No definition available.
Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
E4_HYPOTHALDYSF
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
69 |
4. Check minimum number of eventsNone |
69 |
5. Include endpointsNone |
69 |
6. Filter based on genotype QC (FinnGen only) |
69 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Exclusions for E4_PCOS_BROAD
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 500 | 262 | 235 |
| Only index persons | 443 | 232 | 211 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 36.55 | 37.24 | 35.34 |
| Only index persons | 34.34 | 35.41 | 33.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 40 | 29 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 39.36 | 38.41 | 40.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 63
- Matched controls
- 631
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
253.7
37.4
35
*
E23.3
ICD-10 Finland
Hypothalamic dysfunction, not elsewhere classified
+∞
34.6
30
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
33.3
29
*
E23.1
ICD-10 Finland
Drug-induced hypopituitarism
+∞
33.3
29
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
23.4
21
*
H01AC01
ATC
somatropin; parenteral
+∞
18.6
17
*
H03AA01
ATC
levothyroxine sodium; systemic
11.0
15.8
36
68
E23.03
ICD-10 Finland
Lack of ACTH
+∞
14.1
13
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
14.1
13
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
9.0
11.9
28
51
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.7
10
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
12.8
10.1
18
19
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
20.7
8.5
12
7
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
20.7
8.5
12
7
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
16.0
8.3
13
10
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
7.4
7
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
34.4
7.4
9
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
77.4
6.6
7
*
H02AA02
ATC
fludrocortisone; oral
77.4
6.6
7
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
6.3
6
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
6.3
6
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
6.7
6.0
15
28
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOTHALDYSF and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYPOTHALDYSF.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYPOTHALDYSF – Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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