parathyroid gland isotope imaging, 1 isotope

+∞

7.2

E35.0

ICD-10 Finland

Disorders of thyroid gland in diseases classified elsewhere

+∞

7.2

K43.9

ICD-10 Finland

Other and unspecified ventral hernia without obstruction or gangrene

2.4

7.2

222

SPAT1094

SPAT

Continuous Positive Airway Pressure

5.8

7.2

H02AB04

ATC

methylprednisolone; systemic

1.6

7.2

173

1070

N91.0

ICD-10 Finland

Primary amenorrhoea

8.1

7.2

Z99.2

ICD-10 Finland

Dependence on renal dialysis

8.1

7.2

D89.89

ICD-10 Finland

Other specified disorders involving the immune mechanism, not elsewhere classified

10.6

7.2

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

3.1

7.1

113

E89.01

ICD-10 Finland

Postsurgical hypothyroidism

4.2

7.1

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

2.4

7.1

247

SPAT1310

SPAT

Counselling related to known health issue

1.3

7.1

559

4379

C25.9

ICD-10 Finland

Malignant neoplasm: Pancreas, unspecified

6.1

7.1

K00.40

ICD-10 Finland

Postnatal enamel hypoplasia

2.5

7.0

200

UGC12

NOMESCO Finland

Flexible bronchoscopy

1.9

7.0

470

ED1AA

NOMESCO Finland

Mandipular X-ray examination

7.1

7.0

JJA20

NOMESCO Finland

Open biopsy of liver

7.7

6.9

E03

ICD-10 Finland

Other hypothyroidism

2.1

6.9

362

M03BX01

ATC

baclofen; systemic

3.8

6.9

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.5

6.9

284

1988

TK800

NOMESCO Finland

Hemodialysis

3.2

6.9

105

N18.8

ICD-10 Finland

Other chronic renal failure

2.9

6.9

137

N06AB04

ATC

citalopram; systemic

1.5

6.8

256

1754

YHMAS

NOMESCO Finland

4.6

6.8

TJD20

NOMESCO Finland

Change of gastrostomy tube

4.2

6.8

FM2CE

NOMESCO Finland

2.0

6.8

373

H03BB01

ATC

carbimazole; oral

2.3

6.8

241

BAA40

NOMESCO Finland

Unilateral lobectomy of thyroid gland

3.3

6.7

WX610

NOMESCO Finland

Patient controlled analgesia

5.0

6.7

KAC00

NOMESCO Finland

Nephrectomy

5.7

6.7

JAK10

NOMESCO Finland

Laparotomy and insertion of peritoneal dialysis catheter

5.3

6.7

AA1BD

NOMESCO Finland

Extensive CT of head and brain

3.2

6.7

102

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

1.7

6.7

139

825

R03AC02

ATC

salbutamol; inhalant

1.3

6.7

886

7445

R1230

NOMESCO Finland

Neuropsychological evaluation of need and possibilities to rehabilitation

2.4

6.7

206

E30.8

ICD-10 Finland

Other disorders of puberty

38.9

6.7

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.7

6.7

131

768

JN1CD

NOMESCO Finland

Very extensive CT examination of upper part of abdomen

6.5

6.6

5AB14

NOMESCO Finland

6.5

6.6

N32.82

ICD-10 Finland

Instability of the detrusor vesicae muscle

4.7

6.6

E89.2

ICD-10 Finland

Postprocedural hypoparathyroidism

16.2

6.6

TPX10

NOMESCO Finland

Implantation of vascular injection port

2.5

6.6

189

Z63.7

ICD-10 Finland

Other stressful life events affecting family and household

2.0

6.6

370

V03AG01

ATC

sodium cellulose phosphate; systemic

4.9

6.6

XW1AT

NOMESCO Finland

Biopsy from other organ close to skin with ultrasound quidance

5.9

6.6

WW500

NOMESCO Finland

Blood transfusion

2.2

6.6

301

E89.00

ICD-10 Finland

Postirradiation hypothyroidism

5.5

6.6

A79

ICPC

Malignancy NOS

4.4

6.6

R19.0

ICD-10 Finland

Intra-abdominal and pelvic swelling, mass and lump

3.0

6.5

115

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

1.7

6.5

126

731

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

2.5

6.5

194

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

4.6

6.5

N06AX21

ATC

duloxetine; oral

1.7

6.5

136

810

BAA60

NOMESCO Finland

Total thyroidectomy

3.2

6.5

AA1AA

NOMESCO Finland

Head X-ray examination

4.8

6.5

A08.4

ICD-10 Finland

Viral intestinal infection, unspecified

1.8

6.5

108

600

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

2.3

6.4

223

SPAT1281

SPAT

Other administrative function

1.6

6.4

151

927

C08CA01

ATC

amlodipine; oral

1.4

6.4

327

2380

J01MA02

ATC

ciprofloxacin; systemic

1.3

6.4

438

3346

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

9.8

6.4

C01BD07

ATC

dronedarone; oral

9.8

6.4

A01AB09

ATC

miconazole; local oral

1.7

6.4

118

679

GD2SN

NOMESCO Finland

Lung ventilation SPECT

6.7

6.4

R01AD08

ATC

fluticasone; nasal

1.4

6.4

385

2884

1CB02

NOMESCO Finland

68.0

6.3

D35.1

ICD-10 Finland

Benign neoplasm: Parathyroid gland

68.0

6.3

8246/3-C80.9

ICD-O-3

Neuroendocrine carcinoma, NOS, of unknown primary site

68.0

6.3

E20.0

ICD-10 Finland

Idiopathic hypoparathyroidism

68.0

6.3

R03AK06

ATC

salmeterol and fluticasone; inhalant

1.6

6.3

181

1170

E66.01

ICD-10 Finland

Obesity due to excess calories

1.7

6.3

121

702

C08CA02

ATC

felodipine; oral

1.9

6.3

473

EBA15

NOMESCO Finland

Extraction of large number of teeth

2.2

6.3

294

197

Kela drug reimbursment

Sunitinib

13.9

6.3

SCA02

NOMESCO Finland

Analysis and advice of nutrition with regard to dentistry

1.4

6.3

339

2490

FP4B5

NOMESCO Finland

ECG, prolonged recording (24 h)

4.4

6.3

R4180

NOMESCO Finland

Podiatric therapy

4.4

6.3

K06.18

ICD-10 Finland

Another gingival hyperplasia

4.4

6.3

N25.8

ICD-10 Finland

Other disorders resulting from impaired renal tubular function

7.2

6.3

E000003

ATC

1.9

6.2

436

N17.9

ICD-10 Finland

Acute renal failure, unspecified

2.6

6.2

153

-1

SPAT

1.8

6.2

102

563

E23.08

ICD-10 Finland

Hypopituitarism

+∞

6.2

2522

FHL

Removal of parathyroidism or multiple parathyroidism (including removal of adenoma or total removal)

+∞

6.2

8246/3-C25.9

ICD-O-3

Neuroendocrine carcinoma, NOS, of pancreas, NOS

+∞

6.2

E35.1

ICD-10 Finland

Disorders of adrenal glands in diseases classified elsewhere

+∞

6.2

E89.30

ICD-10 Finland

Postprocedural hypopituitarism

+∞

6.2

E23.09

ICD-10 Finland

Pituitary insufficiency NOS

+∞

6.2

E20.1

ICD-10 Finland

Pseudohypoparathyroidism

+∞

6.2

E27.2

ICD-10 Finland

Addisonian crisis

+∞

6.2

R55

ICD-10 Finland

Syncope and collapse

1.7

6.2

136

822

XLA10

NOMESCO Finland

2.3

6.2

226

Z50.0

ICD-10 Finland

Cardiac rehabilitation

4.8

6.2

ZX070

NOMESCO Finland

Intensity modified radiotherapy

3.3

6.2

KA2AT

NOMESCO Finland

Biopsy of transplanted kidney with ultrasound guidance

4.3

6.1

Q87.4

ICD-10 Finland

Marfan syndrome

26.0

6.1

8240/3-C16.9

ICD-O-3

Neuroendocrine tumor, NOS, of stomach, NOS

26.0

6.1

H05AA02

ATC

teriparatide; parenteral

26.0

6.1

6402

FHL

Small bowel resection

26.0

6.1

J20

ICD-10 Finland

Acute bronchitis

1.7

6.1

131

787

I20.99

ICD-10 Finland

Angina pectoris, unspecified

2.2

6.1

268

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.3

6.1

450

3477

H66.0

ICD-10 Finland

Acute suppurative otitis media

1.4

6.1

280

1999

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

2.9

6.1

110

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

1.4

6.1

260

1830

SPAT1238

SPAT

Brief therapy

2.6

6.1

149

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

2.3

6.1

230

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

2.5

6.1

166

H52.0

ICD-10 Finland

Hypermetropia

2.2

6.0

242

L02AE02

ATC

leuprorelin; implant, parenteral

2.4

6.0

203

C07AB07

ATC

bisoprolol; oral

1.3

6.0

464

3610

J45.0

ICD-10 Finland

Predominantly allergic asthma

1.6

6.0

170

1097

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

1.8

6.0

535

NAME	E4_ENDODIS
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_CARCISDR\|E4_HYPERSEC\|E4_ECTHOR\|E4_SHORT\|E4_TALL\|E4_ANDRORESIST\|E4_ENDODISNAS\|E4_ENDINOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E3[4-5]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E3[4-5]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
E4_ENDODIS	2.214 [1.89, 2.6]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.06

Parameter	HR [95% CI]	p-value
E4_ENDODIS	2.624 [2.25, 3.06]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.011

N-year risk	Females	Males
1	0.208%	0.389%
5	1.229%	2.819%
10	2.919%	6.793%
15	5.687%	13.4%
20	9.654%	22.642%

Other endocrine disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints