Hypothyroidism, levothyroxin purchases

HYPOTHY_LEVOTHY

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Medicine purchases: ATC H03AA01

42784

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Check pre-conditions, main-only, mode, ICD version None

39361

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Check minimum number of events

Min. number of events 3

39361

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Include endpoints None

39361

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HYPOTHY_LEVOTHY

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Hypothyroidism, levothyroxin purchases based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 38127 30611 7516
Unadjusted prevalence (%) 12.36 17.64 5.57
Mean age at first event (years) 52.14 50.65 58.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.35 [1.17, 1.57] 4.9e-5 2355
15 years 0.01 0.96 [0.84, 1.09] 5.4e-1 1211
5 years 0.00 1.73 [1.52, 1.96] 6.3e-17 602
1 year 0.00 1.33 [1.04, 1.70] 2.2e-2 84

Correlations

Index endpoint: HYPOTHY_LEVOTHY – Hypothyroidism, levothyroxin purchases
GWS hits: 37

Survival analyses between endpoints

Plot

before Hypothyroidism, levothyroxin purchases
after Hypothyroidism, levothyroxin purchases

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Drugs most likely to be purchased after Hypothyroidism, levothyroxin purchases