Hypothyroidism and >3 levothyroxin purchases

HYPOTHY_PURCHASE

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

HYPOTHYROIDISM

39875

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

39361

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HYPOTHY_PURCHASE

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Hypothyroidism and >3 levothyroxin purchases based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 38127 30611 7516
Unadjusted prevalence (%) 12.36 17.64 5.57
Mean age at first event (years) 52.14 50.65 58.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.23 [1.05, 1.44] 1.2e-2 2355
15 years 0.01 0.89 [0.78, 1.02] 9.4e-2 1211
5 years 0.00 1.64 [1.44, 1.86] 3.7e-14 602
1 year 0.00 1.27 [0.99, 1.62] 5.8e-2 84

Correlations

Index endpoint: HYPOTHY_PURCHASE – Hypothyroidism and >3 levothyroxin purchases
GWS hits: 37

Survival analyses between endpoints

Plot

before Hypothyroidism and >3 levothyroxin purchases
after Hypothyroidism and >3 levothyroxin purchases

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Drugs most likely to be purchased after Hypothyroidism and >3 levothyroxin purchases