Diseases of thymus

E4_THYMUSDIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E32
  • Cause of death: ICD-10 E32

2 out of 7 registries used, show all original rules.

67

4. Check minimum number of events

None

67

5. Include endpoints

83

6. Filter based on genotype QC (FinnGen only)

80

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Morbi thymi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 615 375 231
Only index persons 454 281 173
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 57.22 60.39 51.51
Only index persons 49.79 52.25 45.80

-FinnGen-

Key figures

All Female Male
Number of individuals 80 48 32
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 47.88 48.23 47.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
83
Matched controls
830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E32.9
ICD-10 Finland
Disease of thymus, unspecified
+∞
41.1
36
*
E32.0
ICD-10 Finland
Persistent hyperplasia of thymus
+∞
21.8
20
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
7.0
10.6
28
56
25499
ICD-8 Finland
Diseases of thymus gland
+∞
9.6
9
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
87.6
7.5
8
*
2540A
ICD-9 Finland
Diseases of thymus gland, Persistent hyperplasia of thymus
+∞
7.4
7
*
E32.8
ICD-10 Finland
Other diseases of thymus
+∞
6.3
6
*

Mortality – FinRegistry

Association

Association between endpoint E4_THYMUSDIS and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYMUSDIS 2.212 [1.49, 3.28] < 0.001
Birth year 0.991 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 234 females with E4_THYMUSDIS died.

Males

Parameter HR [95% CI] p-value
E4_THYMUSDIS 3.602 [1.75, 7.41] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 149 males with E4_THYMUSDIS died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYMUSDIS.

N-year risk Females Males
1 0.18% 0.795%
5 1.148% 4.018%
10 2.685% 9.576%
15 5.111% 17.15%
20 9.273% 29.089%

Relationships between endpoints

Index endpoint: E4_THYMUSDIS – Diseases of thymus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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