Postinfectious hypothyroidism

E4_HYTHYPOSTINF

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E03.3
  • Hospital discharge: ICD-9 2448A
  • Cause of death: ICD-10 E03.3
  • Cause of death: ICD-9 2448A

2 out of 7 registries used, show all original rules.

193

4. Check minimum number of events

None

193

5. Include endpoints

None

193

6. Filter based on genotype QC (FinnGen only)

185

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Hypothyreosis postinfectiosa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2062 1681 349
Only index persons 1434 1198 236
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.01
Only index persons 0.04 0.04 0.01
Median age at first event (years)
Whole population 55.61 56.08 52.28
Only index persons 48.62 49.33 45.03

-FinnGen-

Key figures

All Female Male
Number of individuals 185 157 28
Unadjusted period prevalence (%) 0.05 0.06 0.01
Median age at first event (years) 40.48 39.23 47.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
193
Matched controls
1930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
2237.1
231.1
184
17
104
Kela drug reimbursment
Thyroid insufficiency
2682.3
178.5
145
*
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
165.3
134
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1389.0
135.1
116
*
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
69.0
62
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
511.5
42.9
41
*
E03
ICD-10 Finland
Other hypothyroidism
146.5
35.0
36
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
399.5
34.0
33
*
A10AA02
ATC
NA
20.9
26.2
39
23
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
32.8
25.5
33
12
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
19.6
24.4
37
23
A10AA01
ATC
NA
24.0
24.0
34
17
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
10.2
23.6
49
62
A10AE04
ATC
insulin glargine; parenteral
9.8
22.6
48
63
T86
ICPC
Hypothyroidism/myxoedema
246.8
22.1
22
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
14.5
21.7
37
31
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
10.5
21.4
43
51
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
21.9
20.7
30
16
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
16.3
20.5
33
24
T89
ICPC
Diabetes insulin dependent
14.5
18.4
31
25
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
18.0
17
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
23.7
17.8
25
12
103
Kela drug reimbursment
Diabetes, insulin-treated
4.4
17.5
78
259
H04AA01
ATC
glucagon; nasal, parenteral
25.9
16.9
23
10
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.4
16.4
71
227
A10AE05
ATC
insulin detemir; parenteral
11.2
15.9
30
31
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
19.4
14.2
21
12
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
13.7
13
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
13.6
13.0
22
18
E10
ICD-10 Finland
Type 1 diabetes mellitus
17.9
11.9
18
11
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
46.1
11.1
13
*
K29.4
ICD-10 Finland
Chronic atrophic gastritis
23.1
10.9
15
7
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
116.1
10.5
11
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.6
10.0
36
92
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
58.0
9.7
11
*
SPAT1262
SPAT
Handing over of treatment supplies
3.6
9.5
46
155
H3603, E103
ICD-10 Finland
NA
38.7
9.1
11
*
A12AA04
ATC
calcium carbonate; oral
52.4
8.8
10
*
A11CC03
ATC
alfacalcidol; systemic
35.0
8.2
10
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
8.0
7.9
17
23
A10AA03
ATC
NA
19.3
7.7
11
6
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
19.3
7.7
11
6
B03BA03
ATC
hydroxocobalamin; parenteral
6.1
7.6
20
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
7.5
67
330
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
7.3
7
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
7.3
7
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
21.0
7.2
10
5
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
12.7
7.2
12
10
E66.01
ICD-10 Finland
Obesity due to excess calories
4.7
7.0
23
54
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.2
7.0
16
24
107
Kela drug reimbursment
Pernicious anaemia
11.5
6.9
12
11
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
17.5
6.8
10
6
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
41.6
6.8
8
*
H3601, E113
ICD-10 Finland
NA
41.6
6.8
8
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
41.6
6.8
8
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
23.5
6.7
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
6.6
43
174
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.2
6.4
35
125
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
+∞
6.3
6
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
6.3
6
*
H3600, E103
ICD-10 Finland
NA
27.7
6.3
8
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.1
6.2
14
21
A10AE06
ATC
insulin degludec; parenteral
7.1
6.2
14
21
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.4
6.1
60
308
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.6
6.1
47
212

Mortality – FinRegistry

Association

Association between endpoint E4_HYTHYPOSTINF and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYTHYPOSTINF 1.889 [1.3, 2.75] < 0.001
Birth year 0.995 [0.99, 1.0] 0.278

During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 430 females with E4_HYTHYPOSTINF died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYTHYPOSTINF.

N-year risk Females Males
1 0.184% No data
5 1.234% No data
10 2.848% No data
15 5.051% No data
20 9.149% No data

Relationships between endpoints

Index endpoint: E4_HYTHYPOSTINF – Postinfectious hypothyroidism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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