Age-related macular degeneration (whether dry or wet)

H7_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

6354

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H7_AMD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 6157 3247 2910
Unadjusted prevalence (%) 2.00 1.87 2.16
Mean age at first event (years) 74.57 74.77 74.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.14 [1.62, 2.84] 8.4e-8 1160
15 years 0.01 1.06 [0.85, 1.31] 6.2e-1 512
5 years 0.00 2.03 [1.73, 2.39] 1.8e-17 479
1 year - - - -

Correlations

Index endpoint: H7_AMD – Age-related macular degeneration (whether dry or wet)
GWS hits: 6

Survival analyses between endpoints

Plot

before Age-related macular degeneration (whether dry or wet)
after Age-related macular degeneration (whether dry or wet)

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Drugs most likely to be purchased after Age-related macular degeneration (whether dry or wet)