No definition available.
Disorders of pituitary gland, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_PITUDISNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
211 |
4. Check minimum number of eventsNone |
211 |
5. Include endpointsNone |
211 |
6. Filter based on genotype QC (FinnGen only) |
211 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of pituitary gland, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Exclusions for E4_PCOS_BROAD
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of other endocrine glands
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1524 | 908 | 598 |
| Only index persons | 1235 | 751 | 484 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 43.56 | 42.80 | 44.54 |
| Only index persons | 39.94 | 38.95 | 41.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 211 | 130 | 81 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 42.83 | 40.75 | 46.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 182
- Matched controls
- 1820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
98.0
85
*
H02AB09
ATC
hydrocortisone; systemic
209.8
68.3
67
5
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
58.5
53
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
50.4
46
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
296.4
46.2
45
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
203.4
46.2
46
*
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
+∞
45.8
42
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
28.9
27
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
27.8
26
*
H03AA01
ATC
levothyroxine sodium; systemic
5.7
24.4
90
267
25398
ICD-8 Finland
Diseases of pituitary gland, Alii definiti
+∞
23.4
22
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
50.2
22.1
26
6
25399
ICD-8 Finland
Diseases of pituitary gland, Other and unspecified
+∞
21.3
20
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
+∞
21.3
20
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
19.1
18
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
11.6
17.6
33
34
N04BC06
ATC
cabergoline; oral (dopamine agonists)
+∞
16.9
16
*
H01AC01
ATC
somatropin; parenteral
+∞
15.9
15
*
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
15.9
15
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
12.6
12
*
G02CB01
ATC
bromocriptine; systemic
19.8
12.3
18
10
301
Kela drug reimbursment
Growth hormone
+∞
11.6
11
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
127.7
11.6
12
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
11.6
10.6
19
18
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
116.4
10.5
11
*
E23.05
ICD-10 Finland
Lack of TSH
+∞
10.5
10
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.4
10.5
32
69
XCK00
NOMESCO Finland
Perimetry
5.6
8.4
24
48
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
+∞
8.4
8
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
8.4
8
*
2538X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of the pituitary and other syndromes of diencephalohypophyseal origin[MORBUS HYPOPHYSEOS SEU HYPOTHALAMI ALIA]
+∞
8.4
8
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
8.4
8
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
8.4
8
*
E23.03
ICD-10 Finland
Lack of ACTH
+∞
8.4
8
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
83.3
7.5
8
*
2539X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Unspecified
+∞
7.3
7
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
7.3
7
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
ZXC86
NOMESCO Finland
Use of endoscopic device
41.6
6.8
8
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
6.3
6
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
6.3
6
*
E23.06
ICD-10 Finland
Empty sella
+∞
6.3
6
*
E23.08
ICD-10 Finland
Hypopituitarism
+∞
6.3
6
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.7
6.2
26
78
121
Kela drug reimbursment
Severe hypofunction of sexual glands
9.1
6.2
12
14
Mortality – FinRegistry
↥Association
Association between endpoint E4_PITUDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PITUDISNAS | 2.384 [1.81, 3.14] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.063 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 396 females with E4_PITUDISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PITUDISNAS | 1.387 [0.99, 1.95] | 0.06 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 288 males with E4_PITUDISNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PITUDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.217% |
| 5 | 1.248% | 1.664% |
| 10 | 3.13% | 4.363% |
| 15 | 5.77% | 8.112% |
| 20 | 10.357% | 13.946% |
Relationships between endpoints
↥Index endpoint: E4_PITUDISNAS – Disorders of pituitary gland, other and/or unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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